| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zaheer-ul-Haq, Sobia Ahsan Halim, Reaz Uddin, Jeffry D Madur. Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 28. issue 8. 2010-08-12. PMID:20447848. |
acetylcholinesterase (ache) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2010-08-12 |
2023-08-12 |
Not clear |
| Cristina López-Galindo, Luis Vargas-Chacoff, Enrique Nebot, José F Casanueva, Daniel Rubio, Montserrat Solé, Juan Miguel Mancer. Sublethal effects of the organic antifoulant Mexel(R)432 on osmoregulation and xenobiotic detoxification in the flatfish Solea senegalensis. Chemosphere. vol 79. issue 1. 2010-06-14. PMID:20110101. |
other parameters tested were the antioxidant enzymes (catalase, cat; glutathione peroxidase, gpx; and glutathione reductase, gr), xenobiotic metabolism defenses involved in detoxification (carboxylesterase, cbe; 7-ethoxyresorufin o-deethylase, erod; and glutathione s-transferase, gst) and the neurotransmitter acetylcholinesterase (ache) activity. |
2010-06-14 |
2023-08-12 |
cat |
| Luke A J O'Neil. Boosting the brain's ability to block inflammation via microRNA-132. Immunity. vol 31. issue 6. 2010-02-09. PMID:20064444. |
(2009) describe how mir-132 mediates an anti-inflammatory effect via the targeting of acetylcholinesterase, leading to an increase in the neurotransmitter acetylcholine. |
2010-02-09 |
2023-08-12 |
Not clear |
| Jana Zdarova Karasova, Jiri Bajgar, Daniel Jun, Ruzena Pavlikova, Kamil Kuc. Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX. Neurotoxicity research. vol 16. issue 4. 2010-01-22. PMID:19728005. |
the toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (ache; ec 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. |
2010-01-22 |
2023-08-12 |
rat |
| Swaran J S Flora, Kapil Bhatt, Ashish Meht. Arsenic moiety in gallium arsenide is responsible for neuronal apoptosis and behavioral alterations in rats. Toxicology and applied pharmacology. vol 240. issue 2. 2009-10-08. PMID:19460394. |
we noted that ros induced oxidative stress caused changes in the brain neurotransmitter levels, acetylcholinesterase and nitric oxide synthase, leading to loss of memory and learning in rats. |
2009-10-08 |
2023-08-12 |
rat |
| Haixia Dang, Lihua Sun, Xinmin Liu, Bo Peng, Qiong Wang, William Jia, Ying Chen, Aihua Pan, Peigen Xia. Preventive action of Kai Xin San aqueous extract on depressive-like symptoms and cognition deficit induced by chronic mild stress. Experimental biology and medicine (Maywood, N.J.). vol 234. issue 7. 2009-08-27. PMID:19429857. |
serum corticosterone and adrenocorticotropic hormone (acth) levels, acetylcholinesterase (ache) protein expression in the hippocampus, and monoamine neurotransmitter concentrations in the prefrontal cortex and hippocampus were also determined to elucidate the neurochemical mechanisms. |
2009-08-27 |
2023-08-12 |
Not clear |
| Ellen G Duysen, Bin Li, Oksana Lockridg. The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. Expert opinion on drug metabolism & toxicology. vol 5. issue 5. 2009-07-08. PMID:19416087. |
bche serves as a backup for acetylcholinesterase by hydrolyzing the neurotransmitter acetylcholine in acetylcholinesterase knockout mice. |
2009-07-08 |
2023-08-12 |
mouse |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18765251. |
diisopropylfluorophosphate (dfp) elicits cholinergic toxicity by inhibiting acetylcholinesterase, leading to accumulation of the neurotransmitter acetylcholine and excessive stimulation of cholinergic receptors throughout the body. |
2009-03-26 |
2023-08-12 |
rat |
| Jennifer M Bui, J Andrew McCammo. Intrinsic conformational flexibility of acetylcholinesterase. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18452905. |
to understand the dynamical properties of acetylcholinesterase (ache) in rapid termination of cationic neurotransmitter, acetylcholine at neurosynaptic junctions, multiple molecular dynamics (md) trajectories of ache in the presence and absence of its inhibitors [j.m. |
2008-12-10 |
2023-08-12 |
Not clear |
| Wei Su, Jun Wu, Wei-Yuan Ye, Xue-Jun Zhan. A monoclonal antibody against synaptic AChE: a useful tool for detecting apoptotic cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18538755. |
the classical function of acetylcholinesterase (ache) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ach). |
2008-12-10 |
2023-08-12 |
Not clear |
