| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyoichiro Tsuchiya, Alexander S Banks, Chien-Ping Liang, Ira Tabas, Alan R Tall, Domenico Accil. Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis. Arteriosclerosis, thrombosis, and vascular biology. vol 31. issue 12. 2012-01-27. PMID:21940942. |
insulin resistance renders macrophages more prone to cholesterol-induced apoptosis by promoting nuclear localization of transcription factor forkhead box transcription factor (fox) o1. |
2012-01-27 |
2023-08-12 |
Not clear |
| Maria Ripoli, Valerio Pazienz. Impact of HCV genetic differences on pathobiology of disease. Expert review of anti-infective therapy. vol 9. issue 9. 2012-01-26. PMID:21905784. |
pathways involved in cell proliferation, apoptosis, lipid metabolism, insulin and interferon signaling are impaired to a different extent among genotypes, leading to distinct pathological settings. |
2012-01-26 |
2023-08-12 |
Not clear |
| Xinyuan Huang, Yanying Zhao, Shaohui Jia, Dongjing Yan, Zhengwang Che. Effects of daintain/AIF-1 on β cell dysfunction in INS-1 cells. Bioscience, biotechnology, and biochemistry. vol 75. issue 9. 2012-01-13. PMID:21897012. |
cells incubated with daintain/aif-1 showed decreased cell viability and glucose-stimulated insulin secretion, as well as upregulated apoptosis and no production. |
2012-01-13 |
2023-08-12 |
Not clear |
| Yong-ho Lee, Faidon Magkos, Christos S Mantzoros, Eun Seok Kan. Effects of leptin and adiponectin on pancreatic β-cell function. Metabolism: clinical and experimental. vol 60. issue 12. 2012-01-10. PMID:21632069. |
available evidence concerning the role of these adipokines on insulin secretion, insulin gene expression, and apoptosis is not always entirely consistent; and many fundamental questions remain to be answered by future studies. |
2012-01-10 |
2023-08-12 |
human |
| Mariella Tancredi, Lorella Marselli, Cristina Lencioni, Matilde Masini, Marco Bugliani, Mara Suleiman, Pellegrino Masiello, Ugo Boggi, Franco Filipponi, Francesco Dotta, Piero Marchetti, Graziano Di Ciann. Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: A case report. Islets. vol 3. issue 5. 2012-01-05. PMID:21765242. |
β-cell apoptosis and the presence of ki67 positive islet cells were similar in gd and controls, whereas the amount of insulin positive cells in or close to the ducts was decreased in gd. |
2012-01-05 |
2023-08-12 |
human |
| P B Tirupathi Pichiah, U Suriyakalaa, S Kamalakkannan, P Kokilavani, S Kalaiselvi, D SankarGanesh, J Gowri, G Archunan, Youn-Soo Cha, S Achirama. Spermidine may decrease ER stress in pancreatic beta cells and may reduce apoptosis via activating AMPK dependent autophagy pathway. Medical hypotheses. vol 77. issue 4. 2011-12-29. PMID:21831529. |
hence either inhibition of mtor or activation of ampk by spermidine will play two crucial roles, first being the activation of autophagy and secondly the reduction of endoplasmic reticulum stress which will reduce beta cell death by apoptosis and thus can be a novel therapeutic candidate in the treatment of insulin resistance in type 2 diabetes and preserving pancreatic beta cell mass. |
2011-12-29 |
2023-08-12 |
human |
| Emilyn U Alejandro, Gareth E Lim, Arya E Mehran, Xiaoke Hu, Farnaz Taghizadeh, Dmytro Pelipeychenko, Manuela Baccarini, James D Johnso. Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 11. 2011-12-27. PMID:21817126. |
we have previously reported that insulin protects β cells from apoptosis and promotes proliferation by activating raf-1 signaling in cultured human islets, mouse islets, and min6 cells. |
2011-12-27 |
2023-08-12 |
mouse |
