| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaitlyn A Colglazier, Noyonika Mukherjee, Christopher J Contreras, Andrew T Templi. Evidence for established and emerging forms of β-cell death. The Journal of endocrinology. 2024-06-06. PMID:38842911. |
β-cell death contributes to β-cell loss and insulin insufficiency in type 1 diabetes (t1d), and this β-cell demise has been attributed to apoptosis and necrosis. |
2024-06-06 |
2024-06-08 |
Not clear |
| Reagan E Beliakoff, Claudio F Gonzalez, Graciela L Lorc. Bile promotes Lactobacillus johnsonii N6.2 extracellular vesicle production with conserved immunomodulatory properties. Scientific reports. vol 14. issue 1. 2024-05-28. PMID:38806562. |
recently, lactobacillus johnsonii n6.2-derived extracellular vesicles (evs) were shown to reduce apoptosis in human beta cell lines and stimulate insulin secretion in human islets. |
2024-05-28 |
2024-06-02 |
human |
| Quancheng Han, Yan Li, Yiding Yu, Huajing Yuan, Ziqi Wang, Yonghong Guo, Jingle Shi, Yitao Xue, Xiujuan Li. Exploring the mechanism of diabetic cardiomyopathy treated with Qigui Qiangxin mixture based on UPLC-Q/TOF-MS, network pharmacology and experimental validation. Scientific reports. vol 14. issue 1. 2024-05-28. PMID:38802644. |
enrichment analysis showed that qgqxm mainly treats dcm by regulating pi3k-akt, mapk, mtor, insulin, insulin resistance, and apoptosis signaling pathways. |
2024-05-28 |
2024-05-31 |
rat |
| Laura Cànaves-Gómez, Aarne Fleischer, Josep Muncunill-Farreny, María Paloma Gimenez, Ainhoa Álvarez Ruiz De Larrinaga, Andrés Sánchez Baron, Mercedes Codina Marcet, Mónica De-La-Peña, Daniel Morell-Garcia, José Peña Zarza, Concepción Piñas Zebrian, Susana García Fernández, Alberto Alons. Effect of Obstructive Sleep Apnea during Pregnancy on Fetal Development: Gene Expression Profile of Cord Blood. International journal of molecular sciences. vol 25. issue 10. 2024-05-25. PMID:38791576. |
key biological processes involved in osa were identified, including response to oxidative stress and hypoxia, apoptosis, insulin response and secretion, and placental development. |
2024-05-25 |
2024-05-27 |
Not clear |
| Enver Ciftel, Filiz Mercantepe, Tolga Mercantepe, Kerimali Akyildiz, Adnan Yilmaz, Serpil Cifte. Comparative Analysis of Epigallocatechin-3-Gallate and TNF-Alpha Inhibitors in Mitigating Cisplatin-Induced Pancreatic Damage Through Oxidative Stress and Apoptosis Pathways. Biological trace element research. 2024-05-22. PMID:38776022. |
immunohistochemically, the enhanced presence of insulin and glucagon positivity in the egcg and inf groups, along with the absence of tunel immunopositivity, indicate that both treatments reduced cddp-induced apoptosis. |
2024-05-22 |
2024-05-27 |
rat |
| Deepak Maurya, Gayatri Rai, Debleena Mandal, Bama Charan Monda. Transient caspase-mediated activation of caspase-activated DNase causes DNA damage required for phagocytic macrophage differentiation. Cell reports. vol 43. issue 5. 2024-05-18. PMID:38761374. |
insulin receptor-mediated pi3k/akt signaling regulates the apoptosis signal-regulating kinase 1 (ask1)/c-jun kinase (jnk) axis to control sublethal levels of caspase activation, causing dna strand breaks during macrophage development. |
2024-05-18 |
2024-05-27 |
drosophila_melanogaster |
| Ashuai Du, Rong Xu, Qinglong Yang, Yingxue Lu, Xinhua Lu. Exploration of shared gene signatures and molecular mechanisms between type 2 diabetes and osteoporosis. Journal of cellular and molecular medicine. vol 28. issue 9. 2024-05-14. PMID:38742851. |
remarkably, pdia6 and slc16a1 were observed to inhibit the proliferation of pancreatic β cells and promote apoptosis in vitro, while downregulation of pdia6 and slc16a1 expression led to enhanced insulin secretion. |
2024-05-14 |
2024-05-27 |
Not clear |
| Marina Blanc, Lama Habbouche, Peng Xiao, Cynthia Lebeaupin, Marion Janona, Nathalie Vaillant, Marie Irondelle, Jérôme Gilleron, Florent Murcy, Déborah Rousseau, Carmelo Luci, Thibault Barouillet, Sandrine Marchetti, Sandra Lacas-Gervais, Laurent Yvan-Charvet, Philippe Gual, Alessandra K Cardozo, Béatrice Bailly-Maitr. Bax Inhibitor-1 preserves pancreatic β-cell proteostasis by limiting proinsulin misfolding and programmed cell death. Cell death & disease. vol 15. issue 5. 2024-05-14. PMID:38744890. |
our results uncover a new role for bax inhibitor-one (bi-1), a negative regulator of inositol-requiring enzyme 1 (ire1α) in preserving β-cell health against terminal upr-induced apoptosis and pyroptosis in the context of supraphysiological loads of insulin production. |
2024-05-14 |
2024-05-27 |
mouse |
| Xiufang Chen, Qian Zhou, Huamin Chen, Juan Bai, Ruike An, Keyi Zhang, Xinyue Zhang, Hui An, Jitai Zhang, Yongyu Wang, Ming L. Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671848. |
in vitro experiments have further demonstrated that gsh can prevent β-cell dedifferentiation, apoptosis, and impaired insulin secretion caused by osg. |
