| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ellen G Duysen, Bin Li, Oksana Lockridg. The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. Expert opinion on drug metabolism & toxicology. vol 5. issue 5. 2009-07-08. PMID:19416087. |
bche serves as a backup for acetylcholinesterase by hydrolyzing the neurotransmitter acetylcholine in acetylcholinesterase knockout mice. |
2009-07-08 |
2023-08-12 |
mouse |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18765251. |
diisopropylfluorophosphate (dfp) elicits cholinergic toxicity by inhibiting acetylcholinesterase, leading to accumulation of the neurotransmitter acetylcholine and excessive stimulation of cholinergic receptors throughout the body. |
2009-03-26 |
2023-08-12 |
rat |
| Jennifer M Bui, J Andrew McCammo. Intrinsic conformational flexibility of acetylcholinesterase. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18452905. |
to understand the dynamical properties of acetylcholinesterase (ache) in rapid termination of cationic neurotransmitter, acetylcholine at neurosynaptic junctions, multiple molecular dynamics (md) trajectories of ache in the presence and absence of its inhibitors [j.m. |
2008-12-10 |
2023-08-12 |
Not clear |
| Wei Su, Jun Wu, Wei-Yuan Ye, Xue-Jun Zhan. A monoclonal antibody against synaptic AChE: a useful tool for detecting apoptotic cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18538755. |
the classical function of acetylcholinesterase (ache) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ach). |
2008-12-10 |
2023-08-12 |
Not clear |
| Israel Silman, Joel L Sussma. Acetylcholinesterase: how is structure related to function? Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18586019. |
in accordance with its biological role, termination of neurotransmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase is one of nature's most efficient enzymes. |
2008-12-10 |
2023-08-12 |
Not clear |
| Michal Alon, Fishel Alon, Ralf Nauen, Shai Mori. Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associated with a point mutation in an ace1-type acetylcholinesterase and overexpression of carboxylesterase. Insect biochemistry and molecular biology. vol 38. issue 10. 2008-12-10. PMID:18721883. |
organophosphate (op) insecticides are inhibitors of the enzyme acetylcholinesterase (ache), which terminates nerve impulses by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2008-12-10 |
2023-08-12 |
Not clear |
| Rick L Williams, Gary J Mihlan, Abraham J Tobi. Modeling cholinesterase activity for human dietary risk assessment of carbamate insecticides. Risk analysis : an official publication of the Society for Risk Analysis. vol 28. issue 4. 2008-11-14. PMID:18631301. |
carbamates are a class of chemicals that inhibit the activity of acetylcholinesterase in humans, an enzyme involved in the regulation of the neurotransmitter acetylcholine. |
2008-11-14 |
2023-08-12 |
human |
| Marko Zivin, Peter Pregel. Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system. Psychiatria Danubina. vol 20. issue 2. 2008-09-26. PMID:18587286. |
acetylcholinesterase (ache), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles. |
2008-09-26 |
2023-08-12 |
Not clear |
| Michal Harel, Leilani K Sonoda, Israel Silman, Joel L Sussman, Terrone L Rosenberr. Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site. Journal of the American Chemical Society. vol 130. issue 25. 2008-09-15. PMID:18512913. |
acetylcholinesterase plays a key role in cholinergic synaptic transmission by hydrolyzing the neurotransmitter acetylcholine with one of the highest known catalytic rate constants. |
2008-09-15 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, Peter Klein, Weiming Luo, Yazhou Li, Harold W Holloway, David Tweedie, Nigel H Grei. Kinetics of human serum butyrylcholinesterase inhibition by a novel experimental Alzheimer therapeutic, dihydrobenzodioxepine cymserine. Neurochemical research. vol 33. issue 5. 2008-08-11. PMID:17985237. |
cholinergic loss is the single most replicated neurotransmitter deficiency in alzheimer's disease (ad) and has led to the use of acetylcholinesterase inhibitors (ache-is) and unselective cholinesterase inhibitors (che-is) as the mainstay of treatment. |
