| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiayao Chen, Zhuowen Hao, Hanke Li, Jianping Wang, Tianhong Chen, Ying Wang, Guang Shi, Junwu Wang, Zepu Wang, Zheyuan Zhang, Jingfeng L. Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies. Theranostics. vol 14. issue 10. 2024-07-12. PMID:38994021. |
this review proposes twelve microenvironmental treatment targets for osteoporosis-related pathological changes, including local accumulation of inflammatory factors and reactive oxygen species (ros), imbalance of mitochondrial dynamics, insulin resistance, disruption of bone cell autophagy, imbalance of bone cell apoptosis, changes in neural secretions, aging of bone cells, increased local bone tissue vascular destruction, and decreased regeneration. |
2024-07-12 |
2024-07-14 |
Not clear |
| Hossein Ghazaee, Alireza Raouf Sheibani, Haniyeh Mahdian, Shamim Gholami, Vahid Reza Askari, Vafa Baradaran Rahim. Ellagic acid as potential therapeutic compound for diabetes and its complications: a systematic review from bench to bed. Naunyn-Schmiedeberg's archives of pharmacology. 2024-07-09. PMID:38980410. |
ea counteracted dm and its complications by diminishing inflammation, oxidative stress, hyperglycemia, apoptosis, insulin resistance, obesity, lipid profile, and histopathological alterations. |
2024-07-09 |
2024-07-12 |
Not clear |
| Ayman Hyder, Basma Sheta, Manar Eissa, Jürgen Schrezenmei. Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity. Acta diabetologica. 2024-07-03. PMID:38960943. |
long-term exposure of pancreatic islets to fatty acids (fas), common in obesity, metabolic syndrome, and type 2 diabetes, leads to a compensatory hyperactivity followed by inflammation, apoptosis, dysfunctional beta cells, and results in insulin dependence of the patient. |
2024-07-03 |
2024-07-10 |
Not clear |
| Jane Carissa Sutedja, Bryan Gervais de Liyis, Made Ratna Saraswat. Gamma-aminobutyric acid for delaying type 1 diabetes mellitus: an update. Annals of pediatric endocrinology & metabolism. vol 29. issue 3. 2024-07-03. PMID:38956751. |
various in vitro and in vivo studies have shown that gaba induces proliferation of β cells, increases insulin levels, inhibits β-cell apoptosis, and suppresses t helper 1 cell activity against islet antigens. |
2024-07-03 |
2024-07-06 |
Not clear |
| Minglong Qiu, Leilei Chang, Guoqing Tang, Wenkai Ye, Yiming Xu, Nijiati Tulufu, Zhou Dan, Jin Qi, Lianfu Deng, Changwei L. Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ. Experimental & molecular medicine. 2024-06-30. PMID:38945950. |
in addition to increasing bone mass and reducing blood glucose levels, activating the hif-1α pathway by specifically knocking out von hippel‒lindau (vhl) in osteoblasts partially alleviated the symptoms of streptozotocin (stz)-induced type 1 diabetes mellitus (t1dm), including increased glucose clearance in the diabetic state, protection of pancreatic β cell from stz-induced apoptosis, promotion of pancreatic β cell proliferation, and stimulation of insulin secretion. |
2024-06-30 |
2024-07-03 |
Not clear |
| Maryam Moosavi, Roksana Soukhaklari, Saeid Bagheri-Mohammadi, Bita Firouzan, Pegah Javadpour, Rasoul Ghasem. Nanocurcumin prevents memory impairment, hippocampal apoptosis, Akt and CaMKII-α signaling disruption in the central STZ model of Alzheimer's disease in rat. Behavioural brain research. 2024-06-28. PMID:38942084. |
these findings might suggest that nanocurcumin can restore memory deficit, hippocampal apoptosis as well as akt and camkii-α signaling disruption associated with brain insulin resistance. |
2024-06-28 |
2024-07-01 |
rat |
