| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H E Kim, S J Han, T Kasza, R Han, H S Choi, K C Palmer, H R Ki. Platelet-derived growth factor (PDGF)-signaling mediates radiation-induced apoptosis in human prostate cancer cells with loss of p53 function. International journal of radiation oncology, biology, physics. vol 39. issue 3. 1997-10-29. PMID:9336156. |
the pdgf-induced apoptosis is rescued by insulin, suggesting that g1/s checkpoint is a critical determinant for pdgf-induced apoptosis. |
1997-10-29 |
2023-08-12 |
human |
| B S Chertow, N Q Goking, H K Driscoll, D A Primerano, K A Matthew. Effects of all-trans-retinoic acid (ATRA) and retinoic acid receptor (RAR) expression on secretion, growth, and apoptosis of insulin-secreting RINm5F cells. Pancreas. vol 15. issue 2. 1997-09-25. PMID:9260196. |
in summary, atra increased the insulin secretion and content of rinm5f cells, while inhibiting growth and increasing apoptosis. |
1997-09-25 |
2023-08-12 |
cat |
| A V Morales, J Serna, C Alarcón, E J de la Rosa, F de Pabl. Role of prepancreatic (pro)insulin and the insulin receptor in prevention of embryonic apoptosis. Endocrinology. vol 138. issue 9. 1997-09-18. PMID:9275088. |
role of prepancreatic (pro)insulin and the insulin receptor in prevention of embryonic apoptosis. |
1997-09-18 |
2023-08-12 |
chicken |
| A V Morales, J Serna, C Alarcón, E J de la Rosa, F de Pabl. Role of prepancreatic (pro)insulin and the insulin receptor in prevention of embryonic apoptosis. Endocrinology. vol 138. issue 9. 1997-09-18. PMID:9275088. |
in a whole embryo culture, apoptosis increased by 25-35% with the addition of preproinsulin or insulin receptor mrnas antisense oligodeoxynucleotides, respectively, whereas it decreased by 64% after 10 h in the presence of 10(-8) m chicken insulin. |
1997-09-18 |
2023-08-12 |
chicken |
| J L Kummer, P K Rao, K A Heidenreic. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 272. issue 33. 1997-09-04. PMID:9252360. |
to better understand the relationship between p38 activity and cell survival, we induced apoptosis in two cell lines and examined the ability of insulin or a specific p38 inhibitor (a pyridinyl imidazole compound pd169316) to block p38 activity and cell death. |
1997-09-04 |
2023-08-12 |
Not clear |
| J L Kummer, P K Rao, K A Heidenreic. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 272. issue 33. 1997-09-04. PMID:9252360. |
insulin (50 ng/ml) inhibited p38 activity by approximately 70% and blocked apoptosis by at least 80%. |
1997-09-04 |
2023-08-12 |
Not clear |
| J L Kummer, P K Rao, K A Heidenreic. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 272. issue 33. 1997-09-04. PMID:9252360. |
both insulin and pd169316 markedly blocked the increase in p38 activity and apoptosis. |
1997-09-04 |
2023-08-12 |
Not clear |
| J L Kummer, P K Rao, K A Heidenreic. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 272. issue 33. 1997-09-04. PMID:9252360. |
pd98059 did not influence insulin's ability to block apoptosis, indicating that the extracellular signal-regulated kinase pathway does not mediate insulin's survival effects. |
1997-09-04 |
2023-08-12 |
Not clear |
| J L Kummer, P K Rao, K A Heidenreic. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. The Journal of biological chemistry. vol 272. issue 33. 1997-09-04. PMID:9252360. |
these data further support the role of p38 in cellular apoptosis and support the hypothesis that insulin promotes cell survival, at least in part, by inhibiting the p38 pathway. |
1997-09-04 |
2023-08-12 |
Not clear |
| B A O'Brien, B V Harmon, D P Cameron, D J Alla. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes. vol 46. issue 5. 1997-05-28. PMID:9133540. |
immunohistochemical localization of insulin to the dying cells confirmed the beta-cell origin of the apoptosis. |
1997-05-28 |
2023-08-12 |
mouse |
| B A O'Brien, B V Harmon, D P Cameron, D J Alla. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes. vol 46. issue 5. 1997-05-28. PMID:9133540. |
the maximum mean amount of beta-cell apoptosis occurring in nod/lt mice was at week 15 (50 apoptotic cells per 100 islets), which coincided with the earliest onset of diabetes as determined by blood glucose, urine glucose, and pancreatic immunoreactive insulin measurements. |
1997-05-28 |
