| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lidia Groele, Katarzyna Dżygało, Agnieszka Kowalska, Agnieszka Szypowsk. Prolonged Remission Induced by FENofibrate in children with newly diagnosed type 1 diabetes (PRIFEN): protocol of a randomised controlled trial. BMJ open. vol 14. issue 2. 2024-02-10. PMID:38341215. |
sphingolipids regulate proinsulin folding, insulin secretion and control beta cells apoptosis. |
2024-02-10 |
2024-02-14 |
human |
| M I Farrim, A Gomes, D Milenkovic, R Meneze. Gene expression analysis reveals diabetes-related gene signatures. Human genomics. vol 18. issue 1. 2024-02-07. PMID:38326874. |
the loss of pancreatic β-cell mass by either autoimmune destruction or apoptosis, in type 1-diabetes (t1d) and type 2-diabetes (t2d), respectively, represents a pathophysiological process leading to insulin deficiency. |
2024-02-07 |
2024-02-10 |
Not clear |
| Shan Zeng, Yeying Wang, Li Ai, Liwei Huang, Zhijuan Liu, Chunxia He, Qiaohui Bai, Yongxia L. Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas. Clinical and experimental pharmacology & physiology. vol 51. issue 3. 2024-02-01. PMID:38302075. |
chronic intermittent hypoxia-induced oxidative stress activates trb3 and phosphorylated jnk to mediate insulin resistance and cell apoptosis in the pancreas. |
2024-02-01 |
2024-02-04 |
rat |
| Shan Zeng, Yeying Wang, Li Ai, Liwei Huang, Zhijuan Liu, Chunxia He, Qiaohui Bai, Yongxia L. Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas. Clinical and experimental pharmacology & physiology. vol 51. issue 3. 2024-02-01. PMID:38302075. |
this study explores the potential mechanisms of obstructive sleep apnoea (osa) complicates type 2 diabetes mellitus (t2dm) by which chronic intermittent hypoxia (cih) induces insulin resistance and cell apoptosis in the pancreas through oxidative stress. |
2024-02-01 |
2024-02-04 |
rat |
| Jing Zhou, Chao-Ke Tan. Cytoplasmic Polyadenylation Element Binding Protein 1 and Atherosclerosis: Prospective Target and New Insights. Current vascular pharmacology. 2024-01-29. PMID:38284693. |
according to recent investigations, many pathological processes, including inflammation, lipid metabolism, endothelial dysfunction, angiogenesis, oxidative stress, cellular senescence, apoptosis, and insulin resistance, are regulated by cpeb1. |
2024-01-29 |
2024-01-31 |
Not clear |
| Hugo Borges Dos Reis, Minos Esperândio Carvalho, Rafael Espigolan, Mirele Daiana Poleti, Dewison Ricardo Ambrizi, Mariana Piatto Berton, José Bento Sterman Ferraz, Elisângela Chicaroni de Mattos Oliveira, Joanir Pereira Ele. Genome-Wide Association (GWAS) Applied to Carcass and Meat Traits of Nellore Cattle. Metabolites. vol 14. issue 1. 2024-01-26. PMID:38276296. |
enrichment analyses showed the following significant terms (fdr ≤ 0.05) associated with the characteristics under study: for the rea, heat stress disorders and life cycle stages; for sft, insulin and nonesterified fatty acids; for sf7, apoptosis and heat shock proteins (hsp27); and for imf, metalloproteinase 2. |
2024-01-26 |
2024-01-28 |
cattle |
| Jinxi Zhu, Ziyan Hu, Yifan Luo, Yinuo Liu, Wei Luo, Xiaohong Du, Zhenzhong Luo, Jialing Hu, Shengliang Pen. Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment. Frontiers in endocrinology. vol 14. 2024-01-24. PMID:38264279. |
in addition, abnormalities in the insulin signaling pathway will inhibit neural axon repair and promote apoptosis of damaged cells. |
2024-01-24 |
2024-01-26 |
Not clear |
