| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling L Cai, Yu Pan, Li L Guo, Xiao J Zhu, Feng H Gao, Long Y Tan, Qin J Xu, Hui M Ji. Conventional but not high-purity dialysis fluid induces apoptosis and insulin resistance in adipocytes in vitro. The International journal of artificial organs. vol 35. issue 5. 2012-10-18. PMID:22562372. |
the purpose of this study was to assess the effects of these dialysates on apoptosis and insulin resistance in cultured adipocytes to determine a basis for the superiority of hpdf. |
2012-10-18 |
2023-08-12 |
Not clear |
| R Oubaassine, M Weckering, L Kessler, M Breidert, J C Roegel, P Eftekhar. Insulin interacts directly with Na⁺/K⁺ATPase and protects from digoxin toxicity. Toxicology. vol 299. issue 1. 2012-10-17. PMID:22562035. |
in neonatal rat cardiomyocytes, insulin plus digoxin induced cell apoptosis but not alone. |
2012-10-17 |
2023-08-12 |
rat |
| R Oubaassine, M Weckering, L Kessler, M Breidert, J C Roegel, P Eftekhar. Insulin interacts directly with Na⁺/K⁺ATPase and protects from digoxin toxicity. Toxicology. vol 299. issue 1. 2012-10-17. PMID:22562035. |
in adult rat cardiomyocytes, insulin at optimal dose did not induce apoptosis but prevented the one induced by digoxin. |
2012-10-17 |
2023-08-12 |
rat |
| Jingxuan Pan, Chun Chen, Yanli Jin, Enrique Fuentes-Mattei, Guermarie Velazquez-Tores, Juliana Maria Benito, Marina Konopleva, Michael Andreeff, Mong-Hong Lee, Sai-Ching Jim Yeun. Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells. Cell cycle (Georgetown, Tex.). vol 11. issue 12. 2012-10-17. PMID:22659796. |
metformin and rosiglitazone enhanced daunorubicin-induced apoptosis, while insulin, aspart and glargine antagonized daunorubicin-induced apoptosis. |
2012-10-17 |
2023-08-12 |
human |
| Riccarda Granata, Davide Gallo, Raul M Luque, Alessandra Baragli, Francesca Scarlatti, Cristina Grande, Iacopo Gesmundo, Jose Córdoba-Chacón, Loredana Bergandi, Fabio Settanni, Gabriele Togliatto, Marco Volante, Stefano Garetto, Marta Annunziata, Belén Chanclón, Eleonora Gargantini, Stefano Rocchietto, Lina Matera, Giacomo Datta, Mario Morino, Maria Felice Brizzi, Huy Ong, Giovanni Camussi, Justo P Castaño, Mauro Papotti, Ezio Ghig. Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 8. 2012-10-16. PMID:22601779. |
in hfd-fed mice, obestatin reduced insulin resistance, increased insulin secretion from pancreatic islets, and reduced adipocyte apoptosis and inflammation in metabolic tissues. |
2012-10-16 |
2023-08-12 |
mouse |
| Biagio Arcidiacono, Stefania Iiritano, Aurora Nocera, Katiuscia Possidente, Maria T Nevolo, Valeria Ventura, Daniela Foti, Eusebio Chiefari, Antonio Brunett. Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms. Experimental diabetes research. vol 2012. 2012-10-12. PMID:22701472. |
insulin and igf-i inhibit the hepatic synthesis of sex-hormone binding globulin (shbg), whereas both hormones stimulate the ovarian synthesis of sex steroids, whose effects, in breast epithelium and endometrium, can promote cellular proliferation and inhibit apoptosis. |
2012-10-12 |
2023-08-12 |
Not clear |
| Jill L Buss, Amer Rajab, Elizabeth D Essig, Valerie K Bergdall, Jie Wang, Kwame Ose. Exenatide pretreatment improved graft function in nonhuman primate islet recipients compared to treatment after transplant only. Journal of transplantation. vol 2012. 2012-10-12. PMID:23056916. |
the glp-1 receptor agonist, exenatide, has previously been shown to improve insulin secretion, protect beta cells from apoptosis, and promote beta cell regeneration. |
2012-10-12 |
2023-08-12 |
monkey |
| Bruno Fève, Martine Glorian, Khadija El Hadr. Pathophysiology of the HIV-Associated Lipodystrophy Syndrome. Metabolic syndrome and related disorders. vol 2. issue 4. 2012-10-02. PMID:18370696. |
