| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E E Tyrala, S V Mathews, G S Ra. Effect of intrauterine exposure to cocaine on acetylcholinesterase in primary cultures of fetal mouse brain cells. Neurotoxicology and teratology. vol 14. issue 4. 1992-10-15. PMID:1522827. |
the effect of in utero exposure to cocaine on the developmental pattern of acetylcholinesterase (ache), a major regulator of the central nervous system neurotransmitter acetylcholine, was studied in fetal brain cell cultures collected from mice on gestational day 15 after maternal exposure to cocaine from gestational days 6-14. |
1992-10-15 |
2023-08-11 |
mouse |
| S K Dutta, K Das, B Ghosh, C F Blackma. Dose dependence of acetylcholinesterase activity in neuroblastoma cells exposed to modulated radio-frequency electromagnetic radiation. Bioelectromagnetics. vol 13. issue 4. 1992-09-24. PMID:1510740. |
to explore the physiological importance of these findings, we have examined the impact of rfr exposure on a membrane-bound enzyme, acetylcholinesterase (ache), which is intimately involved with the acetylcholine (ach) neurotransmitter system. |
1992-09-24 |
2023-08-11 |
Not clear |
| J M de Gandarias, J Irazusta, E Echevarría, J Gil, L Casí. [Acetylcholinesterase activity during the cortical development of the cat brain]. Archivos de neurobiologia. vol 55. issue 3. 1992-09-08. PMID:1497415. |
acetylcholinesterase (ache) hydrolyses acetylcholine to choline and acetate, thereby inactivating the neurotransmitter. |
1992-09-08 |
2023-08-11 |
cat |
| H Soreq, Y Lapidot-Lifson, H Zaku. A role for cholinesterases in tumorigenesis? Cancer cells (Cold Spring Harbor, N.Y. : 1989). vol 3. issue 12. 1992-08-06. PMID:1820094. |
hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ache) and butyrylcholinesterase (bche) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions. |
1992-08-06 |
2023-08-11 |
human |
| D D Lund, G A Davey, A R Subieta, B J Pardin. Compensatory recovery of parasympathetic control of heart rate after unilateral vagotomy in rabbits. The American journal of physiology. vol 262. issue 4 Pt 2. 1992-05-21. PMID:1566894. |
vagal stimulation during acetylcholinesterase inhibition by physostigmine and direct neuroeffector stimulation by methacholine indicated that a change in metabolism of the neurotransmitter or an increased sensitivity of the tissue to acetylcholine were not responsible for augmentation of vagal responses. |
1992-05-21 |
2023-08-11 |
Not clear |
| H Hörtnagl, M L Berger, G Sperk, C Pif. Regional heterogeneity in the distribution of neurotransmitter markers in the rat hippocampus. Neuroscience. vol 45. issue 2. 1992-02-07. PMID:1684835. |
in these six hippocampal subregions the concentrations of noradrenaline, dopamine, serotonin, 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid and the putative neurotransmitter amino acids glutamate, aspartate, gaba, glycine and taurine, and the levels of somatostatin and neuropeptide y and the activities of choline acetyltransferase, acetylcholinesterase and glutamate decarboxylase were measured. |
1992-02-07 |
2023-08-11 |
rat |
| N K Dash, M Azam, G Gupta, N Z Baque. Effect of hyperglycemia on acetylcholinesterase and catecholamine levels in rat brain and heart. Biochemistry international. vol 23. issue 2. 1991-08-29. PMID:1859430. |
the decreased activity of acetylcholinesterase observed in diabetes may be due to an early impaired glucose oxidation and glucose transport as a result of lack of insulin, which causes specific alterations in neurotransmitter levels, thereby effecting blood brain barrier transport, thus causing brain dysfunction. |
1991-08-29 |
2023-08-11 |
rat |
| M Mildenberger, T G Beach, E G McGeer, C M Ludgat. An animal model of prophylactic cranial irradiation: histologic effects at acute, early and delayed stages. International journal of radiation oncology, biology, physics. vol 18. issue 5. 1990-07-06. PMID:2347714. |
immunohistochemistry for neurotransmitter synthetic enzymes tyrosine hydroxylase and glutamate decarboxylase, as well as histochemistry for acetylcholinesterase, failed to uncover any changes in the irradiated animals. |
1990-07-06 |
2023-08-11 |
rat |
| R W Russell, R A Booth, C A Smith, D J Jenden, M Roch, K M Rice, S D Lauret. Roles of neurotransmitter receptors in behavior: recovery of function following decreases in muscarinic receptor density induced by cholinesterase inhibition. Behavioral neuroscience. vol 103. issue 4. 1989-09-27. PMID:2765189. |
cholinergic neurotransmitter levels were elevated in rat brain by reducing its inactivating enzyme, acetylcholinesterase (ache), with an anti-ache agent. |
1989-09-27 |
2023-08-11 |
rat |
| R J Polinsky, K V Holmes, R T Brown, V Weis. CSF acetylcholinesterase levels are reduced in multiple system atrophy with autonomic failure. Neurology. vol 39. issue 1. 1989-02-09. PMID:2909912. |
the lack of correlation between the low enzyme levels and low csf levels of monoamine metabolites in these patients indicates that the acetylcholinesterase reduction is not directly related to disruption in these neurotransmitter systems. |
1989-02-09 |
2023-08-11 |
Not clear |
| T Ostholm, P Ekström, A Bruun, T van Vee. Temporal disparity in pineal and retinal ontogeny. Brain research. vol 470. issue 1. 1988-10-11. PMID:3165685. |
