| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olivier Le Bacquer, Luan Shu, Marion Marchand, Bernadette Neve, Federico Paroni, Julie Kerr Conte, Francois Pattou, Philippe Froguel, Kathrin Maedle. TCF7L2 splice variants have distinct effects on beta-cell turnover and function. Human molecular genetics. vol 20. issue 10. 2011-08-09. PMID:21357677. |
type 2 diabetes manifests when the β-cell fails to secrete sufficient amounts of insulin to maintain normoglycemia and undergoes apoptosis. |
2011-08-09 |
2023-08-12 |
human |
| Ya Tuo, Dengfeng Wang, Shengbin Li, Chen Che. Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways. Endocrine. vol 39. issue 2. 2011-08-04. PMID:21161439. |
cell viability, apoptosis, glucose-stimulated insulin secretion, bcl-2, and bax gene expression levels, mitochondrial membrane potential and cytochrome c release were examined. |
2011-08-04 |
2023-08-12 |
rat |
| Xiao-Jun Cai, Hui-Qin Xu, Yi L. C-peptide and diabetic encephalopathy. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. vol 26. issue 2. 2011-08-04. PMID:21703121. |
multiple factors are responsible for neuronal apoptosis, such as disturbed insulin growth factor (igf) system, hyperglycemia, and the aging process. |
2011-08-04 |
2023-08-12 |
Not clear |
| Naim Alkhouri, Christine Carter-Kent, Ariel E Feldstei. Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications. Expert review of gastroenterology & hepatology. vol 5. issue 2. 2011-08-03. PMID:21476915. |
an increase in hepatocyte cell death by apoptosis is typically present in patients with nafld and in experimental models of steatohepatitis, while an increase in adipocyte cell death in visceral adipose tissue may be an important mechanism triggering insulin resistance and hepatic steatosis. |
2011-08-03 |
2023-08-12 |
Not clear |
| Surekha Rani Panjala, Jena J Steinl. Insulin and β-adrenergic receptors inhibit retinal endothelial cell apoptosis through independent pathways. Neurochemical research. vol 36. issue 4. 2011-08-02. PMID:21053068. |
insulin and β-adrenergic receptors inhibit retinal endothelial cell apoptosis through independent pathways. |
2011-08-02 |
2023-08-12 |
human |
| Surekha Rani Panjala, Jena J Steinl. Insulin and β-adrenergic receptors inhibit retinal endothelial cell apoptosis through independent pathways. Neurochemical research. vol 36. issue 4. 2011-08-02. PMID:21053068. |
based on previous studies demonstrating an interaction between β-adrenergic receptors and insulin signaling in hyperglycemic conditions, we hypothesized that β-adrenergic receptor stimulation and insulin stimulation would act synergistically to inhibit one of the hallmarks of diabetic retinopathy, namely retinal endothelial cell apoptosis. |
2011-08-02 |
2023-08-12 |
human |
| Surekha Rani Panjala, Jena J Steinl. Insulin and β-adrenergic receptors inhibit retinal endothelial cell apoptosis through independent pathways. Neurochemical research. vol 36. issue 4. 2011-08-02. PMID:21053068. |
this data suggests that both β-adrenergic receptors and insulin can inhibit retinal endothelial cell apoptosis in hyperglycemic conditions, but inhibition occurs through independent pathways. |
2011-08-02 |
2023-08-12 |
human |
| Soojeong Kang, Elie R Chemaly, Roger J Hajjar, Djamel Lebech. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. The Journal of biological chemistry. vol 286. issue 21. 2011-07-28. PMID:21478152. |
furthermore, resistin increased serine phosphorylation of insulin receptor substrate (irs1) through the activation of the apoptosis signal-regulating kinase 1/c-jun n-terminal kinase (jnk) pathway, a module known to stimulate insulin resistance. |
2011-07-28 |
2023-08-12 |
rat |
| Soojeong Kang, Elie R Chemaly, Roger J Hajjar, Djamel Lebech. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. The Journal of biological chemistry. vol 286. issue 21. 2011-07-28. PMID:21478152. |
these data demonstrate that resistin induces cardiac hypertrophy and myocardial insulin resistance, possibly via the ampk/mtor/p70(s6k) and apoptosis signal-regulating kinase 1/jnk/irs1 pathways. |
2011-07-28 |
2023-08-12 |
rat |
| Chuanxia Ju, Wang Yue, Zhihong Yang, Quanfang Zhang, Xue Yang, Zhantao Liu, Fang Zhan. Antidiabetic effect and mechanism of chitooligosaccharides. Biological & pharmaceutical bulletin. vol 33. issue 9. 2011-07-22. PMID:20823566. |
it was found that cos played important roles in ins-1 cells by promoting proliferation, increasing glucose stimulated insulin release, upregulating the expressions of glut-2 mrna and protecting against stz-induced apoptosis. |
2011-07-22 |
2023-08-12 |
rat |
| Mario Vallej. The aristaless-like homeobox protein Alx3 as an etiopathogenic factor for diabetes mellitus. Islets. vol 3. issue 2. 2011-07-20. PMID:21350340. |
