| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kosuke Yamamoto, Satoshi Shida, Yoshihiro Honda, Mariko Shono, Hiroshi Miyake, Suguru Oguri, Hikaru Sakamoto, Yoshie S Momonok. Overexpression of acetylcholinesterase gene in rice results in enhancement of shoot gravitropism. Biochemical and biophysical research communications. vol 465. issue 3. 2015-11-27. PMID:26277389. |
acetylcholine (ach), a known neurotransmitter in animals and acetylcholinesterase (ache) exists widely in plants, although its role in plant signal transduction is unclear. |
2015-11-27 |
2023-08-13 |
Not clear |
| Sangyun Lee, Ji-Hyun Kim, Sangyoub Le. Internal Diffusion-Controlled Enzyme Reaction: The Acetylcholinesterase Kinetics. Journal of chemical theory and computation. vol 8. issue 2. 2015-11-25. PMID:26596618. |
acetylcholinesterase is an enzyme with a very high turnover rate; it quenches the neurotransmitter, acetylcholine, at the synapse. |
2015-11-25 |
2023-08-13 |
Not clear |
| Da Xiao, Yan-Hui Lu, Qing-Li Shang, Dun-Lun Song, Xi-Wu Ga. Gene silencing of two acetylcholinesterases reveals their cholinergic and non-cholinergic functions in Rhopalosiphum padi and Sitobion avenae. Pest management science. vol 71. issue 4. 2015-11-16. PMID:24729410. |
the function of acetylcholinesterase (ache) is to terminate synaptic transmission by hydrolysing the neurotransmitter acetylcholine (ach) in the synaptic cleft, and thus it is an effective target for organophosphate (op) and carbamate (cb) insecticides. |
2015-11-16 |
2023-08-13 |
Not clear |
| Lucas H Hess, Alina Lyuleeva, Benno M Blaschke, Matthias Sachsenhauser, Max Seifert, Jose A Garrido, Frank Deube. Graphene transistors with multifunctional polymer brushes for biosensing applications. ACS applied materials & interfaces. vol 6. issue 12. 2015-10-16. PMID:24866105. |
to demonstrate the potential of this polymer brush functionalization scaffold, we modified solution-gated graphene field-effect transistors with the enzyme acetylcholinesterase and a transducing group, allowing the detection of the neurotransmitter acetylcholine. |
2015-10-16 |
2023-08-13 |
Not clear |
| b' Dragan Hrn\\xc4\\x8di\\xc4\\x87, Aleksandra Ra\\xc5\\xa1i\\xc4\\x87-Markovi\\xc4\\x87, Tihomir Stojkovi\\xc4\\x87, Milica Velimirovi\\xc4\\x87, Nela Pu\\xc5\\xa1ka\\xc5\\xa1, Radmila Obrenovi\\xc4\\x87, Djuro Macut, Veselinka Su\\xc5\\xa1i\\xc4\\x87, Vladimir Jakovljevi\\xc4\\x87, Dragan Djuric, Nata\\xc5\\xa1a Petronijevi\\xc4\\x87, Olivera Stanojlovi\\xc4\\x8. Hyperhomocysteinemia induced by methionine dietary nutritional overload modulates acetylcholinesterase activity in the rat brain. Molecular and cellular biochemistry. vol 396. issue 1-2. 2015-10-06. PMID:25052005.' |
acetylcholinesterase is a serine protease that rapidly hydrolyzes neurotransmitter acetylcholine. |
2015-10-06 |
2023-08-13 |
rat |
| Ying Li, Shan Hai, Yan Zhou, Bi Rong Don. Cholinesterase inhibitors for rarer dementias associated with neurological conditions. The Cochrane database of systematic reviews. issue 3. 2015-10-02. PMID:25734590. |
cholinesterase inhibitors are hypothesised to work by inhibiting the enzyme acetylcholinesterase (ache) which breaks down the neurotransmitter acetylcholine. |
2015-10-02 |
2023-08-13 |
Not clear |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
acetylcholinesterase (ache) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. |
2015-07-20 |
2023-08-13 |
Not clear |
| Izabela G Arruda, Francisco E G Guimarães, Romildo J Ramos, Nirton C S Vieir. Self-assembly of SiO2 nanoparticles for the potentiometric detection of neurotransmitter acetylcholine and its inhibitor. Journal of nanoscience and nanotechnology. vol 14. issue 9. 2015-07-16. PMID:25924313. |
the biological regulator of this neurotransmitter is acetylcholinesterase (ache), an enzyme that catalyzes the hydrolysis of ach to choline and acetic acid. |
2015-07-16 |
2023-08-13 |
human |
| Shani Shenhar-Tsarfaty, Shlomo Berliner, Natan M Bornstein, Hermona Sore. Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24254221. |
acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (ache and bche, respectively), which are also expressed in the serum. |
2015-04-06 |
2023-08-12 |
Not clear |
| Jonah Cheung, Veena Beri, Kazuro Shiomi, Terrone L Rosenberr. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24573600. |
acetylcholinesterase (ache) is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. |
2015-04-06 |
2023-08-12 |
human |