the development of photoreceptors and two putative neurotransmitter systems in the pineal organ and retina was studied during embryogenesis in the three-spined stickleback gasterosteus aculeatus l. the investigation was performed by aid of immunocytochemistry using well characterized antisera to the retinal proteins alpha-transducin (td alpha) and s-antigen (sa) (photoreceptor-markers), antisera against l-glutamic acid decarboxylase (gad), gamma-aminobutyric acid (gaba), choline-o-acetyltransferase (chat) and with acetylcholinesterase (ache) histochemistry (neurotransmitter-markers). |
1988-10-11 |
2023-08-11 |
Not clear |
| P W Grabham, R J Grand, P J Byrd, P H Gallimor. Differentiation of normal and adenovirus-12 E1 transformed human embryo retinal cells. Experimental eye research. vol 47. issue 1. 1988-10-07. PMID:2842175. |
activity of the neurotransmitter enzyme acetylcholinesterase was also detected and found to increase after differentiation. |
1988-10-07 |
2023-08-11 |
mouse |
| P K Datta, A Banerjee, P S Basu, T K Datt. Acetylcholinesterase (EC 3.1.1.7), a neurotransmitter enzyme in scorpion hemolymph. Biochemical pharmacology. vol 37. issue 5. 1988-04-07. PMID:2964237. |
acetylcholinesterase (ec 3.1.1.7), a neurotransmitter enzyme in scorpion hemolymph. |
1988-04-07 |
2023-08-11 |
Not clear |
| T Wichmann, R B Illing, K Stark. Evidence for a neurotransmitter function of acetylcholine in rabbit superior colliculus. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:2893996. |
acetylcholinesterase staining and studies on the uptake of [3h]choline into the subsequent efflux of tritium from collicular slices were carried out in order to provide evidence for a neurotransmitter function of acetylcholine in rabbit superior colliculus. |
1988-04-05 |
2023-08-11 |
rabbit |
| S P Sivam, B Hoskins, I K H. An assessment of comparative acute toxicity of diisopropyl-fluorophosphate, tabun, sarin, and soman in relation to cholinergic and GABAergic enzyme activities in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 4. issue 4. 1984-11-05. PMID:6479498. |
the results indicate that (a) the acute toxicity of organophosphate acetylcholinesterase inhibitors is directly related to the inhibition of ache though there is a wide difference in their potency; (b) a substantial inhibition of ache activity (over 90% of control) is necessary for lethality to ensue after an acute exposure and the margins between lethal and nonlethal doses are extremely small; and (c) qualitative differences seem to exist among the various organophosphates in affecting noncholinergic neurotransmitter enzymes. |
1984-11-05 |
2023-08-12 |
rat |
| E Borda, N Contreras-Ortiz, R Gutnisky, M F Gimen. In vitro effect of acetylcholine and bethanechol on the contractions of the human detrusor muscle. Influence of prostaglandins. Archives internationales de pharmacodynamie et de therapie. vol 259. issue 1. 1983-02-25. PMID:6129833. |
our results suggest that endogenous pgs facilitate the action of acetylcholine through an increase in the concentration of the cholinergic neurotransmitter probably via an inhibition of the acetylcholinesterase activity. |
1983-02-25 |
2023-08-12 |
human |
| R N Wals. Effects of environmental complexity and deprivation on brain chemistry and physiology: a review. The International journal of neuroscience. vol 11. issue 2. 1981-01-26. PMID:6159333. |
greater complexity of the sensory environment results in increased total cholinesterase and acetylcholinesterase enzyme activity, while other neurotransmitter related substances, the catecholamines, show more variable responses. |
1981-01-26 |
2023-08-12 |
human |
| J A Olschowka, V K Vijaya. Postnatal development of cholinergic neurotransmitter enzymes in the mouse cerebellum. Biochemical, light microscopic and electron microscopic cytochemical investigations. The Journal of comparative neurology. vol 191. issue 1. 1980-10-27. PMID:7400393. |
the activity and distribution of the cholinergic neurotransmitter enzymes acetylcholinesterase (ache) and choline acetyltransferase (chac) in the developing cerebellum of the mouse were investigated using biochemical assays and light microscopic histochemistry for ache and chac, and electron microscopic histochemistry for ache. |
1980-10-27 |
2023-08-12 |
mouse |
| L Wecker, B Laskowski, W D Dettbar. Neuromuscular dysfunction induced by acetylcholinesterase inhibition. Federation proceedings. vol 37. issue 14. 1979-02-21. PMID:214351. |
electrophysiological studies have shown that paraoxon increases neurotransmitter release and causes spontaneous and impulse-related antidromic nerve activity, both of which can be reduced significantly by reactivation of inhibited acetylcholinesterase (ache) with pyridine-2-aldoxime methiodide. |
1979-02-21 |
2023-08-11 |
rat |
| Y Sarne, B K Schrier, H Gaine. Evidence for the local synthesis of a transmitter enzyme (glutamic acid decarboxylase) in crayfish peripheral nerve. Brain research. vol 110. issue 1. 1976-09-01. PMID:1276952. |
the activities of three enzymes of neurotransmitter metabolism (choline acetyl-transferase, cat; acetylcholinesterase, ache; and glutamic acid decarboxylase, gad) were studied in normal, transected, and organ cultured crayfish nerves. |
1976-09-01 |
2023-08-11 |
cat |