| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dilara Kamer Colak, Zeynep Mine Coskun Yazici, Sema Bolken. Protective effects of ghrelin on pancreas in fructose diet and streptozotocin-induced diabetic rats. Journal of molecular histology. vol 56. issue 1. 2024-12-14. PMID:39673670. |
we examined pcna and parp-1 to evaluate the effect of ghrelin on dna repair, caspase-3 and caspase-9 to evaluate its effect on apoptosis, and insulin and glucagon to evaluate its role in regulating glucose homeostasis by immunohistochemistry in diabetic rats. |
2024-12-14 |
2024-12-21 |
rat |
| Jiayu Wang, Yicheng Shen, Heyu Chen, Jinwei Guan, Zhitao Li, Xianna Liu, Shuyuan Guo, Linxin Wang, Baoyue Yan, Chenrun Jin, He Li, Tian Guo, Yun Sun, Weihua Zhang, Zhiguo Zhang, Ye Tian, Zhen Tia. Non-lethal sonodynamic therapy inhibits high glucose and palmitate-induced macrophage inflammasome activation through mtROS-DRP1-mitophagy pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 22. 2024-11-18. PMID:39556373. |
in individuals with t2dm, the infiltration of macrophages into pancreatic islets results in islet inflammation that impairs beta cell function, as evidenced by increased apoptosis and decreased glucose-stimulated insulin secretion. |
2024-11-18 |
2024-11-22 |
mouse |
| Xiaoying Li, Shenggui Liu, Siqi Wang, Xinghui Ai, Lin We. 1-Deoxynojirimycin affects high glucose-induced pancreatic beta-cell dysfunction through regulating CEBPA expression and AMPK pathway. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2024-11-15. PMID:39546764. |
in the study, high glucose treatment of mouse ins-1 cells inhibited cell proliferation and insulin secretion, decreased the expression of bcl-2 protein and ins1 and ins2 genes, promoted apoptosis, and increased cleaved caspase-3 and cleaved caspase-9 expression levels as well as intracellular reactive oxygen species (ros) production. |
2024-11-15 |
2024-11-18 |
mouse |
| Paulina Sepúlveda, Ana Flavia Fernandes Ferreira, Cristian Sandoval, Giovanna Bergoc, Ana Caroline Rippi Moreno, Maria Tereza Nunes, Andréa da Silva Torrã. Thyroid Hormone Supplementation Restores Cognitive Deficit, Insulin Signaling, and Neuroinflammation in the Hippocampus of a Sporadic Alzheimer's-like Disease Rat Model. Cells. vol 13. issue 21. 2024-11-08. PMID:39513900. |
the aim of this study was to assess the neuroprotective effects of triiodothyronine (t3) on insulin signaling, neuroinflammation, apoptosis, and cognitive function in a streptozotocin (stz)-induced sporadic alzheimer's disease-like model. |
2024-11-08 |
2024-11-16 |
rat |
| Giang Huong Vu, Hai Duc Nguye. Molecular mechanisms of sulforaphane in Alzheimer's disease: insights from an in-silico study. In silico pharmacology. vol 12. issue 2. 2024-11-04. PMID:39493676. |
therefore, it may help treat ad by reducing neuroinflammation, insulin resistance, and apoptosis. |
2024-11-04 |
2024-11-06 |
Not clear |
| Ying Zhou, Xisha Chen, Xuyu Z. ZBTB7A as a therapeutic target for cancer. Biochemical and biophysical research communications. vol 736. 2024-11-03. PMID:39490153. |
zbtb7a regulates a range of fundamental biological processes such as cell proliferation, differentiation and apoptosis, b- and t-lymphocyte fate determination and thymic insulin expression and self-tolerance. |
2024-11-03 |
2024-11-06 |
Not clear |
