| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiufang Chen, Qian Zhou, Huamin Chen, Juan Bai, Ruike An, Keyi Zhang, Xinyue Zhang, Hui An, Jitai Zhang, Yongyu Wang, Ming L. Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671848. |
in vitro experiments have further demonstrated that gsh can prevent β-cell dedifferentiation, apoptosis, and impaired insulin secretion caused by osg. |
2024-04-27 |
2024-04-29 |
rat |
| Elena G Novoselova, Sergey M Lunin, Maxim O Khrenov, Olga V Glushkova, Tatyana V Novoselova, Svetlana B Parfenyu. Pancreas Β-Cells in Type 1 and Type 2 Diabetes: Cell Death, Oxidative Stress and Immune Regulation. Recently Appearing Changes in Diabetes Consequences. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 58. issue 2. 2024-04-19. PMID:38639210. |
in t1d, β-cell apoptosis is the main event leading to hyperglycemia, while in t2d, insulin resistance results in an inability to meet insulin requirements. |
2024-04-19 |
2024-04-21 |
Not clear |
| Preethi Krishnan, Renato Chaves Souto Branco, Staci A Weaver, Garrick Chang, Chih-Chun Lee, Farooq Syed, Carmella Evans-Molin. miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis. bioRxiv : the preprint server for biology. 2024-04-02. PMID:38562689. |
others have reported that mir-146a-5p overexpression is associated with β cell apoptosis and impaired insulin secretion. |
2024-04-02 |
2024-04-04 |
Not clear |
| Mubeen A Ansari, Aishah Al-Jarallah, Muddanna S Rao, Ahmed Babiker, Khaled Bensalama. Upregulation of NADPH-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: Development of sporadic Alzheimer's disease. Brain research. 2024-03-29. PMID:38552936. |
upregulation of nadph-oxidase, inducible nitric oxide synthase and apoptosis in the hippocampus following impaired insulin signaling in the rats: development of sporadic alzheimer's disease. |
2024-03-29 |
2024-04-01 |
rat |
| Kyota Aoyagi, Chiyono Nishiwaki, Yoko Nakamichi, Shun-Ichi Yamashita, Tomotake Kanki, Mica Ohara-Imaizum. Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice. Scientific reports. vol 14. issue 1. 2024-03-15. PMID:38485716. |
imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice. |
2024-03-15 |
2024-03-17 |
mouse |
| Kyota Aoyagi, Chiyono Nishiwaki, Yoko Nakamichi, Shun-Ichi Yamashita, Tomotake Kanki, Mica Ohara-Imaizum. Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice. Scientific reports. vol 14. issue 1. 2024-03-15. PMID:38485716. |
concomitantly, imeglimin and insulin, but not metformin, restored the secreted insulin level and reduced β-cell apoptosis in db/db mice. |
2024-03-15 |
2024-03-17 |
mouse |
| Kanikkai Raja Aseer, Caio Henrique Mazucanti, Jennifer F O'Connell, Isabel González- Mariscal, Anjali Verma, Qin Yao, Christopher Dunn, Qing-Rong Liu, Josephine M Egan, Máire E Doyl. Beta cell Specific Cannabinoid 1 Receptor Deletion Counteracts Progression to Hyperglycemia in Non-Obese Diabetic Mice. Molecular metabolism. 2024-02-29. PMID:38423253. |
we previously reported that genetic deletion and pharmacological antagonism of the cannabinoid 1 receptor (cb1) in mice improves insulin synthesis and secretion, upregulates glucose sensing machinery, favors beta cell survival by reducing apoptosis, and enhances beta cell proliferation. |
2024-02-29 |
2024-03-03 |
mouse |
| J Michael Conlon, Bosede O Owolabi, Peter R Flatt, Yasser H A Abdel-Waha. Amphibian host-defense peptides with potential for Type 2 diabetes therapy - an updated review. Peptides. 2024-02-24. PMID:38401671. |
studies in vitro have described peptides that (a) stimulate insulin release from brin-bd11 clonal β-cells and isolated mouse islets, (b) display β-cell proliferative activity and protect against cytokine-mediated apoptosis and (c) stimulate production of the anti-inflammatory cytokine il-10 and inhibit production of the pro-inflammatory cytokines tnf-α and il-1β. |
2024-02-24 |
2024-02-27 |
mouse |
| Gholamreza Taheripak, Niusha Sabeti, Naba Najar, Zahrasadat Razavi, Saber Saharkhiz, Iraj Alipourfar. SIRT1 activation attenuates palmitate induced apoptosis in C Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400872. |
sirt1 activation attenuates palmitate induced apoptosis in c type 2 diabetes is characterized by insulin resistance, which manifests mainly in skeletal muscles. |
2024-02-24 |
2024-02-27 |
Not clear |
| Jalal Taneera, Maha M Saber-Aya. Preservation of β-Cells as a Therapeutic Strategy for Diabetes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2024-02-22. PMID:38387480. |
β-cell dysfunction, reduced mass, and apoptosis are central to insufficient insulin secretion in both types. |
2024-02-22 |
2024-02-25 |
Not clear |
