| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
acetylcholinesterase (ache) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. |
2015-07-20 |
2023-08-13 |
Not clear |
| Izabela G Arruda, Francisco E G Guimarães, Romildo J Ramos, Nirton C S Vieir. Self-assembly of SiO2 nanoparticles for the potentiometric detection of neurotransmitter acetylcholine and its inhibitor. Journal of nanoscience and nanotechnology. vol 14. issue 9. 2015-07-16. PMID:25924313. |
the biological regulator of this neurotransmitter is acetylcholinesterase (ache), an enzyme that catalyzes the hydrolysis of ach to choline and acetic acid. |
2015-07-16 |
2023-08-13 |
human |
| Shani Shenhar-Tsarfaty, Shlomo Berliner, Natan M Bornstein, Hermona Sore. Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24254221. |
acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (ache and bche, respectively), which are also expressed in the serum. |
2015-04-06 |
2023-08-12 |
Not clear |
| Jonah Cheung, Veena Beri, Kazuro Shiomi, Terrone L Rosenberr. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24573600. |
acetylcholinesterase (ache) is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. |
2015-04-06 |
2023-08-12 |
human |
| De Lu Zhang, Jing Zhang, Chun Xiang Hu, Gao Hong Wang, Dun Hai Li, Yong Ding Li. Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins. Aquatic toxicology (Amsterdam, Netherlands). vol 157. 2015-03-02. PMID:25456236. |
morphological alterations and changes in neurotransmitter conduction functions of acetylcholinesterase (ache) and monoamine oxidase (mao) in zebrafish liver were detected at different time points 1-24h post-exposure. |
2015-03-02 |
2023-08-13 |
human |
| C Remya, K V Dileep, I Tintu, E J Variyar, C Sadasiva. Flavanone glycosides as acetylcholinesterase inhibitors: computational and experimental evidence. Indian journal of pharmaceutical sciences. vol 76. issue 6. 2015-01-16. PMID:25593395. |
acetylcholinesterase hydrolyzes the neurotransmitter called acetylcholine and is crucially involved in the regulation of neurotransmission. |
2015-01-16 |
2023-08-13 |
Not clear |
| Shin-Ichi Yokota, Kaai Nakamura, Midori Ando, Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi, Shigenobu Shibat. Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver. FEBS open bio. vol 4. 2014-11-10. PMID:25383314. |
because parasympathetic nervous system activity tends to attenuate the secretion of very-low-density-lipoprotein-triglyceride (vldl-tg) and increase tg stores in the liver, and serum cholinesterase activity is elevated in fatty liver disease, the inhibition of the parasympathetic neurotransmitter acetylcholinesterase (ache) may have some influence on hepatic lipid metabolism. |
2014-11-10 |
2023-08-13 |
mouse |
| Sony Pandey, Ayinampudi Sree, Dipti Priya Sethi, Chityal Ganesh Kumar, Sudha Kakollu, Lipsa Chowdhury, Soumya Suchismita Das. A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds. Microbial cell factories. vol 13. issue 1. 2014-10-28. PMID:24528673. |
acetylcholinesterase (ache) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. |
2014-10-28 |
2023-08-12 |
Not clear |
| Magdolna Pákáski, Agnes Fehér, Anna Juhász, Gergely Drótos, Orsike Csilla Fazekas, János Kovács, Zoltán Janka, János Kálmá. Serum adipokine levels modified by donepezil treatment in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 38. issue 2. 2014-06-27. PMID:23979024. |
neurotransmitter enhancement therapy with acetylcholinesterase inhibitors (acheis) is a clinically proven approach for patients with alzheimer's disease (ad). |
2014-06-27 |
2023-08-12 |
Not clear |
| Faiyaz Ahmed, Raza Murad Ghalib, P Sasikala, K K Mueen Ahme. Cholinesterase inhibitors from botanicals. Pharmacognosy reviews. vol 7. issue 14. 2014-06-24. PMID:24347920. |
decreased concentration of the neurotransmitter, acetylcholine (ach), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat ad and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2014-06-24 |
2023-08-12 |
Not clear |
| Amy Easton, Sethu Sankaranarayanan, An Tanghe, Dick Terwel, Alan X Lin, Nina Hoque, Clotilde Bourin, Huidong Gu, Michael Ahlijanian, Linda Bristo. Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease. Psychopharmacology. vol 230. issue 2. 2014-06-23. PMID:23783773. |
