| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luning Yang, Di Liu, Shide Jiang, Hengzhen Li, Lin Chen, Yuxiang Wu, Anko Elijah Essien, Michael Opoku, Shinen Naranmandakh, ShuGuang Liu, Qin Ru, Yusheng L. SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908209. |
sirt1 functioned as an important role in the occurrence and progression of sarcopenia through regulating key pathways related to protein homeostasis, apoptosis, mitochondrial dysfunction, insulin resistance and autophagy in skeletal muscle, including sirt1/forkhead box o (foxo), amp-activated protein kinase (ampk)/sirt1/nuclear factor κb (nf-κb), sirt1/p53, ampk/sirt1/peroxisome proliferator-activated receptor gamma coactivator-1α (pgc-1α), and sirt1/live kinase b1 (lkb1)/ampk pathways. |
2024-06-22 |
2024-06-25 |
human |
| Xuelin Li, Feifan Wang, Mengzhu Chen, Li Ling, Fengfeng Zhao, Danhong Pen. The association between endometrial polyps and insulin resistance from the expression of PI3K and AKT proteins perspective. BMC women's health. vol 24. issue 1. 2024-06-22. PMID:38909214. |
insulin resistance (ir) induces hyperinsulinemia, which activates downstream signaling pathways such as the phosphatidylinositol-3-kinase/protein kinase b (pi3k/akt) pathway, ultimately leading to abnormal proliferation and apoptosis of endometrial cells. |
2024-06-22 |
2024-06-25 |
Not clear |
| Guilherme Gabriel de Almeida, Anaysa P Bolin, Alice Batistuzzo, Tatiana L Fonseca, Miriam O Ribeiro, Antonio C Bianc. Genetic Background Strongly Influences the Impact of Carrying the Thr92Ala-DIO2 Polymorphism in the Male Mouse. Endocrinology. vol 165. issue 7. 2024-06-17. PMID:38836615. |
whereas b6-ala92-dio2 and b6-thr92-dio2 mice-fed chow or high-fat diet-behaved metabolically similar in studies using indirect calorimetry, glucose- and insulin tolerance tests, and measuring white adipose tissue (wat) weight and liver steatosis, major differences were observed between fvb-ala92-dio2 and fvb-thr92-dio2 mice: carrying the ala92-dio2 allele (on a chow diet) resulted in hypercholesterolemia, smaller wat pads, hepatomegaly, steatosis, and transcriptome changes in the interscapular brown adipose tissue (ibat) typical of er stress and apoptosis. |
2024-06-17 |
2024-06-19 |
mouse |
| Wenxing Cui, Chen Lv, Panling Geng, Mingdi Fu, Wenjing Zhou, Mingxiang Xiong, Tian L. Novel targets and therapies of metformin in dementia: old drug, new insights. Frontiers in pharmacology. vol 15. 2024-06-17. PMID:38881878. |
mechanistically, metformin has been shown to improve insulin resistance, reduce neuronal apoptosis, and decrease oxidative stress and neuroinflammation in the brain. |
2024-06-17 |
2024-06-19 |
Not clear |
| Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaj. Insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in INS-1 pancreatic β-cells. Physiological reports. vol 12. issue 12. 2024-06-17. PMID:38884322. |
insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in ins-1 pancreatic β-cells. |
2024-06-17 |
2024-06-19 |
Not clear |
| Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaj. Insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in INS-1 pancreatic β-cells. Physiological reports. vol 12. issue 12. 2024-06-17. PMID:38884322. |
here, we report that the autocrine/paracrine function of insulin reduces er stress-induced β-cell apoptosis. |
2024-06-17 |
2024-06-19 |
Not clear |
| Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaj. Insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in INS-1 pancreatic β-cells. Physiological reports. vol 12. issue 12. 2024-06-17. PMID:38884322. |
