| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patricio H Contreras, Pilar Vigi. Across-species benefits of adrenalectomy on congenital generalized lipoatrophic diabetes: a review. Frontiers in endocrinology. vol 14. 2024-01-23. PMID:38260129. |
in this manner, leptin resistance should lead to peripheral (adipose tissue, liver, and muscle) insulin resistance and islet beta-cell apoptosis, paving the way to type 2 diabetes. |
2024-01-23 |
2024-01-25 |
mouse |
| Franca Raucci, Claudio Vernieri, Maira Di Tano, Francesca Ligorio, Olga Blaževitš, Samuel Lazzeri, Anastasiya Shmahala, Giuseppe Fragale, Giulia Salvadori, Gabriele Varano, Stefano Casola, Roberta Buono, Euplio Visco, Filippo de Braud, Valter D Long. Cyclic fasting-mimicking diet plus bortezomib and rituximab is an effective treatment for chronic lymphocytic leukemia. Cancer research. 2024-01-19. PMID:38241703. |
fasting mimicking conditions in murine cll models had mild cytotoxic effects, which resulted in apoptosis activation mediated in part by lowered insulin and igf-1 concentrations. |
2024-01-19 |
2024-01-22 |
mouse |
| Chirag P Talati, Jonathan W Lee, Silu Lu, Norma B Ojeda, Varsha Prakash, Nilesh Dankhara, Tanner C Nielson, Sara P Sandifer, Gene L Bidwell, Yi Pang, Lir-Wan Fan, Abhay J Bhat. Intranasal insulin attenuates hypoxia-ischemia-induced short-term sensorimotor behavioral disturbances, neuronal apoptosis, and brain damage in neonatal rats. Current research in neurobiology. vol 6. 2024-01-18. PMID:38235171. |
intranasal insulin attenuates hypoxia-ischemia-induced short-term sensorimotor behavioral disturbances, neuronal apoptosis, and brain damage in neonatal rats. |
2024-01-18 |
2024-01-20 |
human |
| Lan Wu, Xiang-Jian Meng, Tian-Bao Xu, Xian-Cui Zhang, Yong Zhou, Zhu-Feng Tong, Jing-Han Jian. Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. Chemical biology & drug design. vol 103. issue 1. 2024-01-17. PMID:38230770. |
at the same time, ogtt, fasting blood glucose, blood lipids, insulin and other metabolic parameters, oxidative stress, and apoptosis levels were measured. |
2024-01-17 |
2024-01-19 |
human |
| Lan Wu, Xiang-Jian Meng, Tian-Bao Xu, Xian-Cui Zhang, Yong Zhou, Zhu-Feng Tong, Jing-Han Jian. Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. Chemical biology & drug design. vol 103. issue 1. 2024-01-17. PMID:38230770. |
the results showed that the model rats showed obvious glucose intolerance, elevated blood lipids, and insulin resistance, and the levels of oxidative stress and apoptosis were significantly increased. |
2024-01-17 |
2024-01-19 |
human |
| Fei Hu, Yicong Yu, Hongming X. How does exosome cause diabetes? Hormones (Athens, Greece). 2024-01-17. PMID:38233729. |
they have recently been recognized as important means of intercellular communication, being involved, for example, in the development of diabetes by increasing β-cell apoptosis, activating autoimmunity, and regulating cytokines to affect islet β-cell function and insulin sensitivity. |
2024-01-17 |
2024-01-20 |
Not clear |
| Macarena Algañarás, Carolina L Román, Juan J Gagliardino, Bárbara Maiztegui, Luis E Flore. Structural modifications of INGAP-PP present in HTD4010 peptide potentiate its effect on rat islet gene expression and insulin secretion. Peptides. 2024-01-12. PMID:38215942. |
in the present study, we showed that htd4010 included in the culture media of normal rat islets at a dose 100 times lower than that used for ingap-pp was able to modulate, in the same way as the original peptide, both insulin secretion in response to glucose and the expression of key genes related to insular function, insulin and leptin intracellular pathways, neogenesis, apoptosis, and inflammatory response. |
