| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kumiko Kaifu, Hideyasu Kiyomoto, Hirofumi Hitomi, Keisuke Matsubara, Taiga Hara, Kumiko Moriwaki, Genei Ihara, Yoshiko Fujita, Noriko Sugasawa, Daisuke Nagata, Akira Nishiyama, Masakazu Kohn. Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 24. issue 3. 2009-06-16. PMID:18974235. |
insulin attenuates apoptosis induced by high glucose via the pi3-kinase/akt pathway in rat peritoneal mesothelial cells. |
2009-06-16 |
2023-08-12 |
rat |
| Kumiko Kaifu, Hideyasu Kiyomoto, Hirofumi Hitomi, Keisuke Matsubara, Taiga Hara, Kumiko Moriwaki, Genei Ihara, Yoshiko Fujita, Noriko Sugasawa, Daisuke Nagata, Akira Nishiyama, Masakazu Kohn. Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 24. issue 3. 2009-06-16. PMID:18974235. |
in this study, we hypothesized that high glucose levels induce apoptosis, and that insulin attenuates this apoptosis in peritoneal mesothelial cells. |
2009-06-16 |
2023-08-12 |
rat |
| Kumiko Kaifu, Hideyasu Kiyomoto, Hirofumi Hitomi, Keisuke Matsubara, Taiga Hara, Kumiko Moriwaki, Genei Ihara, Yoshiko Fujita, Noriko Sugasawa, Daisuke Nagata, Akira Nishiyama, Masakazu Kohn. Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 24. issue 3. 2009-06-16. PMID:18974235. |
to clarify this hypothesis, we examined the effects of insulin on the phosphatidylinositol 3-kinase/akt signaling pathway and apoptosis in rat peritoneal mesothelial cells. |
2009-06-16 |
2023-08-12 |
rat |
| A A Vireque, L S A Camargo, R V Serapião, A A M Rosa E Silva, Y F Watanabe, E M Ferreira, P A A S Navarro, W P Martins, R A Ferrian. Preimplantation development and expression of Hsp-70 and Bax genes in bovine blastocysts derived from oocytes matured in alpha-MEM supplemented with growth factors and synthetic macromolecules. Theriogenology. vol 71. issue 4. 2009-05-28. PMID:18962879. |
we inferred that bovine oocytes can be matured in serum- and gonadotrophin-free medium supplemented with pva or pvp, enriched with igf-i and insulin, without altering post-cleavage development and relative abundance of some genes associated with stress and apoptosis. |
2009-05-28 |
2023-08-12 |
cattle |
| Mayer B Davidso. Pro's and con's of the early use of insulin in the management of type 2 diabetes: a clinical evaluation. Current opinion in endocrinology, diabetes, and obesity. vol 16. issue 2. 2009-05-28. PMID:19300090. |
the underlying reason given is that insulin will slow down the apoptosis of pancreatic beta-cells, which is increased in type 2 diabetes. |
2009-05-28 |
2023-08-12 |
Not clear |
| Jairam Vanamala, Christopher C Tarver, Peter S Muran. Obesity-enhanced colon cancer: functional food compounds and their mechanisms of action. Current cancer drug targets. vol 8. issue 7. 2009-05-22. PMID:18991570. |
insulin resistance and inflammation, underlying factors in obesity-related diseases, promote colonocyte proliferation and suppress programmed cell death, or apoptosis, by activating the insulin-like growth factor (igf) and prostaglandin pathways. |
2009-05-22 |
2023-08-12 |
Not clear |
| Sheng Zhang, Michael J Carper, Xiaoyong Lei, W Todd Cade, Kevin E Yarasheski, Sasanka Ramanadha. Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion. American journal of physiology. Endocrinology and metabolism. vol 296. issue 4. 2009-05-21. PMID:19208856. |
protease inhibitors used in the treatment of hiv+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion. |
2009-05-21 |
2023-08-12 |
human |
| Peng Lin, Li Chen, Dong Li, Jinbo Liu, Nailong Yang, Yu Sun, Yuxin Xu, Yiling Fu, Xinguo Ho. Adiponectin reduces glucotoxicity-induced apoptosis of INS-1 rat insulin-secreting cells on a microfluidic chip. The Tohoku journal of experimental medicine. vol 217. issue 1. 2009-05-18. PMID:19155609. |
ins-1 cells were cultured on a novel microfluidic chip with persistent perfusion and subsequently exposed to sustained high glucose (shg) (25 mmol/l) or intermittent high glucose (ihg) (11.1 and 25 mmol/l glucose alternating every 12 h) in the absence or presence of adiponectin for 72 h. using this device, we showed that ihg induced more serious impairment in ins-1 cells than did shg, and adiponectin partially rescued ins-1 cells from glucotoxicity-induced apoptosis, dysfunction and reduction of insulin gene expression. |
2009-05-18 |
2023-08-12 |
rat |
| Hamedeh Ghanaat-Pour, Ake Sjöhol. Gene expression regulated by pioglitazone and exenatide in normal and diabetic rat islets exposed to lipotoxicity. Diabetes/metabolism research and reviews. vol 25. issue 2. 2009-05-15. PMID:19065603. |
another recently launched anti-diabetic drug, exenatide, an incretin mimetic, has been shown to stimulate insulin secretion, growth, and proliferation of pancreatic beta-cells and to protect them against apoptosis. |
