| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhaoyun Zhang, Chong Wee Liew, Diane E Handy, Yingyi Zhang, Jane A Leopold, Ji Hu, Lili Guo, Rohit N Kulkarni, Joseph Loscalzo, Robert C Stanto. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 5. 2010-05-18. PMID:20032314. |
inhibition of g6pd with sirna led to increased ros and apoptosis, decreased proliferation, and impaired insulin secretion. |
2010-05-18 |
2023-08-12 |
mouse |
| S Erbel, C Reers, P P Nawroth, R A Ritze. Prolonged culture of human islets induces ER stress. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 118. issue 2. 2010-05-13. PMID:19838981. |
at 0, 1, 2, 3 and 4 weeks aliquots of islets were used for analysis of a) islet-cell turnover (replication by ki-67 and apoptosis by tunel staining), b) the er stress level (chop and phospho-eif2alpha staining), c) fractional beta-cell content (insulin staining) and d) islet function (2 h static incubation). |
2010-05-13 |
2023-08-12 |
human |
| Li Bian, Robert L Hanson, Victoria Ossowski, Kim Wiedrich, Clinton C Mason, Michael Traurig, Yunhua L Muller, Sayuko Kobes, William C Knowler, Leslie J Baier, Clifton Bogardu. Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians. Diabetes. vol 59. issue 5. 2010-05-12. PMID:20185809. |
prior genome-wide association and exon array expression studies both provided suggestive evidence that apoptosis signal regulating kinase 1 (ask1) may influence in vivo insulin action in pima indians. |
2010-05-12 |
2023-08-12 |
Not clear |
| Mark F McCarty, Jorge Barroso-Aranda, Francisco Contrera. NADPH oxidase mediates glucolipotoxicity-induced beta cell dysfunction--clinical implications. Medical hypotheses. vol 74. issue 3. 2010-05-07. PMID:19576699. |
an impairment of glucose-stimulated insulin secretion--reflecting decreased glucokinase expression--and a moderate decrease in beta cell mass attributable to increased apoptosis, constitute the key features of beta cell failure in type 2 diabetes. |
2010-05-07 |
2023-08-12 |
Not clear |
| Jia-ke CHA. [Mechanisms of skeletal muscle wasting after severe burn and its treatment]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 25. issue 4. 2010-05-06. PMID:19951538. |
therapeutic strategies for skeletal muscle wasting after burn mainly include maintenance of room temperature at (31.5 +/- 0.7) degrees c, early active and passive exercise of skeletal muscles, administration of beta adrenergic receptor blocker such as propranolol, recombinant growth hormone, androgen, and insulin, which has lately been proven to possess the effect of suppressing myonuclear apoptosis after burn. |
2010-05-06 |
2023-08-12 |
Not clear |
| Panagiotis D Venieratos, Garyfalia I Drossopoulou, Katerina D Kapodistria, Effie C Tsilibary, Paraskevi V Kitsio. High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells. Cellular signalling. vol 22. issue 5. 2010-05-05. PMID:20067833. |
high glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous il-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells. |
2010-05-05 |
2023-08-12 |
mouse |
| Vincent Poitout, Julie Amyot, Meriem Semache, Bader Zarrouki, Derek Hagman, Ghislaine Fonté. Glucolipotoxicity of the pancreatic beta cell. Biochimica et biophysica acta. vol 1801. issue 3. 2010-05-04. PMID:19715772. |
the combination of excessive levels of fatty acids and glucose therefore leads to decreased insulin secretion, impaired insulin gene expression, and beta-cell death by apoptosis, all of which probably have distinct underlying mechanisms. |
2010-05-04 |
2023-08-12 |
rat |
| Kyong Kim, Dong-Hyun Kim, Hye Young Ki. Compound K protects MIN6N8 pancreatic beta-cells against palmitate-induced apoptosis through modulating SAPK/JNK activation. Cell biology international. vol 34. issue 1. 2010-05-04. PMID:19947945. |
chronic elevation of nefas (non-esterified fatty acids) due to insulin resistance and obesity has been shown to be associated with increased beta-cell apoptosis and with the aetiology of the reduced beta-cell mass of type 2 diabetes. |
2010-05-04 |
2023-08-12 |
mouse |
| Majambu Mbikay, Francine Sirois, Janice Mayne, Gen-Sheng Wang, Andrew Chen, Thilina Dewpura, Annik Prat, Nabil G Seidah, Michel Chretien, Fraser W Scot. PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. FEBS letters. vol 584. issue 4. 2010-05-04. PMID:20026049. |
here we show that, compared to control mice, pcsk9-null male mice over 4 months of age carried more ldlr and less insulin in their pancreas; they were hypoinsulinemic, hyperglycemic and glucose-intolerant; their islets exhibited signs of malformation, apoptosis and inflammation. |
2010-05-04 |
2023-08-12 |
mouse |
| Sam Virtue, Antonio Vidal-Pui. Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective. Biochimica et biophysica acta. vol 1801. issue 3. 2010-05-04. PMID:20056169. |
ectopic lipid accumulation in non-adipocyte cells causes lipotoxic insults including insulin resistance, apoptosis and inflammation. |
2010-05-04 |
2023-08-12 |
Not clear |
| Daniel E Francés, María T Ronco, Juan A Monti, Paola I Ingaramo, Gerardo B Pisani, Juan P Parody, José M Pellegrino, Paloma Martín Sanz, María C Carrillo, Cristina E Carnoval. Hyperglycemia induces apoptosis in rat liver through the increase of hydroxyl radical: new insights into the insulin effect. The Journal of endocrinology. vol 205. issue 2. 2010-04-30. PMID:20164374. |
