| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guiling He, Yang Sun, Fei L. RNA interference of two acetylcholinesterase genes in Plutella xylostella reveals their different functions. Archives of insect biochemistry and physiology. vol 79. issue 2. 2012-05-29. PMID:22392769. |
acetylcholinesterase (ache, ec 3.1.1.7) is an important enzyme with a typical function of degrading the neurotransmitter acetylcholine. |
2012-05-29 |
2023-08-12 |
Not clear |
| Manojkumar Valiyaveettil, Yonas Alamneh, Samuel Oguntayo, Yanling Wei, Ying Wang, Peethambaran Arun, Madhusoodana P Nambia. Regional specific alterations in brain acetylcholinesterase activity after repeated blast exposures in mice. Neuroscience letters. vol 506. issue 1. 2012-04-24. PMID:22079491. |
acetylcholinesterase (ache) which catalyzes the hydrolysis of the neurotransmitter acetylcholine has been recognized as one of the major regulators of stress responses after traumatic brain injury (tbi). |
2012-04-24 |
2023-08-12 |
mouse |
| Lotta Berg, C David Andersson, Elisabet Artursson, Andreas Hörnberg, Anna-Karin Tunemalm, Anna Linusson, Fredrik Ekströ. Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140425. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. |
2012-04-09 |
2023-08-12 |
mouse |
| M Sánchez-Guerra, N Pérez-Herrera, B Quintanilla-Veg. Organophosphorous pesticides research in Mexico: epidemiological and experimental approaches. Toxicology mechanisms and methods. vol 21. issue 9. 2012-01-30. PMID:22003926. |
studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (ache) activity (the main acute op toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of mexican farmers. |
2012-01-30 |
2023-08-12 |
human |
| Shuang Hu, Tony Pawson, Robert M Steve. UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway. Genetics. vol 189. issue 1. 2012-01-17. PMID:21750262. |
although unc-73 rhogef-2 mutants have grossly normal synaptic morphology and weak resistance to the acetylcholinesterase inhibitor aldicarb, they are significantly hypersensitive to the acetylcholine receptor agonist levamisole, indicating alterations in acetylcholine neurotransmitter signaling. |
2012-01-17 |
2023-08-12 |
caenorhabditis_elegans |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
acetylcholinesterase (ache; ec 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. |
2011-11-10 |
2023-08-12 |
mouse |
| Vicky P Chen, Wilson K W Luk, Wallace K B Chan, K Wing Leung, Ava J Y Guo, Gallant K L Chan, Sherry L Xu, Roy C Y Choi, Karl W K Tsi. Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:22046147. |
acetylcholinesterase (ache) is responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system. |
2011-11-10 |
2023-08-12 |
chicken |
| Yukio Ago, Ken Koda, Kazuhiro Takuma, Toshio Matsud. Pharmacological aspects of the acetylcholinesterase inhibitor galantamine. Journal of pharmacological sciences. vol 116. issue 1. 2011-09-22. PMID:21498956. |
since galantamine is a rather weak acetylcholinesterase inhibitor, but has additional allosteric potentiating effects at nicotinic receptors, it affects not only cholinergic transmission but also other neurotransmitter systems such as monoamines, glutamate, and γ-aminobutyric acid (gaba) through its allosteric mechanism. |
2011-09-22 |
2023-08-12 |
Not clear |
| J A Bermúdez-Lugo, M C Rosales-Hernández, O Deeb, J Trujillo-Ferrara, J Correa-Basurt. In silico methods to assist drug developers in acetylcholinesterase inhibitor design. Current medicinal chemistry. vol 18. issue 8. 2011-08-01. PMID:21291371. |
ach is a neurotransmitter hydrolyzed by acetylcholinesterase (ache). |
2011-08-01 |
2023-08-12 |
Not clear |
| Yechun Xu, Jacques-Philippe Colletier, Martin Weik, Guangrong Qin, Hualiang Jiang, Israel Silman, Joel L Sussma. Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase. Biophysical journal. vol 99. issue 12. 2011-03-28. PMID:21156143. |
the principal role of acetylcholinesterase is termination of nerve impulse transmission at cholinergic synapses, by rapid hydrolysis of the neurotransmitter acetylcholine to acetate and choline. |
2011-03-28 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, M Reale, Abdulaziz A Al-Jafar. Multiple approaches to analyse the data for rat brain acetylcholinesterase inhibition by cyclophosphamide. Neurochemical research. vol 35. issue 10. 2011-01-18. PMID:20652634. |
