| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lorna W Harries, Alexander D Fellows, Luke C Pilling, Dena Hernandez, Andrew Singleton, Stefania Bandinelli, Jack Guralnik, Jonathan Powell, Luigi Ferrucci, David Melze. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mechanisms of ageing and development. vol 133. issue 8. 2012-12-31. PMID:22813852. |
genes involved in insulin signaling (pten, pi3k, pdk1), ribosomal biogenesis (s6k), lipid metabolism (srebf1), cellular apoptosis (sgk1), angiogenesis (vegfb), insulin production and sensitivity (foxo), cellular stress response (hif1a) and cytoskeletal remodeling (pkc) were inversely correlated with age, whereas genes relating to inhibition of ribosomal components (4ebp1) and inflammatory mediators (stat3) were positively associated with age in one or both datasets. |
2012-12-31 |
2023-08-12 |
human |
| Chien-Ping Liang, Seongah Han, Gang Li, Ira Tabas, Alan R Tal. Impaired MEK signaling and SERCA expression promote ER stress and apoptosis in insulin-resistant macrophages and are reversed by exenatide treatment. Diabetes. vol 61. issue 10. 2012-12-28. PMID:22751695. |
increased signaling via glp-1 receptor or the crebp activator protein kinase a thus offers a way to rescue insulin-resistant macrophages from excessive er stress responses and apoptosis in insulin resistance and type 2 diabetes. |
2012-12-28 |
2023-08-12 |
mouse |
| Yuanxiao Wang, Lili Zhang, Genlai Zhou, Zhiyong Liao, Hussain Ahmad, Wenbin Liu, Tian Wan. Dietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets. The British journal of nutrition. vol 108. issue 8. 2012-12-26. PMID:22217383. |
iugr piglets had lower (p < 0·05) mucosal concentrations of arg, insulin, insulin growth factor 1, as well as phosphorylated akt, mammalian target of rapamycin (mtor) and p70 s6 kinase but higher (p < 0·05) enterocyte apoptosis index (ai). |
2012-12-26 |
2023-08-12 |
Not clear |
| Domitille Schvartz, Yohann Couté, Yannick Brunner, Claes B Wollheim, Jean-Charles Sanche. Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress. Molecular & cellular proteomics : MCP. vol 11. issue 8. 2012-12-21. PMID:22427704. |
the consequent prolonged glucose exposure is known to exert deleterious effects on the function of various organs, notably impairment of insulin secretion by pancreatic β-cells and induction of apoptosis. |
2012-12-21 |
2023-08-12 |
rat |
| Domitille Schvartz, Yohann Couté, Yannick Brunner, Claes B Wollheim, Jean-Charles Sanche. Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress. Molecular & cellular proteomics : MCP. vol 11. issue 8. 2012-12-21. PMID:22427704. |
in conclusion, the modification of specific β-cell pathways such as apoptosis and oxidative stress may partially explain the impairment of insulin secretion and β-cell failure, observed after prolonged exposure to high glucose concentrations. |
2012-12-21 |
2023-08-12 |
rat |
| Nobuyuki Ura, Hideki Takizawa, Haruki Sasak. [Diabetes mellitus]. Nihon rinsho. Japanese journal of clinical medicine. vol 70. issue 9. 2012-12-20. PMID:23012809. |
actually, ang ii introduces pancreatic beta-cell apoptosis and suppresses insulin signal transduction by modulation of adipokines. |
2012-12-20 |
2023-08-12 |
Not clear |
| Chieko Mineo, Philip W Shau. Novel biological functions of high-density lipoprotein cholesterol. Circulation research. vol 111. issue 8. 2012-12-17. PMID:23023510. |
there are additional actions of hdl of potential cardiovascular consequence that are indirect, including the capacities to promote pancreatic β-cell insulin secretion, to protect pancreatic β cells from apoptosis, and to enhance glucose uptake by skeletal muscle myocytes. |
2012-12-17 |
2023-08-12 |
human |
| Michael J Pagliassott. Endoplasmic reticulum stress in nonalcoholic fatty liver disease. Annual review of nutrition. vol 32. 2012-12-10. PMID:22809102. |
importantly, the signaling pathway activated by disruption of endoplasmic reticulum homeostasis, the unfolded protein response, has been linked to lipid and membrane biosynthesis, insulin action, inflammation, and apoptosis. |
2012-12-10 |
2023-08-12 |
Not clear |
| Ciaran E Fealy, Jacob M Haus, Thomas P J Solomon, Mangesh Pagadala, Chris A Flask, Arthur J McCullough, John P Kirwa. Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease. Journal of applied physiology (Bethesda, Md. : 1985). vol 113. issue 1. 2012-12-07. PMID:22582214. |
we conclude that short-term exercise reduces a circulatory marker of hepatocyte apoptosis in obese individuals with nafld and propose that changes in the proapoptotic environment may be mediated through improved insulin sensitivity and increased oxidative capacity. |
2012-12-07 |
2023-08-12 |
human |
| Mangesh Pagadala, Takhar Kasumov, Arthur J McCullough, Nizar N Zein, John P Kirwa. Role of ceramides in nonalcoholic fatty liver disease. Trends in endocrinology and metabolism: TEM. vol 23. issue 8. 2012-12-03. PMID:22609053. |
