| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maurizio Recanatini, Piero Valent. Acetylcholinesterase inhibitors as a starting point towards improved Alzheimer's disease therapeutics. Current pharmaceutical design. vol 10. issue 25. 2006-04-10. PMID:15544505. |
in this context, in a perspective of drug discovery, the enzyme acetylcholinesterase (ache) holds a key position, as it is a main target for cholinomimetic ad drugs being responsible for the breakdown of the neurotransmitter, and it is also involved in the aggregation of a beta and the formation of the neurotoxic fibrils. |
2006-04-10 |
2023-08-12 |
Not clear |
| J Birk. Cholinesterase inhibitors for Alzheimer's disease. The Cochrane database of systematic reviews. issue 1. 2006-04-07. PMID:16437532. |
since the introduction of the first cholinesterase inhibitor (chei) in 1997, most clinicians and probably most patients would consider the cholinergic drugs, donepezil, galantamine and rivastigmine, to be the first line pharmacotherapy for mild to moderate alzheimer's disease.the drugs have slightly different pharmacological properties, but they all work by inhibiting the breakdown of acetylcholine, an important neurotransmitter associated with memory, by blocking the enzyme acetylcholinesterase. |
2006-04-07 |
2023-08-12 |
Not clear |
| Bryan F Curtin, Lauren M Tetz, Jaimee R Compton, Bhupendra P Doctor, Richard K Gordon, Madhusoodana P Nambia. Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. Journal of cellular biochemistry. vol 96. issue 4. 2006-02-21. PMID:16149071. |
the biological effects of organophosphorous (op) chemical warfare nerve agents (cwnas) are exerted by inhibition of acetylcholinesterase (ache), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. |
2006-02-21 |
2023-08-12 |
human |
| Nigel H Greig, Tadanobu Utsuki, Donald K Ingram, Yue Wang, Giancarlo Pepeu, Carla Scali, Qian-Sheng Yu, Jacek Mamczarz, Harold W Holloway, Tony Giordano, DeMao Chen, Katsutoshi Furukawa, Kumar Sambamurti, Arnold Brossi, Debomoy K Lahir. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16275899. |
like acetylcholinesterase, butyrylcholinesterase (bche) inactivates the neurotransmitter acetylcholine (ach) and is hence a viable therapeutic target in alzheimer's disease, which is characterized by a cholinergic deficit. |
2006-01-12 |
2023-08-12 |
mouse |
| Filomena A Carvalho, Luís M Graça, João Martins-Silva, Carlota Saldanh. Biochemical characterization of human umbilical vein endothelial cell membrane bound acetylcholinesterase. The FEBS journal. vol 272. issue 21. 2005-12-13. PMID:16262697. |
acetylcholinesterase is an enzyme whose best-known function is to hydrolyze the neurotransmitter acetylcholine. |
2005-12-13 |
2023-08-12 |
human |
| Fernando Cañadas, Diana Cardona, Eva Dávila, Fernando Sánchez-Sante. Long-term neurotoxicity of chlorpyrifos: spatial learning impairment on repeated acquisition in a water maze. Toxicological sciences : an official journal of the Society of Toxicology. vol 85. issue 2. 2005-08-18. PMID:15772369. |
their major mechanism of acute toxic action is the inhibition of acetylcholinesterase, which is responsible for the degradation of the neurotransmitter acetylcholine. |
2005-08-18 |
2023-08-12 |
rat |
| Hiroto Tachikawa, Manabu Igarashi, Jun Nishihira, Teruo Ishibash. Ab initio model study on acetylcholinesterase catalysis: potential energy surfaces of the proton transfer reactions. Journal of photochemistry and photobiology. B, Biology. vol 79. issue 1. 2005-07-29. PMID:15792875. |
ab initio molecular orbital (mo) and hybrid density functional theory (dft) calculations have been applied to the initial step of the acylation reaction catalyzed by acetylcholinesterase (ache), which is the nucleophiric addition of ser200 in catalytic triads to a neurotransmitter acetylcholine (ach). |
2005-07-29 |
2023-08-12 |
Not clear |
| Asaad Khalid, M Kamran Azim, Shehnaz Parveen, Atta-ur-Rahman, M Iqbal Choudhar. Structural basis of acetylcholinesterase inhibition by triterpenoidal alkaloids. Biochemical and biophysical research communications. vol 331. issue 4. 2005-07-19. PMID:15959931. |
acetylcholinesterase plays a crucial role in the metabolism of neurotransmitter, acetylcholine. |
2005-07-19 |
2023-08-12 |
Not clear |
| Sabine Traver, Bénédicte Salthun-Lassalle, Marc Marien, Etienne C Hirsch, Francis Colpaert, Patrick P Miche. The neurotransmitter noradrenaline rescues septal cholinergic neurons in culture from degeneration caused by low-level oxidative stress. Molecular pharmacology. vol 67. issue 6. 2005-07-14. PMID:15784847. |
in this study, we showed that cholinergic neurons identified by acetylcholinesterase cytochemistry or choline acetyl transferase immunocytochemistry are rescued efficiently by the neurotransmitter noradrenaline (na). |
2005-07-14 |
2023-08-12 |
rat |