insulin reduced the er-stress inducer tunicamycin- and thapsigargin-induced cell viability loss due to apoptosis in ins-1 β-cells. |
2024-06-17 |
2024-06-19 |
Not clear |
| Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaj. Insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in INS-1 pancreatic β-cells. Physiological reports. vol 12. issue 12. 2024-06-17. PMID:38884322. |
these results demonstrate that insulin protects against er stress-induced β-cell apoptosis in this cell line. |
2024-06-17 |
2024-06-19 |
Not clear |
| Alev Duygu Acun, Deniz Kanta. Modulation of oxidative stress and apoptosis by alteration of bioactive lipids in the pancreas, and effect of zinc chelation in a rat model of Alzheimer's disease. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 85. 2024-06-14. PMID:38875759. |
it is known that zinc (zn2+) chelation is effective in reducing peripheral insulin resistance, cell apoptosis, cell death, and oxidative stress. |
2024-06-14 |
2024-06-17 |
rat |
| Yajun Zhang, Xun Luo, Mengyun Zhu, Yu W. Evaluation the role of insulin signaling pathway in reproductive toxicity of dispersed diesel particulate extract under environmental conditions. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-06-12. PMID:38866378. |
c. elegans were subjected to a semi-fluid medium (ngg) containing different concentrations of dpe or dpe + fa in order to assess germline apoptosis and the expression of important genes in the insulin signaling pathway. |
2024-06-12 |
2024-06-15 |
caenorhabditis_elegans |
| Songren Han, Xueyan Zhang, Ziwei Li, Guilin Cui, Beilin Xue, Yang Yu, Jiaqing Guo, Huan Zhang, Jie Yang, Lesheng Ten. A ginsenoside G-Rg3 PEGylated Long-Circulating liposome for hyperglycemia and insulin resistance therapy in Streptozotocin-Induced type 2 diabetes mice. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024-06-07. PMID:38848783. |
ginsenoside (gs), one of the main active components in ginseng, can enhance insulin sensitivity, improve the function of islet β cells, and reduce cell apoptosis in the treatment of diabetes. |
2024-06-07 |
2024-06-10 |
mouse |
| Jiang Lai, Chunxiao L. Review on the pharmacological effects and pharmacokinetics of scutellarein. Archiv der Pharmazie. 2024-06-07. PMID:38849327. |
these mechanisms encompass the scavenging of free radicals, inhibition of the activation of inflammatory signaling pathways and expression of inflammatory mediators, inhibition of the activity of crucial viral proteins, suppression of gluconeogenesis, amelioration of insulin resistance, improvement of cerebral ischemia-reperfusion injury, induction of apoptosis in cancer cells, and prevention of myocardial hypertrophy, among others. |
2024-06-07 |
2024-06-10 |
Not clear |
| Kaitlyn A Colglazier, Noyonika Mukherjee, Christopher J Contreras, Andrew T Templi. Evidence for established and emerging forms of β-cell death. The Journal of endocrinology. 2024-06-06. PMID:38842911. |
β-cell death contributes to β-cell loss and insulin insufficiency in type 1 diabetes (t1d), and this β-cell demise has been attributed to apoptosis and necrosis. |
2024-06-06 |
2024-06-08 |
Not clear |
| Reagan E Beliakoff, Claudio F Gonzalez, Graciela L Lorc. Bile promotes Lactobacillus johnsonii N6.2 extracellular vesicle production with conserved immunomodulatory properties. Scientific reports. vol 14. issue 1. 2024-05-28. PMID:38806562. |
recently, lactobacillus johnsonii n6.2-derived extracellular vesicles (evs) were shown to reduce apoptosis in human beta cell lines and stimulate insulin secretion in human islets. |
2024-05-28 |
2024-06-02 |
human |