| Hui Yi Chew, Goran Cvetkovic, Slobodan Tepic, James W Well. Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin. Scientific reports. vol 14. issue 1. 2024-02-19. PMID:38374190. |
our study examined the combined impact of insulin and arg on breast, lung, and ovarian cell lines, focusing on cell proliferation, metabolism, apoptosis, and autophagy. |
2024-02-19 |
2024-02-22 |
Not clear |
| Hui Yi Chew, Goran Cvetkovic, Slobodan Tepic, James W Well. Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin. Scientific reports. vol 14. issue 1. 2024-02-19. PMID:38374190. |
moreover, insulin was largely ineffective in altering arg-induced metabolic changes and did not prevent apoptosis. |
2024-02-19 |
2024-02-22 |
Not clear |
| Lidia Groele, Katarzyna Dżygało, Agnieszka Kowalska, Agnieszka Szypowsk. Prolonged Remission Induced by FENofibrate in children with newly diagnosed type 1 diabetes (PRIFEN): protocol of a randomised controlled trial. BMJ open. vol 14. issue 2. 2024-02-10. PMID:38341215. |
sphingolipids regulate proinsulin folding, insulin secretion and control beta cells apoptosis. |
2024-02-10 |
2024-02-14 |
human |
| M I Farrim, A Gomes, D Milenkovic, R Meneze. Gene expression analysis reveals diabetes-related gene signatures. Human genomics. vol 18. issue 1. 2024-02-07. PMID:38326874. |
the loss of pancreatic β-cell mass by either autoimmune destruction or apoptosis, in type 1-diabetes (t1d) and type 2-diabetes (t2d), respectively, represents a pathophysiological process leading to insulin deficiency. |
2024-02-07 |
2024-02-10 |
Not clear |
| Shan Zeng, Yeying Wang, Li Ai, Liwei Huang, Zhijuan Liu, Chunxia He, Qiaohui Bai, Yongxia L. Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas. Clinical and experimental pharmacology & physiology. vol 51. issue 3. 2024-02-01. PMID:38302075. |
chronic intermittent hypoxia-induced oxidative stress activates trb3 and phosphorylated jnk to mediate insulin resistance and cell apoptosis in the pancreas. |
2024-02-01 |
2024-02-04 |
rat |
| Shan Zeng, Yeying Wang, Li Ai, Liwei Huang, Zhijuan Liu, Chunxia He, Qiaohui Bai, Yongxia L. Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas. Clinical and experimental pharmacology & physiology. vol 51. issue 3. 2024-02-01. PMID:38302075. |
this study explores the potential mechanisms of obstructive sleep apnoea (osa) complicates type 2 diabetes mellitus (t2dm) by which chronic intermittent hypoxia (cih) induces insulin resistance and cell apoptosis in the pancreas through oxidative stress. |
2024-02-01 |
2024-02-04 |
rat |
| Jing Zhou, Chao-Ke Tan. Cytoplasmic Polyadenylation Element Binding Protein 1 and Atherosclerosis: Prospective Target and New Insights. Current vascular pharmacology. 2024-01-29. PMID:38284693. |
according to recent investigations, many pathological processes, including inflammation, lipid metabolism, endothelial dysfunction, angiogenesis, oxidative stress, cellular senescence, apoptosis, and insulin resistance, are regulated by cpeb1. |
2024-01-29 |
2024-01-31 |
Not clear |
| Hugo Borges Dos Reis, Minos Esperândio Carvalho, Rafael Espigolan, Mirele Daiana Poleti, Dewison Ricardo Ambrizi, Mariana Piatto Berton, José Bento Sterman Ferraz, Elisângela Chicaroni de Mattos Oliveira, Joanir Pereira Ele. Genome-Wide Association (GWAS) Applied to Carcass and Meat Traits of Nellore Cattle. Metabolites. vol 14. issue 1. 2024-01-26. PMID:38276296. |
enrichment analyses showed the following significant terms (fdr ≤ 0.05) associated with the characteristics under study: for the rea, heat stress disorders and life cycle stages; for sft, insulin and nonesterified fatty acids; for sf7, apoptosis and heat shock proteins (hsp27); and for imf, metalloproteinase 2. |
2024-01-26 |
2024-01-28 |
cattle |
| Jinxi Zhu, Ziyan Hu, Yifan Luo, Yinuo Liu, Wei Luo, Xiaohong Du, Zhenzhong Luo, Jialing Hu, Shengliang Pen. Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment. Frontiers in endocrinology. vol 14. 2024-01-24. PMID:38264279. |
in addition, abnormalities in the insulin signaling pathway will inhibit neural axon repair and promote apoptosis of damaged cells. |
2024-01-24 |
2024-01-26 |
Not clear |
| Qing Liu, Ying Han, Meng Zhang, Peng Yang, Yan Xiang, Min Chen, Fei Xu, Xiaochan Zhou, Dan Zheng, Juan Qi. IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic β cells in gestational diabetes mellitus by upregulating ATG7. Reproductive biology. vol 24. issue 1. 2024-01-23. PMID:38262267. |
collectively, igf1r stimulated cell viability, suppressed apoptosis, amplified insulin secretion, and increased atg7 expression to induce cell autophagy, which could be partially averted by atg7 silencing. |
2024-01-23 |
2024-01-26 |
mouse |