2009-05-15 |
2023-08-12 |
rat |
| Safia Costes, Brigitte Vandewalle, Cécile Tourrel-Cuzin, Christophe Broca, Nathalie Linck, Gyslaine Bertrand, Julie Kerr-Conte, Bernard Portha, François Pattou, Joel Bockaert, Stéphane Dall. Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets. Diabetes. vol 58. issue 5. 2009-05-14. PMID:19223597. |
in type 2 diabetes, chronic hyperglycemia is detrimental to beta-cells, causing apoptosis and impaired insulin secretion. |
2009-05-14 |
2023-08-12 |
human |
| Han Chang Kang, You Han Ba. Transfection of insulin-secreting cell line and rat islets by functional polymeric gene vector. Biomaterials. vol 30. issue 14. 2009-05-08. PMID:19200594. |
the evaluation included transfection efficiency, experimental condition effects, gross morphological observation, cytotoxicity, apoptosis, gene distribution in treated islets, insulin secretion function and time-dependent gene expression pattern. |
2009-05-08 |
2023-08-12 |
rat |
| M Wojcik, K Mac-Marcjanek, L A Woznia. Physiological and pathophysiological functions of SIRT1. Mini reviews in medicinal chemistry. vol 9. issue 3. 2009-05-01. PMID:19275731. |
a variety of sirt1 substrates hints that this protein is involved in the regulation of diverse biological processes, including cell survival, apoptosis, gluconeogenesis, adipogenesis, lipolysis, stress resistance, muscle differentiation, and insulin secretion. |
2009-05-01 |
2023-08-12 |
human |
| M Wojcik, K Mac-Marcjanek, L A Woznia. Physiological and pathophysiological functions of SIRT1. Mini reviews in medicinal chemistry. vol 9. issue 3. 2009-05-01. PMID:19275731. |
this review emphasizes catalytic properties of sirt1 and its role in apoptosis, insulin pathway, and neuron survival. |
2009-05-01 |
2023-08-12 |
human |
| Aron Cseh, Beáta Szebeni, Balázs Szalay, Barna Vásárhely. [Akt enzyme: new therapeutic target in cancer and diabetes?]. Orvosi hetilap. vol 150. issue 8. 2009-04-24. PMID:19218147. |
akt is also a factor in the pathomechanism of diabetes as it determines beta-cell apoptosis of langerhans islets and insulin sensitivity of the cells. |
2009-04-24 |
2023-08-12 |
Not clear |
| Nurit Kaiser, Gil Leibowit. Failure of beta-cell adaptation in type 2 diabetes: Lessons from animal models. Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273118. |
their end-result is the regulation of insulin secretion and biosynthesis, and beta-cell proliferation and apoptosis. |
2009-04-07 |
2023-08-12 |
Not clear |
| Seung-Hoon Baek, Eun-Kyoung Kim, John L Goudreau, Keith J Lookingland, Seong Who Kim, Seong-Woon Y. Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autophagic cell death. Autophagy. vol 5. issue 2. 2009-03-30. PMID:19158478. |
hcn cells have intact apoptotic capability despite the lack of apoptosis following insulin withdrawal. |
2009-03-30 |
2023-08-12 |
human |
| W Zhang, X Wang, H Jin, R Qian, G Zhang, S Chen, R H. Effects of high glucose plus high insulin on proliferation and apoptosis of mouse endothelial progenitor cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 57. issue 12. 2009-03-16. PMID:19109737. |
effects of high glucose plus high insulin on proliferation and apoptosis of mouse endothelial progenitor cells. |
2009-03-16 |
2023-08-12 |
mouse |
| W Zhang, X Wang, H Jin, R Qian, G Zhang, S Chen, R H. Effects of high glucose plus high insulin on proliferation and apoptosis of mouse endothelial progenitor cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 57. issue 12. 2009-03-16. PMID:19109737. |
to study the effects of high glucose plus high insulin (gi) on proliferation, apoptosis, morphology and differentiation of endothelial progenitor cells (epc). |
2009-03-16 |
2023-08-12 |
mouse |
| Anthony A Sauv. Pharmaceutical strategies for activating sirtuins. Current pharmaceutical design. vol 15. issue 1. 2009-03-16. PMID:19149602. |
the human sirtuins (sirt1-7) have been identified to regulate a variety of biological processes, such as glucose homeostasis, gluconeogenesis, mitochondrial biogenesis, insulin secretion, adipogenesis and adipolysis, apoptosis, senescence and metabolism. |
2009-03-16 |
2023-08-12 |
human |
| Giovanni Musso, Roberto Gambino, Giovanni Pacini, Gianfranco Pagano, Marilena Durazzo, Maurizio Cassade. Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH. Hepatology (Baltimore, Md.). vol 49. issue 2. 2009-03-12. PMID:19105201. |
the tcf7l2 ct/tt genotype was more frequent in nafld and predicted the presence and severity of liver disease, of beta-cell dysfunction, of reduced incretin effect and hepatic insulin resistance in nash; it also modulated postprandial hepatocyte apoptosis, lipoproteins, and adipokine profiles in both groups. |
2009-03-12 |
2023-08-12 |
human |