| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya-Li Zheng, Ya-Fang Hu, Aiping Zhang, Wei Wang, Bo Li, Niranjana Amin, Philip Grant, Harish C Pan. Overexpression of p35 in Min6 pancreatic beta cells induces a stressed neuron-like apoptosis. Journal of the neurological sciences. vol 299. issue 1-2. 2011-03-16. PMID:20926102. |
roscovitine or co-infection of dominant negative cdk5 (dncdk5) with p35 increased insulin secretion and inhibited apoptosis. |
2011-03-16 |
2023-08-12 |
Not clear |
| V L Foot, C C Richardson, W Jefferson, P D Taylor, M R Christi. Islets in early life are resistant to detrimental effects of a high-fat maternal diet: a study in rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 42. issue 13. 2011-03-16. PMID:20972941. |
isolated islets were studied for insulin secretory responses and susceptibility to palmitate-induced apoptosis assessed by caspases 3/9 activity. |
2011-03-16 |
2023-08-12 |
rat |
| Danilo M Damas-Souza, Cláudio A Oliveira, Hernandes F Carvalh. Insulin affects tissue organization and the kinetics of epithelial cell death in the rat ventral prostate after castration. Journal of andrology. vol 31. issue 6. 2011-03-10. PMID:20539037. |
this idea is supported by the observation that insulin also reduced the overall rate of apoptosis at all experimental points analyzed before and after castration. |
2011-03-10 |
2023-08-12 |
rat |
| Da-Ni Qin, Chun-Zhao Kou, Yu-Hui Ni, Chun-Mei Zhang, Jin-Gai Zhu, Chun Zhu, Yan-Ping Wang, Guan-Zhong Zhu, Chunmei Shi, Chen-Bo Ji, Xi-Rong Gu. Monoclonal antibody to the six-transmembrane epithelial antigen of prostate 4 promotes apoptosis and inhibits proliferation and glucose uptake in human adipocytes. International journal of molecular medicine. vol 26. issue 6. 2011-03-08. PMID:21042773. |
in conclusion, our results demonstrated that the steap4 antibody does not influence human adipocyte differentiation, but it is likely that the steap4 protein regulates proliferation and apoptosis and plays an important role in modulating the insulin sensitivity of human adipocytes. |
2011-03-08 |
2023-08-12 |
human |
| Carole Henique, Abdelhak Mansouri, Gwladys Fumey, Veronique Lenoir, Jean Girard, Frederic Bouillaud, Carina Prip-Buus, Isabelle Cohe. Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis. The Journal of biological chemistry. vol 285. issue 47. 2011-02-28. PMID:20837491. |
furthermore, similar to preincubation with oleate, cpt1mt expression protected muscle cells from palmitate-induced apoptosis and insulin resistance by decreasing the content of deleterious palmitate derivates (i.e. |
2011-02-28 |
2023-08-12 |
Not clear |
| M A Rashid, Seonmin Lee, Eunyoung Tak, Jisun Lee, Tae Gyu Choi, Joo-Won Lee, Jae Bum Kim, Jang H Youn, Insug Kang, Joohun Ha, Sung Soo Ki. Carbonyl reductase 1 protects pancreatic β-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity. Free radical biology & medicine. vol 49. issue 10. 2011-02-17. PMID:20728534. |
under both conditions, knockdown of cbr1 by specific sirna increased β-cell apoptosis, expression of lipogenic enzymes (such as acc, fas, and abca1), intracellular lipid accumulation, oxidative stress, er stress, and nuclear srebp1c, but decreased glucose-stimulated insulin secretion. |
2011-02-17 |
2023-08-12 |
mouse |
| Yunxia Zhu, Tingting Shu, Yan Lin, Hongdong Wang, Junwei Yang, Yuguang Shi, Xiao Ha. Inhibition of the receptor for advanced glycation endproducts (RAGE) protects pancreatic β-cells. Biochemical and biophysical research communications. vol 404. issue 1. 2011-02-14. PMID:21111711. |
inhibition of rage prevented age-induced pancreatic β-cell apoptosis, but could not restore the function of glucose stimulated insulin secretion (gsis) in rat islets. |
2011-02-14 |
2023-08-12 |
rat |
| Friederike Flachsbart, Andre Franke, Rabea Kleindorp, Amke Caliebe, Hélène Blanché, Stefan Schreiber, Almut Nebe. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. Mutation research. vol 694. issue 1-2. 2011-02-03. PMID:20800603. |
here, we performed a targeted investigation of selected genes (i) involved in longevity pathways (insulin receptor/insulin-like growth factor-i signaling and energy metabolism, intracellular signaling, apoptosis and stress response) and (ii) in which mutations lead to genetic perturbations in animal models or human diseases. |
2011-02-03 |
2023-08-12 |
human |
| Deirdre C Keane, Hilton K Takahashi, Shalinee Dhayal, Noel G Morgan, Rui Curi, Philip Newsholm. Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line. Clinical science (London, England : 1979). vol 120. issue 5. 2011-02-03. PMID:20840078. |
chronic exposure of pancreatic β-cells to saturated non-esterified fatty acids can lead to inhibition of insulin secretion and apoptosis. |
2011-02-03 |
2023-08-12 |
Not clear |
