| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G R Merlo, D Graus-Porta, N Cella, B M Marte, D Taverna, N E Hyne. Growth, differentiation and survival of HC11 mammary epithelial cells: diverse effects of receptor tyrosine kinase-activating peptide growth factors. European journal of cell biology. vol 70. issue 2. 1997-02-25. PMID:8793381. |
competent cultures of hc11 cells maintained in serum-free medium in the presence of only dexamethasone and prolactin undergo apoptosis, which is prevented by the addition of either insulin, igf-1, fgf-2, or egf, but not pdgf or scf. |
1997-02-25 |
2023-08-12 |
mouse |
| Y Xu, Q Nguyen, D C Lo, M J Czaj. c-myc-Dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors. Journal of cellular physiology. vol 170. issue 2. 1997-02-24. PMID:9009148. |
apoptosis was not inhibited by growth factors and was even accelerated by supplementation with insulin-like growth factor i or insulin. |
1997-02-24 |
2023-08-12 |
human |
| B C Yang, H M Chang, Y S Wang, R F Chen, S J Li. Transient induction of apoptosis in serum-starved glioma cells by insulin and IGF-1. Biochimica et biophysica acta. vol 1314. issue 1-2. 1997-01-22. PMID:8972721. |
transient induction of apoptosis in serum-starved glioma cells by insulin and igf-1. |
1997-01-22 |
2023-08-12 |
Not clear |
| A Y Hsing, K Kadomatsu, M J Bonham, D Danielpou. Regulation of apoptosis induced by transforming growth factor-beta1 in nontumorigenic rat prostatic epithelial cell lines. Cancer research. vol 56. issue 22. 1997-01-07. PMID:8912849. |
moreover, the ability of tgf-beta to induce apoptosis of nrp-152 is strictly dependent on culture conditions, because dexamethasone enhances while insulin and insulin-like growth factor-i specifically block apoptosis induced by tgf-beta. |
1997-01-07 |
2023-08-12 |
rat |
| B A O'Brien, B V Harmon, D P Cameron, D J Alla. Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model. The Journal of pathology. vol 178. issue 2. 1996-08-19. PMID:8683386. |
immunohistochemical localization of insulin to the dying cells confirmed the beta-cell origin of the apoptosis. |
1996-08-19 |
2023-08-12 |
mouse |
| C E Stewart, P Rotwei. Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts. The Journal of biological chemistry. vol 271. issue 19. 1996-06-27. PMID:8626686. |
death was accompanied by characteristic markers of apoptosis with more than 90% of cells showing dna fragmentation within 12-16 h. myoblast death was prevented by igf-i, des [1-3] igf-i, igf-ii, and insulin with a dose potency consistent with activation of the igf-i receptor; death also could be blocked by the protein synthesis inhibitor, cycloheximide. |
1996-06-27 |
2023-08-12 |
mouse |
| K A Heidenreich, J L Kumme. Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons. The Journal of biological chemistry. vol 271. issue 17. 1996-06-21. PMID:8626622. |
since p38 map kinase has been recently implicated in neuronal cell apoptosis, negative regulation of this kinase by insulin may be critical for the neurotrophic actions of insulin. |
1996-06-21 |
2023-08-12 |
chicken |
| N Nakamura, Y Shidoji, H Moriwaki, Y Mut. Apoptosis in human hepatoma cell line induced by 4,5-didehydro geranylgeranoic acid (acyclic retinoid) via down-regulation of transforming growth factor-alpha. Biochemical and biophysical research communications. vol 219. issue 1. 1996-06-13. PMID:8619789. |
either exogenous transforming growth factor-alpha (tgf alpha) or epidermal growth factor(egf) prevented the cells from apoptosis in the presence of 4,5-didehydro gga, but hepatocyte growth factor, insulin-like growth factor-ii, insulin or triiodothyronine was essentially inactive. |
1996-06-13 |
2023-08-12 |
human |
| Y Jung, M Miura, J Yua. Suppression of interleukin-1 beta-converting enzyme-mediated cell death by insulin-like growth factor. The Journal of biological chemistry. vol 271. issue 9. 1996-06-11. PMID:8617790. |
ice-mediated apoptosis of cos cells in serum-free medium is suppressed by insulin-like growth factor (igf)-1 and insulin. |
1996-06-11 |