2008-08-11 |
2023-08-12 |
human |
| Wei Zhao, Si-Xin Sun, Jing-Juan Xu, Hong-Yuan Chen, Xiao-Jian Cao, Xiao-Hong Gua. Electrochemical identification of the property of peripheral nerve fiber based on a biocompatible polymer film via in situ incorporating gold nanoparticles. Analytical chemistry. vol 80. issue 10. 2008-08-11. PMID:18363334. |
we report a simple electrochemical method for the identification of properties of peripheral nerve fibers, based on the detection of a neurotransmitter enzyme, acetylcholinesterase (ache). |
2008-08-11 |
2023-08-12 |
cattle |
| Hai Yan Zhang, Han Yan, Xi Can Tan. Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. Cellular and molecular neurobiology. vol 28. issue 2. 2008-07-30. PMID:17657601. |
the use of acetylcholinesterase inhibitors to decrease the breakdown of the neurotransmitter acetylcholine has been the main symptomatic therapy for mild to moderate alzheimer's patients, though the etiology of alzheimer's disease remains unclear and seems to involve multiple factors. |
2008-07-30 |
2023-08-12 |
Not clear |
| Bozica Radić, Ana Lucić Vrdoljak, Davor Zeljezić, Nino Fuchs, Suzana Berend, Nevenka Kopja. Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. Acta biochimica Polonica. vol 54. issue 3. 2008-07-11. PMID:17713603. |
the function of acetylcholinesterase (ache) is the rapid hydrolysis of the neurotransmitter acetylcholine (ach), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. |
2008-07-11 |
2023-08-12 |
human |
| Jere R Virta, Tuula Tolvanen, Kjell Någren, Anna Brück, Anne Roivainen, Juha O Rinn. 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49. issue 3. 2008-05-16. PMID:18287260. |
the neurotransmitter acetylcholine is hydrolyzed in the synaptic clefts by 2 enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2008-05-16 |
2023-08-12 |
human |
| Subramanya Karanth, Todd Holbrook, Charles MacAllister, Carey N Pop. Selective inhibition of butyrylcholinesterase in vivo in horses by the feed-through larvacide Equitrol. Regulatory toxicology and pharmacology : RTP. vol 50. issue 2. 2008-04-23. PMID:18166255. |
as with other organophosphates, tcvp elicits toxicity by inhibiting acetylcholinesterase, leading to accumulation of the neurotransmitter acetylcholine and cholinergic signs. |
2008-04-23 |
2023-08-12 |
Not clear |
| Mercedes Villarroya, Antonio G García, José Marco-Contelles, Manuela G Lópe. An update on the pharmacology of galantamine. Expert opinion on investigational drugs. vol 16. issue 12. 2008-02-25. PMID:18042006. |
this review summarises the current state of the art concerning the pharmacology of galantamine, focusing on the most important details of its possibilities as an acetylcholinesterase inhibitor, an allosteric potentiator of neuronal nicotinic receptors for acetylcholine, a modulator of neurotransmitter release, and an agent causing neuroprotection through an antiapoptotic action. |
2008-02-25 |
2023-08-12 |
Not clear |
| Alemayehu A Gorfe, Chia-en A Chang, Ivaylo Ivanov, J Andrew McCammo. Dynamics of the acetylcholinesterase tetramer. Biophysical journal. vol 94. issue 4. 2008-02-11. PMID:17921202. |
acetylcholinesterase rapidly hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses, including the neuromuscular junction. |
2008-02-11 |
2023-08-12 |
Not clear |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Benzhuo Lu, Y C Zhou, Gary A Huber, Stephen D Bond, Michael J Holst, J Andrew McCammo. Electrodiffusion: a continuum modeling framework for biomolecular systems with realistic spatiotemporal resolution. The Journal of chemical physics. vol 127. issue 13. 2007-11-26. PMID:17919055. |
the second is a time-dependent diffusion process: the consumption of the neurotransmitter acetylcholine by acetylcholinesterase, determined by the se and a single uncoupled solution of the poisson-boltzmann equation. |
2007-11-26 |
2023-08-12 |
Not clear |
| Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboun. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Molecular biology of the cell. vol 18. issue 8. 2007-10-17. PMID:17538015. |
acetylcholinesterase (ache) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses. |
2007-10-17 |
2023-08-12 |
mouse |