| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michaela Keuper, Matthias Blüher, Michael R Schön, Peter Möller, Anna Dzyakanchuk, Kurt Amrein, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszk. An inflammatory micro-environment promotes human adipocyte apoptosis. Molecular and cellular endocrinology. vol 339. issue 1-2. 2011-09-30. PMID:21501656. |
our data suggest a link between insulin resistance and apoptosis sensitivity. |
2011-09-30 |
2023-08-12 |
human |
| Michaela Keuper, Matthias Blüher, Michael R Schön, Peter Möller, Anna Dzyakanchuk, Kurt Amrein, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszk. An inflammatory micro-environment promotes human adipocyte apoptosis. Molecular and cellular endocrinology. vol 339. issue 1-2. 2011-09-30. PMID:21501656. |
accordingly, pharmacological and genetic inhibition of insulin signaling at the level of akt2 sensitized adipocytes to apoptosis induction by macrophage-secreted factors. |
2011-09-30 |
2023-08-12 |
human |
| Michaela Keuper, Matthias Blüher, Michael R Schön, Peter Möller, Anna Dzyakanchuk, Kurt Amrein, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszk. An inflammatory micro-environment promotes human adipocyte apoptosis. Molecular and cellular endocrinology. vol 339. issue 1-2. 2011-09-30. PMID:21501656. |
our data suggest a feed-forward cycle in which macrophages further drive the inflammatory process by inducing insulin resistance and concomitant apoptosis of adipocytes. |
2011-09-30 |
2023-08-12 |
human |
| Miriam Granado, Cristina García-Cáceres, María Tuda, Laura M Frago, Julie A Chowen, Jesús Argent. Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats. Molecular and cellular endocrinology. vol 337. issue 1-2. 2011-09-26. PMID:21352888. |
hence, we analyzed the effect of insulin and gh-releasing peptide 6 (ghrp-6) on diabetes-induced apoptosis in the pituitary, hypothalamus and cerebellum of diabetic rats. |
2011-09-26 |
2023-08-12 |
rat |
| Miriam Granado, Cristina García-Cáceres, María Tuda, Laura M Frago, Julie A Chowen, Jesús Argent. Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats. Molecular and cellular endocrinology. vol 337. issue 1-2. 2011-09-26. PMID:21352888. |
in the pituitary, insulin treatment prevented diabetes-induced apoptosis (p<0.01), as well as the decline in prolactin and gh mrna levels (p<0.05). |
2011-09-26 |
2023-08-12 |
rat |
| Miriam Granado, Cristina García-Cáceres, María Tuda, Laura M Frago, Julie A Chowen, Jesús Argent. Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats. Molecular and cellular endocrinology. vol 337. issue 1-2. 2011-09-26. PMID:21352888. |
in the cerebellum, although insulin treatment increased gfap levels (p<0.01), only the combined treatment of insulin+ ghrp-6 decreased diabetes-induced apoptosis (p<0.05). |
2011-09-26 |
2023-08-12 |
rat |
| Wan-Fu Zhang, Xiong-Xiang Zhu, Da-Hai Hu, Cheng-Feng Xu, Yun-Chuan Wang, Gen-Fa L. Intensive insulin treatment attenuates burn-initiated acute lung injury in rats: role of the protective endothelium. Journal of burn care & research : official publication of the American Burn Association. vol 32. issue 3. 2011-09-19. PMID:21436719. |
overall, intensive insulin treatment efficiently attenuated pulmonary microvascular endothelial cell dysfunction, decreased cell apoptosis, and inhibited acute lung injury after a burn. |
2011-09-19 |
2023-08-12 |
rat |
| Tetsuo Ogawa, Chizu Wakai, Tomomi Saito, Aya Murayama, Yuuichi Mimura, Sachiko Youfu, Tomoya Nakamachi, Makiko Kuwagata, Kazue Satoh, Seiji Shiod. Distribution of the longevity gene product, SIRT1, in developing mouse organs. Congenital anomalies. vol 51. issue 2. 2011-09-13. PMID:21054562. |
the mammalian homolog of sir2, sirt1(sirtuin 1), has been shown to play important roles related to anti-aging effects (regulating apoptosis, stress tolerance, insulin resistance, and fat metabolism). |
2011-09-13 |
2023-08-12 |
mouse |
| John Y Jun, Zhexi Ma, Lakshman Sega. Spontaneously diabetic Ins2(+/Akita):apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis. American journal of physiology. Endocrinology and metabolism. vol 301. issue 1. 2011-09-06. PMID:21447785. |
to address this question, we generated ins2(+/akita):apoe(-/-) mouse by cross-breeding ins2(+/akita) mouse (which has ins2 gene mutation, causing pancreatic β-cell apoptosis and insulin deficiency) with apoe(-/-) mouse. |
2011-09-06 |
2023-08-12 |
mouse |
| Cynthia Khoo, Juxiang Yang, Gautam Rajpal, You Wang, Jiangying Liu, Peter Arvan, Doris A Stoffer. Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells. Endocrinology. vol 152. issue 7. 2011-09-02. PMID:21540283. |
in min6 cells, small interfering rna-mediated silencing of ero1lβ decreased insulin content and increased susceptibility to er stress-induced apoptosis. |
2011-09-02 |
2023-08-12 |
mouse |