in superficial mature adipocytes, haart promotes insulin resistance and apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Chrysi Koliaki, John Doupi. Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 2. issue 2. 2012-10-02. PMID:22127804. |
the pancreatic effects of glp-1 receptor agonists include glucose-lowering effects by stimulating insulin secretion and inhibiting glucagon release in a strictly glucose-dependent manner, increased beta-cell proliferation, and decreased beta-cell apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| Bodo C Melni. Leucine signaling in the pathogenesis of type 2 diabetes and obesity. World journal of diabetes. vol 3. issue 3. 2012-10-02. PMID:22442749. |
high consumption of leucine-rich proteins explains exaggerated mtorc1-dependent insulin secretion, increased β-cell growth and β-cell proliferation promoting an early onset of replicative β-cell senescence with subsequent β-cell apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Bodo C Melni. Leucine signaling in the pathogenesis of type 2 diabetes and obesity. World journal of diabetes. vol 3. issue 3. 2012-10-02. PMID:22442749. |
disturbances of β-cell mass regulation with increased β-cell proliferation and apoptosis as well as insulin resistance are hallmarks of t2d, which are all associated with hyperactivation of mtorc1. |
2012-10-02 |
2023-08-12 |
Not clear |
| Ya-Qian Huang, Xian Wang, Wei Kon. [Diabetic cardiomyopathy]. Sheng li ke xue jin zhan [Progress in physiology]. vol 41. issue 1. 2012-10-01. PMID:21417012. |
previous studies have highlighted the importance of metabolic disturbances (dysfunction of glucose transporters, increased free fatty acids, abnormal changes in calcium homeostasis, disordered copper metabolism, insulin resistance), myocardial fibrosis (association with hyperglycemia, myocyte apoptosis, increases in angiotensin ii , igf-1, and pro-inflammatory cytokines, changes in matrix metalloproteinases activity etc. |
2012-10-01 |
2023-08-12 |
Not clear |
| Jee-Heon Jeong, Simmyung Yook, Yoonsuk Jung, Bok-Hyeon Im, Minhyung Lee, Cheol-Hee Ahn, Dong Yun Lee, Youngro Byu. Functional enhancement of beta cells in transplanted pancreatic islets by secretion signal peptide-linked exendin-4 gene transduction. Journal of controlled release : official journal of the Controlled Release Society. vol 159. issue 3. 2012-09-28. PMID:22306337. |
after the transduction of lentivirus encoding for sp-ex-4 (lv-sp-ex-4) gene into the islets, the therapeutic effects of ex-4 secreted were evaluated by conducting glucose-stimulated insulin secretion and cytokine- or hypoxia-induced apoptosis. |
2012-09-28 |
2023-08-12 |
mouse |
| Taxiarchis V Kourelis, Robert D Siege. Metformin and cancer: new applications for an old drug. Medical oncology (Northwood, London, England). vol 29. issue 2. 2012-09-18. PMID:21301998. |
several potential mechanisms have been suggested for the ability of metformin to suppress cancer growth in vitro and vivo: (1) activation of lkb1/ampk pathway, (2) induction of cell cycle arrest and/or apoptosis, (3) inhibition of protein synthesis, (4) reduction in circulating insulin levels, (5) inhibition of the unfolded protein response (upr), (6) activation of the immune system, and (7) eradication of cancer stem cells. |
2012-09-18 |
2023-08-12 |
Not clear |
| Ingrid K Hals, Hirotaka Ogata, Elin Pettersen, Zuheng Ma, Anneli Björklund, Frank Skorpen, Kjartan Wollo Egeberg, Valdemar Gril. Marked over expression of uncoupling protein-2 in beta cells exerts minor effects on mitochondrial metabolism. Biochemical and biophysical research communications. vol 423. issue 2. 2012-09-17. PMID:22634308. |