| Liwei Sun, Hailong Bing, Chenxi Zhang, Lin Lin, Hongkai Lian, Qinjun Chu, Xiaogao Ji. Short-Term Preconditioning with Insulin and Glucose Efficiently Protected the Kidney Against Ischemia-Reperfusion Injury via the P-AKT-Bax-Caspase-3 Signaling Pathway in Mice. Drug design, development and therapy. vol 18. 2024-06-25. PMID:38915866. |
insulin attaches insulin receptor to activate the pi3-kinase/akt signaling to maintain glucose homeostasis and inhibit apoptosis. |
2024-06-25 |
2024-06-27 |
mouse |
| Sumit Patel, Maria S Remed. Loss of β-cell identity and dedifferentiation, not an irreversible process? Frontiers in endocrinology. vol 15. 2024-06-25. PMID:38915897. |
while the decline in insulin production and secretion was previously attributed to apoptosis of insulin-producing β-cells, recent studies indicate that β-cell apoptosis rates are relatively low in diabetes. |
2024-06-25 |
2024-06-27 |
Not clear |
| Luning Yang, Di Liu, Shide Jiang, Hengzhen Li, Lin Chen, Yuxiang Wu, Anko Elijah Essien, Michael Opoku, Shinen Naranmandakh, ShuGuang Liu, Qin Ru, Yusheng L. SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908209. |
sirt1 functioned as an important role in the occurrence and progression of sarcopenia through regulating key pathways related to protein homeostasis, apoptosis, mitochondrial dysfunction, insulin resistance and autophagy in skeletal muscle, including sirt1/forkhead box o (foxo), amp-activated protein kinase (ampk)/sirt1/nuclear factor κb (nf-κb), sirt1/p53, ampk/sirt1/peroxisome proliferator-activated receptor gamma coactivator-1α (pgc-1α), and sirt1/live kinase b1 (lkb1)/ampk pathways. |
2024-06-22 |
2024-06-25 |
human |
| Xuelin Li, Feifan Wang, Mengzhu Chen, Li Ling, Fengfeng Zhao, Danhong Pen. The association between endometrial polyps and insulin resistance from the expression of PI3K and AKT proteins perspective. BMC women's health. vol 24. issue 1. 2024-06-22. PMID:38909214. |
insulin resistance (ir) induces hyperinsulinemia, which activates downstream signaling pathways such as the phosphatidylinositol-3-kinase/protein kinase b (pi3k/akt) pathway, ultimately leading to abnormal proliferation and apoptosis of endometrial cells. |
2024-06-22 |
2024-06-25 |
Not clear |
| Guilherme Gabriel de Almeida, Anaysa P Bolin, Alice Batistuzzo, Tatiana L Fonseca, Miriam O Ribeiro, Antonio C Bianc. Genetic Background Strongly Influences the Impact of Carrying the Thr92Ala-DIO2 Polymorphism in the Male Mouse. Endocrinology. vol 165. issue 7. 2024-06-17. PMID:38836615. |
whereas b6-ala92-dio2 and b6-thr92-dio2 mice-fed chow or high-fat diet-behaved metabolically similar in studies using indirect calorimetry, glucose- and insulin tolerance tests, and measuring white adipose tissue (wat) weight and liver steatosis, major differences were observed between fvb-ala92-dio2 and fvb-thr92-dio2 mice: carrying the ala92-dio2 allele (on a chow diet) resulted in hypercholesterolemia, smaller wat pads, hepatomegaly, steatosis, and transcriptome changes in the interscapular brown adipose tissue (ibat) typical of er stress and apoptosis. |
2024-06-17 |
2024-06-19 |
mouse |
| Wenxing Cui, Chen Lv, Panling Geng, Mingdi Fu, Wenjing Zhou, Mingxiang Xiong, Tian L. Novel targets and therapies of metformin in dementia: old drug, new insights. Frontiers in pharmacology. vol 15. 2024-06-17. PMID:38881878. |
mechanistically, metformin has been shown to improve insulin resistance, reduce neuronal apoptosis, and decrease oxidative stress and neuroinflammation in the brain. |
2024-06-17 |
2024-06-19 |
Not clear |
| Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaj. Insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in INS-1 pancreatic β-cells. Physiological reports. vol 12. issue 12. 2024-06-17. PMID:38884322. |
insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in ins-1 pancreatic β-cells. |
2024-06-17 |
2024-06-19 |
Not clear |
| Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaj. Insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in INS-1 pancreatic β-cells. Physiological reports. vol 12. issue 12. 2024-06-17. PMID:38884322. |
here, we report that the autocrine/paracrine function of insulin reduces er stress-induced β-cell apoptosis. |
2024-06-17 |
2024-06-19 |
Not clear |
| Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaj. Insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in INS-1 pancreatic β-cells. Physiological reports. vol 12. issue 12. 2024-06-17. PMID:38884322. |
insulin reduced the er-stress inducer tunicamycin- and thapsigargin-induced cell viability loss due to apoptosis in ins-1 β-cells. |
2024-06-17 |
2024-06-19 |
Not clear |
| Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaj. Insulin reduces endoplasmic reticulum stress-induced apoptosis by decreasing mitochondrial hyperpolarization and caspase-12 in INS-1 pancreatic β-cells. Physiological reports. vol 12. issue 12. 2024-06-17. PMID:38884322. |
these results demonstrate that insulin protects against er stress-induced β-cell apoptosis in this cell line. |
2024-06-17 |
2024-06-19 |
Not clear |
| Alev Duygu Acun, Deniz Kanta. Modulation of oxidative stress and apoptosis by alteration of bioactive lipids in the pancreas, and effect of zinc chelation in a rat model of Alzheimer's disease. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 85. 2024-06-14. PMID:38875759. |
it is known that zinc (zn2+) chelation is effective in reducing peripheral insulin resistance, cell apoptosis, cell death, and oxidative stress. |
2024-06-14 |
2024-06-17 |
rat |
| Yajun Zhang, Xun Luo, Mengyun Zhu, Yu W. Evaluation the role of insulin signaling pathway in reproductive toxicity of dispersed diesel particulate extract under environmental conditions. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-06-12. PMID:38866378. |
c. elegans were subjected to a semi-fluid medium (ngg) containing different concentrations of dpe or dpe + fa in order to assess germline apoptosis and the expression of important genes in the insulin signaling pathway. |
2024-06-12 |
2024-06-15 |
caenorhabditis_elegans |
| Songren Han, Xueyan Zhang, Ziwei Li, Guilin Cui, Beilin Xue, Yang Yu, Jiaqing Guo, Huan Zhang, Jie Yang, Lesheng Ten. A ginsenoside G-Rg3 PEGylated Long-Circulating liposome for hyperglycemia and insulin resistance therapy in Streptozotocin-Induced type 2 diabetes mice. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024-06-07. PMID:38848783. |
ginsenoside (gs), one of the main active components in ginseng, can enhance insulin sensitivity, improve the function of islet β cells, and reduce cell apoptosis in the treatment of diabetes. |
2024-06-07 |
2024-06-10 |
mouse |
| Jiang Lai, Chunxiao L. Review on the pharmacological effects and pharmacokinetics of scutellarein. Archiv der Pharmazie. 2024-06-07. PMID:38849327. |
these mechanisms encompass the scavenging of free radicals, inhibition of the activation of inflammatory signaling pathways and expression of inflammatory mediators, inhibition of the activity of crucial viral proteins, suppression of gluconeogenesis, amelioration of insulin resistance, improvement of cerebral ischemia-reperfusion injury, induction of apoptosis in cancer cells, and prevention of myocardial hypertrophy, among others. |
2024-06-07 |
2024-06-10 |
Not clear |