| Tingting Shu, Yunxia Zhu, Hongdong Wang, Yan Lin, Zhuo Ma, Xiao Ha. AGEs decrease insulin synthesis in pancreatic β-cell by repressing Pdx-1 protein expression at the post-translational level. PloS one. vol 6. issue 4. 2011-08-30. PMID:21533167. |
recent studies have shown that ages can impair β-cell function by inducing apoptosis or decreasing insulin secretion. |
2011-08-30 |
2023-08-12 |
rat |
| Takanori Numata, Jun Araya, Satoko Fujii, Hiromichi Hara, Naoki Takasaka, Jun Kojima, Shunsuke Minagawa, Yoko Yumino, Makoto Kawaishi, Jun Hirano, Makoto Odaka, Toshiaki Morikawa, Stephen L Nishimura, Katsutoshi Nakayama, Kazuyoshi Kuwan. Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 1. 2011-08-30. PMID:21646299. |
in addition to metabolic control, insulin signaling was postulated to be protective by inhibiting apoptosis. |
2011-08-30 |
2023-08-12 |
human |
| Takanori Numata, Jun Araya, Satoko Fujii, Hiromichi Hara, Naoki Takasaka, Jun Kojima, Shunsuke Minagawa, Yoko Yumino, Makoto Kawaishi, Jun Hirano, Makoto Odaka, Toshiaki Morikawa, Stephen L Nishimura, Katsutoshi Nakayama, Kazuyoshi Kuwan. Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 1. 2011-08-30. PMID:21646299. |
therefore, we explored the role of insulin signaling in protecting against tlr3-mediated apoptosis of human bronchial epithelial cells. |
2011-08-30 |
2023-08-12 |
human |
| Takanori Numata, Jun Araya, Satoko Fujii, Hiromichi Hara, Naoki Takasaka, Jun Kojima, Shunsuke Minagawa, Yoko Yumino, Makoto Kawaishi, Jun Hirano, Makoto Odaka, Toshiaki Morikawa, Stephen L Nishimura, Katsutoshi Nakayama, Kazuyoshi Kuwan. Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 1. 2011-08-30. PMID:21646299. |
however, insulin efficiently inhibited tlr3/polyinosinic-polycytidylic acid-induced human bronchial epithelial cell apoptosis via pi3k/akt and erk pathways, at least in part, via upregulation of cellular flips and through protein synthesis-independent mechanisms. |
2011-08-30 |
2023-08-12 |
human |
| Takanori Numata, Jun Araya, Satoko Fujii, Hiromichi Hara, Naoki Takasaka, Jun Kojima, Shunsuke Minagawa, Yoko Yumino, Makoto Kawaishi, Jun Hirano, Makoto Odaka, Toshiaki Morikawa, Stephen L Nishimura, Katsutoshi Nakayama, Kazuyoshi Kuwan. Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 1. 2011-08-30. PMID:21646299. |
these results indicate the significance of tlr3-mediated dsrna-induced apoptosis in the pathogenesis of apoptosis-driven lung disease and provide evidence for a novel protective role of insulin. |
2011-08-30 |
2023-08-12 |
human |
| U Rajamani, D Joseph, S Roux, M F Esso. The hexosamine biosynthetic pathway can mediate myocardial apoptosis in a rat model of diet-induced insulin resistance. Acta physiologica (Oxford, England). vol 202. issue 2. 2011-08-29. PMID:21385329. |
the hexosamine biosynthetic pathway can mediate myocardial apoptosis in a rat model of diet-induced insulin resistance. |
2011-08-29 |
2023-08-12 |
rat |
| Yin-Hsun Feng, Guermarie Velazquez-Torres, Christopher Gully, Jian Chen, Mong-Hong Lee, Sai-Ching Jim Yeun. The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. Journal of cellular and molecular medicine. vol 15. issue 4. 2011-08-26. PMID:20455996. |
although high insulin and glucose concentrations promoted chemoresistance, the combination of metformin or rosiglitazone with gemcitabine or doxorubicin, resulted in an additional decrease in live cancer cells and increase in apoptosis. |
2011-08-26 |
2023-08-12 |
human |
| R Puff, P Dames, M Weise, B Göke, J Seissler, K G Parhofer, A Lechne. Reduced proliferation and a high apoptotic frequency of pancreatic beta cells contribute to genetically-determined diabetes susceptibility of db/db BKS mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 43. issue 5. 2011-08-25. PMID:21412687. |
body weight, fasting blood glucose, plasma insulin, homa-ir, alpha cell mass, beta cell mass, proliferation and apoptosis were measured. |
2011-08-25 |
2023-08-12 |
mouse |
| Wei Zhang, Dao-xin Wan. [Study of regulatory effect of insulin on expression of epithelial sodium channel alpha subunit in A549 cells]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. vol 22. issue 7. 2011-08-15. PMID:20663296. |
to observe the effects of insulin on the expression of epithelial sodium channel alpha subunit (enac-alpha) in human pulmonary adenocarcinoma cell line (a549 cells) and its impact on apoptosis of the cells. |
2011-08-15 |
2023-08-12 |
human |
| B K Saha. Insulin therapy at onset of type 2 diabetes mellitus--a new concept. The Journal of the Association of Physicians of India. vol 59 Suppl. 2011-08-11. PMID:21818993. |
thus insulin therapy at onset provides an opportunity to correct all the underlying pathogenic mechanisms, i.e., glucotoxicity, lipotoxicity and prevents beta cell apoptosis and suppresses inflammation, leading to beta cell protection. |
2011-08-11 |
2023-08-12 |
human |