| De Lu Zhang, Jing Zhang, Chun Xiang Hu, Gao Hong Wang, Dun Hai Li, Yong Ding Li. Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins. Aquatic toxicology (Amsterdam, Netherlands). vol 157. 2015-03-02. PMID:25456236. |
morphological alterations and changes in neurotransmitter conduction functions of acetylcholinesterase (ache) and monoamine oxidase (mao) in zebrafish liver were detected at different time points 1-24h post-exposure. |
2015-03-02 |
2023-08-13 |
human |
| C Remya, K V Dileep, I Tintu, E J Variyar, C Sadasiva. Flavanone glycosides as acetylcholinesterase inhibitors: computational and experimental evidence. Indian journal of pharmaceutical sciences. vol 76. issue 6. 2015-01-16. PMID:25593395. |
acetylcholinesterase hydrolyzes the neurotransmitter called acetylcholine and is crucially involved in the regulation of neurotransmission. |
2015-01-16 |
2023-08-13 |
Not clear |
| Shin-Ichi Yokota, Kaai Nakamura, Midori Ando, Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi, Shigenobu Shibat. Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver. FEBS open bio. vol 4. 2014-11-10. PMID:25383314. |
because parasympathetic nervous system activity tends to attenuate the secretion of very-low-density-lipoprotein-triglyceride (vldl-tg) and increase tg stores in the liver, and serum cholinesterase activity is elevated in fatty liver disease, the inhibition of the parasympathetic neurotransmitter acetylcholinesterase (ache) may have some influence on hepatic lipid metabolism. |
2014-11-10 |
2023-08-13 |
mouse |
| Sony Pandey, Ayinampudi Sree, Dipti Priya Sethi, Chityal Ganesh Kumar, Sudha Kakollu, Lipsa Chowdhury, Soumya Suchismita Das. A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds. Microbial cell factories. vol 13. issue 1. 2014-10-28. PMID:24528673. |
acetylcholinesterase (ache) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. |
2014-10-28 |
2023-08-12 |
Not clear |
| Magdolna Pákáski, Agnes Fehér, Anna Juhász, Gergely Drótos, Orsike Csilla Fazekas, János Kovács, Zoltán Janka, János Kálmá. Serum adipokine levels modified by donepezil treatment in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 38. issue 2. 2014-06-27. PMID:23979024. |
neurotransmitter enhancement therapy with acetylcholinesterase inhibitors (acheis) is a clinically proven approach for patients with alzheimer's disease (ad). |
2014-06-27 |
2023-08-12 |
Not clear |
| Faiyaz Ahmed, Raza Murad Ghalib, P Sasikala, K K Mueen Ahme. Cholinesterase inhibitors from botanicals. Pharmacognosy reviews. vol 7. issue 14. 2014-06-24. PMID:24347920. |
decreased concentration of the neurotransmitter, acetylcholine (ach), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat ad and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2014-06-24 |
2023-08-12 |
Not clear |
| Amy Easton, Sethu Sankaranarayanan, An Tanghe, Dick Terwel, Alan X Lin, Nina Hoque, Clotilde Bourin, Huidong Gu, Michael Ahlijanian, Linda Bristo. Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease. Psychopharmacology. vol 230. issue 2. 2014-06-23. PMID:23783773. |
acetylcholinesterase inhibitors (acheis) are approved to treat the symptoms of mild to moderate alzheimer's disease by restoring acetylcholine levels at synapses where the neurotransmitter has been depleted due to neurodegeneration. |
2014-06-23 |
2023-08-12 |
mouse |
| Jonah Cheung, Ebony N Gary, Kazuro Shiomi, Terrone L Rosenberr. Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS medicinal chemistry letters. vol 4. issue 11. 2014-06-05. PMID:24900610. |
acetylcholinesterase is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. |
2014-06-05 |
2023-08-13 |
human |
| Sebastian Aguiar, Thomas Borowsk. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation research. vol 16. issue 4. 2014-05-05. PMID:23772955. |
current evidence suggests bm acts via the following mechanisms-anti-oxidant neuroprotection (via redox and enzyme induction), acetylcholinesterase inhibition and/or choline acetyltransferase activation, β-amyloid reduction, increased cerebral blood flow, and neurotransmitter modulation (acetylcholine [ach], 5-hydroxytryptamine [5-ht], dopamine [da]). |
2014-05-05 |
2023-08-12 |
Not clear |
| Sibelle Feitosa da Cunha Xavier Soares, Andréia Aguiar Vieira, Reinaldo Teixeira Delfino, José Daniel Figueroa-Villa. NMR determination of Electrophorus electricus acetylcholinesterase inhibition and reactivation by neutral oximes. Bioorganic & medicinal chemistry. vol 21. issue 18. 2014-03-26. PMID:23916150. |
the main target of ops is the inhibition of acetylcholinesterase (ache), an enzyme necessary for the control of the neurotransmitter acetylcholine (ach). |
2014-03-26 |
2023-08-12 |
Not clear |