| Emilyn U Alejandro, Gareth E Lim, Arya E Mehran, Xiaoke Hu, Farnaz Taghizadeh, Dmytro Pelipeychenko, Manuela Baccarini, James D Johnso. Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 11. 2011-12-27. PMID:21817126. |
as raf-1 activity is critical for basal apoptosis and insulin secretion in vitro, we hypothesized that raf-1 may play an important role in glucose homeostasis in vivo. |
2011-12-27 |
2023-08-12 |
mouse |
| Anutosh Chakraborty, Seyun Kim, Solomon H Snyde. Inositol pyrophosphates as mammalian cell signals. Science signaling. vol 4. issue 188. 2011-12-19. PMID:21878680. |
mammalian functions for inositol pyrophosphates have been investigated by using cell lines to establish roles in various processes, including insulin secretion and apoptosis. |
2011-12-19 |
2023-08-12 |
mouse |
| Julie E Simpson, Paul G Ince, Pamela J Shaw, Paul R Heath, Rohini Raman, Claire J Garwood, Catherine Gelsthorpe, Lynne Baxter, Gillian Forster, Fiona E Matthews, Carol Brayne, Stephen B Wharto. Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype. Neurobiology of aging. vol 32. issue 10. 2011-12-15. PMID:21705112. |
dysregulation of genes associated with the actin cytoskeleton, proliferation, apoptosis, and ubiquitin-mediated proteolysis occurred at low braak stages, while altered regulation of intracellular signaling pathways, including insulin, phosphatidylinositol 3-kinase (pi3k)/akt, and mitogen-activated protein kinase (mapk) pathways were primarily associated with high levels of alzheimer-type pathology, and occurred at lower braak stages in individuals with the apoeε4 allele. |
2011-12-15 |
2023-08-12 |
Not clear |
| Rodolphe Anty, Maud Lemoin. Liver fibrogenesis and metabolic factors. Clinics and research in hepatology and gastroenterology. vol 35 Suppl 1. 2011-12-15. PMID:21742296. |
major profibrogenic protagonists, such as hepatic stellate cells and kupffer cells, are activated by insulin resistance, apoptosis and local inflammation. |
2011-12-15 |
2023-08-12 |
Not clear |
| Hilton Kenji Takahashi, Tavane David Cambiaghi, Augusto Ducati Luchessi, Sandro Massao Hirabara, Marco Aurelio Ramirez Vinolo, Philip Newsholme, Rui Cur. Activation of survival and apoptotic signaling pathways in lymphocytes exposed to palmitic acid. Journal of cellular physiology. vol 227. issue 1. 2011-12-08. PMID:21437903. |
our results suggest that parameters of insulin signaling and non-oxidative glucose metabolism are stimulated as part of a coordinated response to prompt survival in lymphocytes exposed to pa but at higher concentrations, apoptosis prevails. |
2011-12-08 |
2023-08-12 |
human |
| Hui-qing Li, Bao-ping Wang, Xiu-Ling Deng, Jiao-yue Zhang, Yong-bo Wang, Juan Zheng, Wen-fang Xia, Tian-shu Zeng, Lu-lu Che. Insulin improves β-cell function in glucose-intolerant rat models induced by feeding a high-fat diet. Metabolism: clinical and experimental. vol 60. issue 11. 2011-12-07. PMID:21550078. |
this study investigated the effects of insulin treatment on pancreatic lipid content, and β-cell apoptosis and proliferation in glucose-intolerant rats to explore the protective role of insulin on β-cell function. |
2011-12-07 |
2023-08-12 |
rat |
| Hui-qing Li, Bao-ping Wang, Xiu-Ling Deng, Jiao-yue Zhang, Yong-bo Wang, Juan Zheng, Wen-fang Xia, Tian-shu Zeng, Lu-lu Che. Insulin improves β-cell function in glucose-intolerant rat models induced by feeding a high-fat diet. Metabolism: clinical and experimental. vol 60. issue 11. 2011-12-07. PMID:21550078. |
plasma and pancreatic triglycerides, free fatty acids, and insulin were measured; and pancreatic β-cell cell apoptosis and proliferation were detected by a propidium iodide cell death assay and immunofluorescence for proliferating cell nuclear antigen. |