fourfold induced cells displayed normal viability (mtt, apoptosis), normal cellular insulin contents and, glucose-induced insulin secretion (+27 ± 11%) as well as d-[u-(14)c]-glucose oxidation (+5 ± 9% at 11 mm glucose). |
2012-09-17 |
2023-08-12 |
Not clear |
| Ivana Stojanovic, Tamara Saksida, Stanislava Stosic-Grujici. Beta cell function: the role of macrophage migration inhibitory factor. Immunologic research. vol 52. issue 1-2. 2012-09-13. PMID:22388641. |
this exceptionally versatile molecule regulates insulin secretion in physiological conditions, while in pathological states it alters beta cell function and induces their apoptosis or necrosis and affects beta cell neoplasia. |
2012-09-13 |
2023-08-12 |
Not clear |
| Christina Pettan-Brewer, John Morton, Ruby Mangalindan, Warren Ladige. Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet. Pathobiology of aging & age related diseases. vol 1. 2012-09-06. PMID:22953026. |
high fat diets can promote obesity resulting in insulin resistance and inflammation and the development of oxidative stress, increased cell proliferation, and suppression of apoptosis. |
2012-09-06 |
2023-08-12 |
mouse |
| Lin Wang, Juxiang Huang, Minghu Jiang, Hong Li. Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation. Immunologic research. vol 52. issue 3. 2012-09-04. PMID:22528125. |
tsta3-activated network enhanced the regulation of apoptosis, cyclin-dependent protein kinase activity, cell migration, insulin secretion, transcription, cell division, cell proliferation, dna replication, postreplication repair, cell differentiation, t-cell homeostasis, neutrophil-mediated immunity, neutrophil chemotaxis, interleukin-8 production, inflammatory response, immune response, b-cell activation, humoral immune response, actin filament organization, xenobiotic metabolism, lipid metabolism, phospholipid metabolism, leukotriene biosynthesis, organismal lipid catabolism, phosphatidylcholine metabolism, arachidonic acid secretion, activation of phospholipase a2, deoxyribonucleotide biosynthesis, heterophilic cell adhesion, activation of mapk activity, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, g-protein-coupled receptor protein signaling pathway, response to toxin, acute-phase response, dna damage response, intercellular junction assembly, cell communication, and cell recognition, as a result of inducing immune response-mediated metabolism coupling cell cycle to postreplication repair in no-tumor hepatitis/cirrhotic tissues. |
2012-09-04 |
2023-08-12 |
human |
| M Markelic, K Velickovic, I Golic, V Otasevic, A Stancic, A Jankovic, M Vucetic, B Buzadzic, B Korac, A Kora. Endothelial cell apoptosis in brown adipose tissue of rats induced by hyperinsulinaemia: the possible role of TNF-α. European journal of histochemistry : EJH. vol 55. issue 4. 2012-08-30. PMID:22297440. |
the aim of the present study was to investigate whether hyperinsulinaemia, which frequently precedes insulin resistance syndrome (obesity, diabetes), induces apoptosis of endothelial cells (ecs) in brown adipose tissue (bat) and causes bat atrophy and also, to investigate the possible mechanisms underlying ecs death. |
2012-08-30 |
2023-08-12 |
rat |
| E Roggli, S Gattesco, A Pautz, R Regazz. Involvement of the RNA-binding protein ARE/poly(U)-binding factor 1 (AUF1) in the cytotoxic effects of proinflammatory cytokines on pancreatic beta cells. Diabetologia. vol 55. issue 6. 2012-08-29. PMID:22159912. |
chronic exposure of pancreatic beta cells to proinflammatory cytokines leads to impaired insulin secretion and apoptosis. |
2012-08-29 |
2023-08-12 |
Not clear |