| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Pick, J Clark, C Kubstrup, M Levisetti, W Pugh, S Bonner-Weir, K S Polonsk. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes. vol 47. issue 3. 1998-04-07. PMID:9519740. |
role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male zucker diabetic fatty rat. |
1998-04-07 |
2023-08-12 |
rat |
| N Mizuno, H Yoshitomi, H Ishida, H Kuromi, J Kawaki, Y Seino, S Sein. Altered bcl-2 and bax expression and intracellular Ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion. Endocrinology. vol 139. issue 3. 1998-03-12. PMID:9492080. |
altered bcl-2 and bax expression and intracellular ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion. |
1998-03-12 |
2023-08-12 |
Not clear |
| N Mizuno, H Yoshitomi, H Ishida, H Kuromi, J Kawaki, Y Seino, S Sein. Altered bcl-2 and bax expression and intracellular Ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion. Endocrinology. vol 139. issue 3. 1998-03-12. PMID:9492080. |
min6 cells exhibit reduced insulin secretion induced by glucose regardless of the molecular pathway of apoptosis. |
1998-03-12 |
2023-08-12 |
Not clear |
| N Mizuno, H Yoshitomi, H Ishida, H Kuromi, J Kawaki, Y Seino, S Sein. Altered bcl-2 and bax expression and intracellular Ca2+ signaling in apoptosis of pancreatic cells and the impairment of glucose-induced insulin secretion. Endocrinology. vol 139. issue 3. 1998-03-12. PMID:9492080. |
apoptosis in pancreatic beta-cells, therefore, may be closely related to the impairment of insulin secretion in certain pathological conditions such as diabetes mellitus. |
1998-03-12 |
2023-08-12 |
Not clear |
| F Bertrand, A Atfi, A Cadoret, G L'Allemain, H Robin, O Lascols, J Capeau, G Cherqu. A role for nuclear factor kappaB in the antiapoptotic function of insulin. The Journal of biological chemistry. vol 273. issue 5. 1998-02-23. PMID:9446605. |
insulin (10(-9)-10(-7) m) inhibited apoptosis induced by serum withdrawal in cho-r cells in a concentration-dependent manner. |
1998-02-23 |
2023-08-12 |
Not clear |
| C Bozzo, G Bellomo, L Silengo, G Tarone, F Altrud. Soluble integrin ligands and growth factors independently rescue neuroblastoma cells from apoptosis under nonadherent conditions. Experimental cell research. vol 237. issue 2. 1998-02-03. PMID:9434628. |
in addition to integrin stimulation, serum, insulin, and nerve growth factor inhibited suspension-induced apoptosis of sk-n-be cells. |
1998-02-03 |
2023-08-12 |
human |
| J G Mabley, V Belin, N John, I C Gree. Insulin-like growth factor I reverses interleukin-1beta inhibition of insulin secretion, induction of nitric oxide synthase and cytokine-mediated apoptosis in rat islets of Langerhans. FEBS letters. vol 417. issue 2. 1997-12-22. PMID:9395303. |
insulin-like growth factor i reverses interleukin-1beta inhibition of insulin secretion, induction of nitric oxide synthase and cytokine-mediated apoptosis in rat islets of langerhans. |
1997-12-22 |
2023-08-12 |
rat |
| J G Mabley, V Belin, N John, I C Gree. Insulin-like growth factor I reverses interleukin-1beta inhibition of insulin secretion, induction of nitric oxide synthase and cytokine-mediated apoptosis in rat islets of Langerhans. FEBS letters. vol 417. issue 2. 1997-12-22. PMID:9395303. |
we have previously observed that treatment of rat islets of langerhans with interleukin-1beta for 12 h results in nitric oxide-dependent inhibition of insulin secretion, while 48 h treatment increased rates of islet cell death by apoptosis. |
1997-12-22 |
2023-08-12 |
rat |
| H E Kim, S J Han, T Kasza, R Han, H S Choi, K C Palmer, H R Ki. Platelet-derived growth factor (PDGF)-signaling mediates radiation-induced apoptosis in human prostate cancer cells with loss of p53 function. International journal of radiation oncology, biology, physics. vol 39. issue 3. 1997-10-29. PMID:9336156. |
the pdgf-induced apoptosis is rescued by insulin, suggesting that g1/s checkpoint is a critical determinant for pdgf-induced apoptosis. |
1997-10-29 |
2023-08-12 |
human |
| B S Chertow, N Q Goking, H K Driscoll, D A Primerano, K A Matthew. Effects of all-trans-retinoic acid (ATRA) and retinoic acid receptor (RAR) expression on secretion, growth, and apoptosis of insulin-secreting RINm5F cells. Pancreas. vol 15. issue 2. 1997-09-25. PMID:9260196. |