| Xavier Cousin, Uwe Strähle, Arnaud Chatonne. Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 27. issue 2. 2005-05-16. PMID:15666354. |
acetylcholinesterase (ache) hydrolyses acetylcholine (ach) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. |
2005-05-16 |
2023-08-12 |
Not clear |
| Samuel P Fletcher, Brian C Geyer, Amy Smith, Tama Evron, Lokesh Joshi, Hermona Soreq, Tsafrir S Mo. Tissue distribution of cholinesterases and anticholinesterases in native and transgenic tomato plants. Plant molecular biology. vol 55. issue 1. 2005-01-13. PMID:15604663. |
acetylcholinesterase, a major component of the central and peripheral nervous systems, is ubiquitous among multicellular animals, where its main function is to terminate synaptic transmission by hydrolyzing the neurotransmitter, acetylcholine. |
2005-01-13 |
2023-08-12 |
human |
| Gerald B Downes, Michael Granat. Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental biology. vol 270. issue 1. 2004-07-02. PMID:15136152. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine. |
2004-07-02 |
2023-08-12 |
zebrafish |
| Kwok-On Lai, Yu Chen, Hoi-Man Po, Ka-Chun Lok, Ke Gong, Nancy Y I. Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expression. The Journal of biological chemistry. vol 279. issue 14. 2004-05-11. PMID:14729671. |
by using microarray analysis, we have identified acetylcholinesterase, the critical enzyme that hydrolyzed the neurotransmitter acetylcholine at the nmj, as a downstream target gene of the jak/stat pathway in muscle. |
2004-05-11 |
2023-08-12 |
mouse |
| Fernando Sánchez-Santed, Fernando Cañadas, Pilar Flores, Matilde López-Grancha, Diana Cardon. Long-term functional neurotoxicity of paraoxon and chlorpyrifos: behavioural and pharmacological evidence. Neurotoxicology and teratology. vol 26. issue 2. 2004-05-10. PMID:15019964. |
the major mechanism of acute toxic action is the inhibition of acetylcholinesterase (ache), which is responsible for the degradation of the neurotransmitter acetylcholine. |
2004-05-10 |
2023-08-12 |
Not clear |
| Yvain Nicolet, Oksana Lockridge, Patrick Masson, Juan C Fontecilla-Camps, Florian Nacho. Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products. The Journal of biological chemistry. vol 278. issue 42. 2003-12-03. PMID:12869558. |
they are divided into two groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter acetylcholine, and butyrylcholinesterase of unknown function. |
2003-12-03 |
2023-08-12 |
human |
| Edgar Luttmann, Elmar Linnemann, Gregor Fel. Galanthamine as bis-functional ligand for the acetylcholinesterase. Journal of molecular modeling. vol 8. issue 6. 2003-08-18. PMID:12140604. |
acetylcholinesterase plays a key role in the development of alzheimer's disease as this enzyme is responsible for cleavage of the neurotransmitter acetylcholine, and, according to recent investigations, also promotes aggregation of beta-amyloid peptides, which causes plaque formation in synaptic areas. |
2003-08-18 |
2023-08-12 |
Not clear |
| Timothy A Sanders, Andrew Lumsden, Clifton W Ragsdal. Arcuate plan of chick midbrain development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486167. |
in the mantle layer of the ventral midbrain, an arcuate series of neuronal cell columns (midbrain arcs) is demonstrated by acetylcholinesterase histochemistry and gene expression for class iii beta-tubulin, homeodomain transcription factors, and neurotransmitter synthetic enzymes. |
2003-01-23 |
2023-08-12 |
chicken |
| L Lee, S A Kang, H O Lee, B H Lee, I K Jung, J E Lee, Y S Ho. Effect of supplementation of vitamin E and vitamin C on brain acetylcholinesterase activity and neurotransmitter levels in rats treated with scopolamine, an inducer of dementia. Journal of nutritional science and vitaminology. vol 47. issue 5. 2002-09-10. PMID:11814146. |
effect of supplementation of vitamin e and vitamin c on brain acetylcholinesterase activity and neurotransmitter levels in rats treated with scopolamine, an inducer of dementia. |
2002-09-10 |
2023-08-12 |
rat |
| S D Skaper, G L Adelson, J E Seegmille. Metabolism of biogenic amines in neuroblastoma and glioma cells in culture. Journal of neurochemistry. vol 27. issue 5. 2002-08-27. PMID:12170589. |
the occurrence of considerable mao and acetylcholinesterase activities in glioma cells may indicate a role for these cells in neurotransmitter inactivation. |
2002-08-27 |
2023-08-12 |
mouse |
| M Shapira, C K Thompson, H Soreq, G E Robinso. Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies. Journal of molecular neuroscience : MN. vol 17. issue 1. 2002-05-10. PMID:11665858. |
because acetylcholinesterase (ache) hydrolyzes acetylcholine, a major neurotransmitter associated with learning in the insect brain, we searched for changes in ache expression in the brain during bee behavioral development. |
2002-05-10 |
2023-08-12 |
bee |