hyperglycemia induces apoptosis in rat liver through the increase of hydroxyl radical: new insights into the insulin effect. |
2010-04-30 |
2023-08-12 |
rat |
| Daniel E Francés, María T Ronco, Juan A Monti, Paola I Ingaramo, Gerardo B Pisani, Juan P Parody, José M Pellegrino, Paloma Martín Sanz, María C Carrillo, Cristina E Carnoval. Hyperglycemia induces apoptosis in rat liver through the increase of hydroxyl radical: new insights into the insulin effect. The Journal of endocrinology. vol 205. issue 2. 2010-04-30. PMID:20164374. |
in this study, we analyzed the contribution of hydroxyl radical in the liver apoptosis mediated by hyperglycemia through the bax-caspase pathway and the effects of insulin protection against the apoptosis induced by hyperglycemia. |
2010-04-30 |
2023-08-12 |
rat |
| Daniel E Francés, María T Ronco, Juan A Monti, Paola I Ingaramo, Gerardo B Pisani, Juan P Parody, José M Pellegrino, Paloma Martín Sanz, María C Carrillo, Cristina E Carnoval. Hyperglycemia induces apoptosis in rat liver through the increase of hydroxyl radical: new insights into the insulin effect. The Journal of endocrinology. vol 205. issue 2. 2010-04-30. PMID:20164374. |
importantly, insulin significantly increased apoptosis inhibitor protein expression by induction of its mrna. |
2010-04-30 |
2023-08-12 |
rat |
| Daniel E Francés, María T Ronco, Juan A Monti, Paola I Ingaramo, Gerardo B Pisani, Juan P Parody, José M Pellegrino, Paloma Martín Sanz, María C Carrillo, Cristina E Carnoval. Hyperglycemia induces apoptosis in rat liver through the increase of hydroxyl radical: new insights into the insulin effect. The Journal of endocrinology. vol 205. issue 2. 2010-04-30. PMID:20164374. |
a new anti-apoptosis signal for insulin is shown, given by an increase of apoptosis inhibitor protein. |
2010-04-30 |
2023-08-12 |
rat |
| Marcos Martínez-Clemente, Natàlia Ferré, Ana González-Périz, Marta López-Parra, Raquel Horrillo, Esther Titos, Eva Morán-Salvador, Rosa Miquel, Vicente Arroyo, Colin D Funk, Joan Clàri. 5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice. Hepatology (Baltimore, Md.). vol 51. issue 3. 2010-04-26. PMID:20112424. |
the 5-lo products leukotriene (lt) b(4), ltd(4), and 5-hete consistently triggered tnf-alpha-induced apoptosis and compromised hepatocyte survival by suppressing nf-kappab activity in the presence of actinomycin d. moreover, apoe(-/-)/5-lo(-/-) mice were protected against sustained high-fat diet (hfd)-induced liver injury and hepatic inflammation, macrophage infiltration and insulin resistance were significantly milder than those of apoe(-/-) mice. |
2010-04-26 |
2023-08-12 |
mouse |
| Elodie Roggli, Aurore Britan, Sonia Gattesco, Nathalie Lin-Marq, Amar Abderrahmani, Paolo Meda, Romano Regazz. Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes. vol 59. issue 4. 2010-04-23. PMID:20086228. |
pancreatic beta-cells exposed to proinflammatory cytokines display alterations in gene expression resulting in defective insulin secretion and apoptosis. |
2010-04-23 |
2023-08-12 |
Not clear |
| S S Solomon, O Odunusi, D Carrigan, G Majumdar, D Kakoola, N I Lenchik, I C Gerlin. TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndrome. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 42. issue 2. 2010-04-22. PMID:19960405. |
twenty-six of these 33 genes created a single network centered around: insulin, tnf-alpha, p38-mapk, tgfb1; smad and stat1; and enzymes and cytokines involved in apoptosis (casp3, gadd45b, il2, tnf-alpha, etc.). |
2010-04-22 |
2023-08-12 |
rat |
| S S Solomon, O Odunusi, D Carrigan, G Majumdar, D Kakoola, N I Lenchik, I C Gerlin. TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndrome. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 42. issue 2. 2010-04-22. PMID:19960405. |
moreover, the two datasets combined generated a single molecular network that further identified pten (a phosphatase) as a unique new link between insulin signaling, ir, and apoptosis reflecting the pathophysiology of "metabolic syndrome". |
2010-04-22 |
2023-08-12 |
rat |
| Louise Vedtofte, Thóra B Bodvarsdottir, Carsten F Gotfredsen, Allan E Karlsen, Lotte B Knudsen, R Scott Helle. Liraglutide, but not vildagliptin, restores normoglycaemia and insulin content in the animal model of type 2 diabetes, Psammomys obesus. Regulatory peptides. vol 160. issue 1-3. 2010-04-09. PMID:20005262. |
in order to investigate the effect and mechanism of liraglutide and vildagliptin in diabetic psammomys obesus, we examined proliferation and apoptosis of beta-cells, beta-cell mass (bcm), and pancreatic insulin content after zero, six and fourteen days of treatment compared to control groups. |
2010-04-09 |
2023-08-12 |
Not clear |
| Louise Vedtofte, Thóra B Bodvarsdottir, Carsten F Gotfredsen, Allan E Karlsen, Lotte B Knudsen, R Scott Helle. Liraglutide, but not vildagliptin, restores normoglycaemia and insulin content in the animal model of type 2 diabetes, Psammomys obesus. Regulatory peptides. vol 160. issue 1-3. 2010-04-09. PMID:20005262. |
non-fasting morning blood glucose, body weight, hba(1c) and pancreatic insulin content were measured and beta cell mass (bcm), proliferation and apoptosis frequencies were determined using stereological point counting. |
2010-04-09 |
2023-08-12 |
Not clear |