acetylcholinesterase inhibitors (acheis) are approved to treat the symptoms of mild to moderate alzheimer's disease by restoring acetylcholine levels at synapses where the neurotransmitter has been depleted due to neurodegeneration. |
2014-06-23 |
2023-08-12 |
mouse |
| Jonah Cheung, Ebony N Gary, Kazuro Shiomi, Terrone L Rosenberr. Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS medicinal chemistry letters. vol 4. issue 11. 2014-06-05. PMID:24900610. |
acetylcholinesterase is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. |
2014-06-05 |
2023-08-13 |
human |
| Sebastian Aguiar, Thomas Borowsk. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation research. vol 16. issue 4. 2014-05-05. PMID:23772955. |
current evidence suggests bm acts via the following mechanisms-anti-oxidant neuroprotection (via redox and enzyme induction), acetylcholinesterase inhibition and/or choline acetyltransferase activation, β-amyloid reduction, increased cerebral blood flow, and neurotransmitter modulation (acetylcholine [ach], 5-hydroxytryptamine [5-ht], dopamine [da]). |
2014-05-05 |
2023-08-12 |
Not clear |
| Sibelle Feitosa da Cunha Xavier Soares, Andréia Aguiar Vieira, Reinaldo Teixeira Delfino, José Daniel Figueroa-Villa. NMR determination of Electrophorus electricus acetylcholinesterase inhibition and reactivation by neutral oximes. Bioorganic & medicinal chemistry. vol 21. issue 18. 2014-03-26. PMID:23916150. |
the main target of ops is the inhibition of acetylcholinesterase (ache), an enzyme necessary for the control of the neurotransmitter acetylcholine (ach). |
2014-03-26 |
2023-08-12 |
Not clear |
| Leticia Vidal-Liñán, Juan Bella. Practical procedures for selected biomarkers in mussels, Mytilus galloprovincialis--implications for marine pollution monitoring. The Science of the total environment. vol 461-462. 2014-03-05. PMID:23712116. |
antioxidant enzymes (catalase [cat] and glutathione peroxidase [gpx]), a phase ii detoxification enzyme (glutathione s-transferase [gst]) and a neurotransmitter catabolism enzyme (acetylcholinesterase [ache]), were considered. |
2014-03-05 |
2023-08-12 |
cat |
| Miroslav Pohanka, Vojtech Adam, Rene Kize. An acetylcholinesterase-based chronoamperometric biosensor for fast and reliable assay of nerve agents. Sensors (Basel, Switzerland). vol 13. issue 9. 2014-02-27. PMID:23999806. |
the enzyme acetylcholinesterase (ache) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. |
2014-02-27 |
2023-08-12 |
Not clear |
| María Elena Sale. Cholinergic drugs as therapeutic tools in inflammatory diseases: participation of neuronal and non-neuronal cholinergic systems. Anti-inflammatory & anti-allergy agents in medicinal chemistry. vol 12. issue 2. 2013-11-12. PMID:23360259. |
this knowledge led to expand the role of ach as a neurotransmitter and to consider it as a "cytotransmitter" and also to evaluate the existence of a non-neuronal cholinergic system comprising ach, chat, acetylcholinesterase, and the nicotinic and muscarinic ach receptors, outside the nervous system. |
2013-11-12 |
2023-08-12 |
Not clear |
| b' Mirjana B Colovi\\xc4\\x87, Danijela Z Krsti\\xc4\\x87, Tamara D Lazarevi\\xc4\\x87-Pa\\xc5\\xa1ti, Aleksandra M Bond\\xc5\\xbei\\xc4\\x87, Vesna M Vasi\\xc4\\x8. Acetylcholinesterase inhibitors: pharmacology and toxicology. Current neuropharmacology. vol 11. issue 3. 2013-11-01. PMID:24179466.' |
acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2013-11-01 |
2023-08-12 |
Not clear |
| G A Reid, N Chilukuri, S Darves. Butyrylcholinesterase and the cholinergic system. Neuroscience. vol 234. 2013-10-25. PMID:23305761. |
the cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (chat) and its action terminated by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2013-10-25 |
2023-08-12 |
mouse |
| Xiugong Gao, Hsiuling Lin, Radharaman Ray, Prabhati Ra. Toxicogenomic studies of human neural cells following exposure to organophosphorus chemical warfare nerve agent VX. Neurochemical research. vol 38. issue 5. 2013-10-22. PMID:23440544. |
op compounds are considered acting primarily via cholinergic pathways by binding irreversibly to acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. |
2013-10-22 |
2023-08-12 |
human |