2024-01-12 |
2024-01-15 |
rat |
| Shan-Shan Yu, Jian-Ling D. Current views on selenoprotein S in the pathophysiological processes of diabetes-induced atherosclerosis: potential therapeutics and underlying biomarkers. Diabetology & metabolic syndrome. vol 16. issue 1. 2024-01-04. PMID:38172976. |
hepatic-specific deletion of selenos accelerated the onset and progression of obesity, impaired glucose tolerance and insulin sensitivity, and increased hepatic triglycerides (tg) and diacylglycerol (dag) accumulation; selenos expression in subcutaneous and omental adipose tissue was elevated in obese human subjects, and act as a positive regulator for adipogenesis in 3t3-l1 preadipocytes; knockdown of selenos in min6 β-cells induced β-cell apoptosis and reduced cell proliferation. |
2024-01-04 |
2024-01-06 |
human |
| Dongze Li, Li Zhang, Ping Yang, Yanqiu He, Tingting Zhou, Xi Cheng, Zongzhe Jiang, Yang Long, Qin Wan, Pijun Yan, Chenlin Gao, Wei Huang, Yong X. Sodium benzoate induces pancreatic inflammation and β cell apoptosis partially via benzoylation. Ecotoxicology and environmental safety. vol 270. 2023-12-27. PMID:38150747. |
our study found that, although the experimental concentration of nab is below the maximum allowable concentration in food, it still damaged the insulin secretion function of c57bl/6j mice and induced inflammation and apoptosis of islet β cells. |
2023-12-27 |
2023-12-30 |
mouse |
| Dongze Li, Li Zhang, Ping Yang, Yanqiu He, Tingting Zhou, Xi Cheng, Zongzhe Jiang, Yang Long, Qin Wan, Pijun Yan, Chenlin Gao, Wei Huang, Yong X. Sodium benzoate induces pancreatic inflammation and β cell apoptosis partially via benzoylation. Ecotoxicology and environmental safety. vol 270. 2023-12-27. PMID:38150747. |
when kbz is down-regulated using a485 and acss2 inhibitor, we observed a reduction in β cell inflammation, apoptosis, and insulin secretion damage. |
2023-12-27 |
2023-12-30 |
mouse |
| Asraa Faris Aldoghachi, Daijiro Yanagisawa, Aslina Pahrudin Arrozi, Zulzikry Hafiz Abu Bakar, Hiroyasu Taguchi, Shinsuke Ishigaki, Katsutaro Morino, Ikuo Tooyam. Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes. Biochemical and biophysical research communications. vol 694. 2023-12-24. PMID:38142581. |
on day 29, the mice were euthanized, following which the serum levels of glucose, insulin, and glucagon were measured using elisa, the expression of txnip in pancreatic tissue lysates was determined using western blotting, and the level of β-cell apoptosis was assessed using the tunel assay. |
2023-12-24 |
2023-12-27 |
mouse |
| Min-Woo Song, Wenhao Cui, Chang-Gun Lee, Rihua Cui, Young Ho Son, Young Ha Kim, Yujin Kim, Hae Jin Kim, Sung-E Choi, Yup Kang, Tae Ho Kim, Ja Young Jeon, Kwan-Woo Le. Protective effect of empagliflozin against palmitate-induced lipotoxicity through AMPK in H9c2 cells. Frontiers in pharmacology. vol 14. 2023-12-20. PMID:38116084. |
we found that empa significantly attenuated pa-induced impairments in insulin sensitivity, er stress, inflammatory cytokine gene expression, and cellular apoptosis. |
2023-12-20 |
2023-12-23 |
Not clear |
| Oh Yoen Kim, Juhyun Son. Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia. Life sciences. 2023-12-20. PMID:38123015. |
among polyunsaturated acids, linoleic acid (la, n6-pufa) and α-linolenic acid (ala, n3-pufa), which are two essential fatty acids that should be provided by food sources (e.g., vegetable oils and seeds), have been reported to regulate various cellular mechanisms including apoptosis, inflammatory responses, mitochondrial biogenesis, and insulin signaling. |
