| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lukas Adrian Berchtold, Zenia Marian Størling, Fernanda Ortis, Kasper Lage, Claus Bang-Berthelsen, Regine Bergholdt, Jacob Hald, Caroline Anna Brorsson, Decio Laks Eizirik, Flemming Pociot, Søren Brunak, Joachim Størlin. Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 37. 2011-11-09. PMID:21705657. |
huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis. |
2011-11-09 |
2023-08-12 |
human |
| Minoru Ito, Michiaki Nagasawa, Naoki Omae, Tomohiro Ide, Yunike Akasaka, Koji Murakam. Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes. Journal of lipid research. vol 52. issue 8. 2011-11-08. PMID:21636835. |
both insulin and the cell death-inducing dna fragmentation factor-α-like effector (cide) family play important roles in apoptosis and lipid droplet formation. |
2011-11-08 |
2023-08-12 |
human |
| M-C Lacroix, A Rodriguez-Enfedaque, D Grébert, I Laziz, N Meunier, R Monnerie, M-A Persuy, S Riviere, M Caillol, F Renau. Insulin but not leptin protects olfactory mucosa from apoptosis. Journal of neuroendocrinology. vol 23. issue 7. 2011-11-07. PMID:21554433. |
insulin but not leptin protects olfactory mucosa from apoptosis. |
2011-11-07 |
2023-08-12 |
Not clear |
| Jinbiao Peng, Geoffrey N Gobert, Yang Hong, Weibin Jiang, Hongxiao Han, Donald P McManus, Xinzhi Wang, Jinming Liu, Zhiqiang Fu, Yaojun Shi, Jiaojiao Li. Apoptosis governs the elimination of Schistosoma japonicum from the non-permissive host Microtus fortis. PloS one. vol 6. issue 6. 2011-11-02. PMID:21731652. |
genes that were down-regulated in schistosomula from m. fortis included apoptosis-inhibited genes encoding a baculoviral iap repeat-containing protein (sjiap) and cytokine-induced apoptosis inhibitor (sjciap), genes encoding molecules involved in insulin metabolism, long-chain fatty acid metabolism, signal transduction, the transforming growth factor (tgf) pathway, the wnt pathway and in development. |
2011-11-02 |
2023-08-12 |
mouse |
| Eli C Lewis, Lykke Blaabjerg, Joachim Størling, Sif G Ronn, Paolo Mascagni, Charles A Dinarello, Thomas Mandrup-Poulse. The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro. Molecular medicine (Cambridge, Mass.). vol 17. issue 5-6. 2011-10-27. PMID:21193899. |
in vitro, at 25 and 250 nmol/l, itf2357 increased islet cell viability, enhanced insulin secretion, inhibited mip-1α and mip-2 release, reduced nitric oxide production and decreased apoptosis rates from 14.3% (vehicle) to 2.6% (itf2357). |
2011-10-27 |
2023-08-12 |
mouse |
| Marc G Jeschke, Robert Kraft, Juquan Song, Gerd G Gauglitz, Robert A Cox, Natasha C Brooks, Celeste C Finnerty, Gabriela A Kulp, David N Herndon, Darren Boehnin. Insulin protects against hepatic damage postburn. Molecular medicine (Cambridge, Mass.). vol 17. issue 5-6. 2011-10-27. PMID:21267509. |
we therefore hypothesized that insulin administration exerts its effects by attenuating postburn hepatic er stress and subsequent apoptosis. |
2011-10-27 |
2023-08-12 |
rat |
| Marc G Jeschke, Robert Kraft, Juquan Song, Gerd G Gauglitz, Robert A Cox, Natasha C Brooks, Celeste C Finnerty, Gabriela A Kulp, David N Herndon, Darren Boehnin. Insulin protects against hepatic damage postburn. Molecular medicine (Cambridge, Mass.). vol 17. issue 5-6. 2011-10-27. PMID:21267509. |
insulin decreased hepatocyte caspase-3 activation and apoptosis significantly at 24 and 48 h postburn. |
2011-10-27 |
2023-08-12 |
rat |
| Marc G Jeschke, Robert Kraft, Juquan Song, Gerd G Gauglitz, Robert A Cox, Natasha C Brooks, Celeste C Finnerty, Gabriela A Kulp, David N Herndon, Darren Boehnin. Insulin protects against hepatic damage postburn. Molecular medicine (Cambridge, Mass.). vol 17. issue 5-6. 2011-10-27. PMID:21267509. |
insulin alleviates burn-induced er stress, hepatocyte apoptosis, mitochondrial abnormalities, and inflammation leading to improved hepatic structure and function significantly. |
2011-10-27 |
2023-08-12 |
rat |
| Mariea D Bosco, Daisy M Mohanasundaram, Chris J Drogemuller, Carol J Lang, Peter D Zalewski, P Toby Coate. Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation. The review of diabetic studies : RDS. vol 7. issue 4. 2011-10-27. PMID:21713314. |
the critical trace element zinc is essential for normal insulin production, and plays a central role in cellular protection against apoptosis and oxidative stress. |
2011-10-27 |
2023-08-12 |
Not clear |
| Daniela Molè, Teresa Gagliano, Erica Gentilin, Federico Tagliati, Claudio Pasquali, Maria Rosaria Ambrosio, Giancarlo Pansini, Ettore C Degli Uberti, Maria Chiara Zatell. Targeting protein kinase C by Enzastaurin restrains proliferation and secretion in human pancreatic endocrine tumors. Endocrine-related cancer. vol 18. issue 4. 2011-10-25. PMID:21606156. |
cell viability and apoptosis were evaluated after 48-72 h; chromogranin a (cga) and/or insulin secretion was assessed after 6 h of incubation. |
2011-10-25 |
2023-08-12 |
human |