| Quancheng Han, Yan Li, Yiding Yu, Huajing Yuan, Ziqi Wang, Yonghong Guo, Jingle Shi, Yitao Xue, Xiujuan Li. Exploring the mechanism of diabetic cardiomyopathy treated with Qigui Qiangxin mixture based on UPLC-Q/TOF-MS, network pharmacology and experimental validation. Scientific reports. vol 14. issue 1. 2024-05-28. PMID:38802644. |
enrichment analysis showed that qgqxm mainly treats dcm by regulating pi3k-akt, mapk, mtor, insulin, insulin resistance, and apoptosis signaling pathways. |
2024-05-28 |
2024-05-31 |
rat |
| Laura Cànaves-Gómez, Aarne Fleischer, Josep Muncunill-Farreny, María Paloma Gimenez, Ainhoa Álvarez Ruiz De Larrinaga, Andrés Sánchez Baron, Mercedes Codina Marcet, Mónica De-La-Peña, Daniel Morell-Garcia, José Peña Zarza, Concepción Piñas Zebrian, Susana García Fernández, Alberto Alons. Effect of Obstructive Sleep Apnea during Pregnancy on Fetal Development: Gene Expression Profile of Cord Blood. International journal of molecular sciences. vol 25. issue 10. 2024-05-25. PMID:38791576. |
key biological processes involved in osa were identified, including response to oxidative stress and hypoxia, apoptosis, insulin response and secretion, and placental development. |
2024-05-25 |
2024-05-27 |
Not clear |
| Enver Ciftel, Filiz Mercantepe, Tolga Mercantepe, Kerimali Akyildiz, Adnan Yilmaz, Serpil Cifte. Comparative Analysis of Epigallocatechin-3-Gallate and TNF-Alpha Inhibitors in Mitigating Cisplatin-Induced Pancreatic Damage Through Oxidative Stress and Apoptosis Pathways. Biological trace element research. 2024-05-22. PMID:38776022. |
immunohistochemically, the enhanced presence of insulin and glucagon positivity in the egcg and inf groups, along with the absence of tunel immunopositivity, indicate that both treatments reduced cddp-induced apoptosis. |
2024-05-22 |
2024-05-27 |
rat |
| Deepak Maurya, Gayatri Rai, Debleena Mandal, Bama Charan Monda. Transient caspase-mediated activation of caspase-activated DNase causes DNA damage required for phagocytic macrophage differentiation. Cell reports. vol 43. issue 5. 2024-05-18. PMID:38761374. |
insulin receptor-mediated pi3k/akt signaling regulates the apoptosis signal-regulating kinase 1 (ask1)/c-jun kinase (jnk) axis to control sublethal levels of caspase activation, causing dna strand breaks during macrophage development. |
2024-05-18 |
2024-05-27 |
drosophila_melanogaster |
| Ashuai Du, Rong Xu, Qinglong Yang, Yingxue Lu, Xinhua Lu. Exploration of shared gene signatures and molecular mechanisms between type 2 diabetes and osteoporosis. Journal of cellular and molecular medicine. vol 28. issue 9. 2024-05-14. PMID:38742851. |
remarkably, pdia6 and slc16a1 were observed to inhibit the proliferation of pancreatic β cells and promote apoptosis in vitro, while downregulation of pdia6 and slc16a1 expression led to enhanced insulin secretion. |
2024-05-14 |
2024-05-27 |
Not clear |
| Marina Blanc, Lama Habbouche, Peng Xiao, Cynthia Lebeaupin, Marion Janona, Nathalie Vaillant, Marie Irondelle, Jérôme Gilleron, Florent Murcy, Déborah Rousseau, Carmelo Luci, Thibault Barouillet, Sandrine Marchetti, Sandra Lacas-Gervais, Laurent Yvan-Charvet, Philippe Gual, Alessandra K Cardozo, Béatrice Bailly-Maitr. Bax Inhibitor-1 preserves pancreatic β-cell proteostasis by limiting proinsulin misfolding and programmed cell death. Cell death & disease. vol 15. issue 5. 2024-05-14. PMID:38744890. |
our results uncover a new role for bax inhibitor-one (bi-1), a negative regulator of inositol-requiring enzyme 1 (ire1α) in preserving β-cell health against terminal upr-induced apoptosis and pyroptosis in the context of supraphysiological loads of insulin production. |
2024-05-14 |
2024-05-27 |
mouse |