| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroshi Masutani, Eiji Yoshihara, So Masaki, Zhe Chen, Junji Yodo. Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus. Journal of clinical biochemistry and nutrition. vol 50. issue 1. 2012-08-23. PMID:22247597. |
enhancement of thioredoxin binding protein -2 expression causes impairment of insulin sensitivity and glucose-induced insulin secretion, and β-cell apoptosis. |
2012-08-23 |
2023-08-12 |
mouse |
| Luiz Claudio Gonçalves de Castr. [The vitamin D endocrine system]. Arquivos brasileiros de endocrinologia e metabologia. vol 55. issue 8. 2012-08-08. PMID:22218438. |
in addition to its classic role in the regulation of calcium metabolism and bone health, evidence suggests that 1,25(oh)(2)d directly or indirectly modulates about 3% of the human genome, participating in the regulation of chief functions of systemic homeostasis, such as cell growth, differentiation and apoptosis, regulation of immune, cardiovascular and musculoskeletal systems, and insulin metabolism. |
2012-08-08 |
2023-08-12 |
human |
| Dan Donnell. The structure and function of the glucagon-like peptide-1 receptor and its ligands. British journal of pharmacology. vol 166. issue 1. 2012-08-06. PMID:21950636. |
it potentiates the glucose-induced secretion of insulin from pancreatic beta cells, increases insulin expression, inhibits beta-cell apoptosis, promotes beta-cell neogenesis, reduces glucagon secretion, delays gastric emptying, promotes satiety and increases peripheral glucose disposal. |
2012-08-06 |
2023-08-12 |
Not clear |
| L S Nierobisz, K R B Sporer, G M Strasburg, K M Reed, S G Velleman, C M Ashwell, J V Felts, P E Mozdzia. Differential expression of genes characterizing myofibre phenotype. Animal genetics. vol 43. issue 3. 2012-08-06. PMID:22486501. |
muscle-specific differences were observed in expression levels of genes coding for proteins involved in mrna processing and translation regulation, proteosomal degradation, apoptosis and insulin resistance. |
2012-08-06 |
2023-08-12 |
Not clear |
| Tasneem Bhaiji, Zheng-Liang Zhi, John C Picku. Improving cellular function and immune protection via layer-by-layer nanocoating of pancreatic islet β-cell spheroids cocultured with mesenchymal stem cells. Journal of biomedical materials research. Part A. vol 100. issue 6. 2012-08-01. PMID:22447690. |
coculturing mscs with min6 cells allowed the cell constructs to enhance structural and morphologic stability with improved insulin secretory function and render them less susceptible to inflammatory cytokine-induced apoptosis. |
2012-08-01 |
2023-08-12 |
human |
| Gen-fa Lv, Hong-wei Shi, Lei Fan, Zhong-ming Feng, Guang-yuang Wan. [Intensive insulin treatment protected the cardiac myocytes against apoptosis in severely scalded rats]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. vol 23. issue 12. 2012-07-30. PMID:22153006. |
[intensive insulin treatment protected the cardiac myocytes against apoptosis in severely scalded rats]. |
2012-07-30 |
2023-08-12 |
rat |
| Gen-fa Lv, Hong-wei Shi, Lei Fan, Zhong-ming Feng, Guang-yuang Wan. [Intensive insulin treatment protected the cardiac myocytes against apoptosis in severely scalded rats]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. vol 23. issue 12. 2012-07-30. PMID:22153006. |
to investigate the effect of intensive insulin treatment, in the protection of myocardiocytes against apoptosis in severely scalded rats and its underlying mechanism. |
2012-07-30 |
2023-08-12 |
rat |
| Muhammad Sajid Hamid Akash, Qi Shen, Kanwal Rehman, Shuqing Che. Interleukin-1 receptor antagonist: a new therapy for type 2 diabetes mellitus. Journal of pharmaceutical sciences. vol 101. issue 5. 2012-07-27. PMID:22271340. |
various complex mechanisms and their multifactorial pathways decisively provoke low-grade local and systemic inflammation in β-cells of pancreatic islets and peripheral tissues to induce β-cells' dysfunction and apoptosis, insulin resistance, and ultimately, overt type 2 diabetes mellitus (t2dm). |
2012-07-27 |
2023-08-12 |
human |
| Zhuo Fu, Elizabeth R Gilbert, Liliane Pfeiffer, Yanling Zhang, Yu Fu, Dongmin Li. Genistein ameliorates hyperglycemia in a mouse model of nongenetic type 2 diabetes. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 37. issue 3. 2012-07-26. PMID:22509809. |
while peripheral insulin resistance is common during obesity and aging in mice and people, the progression to type 2 diabetes (t2d) is largely due to loss of β-cell mass and function through apoptosis. |
2012-07-26 |
2023-08-12 |
mouse |
| A Lombardi, L Ulianich, A S Treglia, C Nigro, L Parrillo, D D Lofrumento, G Nicolardi, C Garbi, F Beguinot, C Miele, B Di Jes. Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway. Diabetologia. vol 55. issue 1. 2012-07-18. PMID:22006246. |
beta cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction (decline of glucose-stimulated insulin secretion, downregulation of specific gene expression). |