| Israel Silman, Joel L Sussma. Acetylcholinesterase: how is structure related to function? Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18586019. |
in accordance with its biological role, termination of neurotransmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase is one of nature's most efficient enzymes. |
2008-12-10 |
2023-08-12 |
Not clear |
| Michal Alon, Fishel Alon, Ralf Nauen, Shai Mori. Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associated with a point mutation in an ace1-type acetylcholinesterase and overexpression of carboxylesterase. Insect biochemistry and molecular biology. vol 38. issue 10. 2008-12-10. PMID:18721883. |
organophosphate (op) insecticides are inhibitors of the enzyme acetylcholinesterase (ache), which terminates nerve impulses by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2008-12-10 |
2023-08-12 |
Not clear |
| Rick L Williams, Gary J Mihlan, Abraham J Tobi. Modeling cholinesterase activity for human dietary risk assessment of carbamate insecticides. Risk analysis : an official publication of the Society for Risk Analysis. vol 28. issue 4. 2008-11-14. PMID:18631301. |
carbamates are a class of chemicals that inhibit the activity of acetylcholinesterase in humans, an enzyme involved in the regulation of the neurotransmitter acetylcholine. |
2008-11-14 |
2023-08-12 |
human |
| Marko Zivin, Peter Pregel. Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system. Psychiatria Danubina. vol 20. issue 2. 2008-09-26. PMID:18587286. |
acetylcholinesterase (ache), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles. |
2008-09-26 |
2023-08-12 |
Not clear |
| Michal Harel, Leilani K Sonoda, Israel Silman, Joel L Sussman, Terrone L Rosenberr. Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site. Journal of the American Chemical Society. vol 130. issue 25. 2008-09-15. PMID:18512913. |
acetylcholinesterase plays a key role in cholinergic synaptic transmission by hydrolyzing the neurotransmitter acetylcholine with one of the highest known catalytic rate constants. |
2008-09-15 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, Peter Klein, Weiming Luo, Yazhou Li, Harold W Holloway, David Tweedie, Nigel H Grei. Kinetics of human serum butyrylcholinesterase inhibition by a novel experimental Alzheimer therapeutic, dihydrobenzodioxepine cymserine. Neurochemical research. vol 33. issue 5. 2008-08-11. PMID:17985237. |
cholinergic loss is the single most replicated neurotransmitter deficiency in alzheimer's disease (ad) and has led to the use of acetylcholinesterase inhibitors (ache-is) and unselective cholinesterase inhibitors (che-is) as the mainstay of treatment. |
2008-08-11 |
2023-08-12 |
human |
| Wei Zhao, Si-Xin Sun, Jing-Juan Xu, Hong-Yuan Chen, Xiao-Jian Cao, Xiao-Hong Gua. Electrochemical identification of the property of peripheral nerve fiber based on a biocompatible polymer film via in situ incorporating gold nanoparticles. Analytical chemistry. vol 80. issue 10. 2008-08-11. PMID:18363334. |
we report a simple electrochemical method for the identification of properties of peripheral nerve fibers, based on the detection of a neurotransmitter enzyme, acetylcholinesterase (ache). |
2008-08-11 |
2023-08-12 |
cattle |
| Hai Yan Zhang, Han Yan, Xi Can Tan. Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. Cellular and molecular neurobiology. vol 28. issue 2. 2008-07-30. PMID:17657601. |
the use of acetylcholinesterase inhibitors to decrease the breakdown of the neurotransmitter acetylcholine has been the main symptomatic therapy for mild to moderate alzheimer's patients, though the etiology of alzheimer's disease remains unclear and seems to involve multiple factors. |
2008-07-30 |
2023-08-12 |
Not clear |
| Bozica Radić, Ana Lucić Vrdoljak, Davor Zeljezić, Nino Fuchs, Suzana Berend, Nevenka Kopja. Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. Acta biochimica Polonica. vol 54. issue 3. 2008-07-11. PMID:17713603. |
the function of acetylcholinesterase (ache) is the rapid hydrolysis of the neurotransmitter acetylcholine (ach), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. |
2008-07-11 |
2023-08-12 |
human |
| Jere R Virta, Tuula Tolvanen, Kjell Någren, Anna Brück, Anne Roivainen, Juha O Rinn. 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49. issue 3. 2008-05-16. PMID:18287260. |
the neurotransmitter acetylcholine is hydrolyzed in the synaptic clefts by 2 enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2008-05-16 |
2023-08-12 |
human |