inactivation of the gene encoding the aristaless-related homeodomain transcription factor alx3 results in islet cell apoptosis and impaired glucose homeostasis that worsens with age due to the appearance of insulin resistance. |
2011-07-20 |
2023-08-12 |
mouse |
| John Zeqi Luo, Luguang Lu. American ginseng stimulates insulin production and prevents apoptosis through regulation of uncoupling protein-2 in cultured beta cells. Evidence-based complementary and alternative medicine : eCAM. vol 3. issue 3. 2011-07-14. PMID:16951721. |
american ginseng stimulates insulin production and prevents apoptosis through regulation of uncoupling protein-2 in cultured beta cells. |
2011-07-14 |
2023-08-12 |
Not clear |
| John Zeqi Luo, Luguang Lu. American ginseng stimulates insulin production and prevents apoptosis through regulation of uncoupling protein-2 in cultured beta cells. Evidence-based complementary and alternative medicine : eCAM. vol 3. issue 3. 2011-07-14. PMID:16951721. |
to test the hypothesis, the serum-deprived quiescent beta cells were cultured with or without interleukin-1beta (il-1beta), (200 pg ml(-1), a cytokine to induce beta cell apoptosis) and water extracts of american ginseng (25 mug per 5 mul administered to wells of 0.5 ml culture) for 24 h. we evaluated effects of ginseng on ucp-2 expression, insulin production, anti-/pro-apoptotic factors bcl-2/caspase-9 expression and cellular atp levels. |
2011-07-14 |
2023-08-12 |
Not clear |
| John Zeqi Luo, Luguang Lu. American ginseng stimulates insulin production and prevents apoptosis through regulation of uncoupling protein-2 in cultured beta cells. Evidence-based complementary and alternative medicine : eCAM. vol 3. issue 3. 2011-07-14. PMID:16951721. |
we found that ginseng suppresses ucp-2, down-regulates caspase-9 while increasing atp and insulin production/secretion and up-regulates bcl-2, reducing apoptosis. |
2011-07-14 |
2023-08-12 |
Not clear |
| John Zeqi Luo, Luguang Lu. American ginseng stimulates insulin production and prevents apoptosis through regulation of uncoupling protein-2 in cultured beta cells. Evidence-based complementary and alternative medicine : eCAM. vol 3. issue 3. 2011-07-14. PMID:16951721. |
these findings suggest that stimulation of insulin production and prevention of beta cell loss by american ginseng extracts can occur via the inhibition of mitochondrial ucp-2, resulting in increase in the atp level and the anti-apoptotic factor bcl-2, while down-regulation of pro-apoptotic factor caspase-9 occurs, lowering the occurrence of apoptosis, which support the hypothesis. |
2011-07-14 |
2023-08-12 |
Not clear |
| Dan Kawamori, Hideaki Kanet. [Effects of incretins on the regulation of beta-cell mass, proliferation and survival]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 5. 2011-07-08. PMID:21595265. |
not only enhancing glucose-stimulated insulin secretion, but incretins exert beta-cell mass maintaining effects by upregulation of proliferation and prevention of cell death (apoptosis). |
2011-07-08 |
2023-08-12 |
Not clear |
| Jun-Ichiro Miyagawa, Masayuki Miuchi, Mitsuyoshi Namb. [Incretin-based therapy in patients with type 1 diabetes mellitus]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 5. 2011-07-08. PMID:21595283. |
glp-1 has multiple physiological functions including glucose-dependent insulin secretion and glucagon suppression, delay of gastic emptying, suppression of hepatic glucose production, stimulation of beta cell replication and neogenesis, inhibition of beta cell apoptosis. |
2011-07-08 |
2023-08-12 |
Not clear |
| Marco Gallo, Donha Park, Dan S Luciani, Katarzyna Kida, Ferdinando Palmieri, Oliver E Blacque, James D Johnson, Donald L Riddl. MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion. PloS one. vol 6. issue 3. 2011-07-05. PMID:21448454. |
misc-1/ogc links mitochondrial metabolism, apoptosis and insulin secretion. |
2011-07-05 |
2023-08-12 |
human |
| Simona Cernea, Itamar Ra. Therapy in the early stage: incretins. Diabetes care. vol 34 Suppl 2. 2011-07-01. PMID:21525466. |
importantly, short-term studies have shown that incretins/incretin-based therapies protect β-cells (by enhancing cell proliferation and differentiation and inhibiting apoptosis) and stimulate their function (by recruiting β-cells to the secretory process and increasing insulin biosynthesis/secretion). |
2011-07-01 |
2023-08-12 |
Not clear |
| Vivian C Calegari, Adriana S Torsoni, Emerielle C Vanzela, Eliana P Araújo, Joseane Morari, Claudio C Zoppi, Lourenço Sbragia, Antonio C Boschero, Lício A Vellos. Inflammation of the hypothalamus leads to defective pancreatic islet function. The Journal of biological chemistry. vol 286. issue 15. 2011-06-28. PMID:21257748. |
intracerebroventricular injection of a low dose of tumor necrosis factor α leads to a dysfunctional increase in insulin secretion and activates the expression of a number of markers of apoptosis in pancreatic islets. |
2011-06-28 |
2023-08-12 |
Not clear |