| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristóbal de los Río. Cholinesterase inhibitors: a patent review (2007 - 2011). Expert opinion on therapeutic patents. vol 22. issue 8. 2012-11-27. PMID:22764681. |
cholinesterase inhibitors participate in the maintenance of the levels of the neurotransmitter acetylcholine by inhibiting the enzymes implicated in its degradation, namely, butyrylcholinesterase and acetylcholinesterase. |
2012-11-27 |
2023-08-12 |
Not clear |
| D Qujeq, T Roushan, A Norouzy, M Habibi-Rezaei, M Mehdinejad-Shan. Effects of dichlorvos and carbaryl on the activity of free and immobilized acetylcholinesterase. Toxicology and industrial health. vol 28. issue 4. 2012-10-17. PMID:21937528. |
acetylcholinesterase (ache) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. |
2012-10-17 |
2023-08-12 |
Not clear |
| Xavier Brazzolotto, Marielle Wandhammer, Cyril Ronco, Marie Trovaslet, Ludovic Jean, Oksana Lockridge, Pierre-Yves Renard, Florian Nacho. Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure. The FEBS journal. vol 279. issue 16. 2012-10-09. PMID:22726956. |
it can accommodate larger substrates or inhibitors than acetylcholinesterase (ache), the enzyme responsible for hydrolysis of the neurotransmitter acetylcholine in the central nervous system and neuromuscular junctions. |
2012-10-09 |
2023-08-12 |
human |
| Miroslav Pohanka, Oto Pavlis, Hana Svobodova, Jiri Pikul. Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice. Interdisciplinary toxicology. vol 5. issue 1. 2012-10-02. PMID:22783145. |
the present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (ache) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ach). |
2012-10-02 |
2023-08-12 |
mouse |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
other neurotransmitter is a classical neurotransmitter acetylcholine (ach), regulated by enzyme acetylcholinesterase (ache) that hydrolyses the acetylcholine after its releasing. |
2012-06-21 |
2023-08-12 |
rat |
| Amy C Halliday, Susan A Greenfiel. From protein to peptides: a spectrum of non-hydrolytic functions of acetylcholinesterase. Protein and peptide letters. vol 19. issue 2. 2012-06-08. PMID:21933122. |
acetylcholinesterase (ache), a member of the α/β-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ach). |
2012-06-08 |
2023-08-12 |
Not clear |
| Guiling He, Yang Sun, Fei L. RNA interference of two acetylcholinesterase genes in Plutella xylostella reveals their different functions. Archives of insect biochemistry and physiology. vol 79. issue 2. 2012-05-29. PMID:22392769. |
acetylcholinesterase (ache, ec 3.1.1.7) is an important enzyme with a typical function of degrading the neurotransmitter acetylcholine. |
2012-05-29 |
2023-08-12 |
Not clear |
| Manojkumar Valiyaveettil, Yonas Alamneh, Samuel Oguntayo, Yanling Wei, Ying Wang, Peethambaran Arun, Madhusoodana P Nambia. Regional specific alterations in brain acetylcholinesterase activity after repeated blast exposures in mice. Neuroscience letters. vol 506. issue 1. 2012-04-24. PMID:22079491. |
acetylcholinesterase (ache) which catalyzes the hydrolysis of the neurotransmitter acetylcholine has been recognized as one of the major regulators of stress responses after traumatic brain injury (tbi). |
2012-04-24 |
2023-08-12 |
mouse |
| Lotta Berg, C David Andersson, Elisabet Artursson, Andreas Hörnberg, Anna-Karin Tunemalm, Anna Linusson, Fredrik Ekströ. Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140425. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. |
2012-04-09 |
2023-08-12 |
mouse |
| M Sánchez-Guerra, N Pérez-Herrera, B Quintanilla-Veg. Organophosphorous pesticides research in Mexico: epidemiological and experimental approaches. Toxicology mechanisms and methods. vol 21. issue 9. 2012-01-30. PMID:22003926. |
studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (ache) activity (the main acute op toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of mexican farmers. |
2012-01-30 |
2023-08-12 |
human |
| Shuang Hu, Tony Pawson, Robert M Steve. UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway. Genetics. vol 189. issue 1. 2012-01-17. PMID:21750262. |
