| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-Feng Du, Peng Yan, Shou-Gang Guo, Chuan-Qiang Q. Effects of fibrillar Aβ(1-40) on the viability of primary cultures of cholinergic neurons and the expression of insulin signaling-related proteins. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 2. 2011-04-25. PMID:21235004. |
we speculate that fibrillar aβ(1-40) may contribute to the pathogenesis of alzheimer's through disrupting the insulin signaling pathway, therefore decreasing neuronal activity and eventually leading to the apoptosis and cell loss. |
2011-04-25 |
2023-08-12 |
rat |
| Angel Nadal, Paloma Alonso-Magdalena, Sergi Soriano, Cristina Ripoll, Esther Fuentes, Ivan Quesada, Ana Belen Roper. Role of estrogen receptors alpha, beta and GPER1/GPR30 in pancreatic beta-cells. Frontiers in bioscience (Landmark edition). vol 16. 2011-04-21. PMID:21196169. |
the increased demand of insulin production for long time may lead to beta-cell stress and apoptosis. |
2011-04-21 |
2023-08-12 |
Not clear |
| Xiangqun Deng, Jinluo Cheng, Yunping Zhang, Ningxu Li, Lulu Che. Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats. Acta diabetologica. vol 47 Suppl 1. 2011-04-15. PMID:19876588. |
these data show that caloric restriction notably improves the sensitivity to insulin and significantly increases mrna and protein expression of sirt1 while decreasing the apoptosis ratio of islet beta cells in diabetic rats. |
2011-04-15 |
2023-08-12 |
rat |
| Kenichiro Shibata, Toshiyuki Nakayama, Hiroshi Hirakawa, Shigekazu Hidaka, Takeshi Nagayas. Clinicopathological significance of angiopoietin-like protein 4 expression in oesophageal squamous cell carcinoma. Journal of clinical pathology. vol 63. issue 12. 2011-04-06. PMID:20861003. |
angiopoietin-like protein 4 (angptl4) is involved in regulating glucose homeostasis, insulin sensitivity, angiogenesis and lipid metabolism, and also acts as an apoptosis survival factor for vascular endothelial cells. |
2011-04-06 |
2023-08-12 |
Not clear |
| Qinghua Wang, Tianru Ji. The role of insulin signaling in the development of β-cell dysfunction and diabetes. Islets. vol 1. issue 2. 2011-03-31. PMID:21099255. |
indeed, impaired insulin signaling in the β-cells and increased β-cell apoptosis are associated with the onset of diabetes in obese insulin resistant type 2 diabetes mellitus (t2dm). |
2011-03-31 |
2023-08-12 |
mouse |
| Ayman Hyder, Marwa Zenhom, Maja Klapper, Julia Herrmann, Jürgen Schrezenmei. Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose. Islets. vol 2. issue 3. 2011-03-31. PMID:21099311. |
although fas are known to stimulate insulin secretion from pancreatic islets when transiently elevated, while contributing to islet loss of function, lipotoxicity and apoptosis when chronically elevated, almost nothing is known regarding the fabps in this tissue. |
2011-03-31 |
2023-08-12 |
rat |
| Martins Kalis, Rajesh Kumar, Sabina Janciauskiene, Albert Salehi, Corrado M Cili. α 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells. Islets. vol 2. issue 3. 2011-03-31. PMID:21099312. |
α 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells. |
2011-03-31 |
2023-08-12 |
rat |
| Martins Kalis, Rajesh Kumar, Sabina Janciauskiene, Albert Salehi, Corrado M Cili. α 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells. Islets. vol 2. issue 3. 2011-03-31. PMID:21099312. |
ins-1e cells or primary rat pancreatic islets were used to study the effect of aat on insulin secretion after glucose, glucagon-like peptide-1 (glp-1) and forskolin stimulation and on cytokine-mediated apoptosis. |
2011-03-31 |
2023-08-12 |
rat |
| Martins Kalis, Rajesh Kumar, Sabina Janciauskiene, Albert Salehi, Corrado M Cili. α 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells. Islets. vol 2. issue 3. 2011-03-31. PMID:21099312. |
the secreted insulin and total cyclic amp (camp) were determined using radioimmunoassay and apoptosis was evaluated by propidium iodide staining followed by facs analysis. |
2011-03-31 |
2023-08-12 |
rat |
| Martins Kalis, Rajesh Kumar, Sabina Janciauskiene, Albert Salehi, Corrado M Cili. α 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells. Islets. vol 2. issue 3. 2011-03-31. PMID:21099312. |
our findings show that aat stimulates insulin secretion and protects β-cells against cytokine-induced apoptosis, and these effects of aat seem to be mediated through the camp pathway. |
2011-03-31 |
2023-08-12 |
rat |
| Tien-Hui Lu, Chin-Chuan Su, Ya-Wen Chen, Ching-Yao Yang, Chin-Ching Wu, Dong-Zong Hung, Chun-Hung Chen, Po-Wen Cheng, Shing-Hwa Liu, Chun-Fa Huan. Arsenic induces pancreatic β-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways. Toxicology letters. vol 201. issue 1. 2011-03-30. PMID:21145380. |