| Cheng Tan, Ji-ping Zhao, Chang Zhan. [Survey of clinical and experimental researches on mechanisms of acupuncture treatment of bronchial asthma]. Zhen ci yan jiu = Acupuncture research. vol 36. issue 4. 2011-10-25. PMID:21942186. |
animal experiments showed that acupuncture could function in (1) improving pulmonary function; (2) reducing accumulation of the peripheral eosinophile granulocytes (eos), relieving the infiltration of inflammatory cells in the air-passage mucosa and promoting the apoptosis of eos in the lung and air-passages; (3) down-regulating the expression of air-passage remodeling-related protein insulin growth factor-1; (4) suppressing the secretion of tumor necrosis factor and endothelin; (5) attenuating allergic reaction; (6) regulating neuroendocrine activity; and (7) modulating intracellular second messenger activities. |
2011-10-25 |
2023-08-12 |
Not clear |
| Christopher L Gentile, Melinda Frye, Michael J Pagliassott. Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease. Antioxidants & redox signaling. vol 15. issue 2. 2011-10-19. PMID:21128705. |
importantly, the signaling pathway activated by disruption of er homeostasis, the unfolded protein response, has been linked to lipid biosynthesis, insulin action, inflammation, and apoptosis. |
2011-10-19 |
2023-08-12 |
Not clear |
| Yang Li, Wujun Xue, Xiaohui Tian, Xiaoming Ding, Puxun Tian, Xinshun Feng, Yong Song, Xiaohui Luo, Hongbao Liu, Xiaohong Wang, Chenguang Din. Improved survival and function of rat cryopreserved islets by coculture with sertoli cells. Artificial organs. vol 35. issue 6. 2011-10-04. PMID:21371055. |
using light and transmission electron microscopes, we examined the morphology of islets and measured their apoptosis index (ai) and insulin release stimulation index (si). |
2011-10-04 |
2023-08-12 |
mouse |
| D M S Ferreira, R E Castro, M V Machado, T Evangelista, A Silvestre, A Costa, J Coutinho, F Carepa, H Cortez-Pinto, C M P Rodrigue. Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease. Diabetologia. vol 54. issue 7. 2011-10-04. PMID:21455726. |
apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease. |
2011-10-04 |
2023-08-12 |
Not clear |
| D M S Ferreira, R E Castro, M V Machado, T Evangelista, A Silvestre, A Costa, J Coutinho, F Carepa, H Cortez-Pinto, C M P Rodrigue. Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease. Diabetologia. vol 54. issue 7. 2011-10-04. PMID:21455726. |
its pathogenesis and correlation with apoptosis and insulin resistance in insulin target tissues remains incompletely understood. |
2011-10-04 |
2023-08-12 |
Not clear |
| D M S Ferreira, R E Castro, M V Machado, T Evangelista, A Silvestre, A Costa, J Coutinho, F Carepa, H Cortez-Pinto, C M P Rodrigue. Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease. Diabetologia. vol 54. issue 7. 2011-10-04. PMID:21455726. |
we investigated how insulin signalling, caspase activation and apoptosis correlate with different nafld stages in liver, muscle and visceral adipose tissues. |
2011-10-04 |
2023-08-12 |
Not clear |
| V S C Wong, A H Oh, A A Chassot, M C Chaboissier, P L Brubake. R-spondin1 deficiency in mice improves glycaemic control in association with increased beta cell mass. Diabetologia. vol 54. issue 7. 2011-10-04. PMID:21484214. |
we have demonstrated that rspo1 is expressed in murine beta cells, and that it stimulates proliferation and insulin secretion, and inhibits cytokine-induced apoptosis, in mouse insulinoma (min6) and beta cells. |
2011-10-04 |
2023-08-12 |
mouse |
| Karan P Sanghera, Nurit Mathalone, Ramteen Baigi, Elan Panov, Dan Wang, Xu Zhao, Howard Hsu, Hai Wang, Vincent Tropepe, Michael Ward, Shelley R Boy. The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress. Molecular and cellular neurosciences. vol 47. issue 2. 2011-10-03. PMID:21463685. |
under hypoxic conditions, multipotent rpcs upregulate epo receptors, and epo, along with insulin, protects against both superoxide- and severe hypoxia- (0.25% o₂) induced apoptosis through activation of the canonical pi3k/akt/mtor pathway. |
2011-10-03 |
2023-08-12 |
Not clear |
| Emma M Carrington, Cameron Kos, Yifan Zhan, Balasubramanian Krishnamurthy, Janette Alliso. Reducing or increasing β-cell apoptosis without inflammation does not affect diabetes initiation in neonatal NOD mice. European journal of immunology. vol 41. issue 8. 2011-10-03. PMID:21674480. |
we used transgenic over-expression of either an anti-apoptotic protein (bcl-2) or a toxic transgene (rat insulin promoter-kb) in mouse β cells to reduce or increase neonatal β-cell apoptosis, respectively. |
2011-10-03 |
2023-08-12 |
mouse |
| Michaela Keuper, Matthias Blüher, Michael R Schön, Peter Möller, Anna Dzyakanchuk, Kurt Amrein, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszk. An inflammatory micro-environment promotes human adipocyte apoptosis. Molecular and cellular endocrinology. vol 339. issue 1-2. 2011-09-30. PMID:21501656. |
macrophage-secreted factors induced insulin resistance, inhibited insulin-stimulated akt phosphorylation, and induced apoptosis of adipocytes. |
2011-09-30 |
2023-08-12 |
human |