| Ai-jing Xu, Zhi-hong Chen, Fei Tian, Li-hua Yan, Tang L. [Effects of adenovirus-mediated interleukin-10 gene transfer on apoptosis and insulin secretion function of beta cell]. Zhonghua yi xue za zhi. vol 90. issue 24. 2011-02-03. PMID:20979884. |
[effects of adenovirus-mediated interleukin-10 gene transfer on apoptosis and insulin secretion function of beta cell]. |
2011-02-03 |
2023-08-12 |
rat |
| Andreas B Petersen, Kamille Smidt, Nils E Magnusson, Fabrice Moore, Laerke Egefjord, Jørgen Rungb. siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and secretion of insulin and apoptosis in INS-1E cells. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 119. issue 2. 2011-02-02. PMID:21208276. |
sirna-mediated knock-down of znt3 and znt8 affects production and secretion of insulin and apoptosis in ins-1e cells. |
2011-02-02 |
2023-08-12 |
Not clear |
| Andreas B Petersen, Kamille Smidt, Nils E Magnusson, Fabrice Moore, Laerke Egefjord, Jørgen Rungb. siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and secretion of insulin and apoptosis in INS-1E cells. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 119. issue 2. 2011-02-02. PMID:21208276. |
zinc is essential for the crystallization of insulin in pancreatic β-cells and is thought to induce apoptosis in a dose-dependent manner, thereby regulating β-cell mass. |
2011-02-02 |
2023-08-12 |
Not clear |
| Andreas B Petersen, Kamille Smidt, Nils E Magnusson, Fabrice Moore, Laerke Egefjord, Jørgen Rungb. siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and secretion of insulin and apoptosis in INS-1E cells. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 119. issue 2. 2011-02-02. PMID:21208276. |
the aim of this study was to examine the effect of the zinc transporters znt3 and znt8 on insulin metabolism and apoptosis. |
2011-02-02 |
2023-08-12 |
Not clear |
| Marion Peyrou, Lucie Bourgoin, Michelangelo Fot. PTEN in liver diseases and cancer. World journal of gastroenterology. vol 16. issue 37. 2011-01-28. PMID:20872961. |
the phosphoinositide 3-kinase (pi3k)/phosphatase and tensin homolog (pten)/akt axis is a key signal transduction node that regulates crucial cellular functions, including insulin and other growth factors signaling, lipid and glucose metabolism, as well as cell survival and apoptosis. |
2011-01-28 |
2023-08-12 |
Not clear |
| Kristofer Thörn, Peter Bergste. Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate. Journal of cellular biochemistry. vol 111. issue 2. 2011-01-25. PMID:20524206. |
palmitate negatively affects insulin secretion and apoptosis in the pancreatic β-cell. |
2011-01-25 |
2023-08-12 |
Not clear |
| Kristofer Thörn, Peter Bergste. Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate. Journal of cellular biochemistry. vol 111. issue 2. 2011-01-25. PMID:20524206. |
insulin secretion was impaired and apoptosis accentuated in palmitate-, and to some extent, stearate-treated cells. |
2011-01-25 |
2023-08-12 |
Not clear |
| Antonio Hernández Mijares, Eva Solá Izquierdo, Katherinne García Malpartida, Danilo Verg. [Safety of insulin analogues: what to evaluate, how to do it, and how to interpret the results]. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. vol 57. issue 8. 2011-01-24. PMID:20621572. |
the mechanism of increased tumor activity of insulin analogues is explained by the fact that they act through insulin receptors (ir) and insulin-like growth factor-1 (igf-1r), stimulating cell growth and inhibiting apoptosis. |
2011-01-24 |
2023-08-12 |
Not clear |
| Iván Restrepo-Angulo, Andrea De Vizcaya-Ruiz, Javier Camach. Ion channels in toxicology. Journal of applied toxicology : JAT. vol 30. issue 6. 2011-01-20. PMID:20583319. |
cardiac contraction, neural transmission, temperature sensing, insulin release, regulation of apoptosis, cellular ph and oxidative stress, as well as detection of active compounds from chilli, are some of the processes in which ion channels have an important role. |
2011-01-20 |
2023-08-12 |
human |
| Carla R Bromati, Camilo Lellis-Santos, Tatiana S Yamanaka, Tatiane C A Nogueira, Mauro Leonelli, Luciana C Caperuto, Renata Gorjão, Adriana R Leite, Gabriel F Anhê, Silvana Bordi. UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression. American journal of physiology. Regulatory, integrative and comparative physiology. vol 300. issue 1. 2011-01-20. PMID:21068199. |
endocrine pancreas from pregnant rats undergoes several adaptations that comprise increase in β-cell number, mass and insulin secretion, and reduction of apoptosis. |
2011-01-20 |
2023-08-12 |
rat |
| Mervi E Hyvönen, Pauliina Saurus, Anita Wasik, Eija Heikkilä, Marika Havana, Ras Trokovic, Moin Saleem, Harry Holthöfer, Sanna Lehtone. Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes. Molecular and cellular endocrinology. vol 328. issue 1-2. 2011-01-18. PMID:20654688. |
overexpression of ship2 in cultured podocytes reduces akt activation in response to insulin, and promotes apoptosis. |
2011-01-18 |
2023-08-12 |
rat |