| Jing Ma, Yuyan Dong, Juxiang Liu, Shuo Gao, Jinxing Qua. The role of GRB2 in diabetes, diabetes complications and related disorders. Diabetes, obesity & metabolism. 2024-10-31. PMID:39478285. |
emerging evidence suggests that grb2 plays a crucial role in insulin resistance, inflammation, immune activation and the regulation of cellular processes such as cell proliferation, growth, metabolism, angiogenesis, apoptosis and differentiation. |
2024-10-31 |
2024-11-02 |
Not clear |
| Shao-Hong Tao, Yu-Qing Lei, Yi-Mei Tan, Yu-Bo Yang, Wei-Ning Xi. Chinese herbal formula in the treatment of metabolic dysfunction-associated steatotic liver disease: current evidence and practice. Frontiers in medicine. vol 11. 2024-10-23. PMID:39440040. |
masld is regarded as a multifaceted pathological process encompassing aberrant lipid metabolism, insulin resistance, inflammation, gut microbiota imbalance, apoptosis, fibrosis, and cirrhosis. |
2024-10-23 |
2024-10-25 |
human |
| Yuna Zhang, Guihong Liu, Haiyan Ding, Bingge Fa. High expression of CNOT6L contributes to the negative development of type 2 diabetes. Scientific reports. vol 14. issue 1. 2024-10-21. PMID:39433858. |
cnot6l is involved in glucose metabolism, insulin secretion regulation, pancreatic beta-cell proliferation, and apoptosis. |
2024-10-21 |
2024-10-24 |
Not clear |
| Miwon Ahn, Sangeeta Dhawan, Erika M McCown, Pablo A Garcia, Supriyo Bhattacharya, Roland Stein, Debbie C Thurmon. Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance in mice by promoting insulin biogenesis and minimising beta cell apoptosis. Diabetologia. 2024-10-15. PMID:39404845. |
beta cell-specific pak1 enrichment ameliorates diet-induced glucose intolerance in mice by promoting insulin biogenesis and minimising beta cell apoptosis. |
2024-10-15 |
2024-10-17 |
mouse |
| Yu Jiang, Jia-Qi Guo, Ya Wu, Peng Zheng, Shao-Fan Wang, Meng-Chen Yang, Gen-Shan Ma, Yu-Yu Ya. Excessive or sustained endoplasmic reticulum stress: one of the culprits of adipocyte dysfunction in obesity. Therapeutic advances in endocrinology and metabolism. vol 15. 2024-10-09. PMID:39381518. |
prolonged or excessive ers in adipocytes can aggravate lipolysis, insulin resistance, and apoptosis and affect the bioactive molecule production. |
2024-10-09 |
2024-10-11 |
Not clear |
| Zhang Yong, Chen Mimi, Li Yingjie, Guo Yichen, Yu Yansu, Zhou Zhi, Lu Hui, Yao Si, Wu Chongming, Zhang Xiaopo, Ma Ning, Lu Weiyin. Mangiferin ameliorates polycystic ovary syndrome in rats by modulating insulin resistance, gut microbiota, and ovarian cell apoptosis. Frontiers in pharmacology. vol 15. 2024-10-08. PMID:39376609. |
mangiferin ameliorates polycystic ovary syndrome in rats by modulating insulin resistance, gut microbiota, and ovarian cell apoptosis. |
2024-10-08 |
2024-10-10 |
rat |
| Preethi Krishnan, Renato Chaves Souto Branco, Staci A Weaver, Garrick Chang, Chih-Chun Lee, Farooq Syed, Carmella Evans-Molin. miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis. The Journal of biological chemistry. 2024-09-29. PMID:39342996. |
others have reported that mir-146a-5p overexpression is associated with β cell apoptosis and impaired insulin secretion. |
2024-09-29 |
2024-10-02 |
mouse |
| Preethi Krishnan, Renato Chaves Souto Branco, Staci A Weaver, Garrick Chang, Chih-Chun Lee, Farooq Syed, Carmella Evans-Molin. miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis. The Journal of biological chemistry. 2024-09-29. PMID:39342996. |