2011-12-07 |
2023-08-12 |
rat |
| Hui-qing Li, Bao-ping Wang, Xiu-Ling Deng, Jiao-yue Zhang, Yong-bo Wang, Juan Zheng, Wen-fang Xia, Tian-shu Zeng, Lu-lu Che. Insulin improves β-cell function in glucose-intolerant rat models induced by feeding a high-fat diet. Metabolism: clinical and experimental. vol 60. issue 11. 2011-12-07. PMID:21550078. |
insulin therapy reduced blood glucose, inhibited pancreatic lipid accumulation and islet β-cell apoptosis, and increased β-cell proliferation and β-cell area in glucose-intolerant rats. |
2011-12-07 |
2023-08-12 |
rat |
| Chang Hee Jung, Woo Je Lee, Jenie Yoonoo Hwang, So Mi Seol, Yun Mi Kim, Yoo La Lee, Joong-Yeol Par. Vaspin protects vascular endothelial cells against free fatty acid-induced apoptosis through a phosphatidylinositol 3-kinase/Akt pathway. Biochemical and biophysical research communications. vol 413. issue 2. 2011-12-05. PMID:21893030. |
we examined whether vaspin affects the insulin-signaling pathway in cultured endothelial cells and is capable of preventing free fatty acid (ffa)-induced apoptosis in endothelial cells through its insulin sensitizing effect, specifically, through its stimulatory effect on pi3-kinase/akt signaling pathways. |
2011-12-05 |
2023-08-12 |
rat |
| Huasheng Liang, Yuhua Zhong, Shaobi Zhou, Qingdi Quentin L. Palmitic acid-induced apoptosis in pancreatic β-cells is increased by liver X receptor agonist and attenuated by eicosapentaenoate. In vivo (Athens, Greece). vol 25. issue 5. 2011-11-30. PMID:21753123. |
these results demonstrate that palmitic acid-induced apoptosis in β-cells is enhanced by t0901317 via the activation of lxrs and is blocked by epa via the inhibition of srebp-1c, suggesting that the regulation of lipogenesis and lipotoxicity affecting pancreatic β-cell viability and insulin production may be a unique strategy for diabetes therapy. |
2011-11-30 |
2023-08-12 |
Not clear |
| Zhi-Hong Yang, Hiroko Miyahara, Akimasa Hatanak. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes. Lipids in health and disease. vol 10. 2011-11-22. PMID:21774832. |
studies have demonstrated the beneficial effect of palmitoleic acid (c16:1 n-7) on reducing muscle insulin resistance and preventing beta-cell apoptosis. |
2011-11-22 |
2023-08-12 |
mouse |
| Bengt-Olof Nilsson, Björn Olde, L M Fredrik Leeb-Lundber. G protein-coupled oestrogen receptor 1 (GPER1)/GPR30: a new player in cardiovascular and metabolic oestrogenic signalling. British journal of pharmacology. vol 163. issue 6. 2011-11-15. PMID:21250980. |
these tools have revealed that gper1 activation may have several beneficial effects in the cardiovascular system including vasorelaxation, inhibition of smooth muscle cell proliferation, and protection of the myocardium against ischaemia/reperfusion injury, and in the metabolic system including stimulation of insulin release and protection against pancreatic β-cell apoptosis. |
2011-11-15 |
2023-08-12 |
Not clear |
| Shoshana M Bartell, Srujana Rayalam, Suresh Ambati, Dhanunjaya R Gaddam, Diane L Hartzell, Mark Hamrick, Jin-Xiong She, Mary Anne Della-Fera, Clifton A Bail. Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 26. issue 8. 2011-11-09. PMID:21520275. |
in experiment 2, expression of genes in adipose tissue associated with apoptosis, lipid mobilization, insulin sensitivity, and thermogenesis was increased, whereas expression of genes associated with cell differentiation and maturation was decreased regardless of mode of administration. |
2011-11-09 |
2023-08-12 |
mouse |