2023-08-12 |
mouse |
| A Hague, D J Hicks, T S Bracey, C Paraskev. Cell-cell contact and specific cytokines inhibit apoptosis of colonic epithelial cells: growth factors protect against c-myc-independent apoptosis. British journal of cancer. vol 75. issue 7. 1997-04-17. PMID:9083330. |
insulin, the insulin-like growth factors i and ii, hydrocortisone and epidermal growth factor (egf) protect cells from the induction of apoptosis in the absence of serum over a short-term period of 24 h. this approach may give insight into the factors governing growth and survival of colonic epithelial cells in vivo. |
1997-04-17 |
2023-08-12 |
human |
| G R Merlo, D Graus-Porta, N Cella, B M Marte, D Taverna, N E Hyne. Growth, differentiation and survival of HC11 mammary epithelial cells: diverse effects of receptor tyrosine kinase-activating peptide growth factors. European journal of cell biology. vol 70. issue 2. 1997-02-25. PMID:8793381. |
competent cultures of hc11 cells maintained in serum-free medium in the presence of only dexamethasone and prolactin undergo apoptosis, which is prevented by the addition of either insulin, igf-1, fgf-2, or egf, but not pdgf or scf. |
1997-02-25 |
2023-08-12 |
mouse |
| Y Xu, Q Nguyen, D C Lo, M J Czaj. c-myc-Dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors. Journal of cellular physiology. vol 170. issue 2. 1997-02-24. PMID:9009148. |
apoptosis was not inhibited by growth factors and was even accelerated by supplementation with insulin-like growth factor i or insulin. |
1997-02-24 |
2023-08-12 |
human |
| B C Yang, H M Chang, Y S Wang, R F Chen, S J Li. Transient induction of apoptosis in serum-starved glioma cells by insulin and IGF-1. Biochimica et biophysica acta. vol 1314. issue 1-2. 1997-01-22. PMID:8972721. |
transient induction of apoptosis in serum-starved glioma cells by insulin and igf-1. |
1997-01-22 |
2023-08-12 |
Not clear |
| A Y Hsing, K Kadomatsu, M J Bonham, D Danielpou. Regulation of apoptosis induced by transforming growth factor-beta1 in nontumorigenic rat prostatic epithelial cell lines. Cancer research. vol 56. issue 22. 1997-01-07. PMID:8912849. |
moreover, the ability of tgf-beta to induce apoptosis of nrp-152 is strictly dependent on culture conditions, because dexamethasone enhances while insulin and insulin-like growth factor-i specifically block apoptosis induced by tgf-beta. |
1997-01-07 |
2023-08-12 |
rat |
| B A O'Brien, B V Harmon, D P Cameron, D J Alla. Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model. The Journal of pathology. vol 178. issue 2. 1996-08-19. PMID:8683386. |
immunohistochemical localization of insulin to the dying cells confirmed the beta-cell origin of the apoptosis. |
1996-08-19 |
2023-08-12 |
mouse |
| C E Stewart, P Rotwei. Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts. The Journal of biological chemistry. vol 271. issue 19. 1996-06-27. PMID:8626686. |
death was accompanied by characteristic markers of apoptosis with more than 90% of cells showing dna fragmentation within 12-16 h. myoblast death was prevented by igf-i, des [1-3] igf-i, igf-ii, and insulin with a dose potency consistent with activation of the igf-i receptor; death also could be blocked by the protein synthesis inhibitor, cycloheximide. |
1996-06-27 |
2023-08-12 |
mouse |
| K A Heidenreich, J L Kumme. Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons. The Journal of biological chemistry. vol 271. issue 17. 1996-06-21. PMID:8626622. |
since p38 map kinase has been recently implicated in neuronal cell apoptosis, negative regulation of this kinase by insulin may be critical for the neurotrophic actions of insulin. |
1996-06-21 |
2023-08-12 |
chicken |
| N Nakamura, Y Shidoji, H Moriwaki, Y Mut. Apoptosis in human hepatoma cell line induced by 4,5-didehydro geranylgeranoic acid (acyclic retinoid) via down-regulation of transforming growth factor-alpha. Biochemical and biophysical research communications. vol 219. issue 1. 1996-06-13. PMID:8619789. |
either exogenous transforming growth factor-alpha (tgf alpha) or epidermal growth factor(egf) prevented the cells from apoptosis in the presence of 4,5-didehydro gga, but hepatocyte growth factor, insulin-like growth factor-ii, insulin or triiodothyronine was essentially inactive. |
1996-06-13 |
2023-08-12 |
human |