additionally, inhibition of mir-146a-5p increased insulin secretion, mitochondrial dna copy number, respiration rate, and atp production further, rna sequencing data showed enrichment of pathways related to insulin secretion, apoptosis, and mitochondrial function when the expression levels of mir-146a-5p were altered. |
2024-09-29 |
2024-10-02 |
mouse |
| Tamsheel Fatima Roohi, K L Krishna, Faiyaz Shakee. Synergistic modulation of endoplasmic reticulum stress pathway, oxidative DNA damage and apoptosis by β-amyrin and metformin in mitigating hyperglycemia-induced renal damage using adult zebrafish model. BMC pharmacology & toxicology. vol 25. issue 1. 2024-09-28. PMID:39334288. |
treatment efficacy was assessed by measuring serum glucose and insulin levels and antioxidant, er stress, apoptosis, and proinflammatory markers. |
2024-09-28 |
2024-10-01 |
zebrafish |
| Esther García-Díez, María Elvira López-Oliva, Jara Pérez-Jiménez, María Ángeles Martín, Sonia Ramo. Cocoa and Carob Supplementation, Alone or in Combination with Metformin, Protects against Hepatorenal Injury in Zucker Diabetic Fatty Rats. Nutrients. vol 16. issue 18. 2024-09-28. PMID:39339687. |
the cc-supplemented diet also ameliorated oxidative stress, downregulated apoptosis, and improved insulin signalling and glucose homeostasis. |
2024-09-28 |
2024-10-01 |
rat |
| Esther García-Díez, María Elvira López-Oliva, Jara Pérez-Jiménez, María Ángeles Martín, Sonia Ramo. Cocoa and Carob Supplementation, Alone or in Combination with Metformin, Protects against Hepatorenal Injury in Zucker Diabetic Fatty Rats. Nutrients. vol 16. issue 18. 2024-09-28. PMID:39339687. |
the combination of cc and metformin boosted several benefits as certain parameters related to morphological and structural alterations, apoptosis, oxidative stress, glucose homeostasis, and insulin resistance, were improved in comparison to animals receiving the cc-supplemented diet or metformin alone; these include the following: apoptotic index, bax, hepatic insulin receptor or glutathione content, among others. |
2024-09-28 |
2024-10-01 |
rat |
| Warisara Parichatikanond, Sudhir Pandey, Supachoke Mangmoo. Exendin-4 exhibits cardioprotective effects against high glucose-induced mitochondrial abnormalities: Potential role of GLP-1 receptor and mTOR signaling. Biochemical pharmacology. 2024-09-22. PMID:39307319. |
mitochondrial dysfunction is associated with hyperglycemic conditions and insulin resistance leading to cellular damage and apoptosis of cardiomyocytes in diabetic cardiomyopathy. |
2024-09-22 |
2024-09-26 |
Not clear |
| Hediye Fahandezh Saadi, Mozhdeh Zamani, Farhad Koohpeyma, Alireza Raeisi, Zahra Amirahmadi, Narges Rezaei, Zahra Joolidehpoor, Mesbah Shams, Sanaz Dastghai. Therapeutic potential of aquatic Stevia extract in alleviating endoplasmic reticulum stress and liver damage in streptozotocin-induced diabetic rats. Molecular biology reports. vol 51. issue 1. 2024-09-18. PMID:39292293. |
chronic er stress increases inflammation, insulin resistance, and apoptosis. |
2024-09-18 |
2024-09-20 |
rat |
| Atilla Engi. Adipose Tissue Hypoxia in Obesity: Clinical Reappraisal of Hypoxia Hypothesis. Advances in experimental medicine and biology. vol 1460. 2024-09-17. PMID:39287857. |
hypoxia contributes to several biological functions, such as angiogenesis, cell proliferation, apoptosis, inflammation, and insulin resistance (ir). |
2024-09-17 |
2024-09-20 |
human |