in summary, atra increased the insulin secretion and content of rinm5f cells, while inhibiting growth and increasing apoptosis. |
1997-09-25 |
2023-08-12 |
cat |
| A V Morales, J Serna, C Alarcón, E J de la Rosa, F de Pabl. Role of prepancreatic (pro)insulin and the insulin receptor in prevention of embryonic apoptosis. Endocrinology. vol 138. issue 9. 1997-09-18. PMID:9275088. |
role of prepancreatic (pro)insulin and the insulin receptor in prevention of embryonic apoptosis. |
1997-09-18 |
2023-08-12 |
chicken |
| A V Morales, J Serna, C Alarcón, E J de la Rosa, F de Pabl. Role of prepancreatic (pro)insulin and the insulin receptor in prevention of embryonic apoptosis. Endocrinology. vol 138. issue 9. 1997-09-18. PMID:9275088. |
in a whole embryo culture, apoptosis increased by 25-35% with the addition of preproinsulin or insulin receptor mrnas antisense oligodeoxynucleotides, respectively, whereas it decreased by 64% after 10 h in the presence of 10(-8) m chicken insulin. |
1997-09-18 |
2023-08-12 |
chicken |
| J L Kummer, P K Rao, K A Heidenreic. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 272. issue 33. 1997-09-04. PMID:9252360. |
to better understand the relationship between p38 activity and cell survival, we induced apoptosis in two cell lines and examined the ability of insulin or a specific p38 inhibitor (a pyridinyl imidazole compound pd169316) to block p38 activity and cell death. |
1997-09-04 |
2023-08-12 |
Not clear |
| J L Kummer, P K Rao, K A Heidenreic. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 272. issue 33. 1997-09-04. PMID:9252360. |
insulin (50 ng/ml) inhibited p38 activity by approximately 70% and blocked apoptosis by at least 80%. |
1997-09-04 |
2023-08-12 |
Not clear |
| J L Kummer, P K Rao, K A Heidenreic. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 272. issue 33. 1997-09-04. PMID:9252360. |
both insulin and pd169316 markedly blocked the increase in p38 activity and apoptosis. |
1997-09-04 |
2023-08-12 |
Not clear |
| J L Kummer, P K Rao, K A Heidenreic. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 272. issue 33. 1997-09-04. PMID:9252360. |
pd98059 did not influence insulin's ability to block apoptosis, indicating that the extracellular signal-regulated kinase pathway does not mediate insulin's survival effects. |
1997-09-04 |
2023-08-12 |
Not clear |
| J L Kummer, P K Rao, K A Heidenreic. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 272. issue 33. 1997-09-04. PMID:9252360. |
these data further support the role of p38 in cellular apoptosis and support the hypothesis that insulin promotes cell survival, at least in part, by inhibiting the p38 pathway. |
1997-09-04 |
2023-08-12 |
Not clear |
| B A O'Brien, B V Harmon, D P Cameron, D J Alla. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes. vol 46. issue 5. 1997-05-28. PMID:9133540. |
immunohistochemical localization of insulin to the dying cells confirmed the beta-cell origin of the apoptosis. |
1997-05-28 |
2023-08-12 |
mouse |
| B A O'Brien, B V Harmon, D P Cameron, D J Alla. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes. vol 46. issue 5. 1997-05-28. PMID:9133540. |
the maximum mean amount of beta-cell apoptosis occurring in nod/lt mice was at week 15 (50 apoptotic cells per 100 islets), which coincided with the earliest onset of diabetes as determined by blood glucose, urine glucose, and pancreatic immunoreactive insulin measurements. |
1997-05-28 |
2023-08-12 |
mouse |
| A Hague, D J Hicks, T S Bracey, C Paraskev. Cell-cell contact and specific cytokines inhibit apoptosis of colonic epithelial cells: growth factors protect against c-myc-independent apoptosis. British journal of cancer. vol 75. issue 7. 1997-04-17. PMID:9083330. |
insulin, the insulin-like growth factors i and ii, hydrocortisone and epidermal growth factor (egf) protect cells from the induction of apoptosis in the absence of serum over a short-term period of 24 h. this approach may give insight into the factors governing growth and survival of colonic epithelial cells in vivo. |
1997-04-17 |
2023-08-12 |
human |