acetylcholinesterase (ache) is an externally oriented membrane-bound enzyme and its main physiological role is termination of chemical transmission at cholinergic synapses and secretory organs by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2011-01-18 |
2023-08-12 |
rat |
| Ana Viñuela, L Basten Snoek, Joost A G Riksen, Jan E Kammeng. Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808445. |
organophosphorus pesticides (ops) were originally designed to affect the nervous system by inhibiting the enzyme acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. |
2010-11-04 |
2023-08-12 |
caenorhabditis_elegans |
| Steeve Hervé Thany, Hélène Tricoire-Leignel, Bruno Lapie. Identification of cholinergic synaptic transmission in the insect nervous system. Advances in experimental medicine and biology. vol 683. 2010-09-30. PMID:20737784. |
a major criteria initially used to localize cholinergic neuronal elements in nervous systems tissues that involve acetylcholine (ach) as neurotransmitter is mainly based on immunochemical studies using choline acetyltransferase (chat), an enzyme which catalyzes ach biosynthesis and the ach degradative enzyme named acetylcholinesterase (ache). |
2010-09-30 |
2023-08-12 |
Not clear |
| Hay Dvir, Israel Silman, Michal Harel, Terrone L Rosenberry, Joel L Sussma. Acetylcholinesterase: from 3D structure to function. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20138030. |
by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. |
2010-09-01 |
2023-08-12 |
human |
| Zaheer-ul-Haq, Sobia Ahsan Halim, Reaz Uddin, Jeffry D Madur. Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 28. issue 8. 2010-08-12. PMID:20447848. |
acetylcholinesterase (ache) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2010-08-12 |
2023-08-12 |
Not clear |
| Cristina López-Galindo, Luis Vargas-Chacoff, Enrique Nebot, José F Casanueva, Daniel Rubio, Montserrat Solé, Juan Miguel Mancer. Sublethal effects of the organic antifoulant Mexel(R)432 on osmoregulation and xenobiotic detoxification in the flatfish Solea senegalensis. Chemosphere. vol 79. issue 1. 2010-06-14. PMID:20110101. |
other parameters tested were the antioxidant enzymes (catalase, cat; glutathione peroxidase, gpx; and glutathione reductase, gr), xenobiotic metabolism defenses involved in detoxification (carboxylesterase, cbe; 7-ethoxyresorufin o-deethylase, erod; and glutathione s-transferase, gst) and the neurotransmitter acetylcholinesterase (ache) activity. |
2010-06-14 |
2023-08-12 |
cat |
| Luke A J O'Neil. Boosting the brain's ability to block inflammation via microRNA-132. Immunity. vol 31. issue 6. 2010-02-09. PMID:20064444. |
(2009) describe how mir-132 mediates an anti-inflammatory effect via the targeting of acetylcholinesterase, leading to an increase in the neurotransmitter acetylcholine. |
2010-02-09 |
2023-08-12 |
Not clear |
| Jana Zdarova Karasova, Jiri Bajgar, Daniel Jun, Ruzena Pavlikova, Kamil Kuc. Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX. Neurotoxicity research. vol 16. issue 4. 2010-01-22. PMID:19728005. |
the toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (ache; ec 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. |
2010-01-22 |
2023-08-12 |
rat |
| Swaran J S Flora, Kapil Bhatt, Ashish Meht. Arsenic moiety in gallium arsenide is responsible for neuronal apoptosis and behavioral alterations in rats. Toxicology and applied pharmacology. vol 240. issue 2. 2009-10-08. PMID:19460394. |
we noted that ros induced oxidative stress caused changes in the brain neurotransmitter levels, acetylcholinesterase and nitric oxide synthase, leading to loss of memory and learning in rats. |
2009-10-08 |
2023-08-12 |
rat |
| Haixia Dang, Lihua Sun, Xinmin Liu, Bo Peng, Qiong Wang, William Jia, Ying Chen, Aihua Pan, Peigen Xia. Preventive action of Kai Xin San aqueous extract on depressive-like symptoms and cognition deficit induced by chronic mild stress. Experimental biology and medicine (Maywood, N.J.). vol 234. issue 7. 2009-08-27. PMID:19429857. |
serum corticosterone and adrenocorticotropic hormone (acth) levels, acetylcholinesterase (ache) protein expression in the hippocampus, and monoamine neurotransmitter concentrations in the prefrontal cortex and hippocampus were also determined to elucidate the neurochemical mechanisms. |
2009-08-27 |
2023-08-12 |
Not clear |