although unc-73 rhogef-2 mutants have grossly normal synaptic morphology and weak resistance to the acetylcholinesterase inhibitor aldicarb, they are significantly hypersensitive to the acetylcholine receptor agonist levamisole, indicating alterations in acetylcholine neurotransmitter signaling. |
2012-01-17 |
2023-08-12 |
caenorhabditis_elegans |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
acetylcholinesterase (ache; ec 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. |
2011-11-10 |
2023-08-12 |
mouse |
| Vicky P Chen, Wilson K W Luk, Wallace K B Chan, K Wing Leung, Ava J Y Guo, Gallant K L Chan, Sherry L Xu, Roy C Y Choi, Karl W K Tsi. Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:22046147. |
acetylcholinesterase (ache) is responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system. |
2011-11-10 |
2023-08-12 |
chicken |
| Yukio Ago, Ken Koda, Kazuhiro Takuma, Toshio Matsud. Pharmacological aspects of the acetylcholinesterase inhibitor galantamine. Journal of pharmacological sciences. vol 116. issue 1. 2011-09-22. PMID:21498956. |
since galantamine is a rather weak acetylcholinesterase inhibitor, but has additional allosteric potentiating effects at nicotinic receptors, it affects not only cholinergic transmission but also other neurotransmitter systems such as monoamines, glutamate, and γ-aminobutyric acid (gaba) through its allosteric mechanism. |
2011-09-22 |
2023-08-12 |
Not clear |
| J A Bermúdez-Lugo, M C Rosales-Hernández, O Deeb, J Trujillo-Ferrara, J Correa-Basurt. In silico methods to assist drug developers in acetylcholinesterase inhibitor design. Current medicinal chemistry. vol 18. issue 8. 2011-08-01. PMID:21291371. |
ach is a neurotransmitter hydrolyzed by acetylcholinesterase (ache). |
2011-08-01 |
2023-08-12 |
Not clear |
| Yechun Xu, Jacques-Philippe Colletier, Martin Weik, Guangrong Qin, Hualiang Jiang, Israel Silman, Joel L Sussma. Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase. Biophysical journal. vol 99. issue 12. 2011-03-28. PMID:21156143. |
the principal role of acetylcholinesterase is termination of nerve impulse transmission at cholinergic synapses, by rapid hydrolysis of the neurotransmitter acetylcholine to acetate and choline. |
2011-03-28 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, M Reale, Abdulaziz A Al-Jafar. Multiple approaches to analyse the data for rat brain acetylcholinesterase inhibition by cyclophosphamide. Neurochemical research. vol 35. issue 10. 2011-01-18. PMID:20652634. |
acetylcholinesterase (ache) is an externally oriented membrane-bound enzyme and its main physiological role is termination of chemical transmission at cholinergic synapses and secretory organs by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2011-01-18 |
2023-08-12 |
rat |
| Ana Viñuela, L Basten Snoek, Joost A G Riksen, Jan E Kammeng. Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808445. |
organophosphorus pesticides (ops) were originally designed to affect the nervous system by inhibiting the enzyme acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. |
2010-11-04 |
2023-08-12 |
caenorhabditis_elegans |
| Steeve Hervé Thany, Hélène Tricoire-Leignel, Bruno Lapie. Identification of cholinergic synaptic transmission in the insect nervous system. Advances in experimental medicine and biology. vol 683. 2010-09-30. PMID:20737784. |
a major criteria initially used to localize cholinergic neuronal elements in nervous systems tissues that involve acetylcholine (ach) as neurotransmitter is mainly based on immunochemical studies using choline acetyltransferase (chat), an enzyme which catalyzes ach biosynthesis and the ach degradative enzyme named acetylcholinesterase (ache). |
2010-09-30 |
2023-08-12 |
Not clear |
| Hay Dvir, Israel Silman, Michal Harel, Terrone L Rosenberry, Joel L Sussma. Acetylcholinesterase: from 3D structure to function. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20138030. |
by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. |
2010-09-01 |
2023-08-12 |
human |