we next observed that exposure of mice to ias in drinking water for 6 consecutive weeks significantly decreased decreased the plasma insulin, elevated glucose intolerance and plasma lipid peroxidation, and induced islet cells apoptosis, which accompanied with arsenic accumulation in the whole blood and pancreas. |
2011-03-30 |
2023-08-12 |
mouse |
| Anutosh Chakraborty, J Kent Werner, Michael A Koldobskiy, Asif K Mustafa, Krishna R Juluri, Joseph Pietropaoli, Adele M Snowman, Solomon H Snyde. Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 6. 2011-03-30. PMID:21262846. |
the inositol pyrophosphate, diphosphoinositol pentakisphosphate, regulates p53 and protein kinase akt signaling, and its aberrant increase in cells has been implicated in apoptosis and insulin resistance. |
2011-03-30 |
2023-08-12 |
Not clear |
| Guorui Huang, Gaoxiang Ge, Dingyan Wang, Bagavathi Gopalakrishnan, Delana H Butz, Ricki J Colman, Andras Nagy, Daniel S Greenspa. α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues. The Journal of clinical investigation. vol 121. issue 2. 2011-03-28. PMID:21293061. |
col5a3–/– mice demonstrated decreased numbers of pancreatic islets, which were more susceptible to streptozotocin-induced apoptosis, and islets isolated from mutant mice displayed blunted glucose-stimulated insulin secretion. |
2011-03-28 |
2023-08-12 |
mouse |
| Carmelo García-Monzón, Oreste Lo Iacono, Rafael Mayoral, Agueda González-Rodríguez, María E Miquilena-Colina, Tamara Lozano-Rodríguez, Leonor García-Pozo, Javier Vargas-Castrillón, Marta Casado, Lisardo Boscá, Angela M Valverde, Paloma Martín-San. Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C. Journal of hepatology. vol 54. issue 1. 2011-03-24. PMID:20888662. |
hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis c. we aimed to elucidate whether hepatic insulin resistance may contribute to hepatocyte apoptosis and fibrogenesis in nonalcoholic fatty liver disease (nafld) and in chronic hepatitis c virus (hcv) infection. |
2011-03-24 |
2023-08-12 |
Not clear |
| Ajit Vikram, Gopabandhu Jena, Poduri Ramara. Insulin-resistance reduces botulinum neurotoxin-type A induced prostatic atrophy and apoptosis in rats. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20940009. |
in the present investigation we report that diet-induced insulin-resistance activates mitogenic signaling of insulin, increases cellular proliferation and reduces bonta-induced prostatic atrophy and apoptosis in rats. |
2011-03-24 |
2023-08-12 |
rat |
| Vijay Shivaswamy, Marissa McClure, Joel Passer, Christin Frahm, LuAnn Ochsner, Judi Erickson, Robert G Bennett, Frederick G Hamel, Jennifer L Larse. Hyperglycemia induced by tacrolimus and sirolimus is reversible in normal sprague-dawley rats. Endocrine. vol 37. issue 3. 2011-03-24. PMID:20960173. |
insulin content was decreased in tac and tac+sir, and islet apoptosis was also increased after tac+sir treatment (p < 0.05). |
2011-03-24 |
2023-08-12 |
rat |
| Vijay Shivaswamy, Marissa McClure, Joel Passer, Christin Frahm, LuAnn Ochsner, Judi Erickson, Robert G Bennett, Frederick G Hamel, Jennifer L Larse. Hyperglycemia induced by tacrolimus and sirolimus is reversible in normal sprague-dawley rats. Endocrine. vol 37. issue 3. 2011-03-24. PMID:20960173. |
in conclusion, tac, sir, and the combination of tac+sir-induced changes in glucose and insulin responses to glucose challenge that were accompanied by changes in islet apoptosis and insulin content. |
2011-03-24 |
2023-08-12 |
rat |
| Zoltan Derdak, Charles H Lang, Kristine A Villegas, Ming Tong, Nicholas M Mark, Suzanne M de la Monte, Jack R Wand. Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. Journal of hepatology. vol 54. issue 1. 2011-03-24. PMID:20961644. |
activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. |
2011-03-24 |
2023-08-12 |
rat |
| Taila Hartley, Madura Siva, Elida Lai, Tracy Teodoro, Liling Zhang, Allen Volchu. Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin. BMC cell biology. vol 11. 2011-03-21. PMID:20659334. |
this mouse strain expresses a mutant insulin 2 gene (c96y), which prevents normal proinsulin folding causing er stress and eventual beta-cell apoptosis. |
2011-03-21 |
2023-08-12 |
mouse |
| P Hillon, B Guiu, J Vincent, J-M Peti. Obesity, type 2 diabetes and risk of digestive cancer. Gastroenterologie clinique et biologique. vol 34. issue 10. 2011-03-21. PMID:20864282. |
insulin and non-protein banded igf-1, whose levels are increased in type 2 diabetes, stimulate cellular growth and inhibit apoptosis. |
2011-03-21 |
2023-08-12 |
Not clear |