| Qing Liu, Ying Han, Meng Zhang, Peng Yang, Yan Xiang, Min Chen, Fei Xu, Xiaochan Zhou, Dan Zheng, Juan Qi. IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic β cells in gestational diabetes mellitus by upregulating ATG7. Reproductive biology. vol 24. issue 1. 2024-01-23. PMID:38262267. |
collectively, igf1r stimulated cell viability, suppressed apoptosis, amplified insulin secretion, and increased atg7 expression to induce cell autophagy, which could be partially averted by atg7 silencing. |
2024-01-23 |
2024-01-26 |
mouse |
| Patricio H Contreras, Pilar Vigi. Across-species benefits of adrenalectomy on congenital generalized lipoatrophic diabetes: a review. Frontiers in endocrinology. vol 14. 2024-01-23. PMID:38260129. |
in this manner, leptin resistance should lead to peripheral (adipose tissue, liver, and muscle) insulin resistance and islet beta-cell apoptosis, paving the way to type 2 diabetes. |
2024-01-23 |
2024-01-25 |
mouse |
| Franca Raucci, Claudio Vernieri, Maira Di Tano, Francesca Ligorio, Olga Blaževitš, Samuel Lazzeri, Anastasiya Shmahala, Giuseppe Fragale, Giulia Salvadori, Gabriele Varano, Stefano Casola, Roberta Buono, Euplio Visco, Filippo de Braud, Valter D Long. Cyclic fasting-mimicking diet plus bortezomib and rituximab is an effective treatment for chronic lymphocytic leukemia. Cancer research. 2024-01-19. PMID:38241703. |
fasting mimicking conditions in murine cll models had mild cytotoxic effects, which resulted in apoptosis activation mediated in part by lowered insulin and igf-1 concentrations. |
2024-01-19 |
2024-01-22 |
mouse |
| Chirag P Talati, Jonathan W Lee, Silu Lu, Norma B Ojeda, Varsha Prakash, Nilesh Dankhara, Tanner C Nielson, Sara P Sandifer, Gene L Bidwell, Yi Pang, Lir-Wan Fan, Abhay J Bhat. Intranasal insulin attenuates hypoxia-ischemia-induced short-term sensorimotor behavioral disturbances, neuronal apoptosis, and brain damage in neonatal rats. Current research in neurobiology. vol 6. 2024-01-18. PMID:38235171. |
intranasal insulin attenuates hypoxia-ischemia-induced short-term sensorimotor behavioral disturbances, neuronal apoptosis, and brain damage in neonatal rats. |
2024-01-18 |
2024-01-20 |
human |
| Lan Wu, Xiang-Jian Meng, Tian-Bao Xu, Xian-Cui Zhang, Yong Zhou, Zhu-Feng Tong, Jing-Han Jian. Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. Chemical biology & drug design. vol 103. issue 1. 2024-01-17. PMID:38230770. |
at the same time, ogtt, fasting blood glucose, blood lipids, insulin and other metabolic parameters, oxidative stress, and apoptosis levels were measured. |
2024-01-17 |
2024-01-19 |
human |
| Lan Wu, Xiang-Jian Meng, Tian-Bao Xu, Xian-Cui Zhang, Yong Zhou, Zhu-Feng Tong, Jing-Han Jian. Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. Chemical biology & drug design. vol 103. issue 1. 2024-01-17. PMID:38230770. |
the results showed that the model rats showed obvious glucose intolerance, elevated blood lipids, and insulin resistance, and the levels of oxidative stress and apoptosis were significantly increased. |
2024-01-17 |
2024-01-19 |
human |
| Fei Hu, Yicong Yu, Hongming X. How does exosome cause diabetes? Hormones (Athens, Greece). 2024-01-17. PMID:38233729. |
they have recently been recognized as important means of intercellular communication, being involved, for example, in the development of diabetes by increasing β-cell apoptosis, activating autoimmunity, and regulating cytokines to affect islet β-cell function and insulin sensitivity. |
2024-01-17 |
2024-01-20 |
Not clear |
| Macarena Algañarás, Carolina L Román, Juan J Gagliardino, Bárbara Maiztegui, Luis E Flore. Structural modifications of INGAP-PP present in HTD4010 peptide potentiate its effect on rat islet gene expression and insulin secretion. Peptides. 2024-01-12. PMID:38215942. |