2023-12-20 |
2023-12-23 |
Not clear |
| S-Y Liu, S-L Cao, H-Y Luo, L Bao, J E, B Li, X-M Lan, G-Q Zhang, X Bao, Y-L Zhen. TFP5, a Peptide Derived from Cdk5 Activator p35, Protects Pancreatic β Cells from Glucose Toxicity. Bulletin of experimental biology and medicine. 2023-12-12. PMID:38087140. |
tfp5 effectively inhibited the pathological hyperactivity of cdk5, enhanced insulin secretion, and protected pancreatic β cells from apoptosis in vitro and in vivo. |
2023-12-12 |
2023-12-17 |
mouse |
| Brenda Vidrio-Huerta, Thomas Plötz, Stephan Lort. Oxidative and ER stress by elevated insulin biosynthesis and palmitic acid in insulin-producing cells. Journal of molecular endocrinology. 2023-12-06. PMID:38054640. |
elevated insulin expression increased er luminal h2o2 concentration quantified by the fluorescent sensor protein triper and reduced viability, but did not activate apoptosis. |
2023-12-06 |
2023-12-10 |
Not clear |
| Brenda Vidrio-Huerta, Thomas Plötz, Stephan Lort. Oxidative and ER stress by elevated insulin biosynthesis and palmitic acid in insulin-producing cells. Journal of molecular endocrinology. 2023-12-06. PMID:38054640. |
however, when combined with pa, insulin expression resulted in a significant increase in er stress and apoptosis. |
2023-12-06 |
2023-12-10 |
Not clear |
| Kenneth Maies. The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk. Frontiers in immunology. vol 14. 2023-12-01. PMID:38022638. |
programmed cell death pathways that involve autophagy, apoptosis, ferroptosis, and pyroptosis can play a critical role in metabolic and neurodegenerative disorders and oversee processes that include insulin resistance, β-cell function, mitochondrial integrity, reactive oxygen species release, and inflammatory cell activation. |
2023-12-01 |
2023-12-07 |
Not clear |
| Yanzhong Liu, Dan Wang, Yi-Ping Li. Metabolite profiles of diabetes mellitus and response to intervention in anti-hyperglycemic drugs. Frontiers in endocrinology. vol 14. 2023-12-01. PMID:38027178. |
for example, excess free fatty acids can lead to reduced glucose utilization in skeletal muscle and induce insulin resistance; metabolism disorder of branched-chain amino acids contributes to the accumulation of toxic metabolic intermediates, and promotes the dysfunction of β-cell mitochondria, stress signal transduction, and apoptosis. |
2023-12-01 |
2023-12-10 |
Not clear |
| Kenneth Maies. The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk. Frontiers in immunology. vol 14. 2023-12-01. PMID:38022638. |
programmed cell death pathways that involve autophagy, apoptosis, ferroptosis, and pyroptosis can play a critical role in metabolic and neurodegenerative disorders and oversee processes that include insulin resistance, β-cell function, mitochondrial integrity, reactive oxygen species release, and inflammatory cell activation. |
2023-11-29 |
2023-12-07 |
Not clear |
| b' Milena Veskovi\\xc4\\x87, Nikola \\xc5\\xa0utulovi\\xc4\\x87, Dragan Hrn\\xc4\\x8di\\xc4\\x87, Olivera Stanojlovi\\xc4\\x87, Djuro Macut, Du\\xc5\\xa1an Mladenovi\\xc4\\x8. The Interconnection between Hepatic Insulin Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease-The Transition from an Adipocentric to Liver-Centric Approach. Current issues in molecular biology. vol 45. issue 11. 2023-11-25. PMID:37998747.' |
er stress and unfolded protein response play significant roles in insulin resistance aggravation through the activation of apoptosis, inflammatory response, and insulin signaling impairment mediated via ire1/perk/atf6 signaling pathways and the upregulation of srebp 1c. |
2023-11-25 |
2023-11-28 |
Not clear |