| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masahiro Okouchi, Naotsuka Okayama, Tak Yee A. Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosis. Current neurovascular research. vol 6. issue 4. 2010-01-26. PMID:19807652. |
this study sought to determine the contribution of carbonyl (methylglyoxal, mg) stress to human brain endothelial cell (ihec) apoptosis, the relationship to cellular redox status and mitochondrial membrane potential, and the protection by thiol antioxidant and insulin sensitizers. |
2010-01-26 |
2023-08-12 |
human |
| Suzanne M de la Monte, Lisa Longato, Ming Tong, Jack R Wand. Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis. Current opinion in investigational drugs (London, England : 2000). vol 10. issue 10. 2010-01-22. PMID:19777393. |
insulin resistance compromises cell survival, metabolism and neuronal plasticity, and increases oxidative stress, cytokine activation and apoptosis. |
2010-01-22 |
2023-08-12 |
Not clear |
| Ira Tabas, Alan Tall, Domenico Accil. The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression. Circulation research. vol 106. issue 1. 2010-01-22. PMID:20056946. |
macrophages have a functional insulin receptor signaling pathway, and downregulation of this pathway in the setting insulin resistance enhances unfolded protein response-induced apoptosis. |
2010-01-22 |
2023-08-12 |
human |
| Irina Tsoy Nizamutdinova, Yong Chun Jin, Jong Il Chung, Sung Chul Shin, Sung Joong Lee, Han Geuk Seo, Jae Heun Lee, Ki Churl Chang, Hye Jung Ki. The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Molecular nutrition & food research. vol 53. issue 11. 2010-01-21. PMID:19785000. |
the anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. |
2010-01-21 |
2023-08-12 |
rat |
| Irina Tsoy Nizamutdinova, Yong Chun Jin, Jong Il Chung, Sung Chul Shin, Sung Joong Lee, Han Geuk Seo, Jae Heun Lee, Ki Churl Chang, Hye Jung Ki. The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Molecular nutrition & food research. vol 53. issue 11. 2010-01-21. PMID:19785000. |
taken together, ant from black soybean seed coat have anti-diabetic effects that are due, in part, to the regulation of glucose transporter 4 and prevention of insulin resistance and pancreatic apoptosis, suggesting a possible use as a drug to regulate diabetes. |
2010-01-21 |
2023-08-12 |
rat |
| Hu-Ping Deng, Jia-Ke Cha. The effects and mechanisms of insulin on systemic inflammatory response and immune cells in severe trauma, burn injury, and sepsis. International immunopharmacology. vol 9. issue 11. 2010-01-05. PMID:19647101. |
moreover, in recent years, it has been proven that insulin can attenuate systemic inflammatory responses and modulate the proliferation, apoptosis, differentiation and immune functions of certain immune cells, especially monocytes/macrophages, neutrophils, and t cells associated with severe trauma, burn injury, or sepsis. |
2010-01-05 |
2023-08-12 |
Not clear |
| Bodo C Melni. Permanent impairment of insulin resistance from pregnancy to adulthood: the primary basic risk factor of chronic Western diseases. Medical hypotheses. vol 73. issue 5. 2010-01-04. PMID:19515499. |
ir increases serum hormone levels of insulin and insulin-like growth factor-1 (igf-1), which are most important mediators of cell proliferation, differentiation and inhibitors of apoptosis. |
2010-01-04 |
2023-08-12 |
human |
| Jörn M Schattenberg, Marcus Schuchman. Diabetes and apoptosis: liver. Apoptosis : an international journal on programmed cell death. vol 14. issue 12. 2010-01-04. PMID:19544096. |
the dissection of these signaling pathways has shown that the regulators of apoptosis signaling events in hepatocytes can also modulate insulin signaling pathways and that mediators of insulin resistance in turn influence liver cell apoptosis. |
2010-01-04 |
2023-08-12 |
Not clear |
| Jörn M Schattenberg, Marcus Schuchman. Diabetes and apoptosis: liver. Apoptosis : an international journal on programmed cell death. vol 14. issue 12. 2010-01-04. PMID:19544096. |
this review will summarize the potential crosstalk between apoptosis and insulin resistance signaling events and discuss the involved mediators. |
2010-01-04 |
2023-08-12 |
Not clear |
| Brandi D Sanders, Brittany Jackson, Michael Brent, Alexander M Taylor, Weiwei Dang, Shelley L Berger, Stuart L Schreiber, Konrad Howitz, Ronen Marmorstei. Identification and characterization of novel sirtuin inhibitor scaffolds. Bioorganic & medicinal chemistry. vol 17. issue 19. 2010-01-04. PMID:19734050. |
the sirtuin proteins are broadly conserved nad(+)-dependent deacetylases that are implicated in diverse biological processes including dna recombination and repair, transcriptional silencing, longevity, apoptosis, axonal protection, insulin signaling, and fat mobilization. |
2010-01-04 |
2023-08-12 |
human |