ceramides are a lipid species that exert biological effects through cellular proliferation, differentiation, and cell death, and interact with several pathways involved in insulin resistance, oxidative stress, inflammation, and apoptosis, all of which are linked to nafld. |
2012-12-03 |
2023-08-12 |
Not clear |
| L P Roma, S M Pascal, J Duprez, J-C Jona. Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non-stimulating glucose concentration. Diabetologia. vol 55. issue 8. 2012-11-21. PMID:22643931. |
mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non-stimulating glucose concentration. |
2012-11-21 |
2023-08-12 |
rat |
| L P Roma, S M Pascal, J Duprez, J-C Jona. Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non-stimulating glucose concentration. Diabetologia. vol 55. issue 8. 2012-11-21. PMID:22643931. |
pancreatic beta cells chronically exposed to low glucose concentrations show signs of oxidative stress, loss of glucose-stimulated insulin secretion (gsis) and increased apoptosis. |
2012-11-21 |
2023-08-12 |
rat |
| Melissa Kazantzis, Andreas Stah. Fatty acid transport proteins, implications in physiology and disease. Biochimica et biophysica acta. vol 1821. issue 5. 2012-11-13. PMID:21979150. |
many obesity-associated diseases, such as insulin resistance in skeletal muscle, cardiac lipotoxicity, and hepatic steatosis, are thought to be driven by the overflow of fatty acids from adipose stores and the subsequent ectopic accumulation of lipids resulting in apoptosis, er stress, and inactivation of the insulin receptor signaling cascade. |
2012-11-13 |
2023-08-12 |
human |
| Jalal Taneera, Stefan Lang, Amitabh Sharma, Joao Fadista, Yuedan Zhou, Emma Ahlqvist, Anna Jonsson, Valeriya Lyssenko, Petter Vikman, Ola Hansson, Hemang Parikh, Olle Korsgren, Arvind Soni, Ulrika Krus, Enming Zhang, Xing-Jun Jing, Jonathan L S Esguerra, Claes B Wollheim, Albert Salehi, Anders Rosengren, Erik Renström, Leif Groo. A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell metabolism. vol 16. issue 1. 2012-10-30. PMID:22768844. |
we integrated our data to form a rank list of putative t2d genes, of which chl1, lrfn2, rasgrp1, and ppm1k were validated in ins-1 cells to influence insulin secretion, whereas gpr120 affected apoptosis in islets. |
2012-10-30 |
2023-08-12 |
human |
| Telford Y Yeung, Karen L Seeberger, Tatsuya Kin, Adetola Adesida, Nadr Jomha, A M James Shapiro, Gregory S Korbut. Human mesenchymal stem cells protect human islets from pro-inflammatory cytokines. PloS one. vol 7. issue 5. 2012-10-29. PMID:22666480. |
for all conditions, glucose stimulated insulin secretion (gsis), total islet cellular insulin content, islet β cell apoptosis, and potential cytoprotective factors secreted in the culture media were determined. |
2012-10-29 |
2023-08-12 |
human |
| Balázs Tóth, László Csanád. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 33. 2012-10-29. PMID:22847436. |
the ca(2+)-permeable cation channel transient receptor potential melastatin 2 (trpm2) plays a key role in pathogen-evoked phagocyte activation, postischemic neuronal apoptosis, and glucose-evoked insulin secretion, by linking these cellular responses to oxidative stress. |
2012-10-29 |
2023-08-12 |
Not clear |
| Joseph P Tiano, Franck Mauvais-Jarvi. Importance of oestrogen receptors to preserve functional β-cell mass in diabetes. Nature reviews. Endocrinology. vol 8. issue 6. 2012-10-26. PMID:22330739. |
however, activation of gper protects β cells from apoptosis, raises glucose-stimulated insulin secretion and lipid homeostasis without affecting insulin biosynthesis. |
2012-10-26 |
2023-08-12 |
human |
| Michael Weichhaus, John Broom, Klaus Wahle, Giovanna Berman. A novel role for insulin resistance in the connection between obesity and postmenopausal breast cancer. International journal of oncology. vol 41. issue 2. 2012-10-19. PMID:22614942. |
insulin did not induce a physiologically significant change in proliferation or apoptosis in either cell line. |
2012-10-19 |
2023-08-12 |
Not clear |
| Michael Weichhaus, John Broom, Klaus Wahle, Giovanna Berman. A novel role for insulin resistance in the connection between obesity and postmenopausal breast cancer. International journal of oncology. vol 41. issue 2. 2012-10-19. PMID:22614942. |
normal breast epithelial cells (mcf-10a) showed intact insulin signalling, increased cell proliferation and reduced apoptosis after insulin treatment, suggesting cell growth and survival-promoting effects of insulin on these cells. |
2012-10-19 |
2023-08-12 |
Not clear |
| Ling L Cai, Yu Pan, Li L Guo, Xiao J Zhu, Feng H Gao, Long Y Tan, Qin J Xu, Hui M Ji. Conventional but not high-purity dialysis fluid induces apoptosis and insulin resistance in adipocytes in vitro. The International journal of artificial organs. vol 35. issue 5. 2012-10-18. PMID:22562372. |
conventional but not high-purity dialysis fluid induces apoptosis and insulin resistance in adipocytes in vitro. |
2012-10-18 |
2023-08-12 |
Not clear |