2024-04-27 |
2024-04-29 |
rat |
| Elena G Novoselova, Sergey M Lunin, Maxim O Khrenov, Olga V Glushkova, Tatyana V Novoselova, Svetlana B Parfenyu. Pancreas Β-Cells in Type 1 and Type 2 Diabetes: Cell Death, Oxidative Stress and Immune Regulation. Recently Appearing Changes in Diabetes Consequences. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 58. issue 2. 2024-04-19. PMID:38639210. |
in t1d, β-cell apoptosis is the main event leading to hyperglycemia, while in t2d, insulin resistance results in an inability to meet insulin requirements. |
2024-04-19 |
2024-04-21 |
Not clear |
| Preethi Krishnan, Renato Chaves Souto Branco, Staci A Weaver, Garrick Chang, Chih-Chun Lee, Farooq Syed, Carmella Evans-Molin. miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis. bioRxiv : the preprint server for biology. 2024-04-02. PMID:38562689. |
others have reported that mir-146a-5p overexpression is associated with β cell apoptosis and impaired insulin secretion. |
2024-04-02 |
2024-04-04 |
Not clear |
| Mubeen A Ansari, Aishah Al-Jarallah, Muddanna S Rao, Ahmed Babiker, Khaled Bensalama. Upregulation of NADPH-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: Development of sporadic Alzheimer's disease. Brain research. 2024-03-29. PMID:38552936. |
upregulation of nadph-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: development of sporadic alzheimer's disease. |
2024-03-29 |
2024-04-01 |
rat |
| Kyota Aoyagi, Chiyono Nishiwaki, Yoko Nakamichi, Shun-Ichi Yamashita, Tomotake Kanki, Mica Ohara-Imaizum. Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice. Scientific reports. vol 14. issue 1. 2024-03-15. PMID:38485716. |
imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice. |
2024-03-15 |
2024-03-17 |
mouse |
| Kyota Aoyagi, Chiyono Nishiwaki, Yoko Nakamichi, Shun-Ichi Yamashita, Tomotake Kanki, Mica Ohara-Imaizum. Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice. Scientific reports. vol 14. issue 1. 2024-03-15. PMID:38485716. |
concomitantly, imeglimin and insulin, but not metformin, restored the secreted insulin level and reduced β-cell apoptosis in db/db mice. |
2024-03-15 |
2024-03-17 |
mouse |
| Kanikkai Raja Aseer, Caio Henrique Mazucanti, Jennifer F O'Connell, Isabel González- Mariscal, Anjali Verma, Qin Yao, Christopher Dunn, Qing-Rong Liu, Josephine M Egan, Máire E Doyl. Beta cell Specific Cannabinoid 1 Receptor Deletion Counteracts Progression to Hyperglycemia in Non-Obese Diabetic Mice. Molecular metabolism. 2024-02-29. PMID:38423253. |
we previously reported that genetic deletion and pharmacological antagonism of the cannabinoid 1 receptor (cb1) in mice improves insulin synthesis and secretion, upregulates glucose sensing machinery, favors beta cell survival by reducing apoptosis, and enhances beta cell proliferation. |
2024-02-29 |
2024-03-03 |
mouse |
| J Michael Conlon, Bosede O Owolabi, Peter R Flatt, Yasser H A Abdel-Waha. Amphibian host-defense peptides with potential for Type 2 diabetes therapy - an updated review. Peptides. 2024-02-24. PMID:38401671. |
studies in vitro have described peptides that (a) stimulate insulin release from brin-bd11 clonal β-cells and isolated mouse islets, (b) display β-cell proliferative activity and protect against cytokine-mediated apoptosis and (c) stimulate production of the anti-inflammatory cytokine il-10 and inhibit production of the pro-inflammatory cytokines tnf-α and il-1β. |
2024-02-24 |
2024-02-27 |
mouse |
| Gholamreza Taheripak, Niusha Sabeti, Naba Najar, Zahrasadat Razavi, Saber Saharkhiz, Iraj Alipourfar. SIRT1 activation attenuates palmitate induced apoptosis in C Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400872. |
sirt1 activation attenuates palmitate induced apoptosis in c type 2 diabetes is characterized by insulin resistance, which manifests mainly in skeletal muscles. |
2024-02-24 |
2024-02-27 |
Not clear |
| Jalal Taneera, Maha M Saber-Aya. Preservation of β-Cells as a Therapeutic Strategy for Diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2024-02-22. PMID:38387480. |
β-cell dysfunction, reduced mass, and apoptosis are central to insufficient insulin secretion in both types. |
2024-02-22 |
2024-02-25 |
Not clear |
| Hui Yi Chew, Goran Cvetkovic, Slobodan Tepic, James W Well. Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin. Scientific reports. vol 14. issue 1. 2024-02-19. PMID:38374190. |
our study examined the combined impact of insulin and arg on breast, lung, and ovarian cell lines, focusing on cell proliferation, metabolism, apoptosis, and autophagy. |
2024-02-19 |
2024-02-22 |
Not clear |
| Hui Yi Chew, Goran Cvetkovic, Slobodan Tepic, James W Well. Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin. Scientific reports. vol 14. issue 1. 2024-02-19. PMID:38374190. |
moreover, insulin was largely ineffective in altering arg-induced metabolic changes and did not prevent apoptosis. |
2024-02-19 |
2024-02-22 |
Not clear |