| Masayuki Arakawa, Chie Ebato, Tomoya Mita, Takahisa Hirose, Ryuzo Kawamori, Yoshio Fujitani, Hirotaka Watad. Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents. Biochemical and biophysical research communications. vol 390. issue 3. 2009-12-29. PMID:19836346. |
in addition to enhancement of glucose-induced insulin secretion, agonists for glucagon-like peptide-1 receptor (glp-1r) stimulate proliferation and inhibit apoptosis of beta-cells, thereby probably preserve beta-cell mass. |
2009-12-29 |
2023-08-12 |
mouse |
| Zhiwen Yu, Tianru Ji. New insights into the role of cAMP in the production and function of the incretin hormone glucagon-like peptide-1 (GLP-1). Cellular signalling. vol 22. issue 1. 2009-12-14. PMID:19772917. |
glp-1 also enhances pancreatic beta-cell proliferation, inhibits cell apoptosis, and has been utilized in the trans-differentiation of insulin producing cells. |
2009-12-14 |
2023-08-12 |
Not clear |
| Ji Cao, Danqing Xu, Duoduo Wang, Rui Wu, Lei Zhang, Hong Zhu, Qiaojun He, Bo Yan. ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells. Free radical biology & medicine. vol 47. issue 5. 2009-12-07. PMID:19482076. |
of note is the fact that the expression of pi3k (p110) does not change obviously, and neither ly294002 nor insulin could influence the apoptosis induced by 4-hpr. |
2009-12-07 |
2023-08-12 |
Not clear |
| Ana I Arroba, Deborah Wallace, Ashley Mackey, Enrique J de la Rosa, Thomas G Cotte. IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death. The European journal of neuroscience. vol 30. issue 6. 2009-11-17. PMID:19723289. |
insulin like-growth factor-i (igf-i) attenuated this ca(2+)-induced apoptosis, as well as decreased the activation of calpain-2 and maintained calpastatin levels through the activation of the akt-creb pathway. |
2009-11-17 |
2023-08-12 |
mouse |
| Claus M Larsen, Mirjam Faulenbach, Allan Vaag, Jan A Ehses, Marc Y Donath, Thomas Mandrup-Poulse. Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes care. vol 32. issue 9. 2009-11-16. PMID:19542207. |
interleukin (il)-1 impairs insulin secretion and induces beta-cell apoptosis. |
2009-11-16 |
2023-08-12 |
Not clear |
| Karim Bouzakri, Pascale Ribaux, Philippe A Halba. Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion. The Journal of biological chemistry. vol 284. issue 41. 2009-11-10. PMID:19690174. |
human and rat primary beta cells were sorted by facs and cultured for 24 h +/- 20 ng/ml tnf-alpha to explore the impact on apoptosis, proliferation, and short-term insulin secretion (1 h, 2.8 mm glucose followed by 1 h, 16.7 mm glucose at the end of the 24-h culture period) as well as key signaling protein phosphorylation and expression. |
2009-11-10 |
2023-08-12 |
human |
| Lin Liu, Padma L Channavajhala, Vikram R Rao, Ioannis Moutsatsos, Leeying Wu, Yuhua Zhang, Lih-Ling Lin, Yongchang Qi. Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway. Biochimica et biophysica acta. vol 1794. issue 10. 2009-10-30. PMID:19563921. |
in addition, ksr-2 may be involved in the activation of many mapk downstream signaling molecules such as p38 mapk, ikap, aif, and proteins involved in ubiquitin-proteasome, apoptosis, cell cycle control, and dna synthesis and repair pathways, as well as mediating crosstalks between mapk and several other signaling pathways, including pi3k and insulin signaling. |
2009-10-30 |
2023-08-12 |
Not clear |
| Wenjuan Xing, Wenjun Yan, Feng Fu, Yulan Jin, Lele Ji, Wenchong Liu, Li Wang, Anlin Lv, Yunyan Duan, Jun Zhang, Haifeng Zhang, Feng Ga. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function. Apoptosis : an international journal on programmed cell death. vol 14. issue 9. 2009-10-21. PMID:19590963. |
insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function. |
2009-10-21 |
2023-08-12 |
rat |
| Wenjuan Xing, Wenjun Yan, Feng Fu, Yulan Jin, Lele Ji, Wenchong Liu, Li Wang, Anlin Lv, Yunyan Duan, Jun Zhang, Haifeng Zhang, Feng Ga. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function. Apoptosis : an international journal on programmed cell death. vol 14. issue 9. 2009-10-21. PMID:19590963. |
treatment with insulin significantly reduced infarct size, decreased plasma creatine kinase and lactate dehydrogenase activities, decreased apoptosis index and caspase-3 activity (all p < 0.01 vs. saline), and improved cardiac function 24 h after ischemia. |
2009-10-21 |
2023-08-12 |
rat |
| Wenjuan Xing, Wenjun Yan, Feng Fu, Yulan Jin, Lele Ji, Wenchong Liu, Li Wang, Anlin Lv, Yunyan Duan, Jun Zhang, Haifeng Zhang, Feng Ga. Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function. Apoptosis : an international journal on programmed cell death. vol 14. issue 9. 2009-10-21. PMID:19590963. |
these data indicate that inhibition of apoptosis by early insulin treatment alleviates chronic adverse changes in post-ischemic cardiac structure and function. |
2009-10-21 |
2023-08-12 |
rat |