in the present study, we showed that htd4010 included in the culture media of normal rat islets at a dose 100 times lower than that used for ingap-pp was able to modulate, in the same way as the original peptide, both insulin secretion in response to glucose and the expression of key genes related to insular function, insulin and leptin intracellular pathways, neogenesis, apoptosis, and inflammatory response. |
2024-01-12 |
2024-01-15 |
rat |
| Shan-Shan Yu, Jian-Ling D. Current views on selenoprotein S in the pathophysiological processes of diabetes-induced atherosclerosis: potential therapeutics and underlying biomarkers. Diabetology & metabolic syndrome. vol 16. issue 1. 2024-01-04. PMID:38172976. |
hepatic-specific deletion of selenos accelerated the onset and progression of obesity, impaired glucose tolerance and insulin sensitivity, and increased hepatic triglycerides (tg) and diacylglycerol (dag) accumulation; selenos expression in subcutaneous and omental adipose tissue was elevated in obese human subjects, and act as a positive regulator for adipogenesis in 3t3-l1 preadipocytes; knockdown of selenos in min6 β-cells induced β-cell apoptosis and reduced cell proliferation. |
2024-01-04 |
2024-01-06 |
human |
| Dongze Li, Li Zhang, Ping Yang, Yanqiu He, Tingting Zhou, Xi Cheng, Zongzhe Jiang, Yang Long, Qin Wan, Pijun Yan, Chenlin Gao, Wei Huang, Yong X. Sodium benzoate induces pancreatic inflammation and β cell apoptosis partially via benzoylation. Ecotoxicology and environmental safety. vol 270. 2023-12-27. PMID:38150747. |
our study found that, although the experimental concentration of nab is below the maximum allowable concentration in food, it still damaged the insulin secretion function of c57bl/6j mice and induced inflammation and apoptosis of islet β cells. |
2023-12-27 |
2023-12-30 |
mouse |
| Dongze Li, Li Zhang, Ping Yang, Yanqiu He, Tingting Zhou, Xi Cheng, Zongzhe Jiang, Yang Long, Qin Wan, Pijun Yan, Chenlin Gao, Wei Huang, Yong X. Sodium benzoate induces pancreatic inflammation and β cell apoptosis partially via benzoylation. Ecotoxicology and environmental safety. vol 270. 2023-12-27. PMID:38150747. |
when kbz is down-regulated using a485 and acss2 inhibitor, we observed a reduction in β cell inflammation, apoptosis, and insulin secretion damage. |
2023-12-27 |
2023-12-30 |
mouse |
| Asraa Faris Aldoghachi, Daijiro Yanagisawa, Aslina Pahrudin Arrozi, Zulzikry Hafiz Abu Bakar, Hiroyasu Taguchi, Shinsuke Ishigaki, Katsutaro Morino, Ikuo Tooyam. Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes. Biochemical and biophysical research communications. vol 694. 2023-12-24. PMID:38142581. |
on day 29, the mice were euthanized, following which the serum levels of glucose, insulin, and glucagon were measured using elisa, the expression of txnip in pancreatic tissue lysates was determined using western blotting, and the level of β-cell apoptosis was assessed using the tunel assay. |
2023-12-24 |
2023-12-27 |
mouse |
| Min-Woo Song, Wenhao Cui, Chang-Gun Lee, Rihua Cui, Young Ho Son, Young Ha Kim, Yujin Kim, Hae Jin Kim, Sung-E Choi, Yup Kang, Tae Ho Kim, Ja Young Jeon, Kwan-Woo Le. Protective effect of empagliflozin against palmitate-induced lipotoxicity through AMPK in H9c2 cells. Frontiers in pharmacology. vol 14. 2023-12-20. PMID:38116084. |
we found that empa significantly attenuated pa-induced impairments in insulin sensitivity, er stress, inflammatory cytokine gene expression, and cellular apoptosis. |
2023-12-20 |
2023-12-23 |
Not clear |