2023-08-12 |
Not clear |
| M Tanaka, M Sawada, S Yoshida, F Hanaoka, T Marunouch. Insulin prevents apoptosis of external granular layer neurons in rat cerebellar slice cultures. Neuroscience letters. vol 199. issue 1. 1996-03-19. PMID:8584221. |
insulin prevents apoptosis of external granular layer neurons in rat cerebellar slice cultures. |
1996-03-19 |
2023-08-12 |
rat |
| M Tanaka, M Sawada, S Yoshida, F Hanaoka, T Marunouch. Insulin prevents apoptosis of external granular layer neurons in rat cerebellar slice cultures. Neuroscience letters. vol 199. issue 1. 1996-03-19. PMID:8584221. |
insulin deprivation induced apoptosis of granule neurons largely in the external granular layer, but scarcely in the internal granular layer. |
1996-03-19 |
2023-08-12 |
rat |
| M Tanaka, M Sawada, S Yoshida, F Hanaoka, T Marunouch. Insulin prevents apoptosis of external granular layer neurons in rat cerebellar slice cultures. Neuroscience letters. vol 199. issue 1. 1996-03-19. PMID:8584221. |
these results suggest that insulin may prevent apoptosis of premigratory granule neurons during the development of the cerebellar cortex. |
1996-03-19 |
2023-08-12 |
rat |
| C Minshall, S Arkins, G G Freund, K W Kelle. Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 3. 1996-02-27. PMID:8558020. |
recently, phosphatidylinositol 3'-kinase (pi 3-kinase) has been shown to be integral in the pathway by which insulin and nerve growth factor prevent apoptosis. |
1996-02-27 |
2023-08-12 |
Not clear |
| A M Rampalli, P S Zelenk. Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 6. issue 8. 1996-02-20. PMID:8547223. |
insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells. |
1996-02-20 |
2023-08-12 |
chicken |
| A M Rampalli, P S Zelenk. Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 6. issue 8. 1996-02-20. PMID:8547223. |
in the absence of insulin, 6-day embryonic chicken lens epithelial explants undergo apoptosis as shown by changes in cell morphology, dna fragmentation, and loss of trypan blue exclusion. |
1996-02-20 |
2023-08-12 |
chicken |
| A M Rampalli, P S Zelenk. Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 6. issue 8. 1996-02-20. PMID:8547223. |
expression of these genes was also induced in the absence of insulin, but mrna levels remained elevated as the cells underwent apoptosis. |
1996-02-20 |
2023-08-12 |
chicken |
| A M Rampalli, P S Zelenk. Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 6. issue 8. 1996-02-20. PMID:8547223. |
since c-fos and c-jun have been shown to play a role in apoptosis in other cell types, the ability of insulin to regulate expression of these genes may be central to its ability to act as a survival factor for lens epithelial cells. |
1996-02-20 |
2023-08-12 |
chicken |
| H R Kim, S Upadhyay, G Li, K C Palmer, T F Deue. Platelet-derived growth factor induces apoptosis in growth-arrested murine fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 21. 1995-11-14. PMID:7568162. |
furthermore, we show that epidermal growth factor also induces apoptotic cell death in serum-deprived nrk cells, epidermal growth factor enhances the rate of apoptosis in pdgf-treated cells, and a progression factor (insulin) but not endogenously expressed bc1-2 fully protects nrk cells from pdgf-stimulated apoptosis. |
1995-11-14 |
2023-08-12 |
rat |
| A G Estévez, R Radi, L Barbeito, J T Shin, J A Thompson, J S Beckma. Peroxynitrite-induced cytotoxicity in PC12 cells: evidence for an apoptotic mechanism differentially modulated by neurotrophic factors. Journal of neurochemistry. vol 65. issue 4. 1995-10-25. PMID:7561848. |
furthermore, pretreatment of cells with nerve growth factor or insulin, but not epidermal growth factor, was protective against peroxynitrite-induced apoptosis. |
1995-10-25 |
2023-08-12 |
Not clear |
| X Wu, Z Fan, H Masui, N Rosen, J Mendelsoh. Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. The Journal of clinical investigation. vol 95. issue 4. 1995-05-09. PMID:7706497. |
apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. |
1995-05-09 |
2023-08-12 |
human |