2012-07-18 |
2023-08-12 |
Not clear |
| Christian Langelueddecke, Martin Jakab, Nina Ketterl, Lukas Lehner, Clemens Hufnagl, Sabine Schmidt, John P Geibel, Johannes Fuerst, Markus Ritte. Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 29. issue 1-2. 2012-07-17. PMID:22415077. |
we therefore tested the effects of ampk activators (aicar and metformin), and compound c on ampk phosphorylation, insulin secretion, k(atp) channel currents, cell membrane potential, intracellular calcium concentration, apoptosis and cell cycle distribution of ins-1e cells under standard cell culture conditions (11 mm glucose). |
2012-07-17 |
2023-08-12 |
rat |
| Itoro E Elijah, Elisabet Børsheim, Dirk M Maybauer, Celeste C Finnerty, David N Herndon, Marc O Maybaue. Role of the PPAR-α agonist fenofibrate in severe pediatric burn. Burns : journal of the International Society for Burn Injuries. vol 38. issue 4. 2012-07-12. PMID:22226866. |
the long term use of fenofibrate in severely burned patients may improve hyperglycemia and insulin resistance, as well as improve wound healing, and reduce apoptosis, and oxidative stress. |
2012-07-12 |
2023-08-12 |
Not clear |
| L M Bershteĭn, D A Vasil'ev, I G Kovalenko, T E Poroshina, K S Kisel'nikov, M P Boiarkina, A N Zaĭtse. [The influence of metformin and N-acetylcysteine on mammographic density in postmenopausal women]. Voprosy onkologii. vol 58. issue 1. 2012-06-22. PMID:22629827. |
therefore, the similar effects of metformin and n-acetylcysteine are probably explained mostly not by insulin resistance elimination by metformin, but by altered cell proliferation, apoptosis and dna repair. |
2012-06-22 |
2023-08-12 |
Not clear |
| Lei Guo, Zhaoping Qiu, Liuping Wei, Xiufeng Yu, Xu Gao, Shulin Jiang, Hai Tian, Chun Jiang, Daling Zh. The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 receptor and L-type calcium channel-α1C. Hypertension (Dallas, Tex. : 1979). vol 59. issue 5. 2012-06-14. PMID:22392900. |
furthermore, mirna-328 suppressed the insulin growth factor 1 receptor, ultimately leading to apoptosis of pulmonary arterial smooth muscle cells. |
2012-06-14 |
2023-08-12 |
mouse |
| Adeeb Shehzad, Salman Khan, Young Sup Le. Curcumin molecular targets in obesity and obesity-related cancers. Future oncology (London, England). vol 8. issue 2. 2012-06-13. PMID:22335582. |
the increased risk of obesity-related cancers could be mediated by insulin resistance, adipokines, obesity-related inflammatory cytokines, sex hormones, transcription factors and oxidative stress, which disrupt the balance between cell proliferation and apoptosis. |
2012-06-13 |
2023-08-12 |
Not clear |
| S-C DU, Q-M Ge, N Lin, Y Dong, Q S. ROS-mediated lipopolysaccharide-induced apoptosis in INS-1 cells by modulation of Bcl-2 and Bax. Cellular and molecular biology (Noisy-le-Grand, France). vol 58 Suppl. 2012-06-12. PMID:22455982. |
overproduction of reactive oxygen species (ros) or exhaustion of antioxidants may cause oxidative stress which is a major factor of defective insulin secretion and increases apoptosis of pancreatic β-cells in diabetes. |
2012-06-12 |
2023-08-12 |
rat |
| S-C DU, Q-M Ge, N Lin, Y Dong, Q S. ROS-mediated lipopolysaccharide-induced apoptosis in INS-1 cells by modulation of Bcl-2 and Bax. Cellular and molecular biology (Noisy-le-Grand, France). vol 58 Suppl. 2012-06-12. PMID:22455982. |
in this study, we explored the mechanism of oxidative stress mediated lipopolysaccharide (lps) induced apoptosis in insulin secreting (ins-1) cells from a rat pancreatic β-cell line. |
2012-06-12 |
2023-08-12 |
rat |
| S-C DU, Q-M Ge, N Lin, Y Dong, Q S. ROS-mediated lipopolysaccharide-induced apoptosis in INS-1 cells by modulation of Bcl-2 and Bax. Cellular and molecular biology (Noisy-le-Grand, France). vol 58 Suppl. 2012-06-12. PMID:22455982. |
furthermore, α-lipoic acid (α-la) inhibits lps-induced apoptosis, but can not restore the function of glucose stimulated insulin secretion (gsis) in ins-1 cells. |
2012-06-12 |
2023-08-12 |
rat |
| Tatiana Takiishi, Conny Gysemans, Roger Bouillon, Chantal Mathie. Vitamin D and diabetes. Rheumatic diseases clinics of North America. vol 38. issue 1. 2012-06-08. PMID:22525851. |
there is also compelling evidence that 1,25(oh)2d regulates b-cell function by different mechanisms, such as influencing insulin secretion by regulating intracellular levels of ca2+, increasing β-cell resistance to apoptosis, and perhaps also increasing β-cell replication. |
2012-06-08 |
2023-08-12 |
human |
| Youde Jiang, Qiuhua Zhang, Carl Soderland, Jena J Steinl. TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis. Cellular signalling. vol 24. issue 5. 2012-06-06. PMID:22266116. |
the hypothesis was that hyperglycemia-induced tnfα leads to retinal endothelial cell apoptosis through inhibition of insulin signaling. |
2012-06-06 |
2023-08-12 |
human |