| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuseppe Lisco, Anna De Tullio, Michele Iovino, Olga Disoteo, Edoardo Guastamacchia, Vito Angelo Giagulli, Vincenzo Triggian. Dopamine in the Regulation of Glucose Homeostasis, Pathogenesis of Type 2 Diabetes, and Chronic Conditions of Impaired Dopamine Activity/Metabolism: Implication for Pathophysiological and Therapeutic Purposes. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001993. |
on the other hand, although specific trials are probably needed, certain medications approved for t2d (e.g., metformin, pioglitazone, incretin-based therapy, and gliflozins) may have a therapeutic role in such dopamine-related disorders due to anti-inflammatory and anti-oxidative effects, improvement in insulin signaling, neuroinflammation, mitochondrial dysfunction, autophagy, and apoptosis, restoration of striatal dopamine synthesis, and modulation of dopamine signaling associated with reward and hedonic eating. |
2023-11-25 |
2023-11-28 |
Not clear |
| Yu Wang, Hidekatsu Ih. The Novel Link between Gene Expression Profiles of Adult T-Cell Leukemia/Lymphoma Patients' Peripheral Blood Lymphocytes and Ferroptosis Susceptibility. Genes. vol 14. issue 11. 2023-11-25. PMID:38002949. |
autophagy-related degs are linked to autophagy, apoptosis, nod-like receptor signaling, tnf signaling, and the insulin resistance pathway. |
2023-11-25 |
2023-11-28 |
Not clear |
| Long Zhao, Jianheng Zheng, Jin Qin, Xin Xu, Xinyuan Liu, Shuyu Yang, Shuguang Li, Bo Chen, Jun Du, Ruihua Don. Combined Astragalus, vitamin C, and vitamin E alleviate DEHP-induced oxidative stress and the decreased of insulin synthesis and secretion in INS-1 cells. Ecotoxicology and environmental safety. vol 268. 2023-11-20. PMID:37984288. |
based on these results, the underlying mechanism of dehp impairing the function of ins-1 cells might be through apoptosis pathways induced by oxidative stress and direct reduction of insulin levels (both synthesis and secretion), while the optimal combination of astragalus and vitamins (c and e) could exert an alleviating effect. |
2023-11-20 |
2023-11-29 |
rat |
| Wenwen Gao, Yanxi Wang, Siyu Liu, Guojin Li, Qi Shao, Cai Zhang, Liguang Cao, Kai Liu, Wenrui Gao, Zifeng Yang, Yifei Dong, Xiliang Du, Lin Lei, Guowen Liu, Xinwei L. IRE1α-JNK axis activation contributes to intracellular lipid accumulation in calf hepatocytes. Journal of dairy science. 2023-11-08. PMID:37939835. |
both ire1α and jnk have been validated for their association with hepatic lipid accumulation, including their regulatory functions in calf hepatocyte insulin resistance, oxidative stress and apoptosis. |
2023-11-08 |
2023-11-20 |
cattle |
| Zhengwei Zhang, Beier Tong, Jie Liu, Jieyuan Feng, Linyang Song, Huawei Wang, Mengting Ke, Chengkai Xu, Yancheng X. PP2Ac knockdown attenuates lipotoxicity‑induced pancreatic β‑cell dysfunction and apoptosis. Experimental and therapeutic medicine. vol 26. issue 6. 2023-11-06. PMID:37928506. |
serine/threonine phosphatase assay system, cell counting kit-8, flow cytometry, enzyme-linked immunosorbent assay and western blotting were used to measure pp2a activity, cell viability, apoptosis, oxidative stress and insulin secretion in the cells. |
2023-11-06 |
2023-11-08 |
mouse |
| Abdolreza Esmaeilzadeh, Vahid Mohammadi, Reza Elahi, Negin Rezakhan. The role of heat shock proteins (HSPs) in type 2 diabetes mellitus pathophysiology. Journal of diabetes and its complications. vol 37. issue 11. 2023-11-05. PMID:37852076. |
to do this, hsps interact with diverse intra-and extracellular pathways among which are the insulin signaling, insulin secretion, and apoptosis pathways. |
2023-11-05 |
2023-11-08 |
human |
| Shivani Singhal, Vibha Ran. Cardioprotective Role of Tinospora cordifolia against Trimethylamine-NOxide and Glucose Induced Stress in Rat Cardiomyocytes. Cardiovascular & hematological agents in medicinal chemistry. 2023-11-01. PMID:37907489. |
the cause of diabetic cardiomyopathy is multi-factorial which includes oxidative stress, insulin resistance, inflammation, apoptosis, and autophagy. |
2023-11-01 |
2023-11-08 |
rat |
| Farah Khaznadar, Ana Petrovic, Omar Khaznadar, Hrvoje Roguljic, Kristina Bojanic, Lucija Kuna Roguljic, Stjepan Siber, Robert Smolic, Ines Bilic-Curcic, George Y Wu, Martina Smoli. Biomarkers for Assessing Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus on Sodium-Glucose Cotransporter 2 Inhibitor Therapy. Journal of clinical medicine. vol 12. issue 20. 2023-10-30. PMID:37892698. |
studies in animals have reported favorable effects of sglt2 inhibitors, and studies in patients also found positive effects on body mass index (bmi), insulin resistance, glucose levels, liver enzymes, apoptosis, and transcription factors. |
2023-10-30 |
2023-11-08 |
Not clear |
| Yu Zhang, Ling Chu, Xi'an Zhou, Tingxia Xu, Qingwu Shen, Tao Li, Yanyang W. Vitamin B12-Induced Autophagy Alleviates High Glucose-Mediated Apoptosis of Islet β Cells. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37894898. |
in this study, we investigated the influence of vitamin b12 on high glucose-induced apoptosis and autophagy in rin-m5f cells to elucidate how vitamin b12 modulates insulin release. |
2023-10-30 |
2023-11-08 |
Not clear |
| Liu Ye, Xin Liu, Kai Jin, Yingjie Niu, Qisheng Zuo, Jiuzhou Song, Wei Han, Guohong Chen, Bichun L. Effects of Insulin on Proliferation, Apoptosis, and Ferroptosis in Primordial Germ Cells via PI3K-AKT-mTOR Signaling Pathway. Genes. vol 14. issue 10. 2023-10-30. PMID:37895324. |
effects of insulin on proliferation, apoptosis, and ferroptosis in primordial germ cells via pi3k-akt-mtor signaling pathway. |
2023-10-30 |
2023-11-08 |
chicken |
| Liu Ye, Xin Liu, Kai Jin, Yingjie Niu, Qisheng Zuo, Jiuzhou Song, Wei Han, Guohong Chen, Bichun L. Effects of Insulin on Proliferation, Apoptosis, and Ferroptosis in Primordial Germ Cells via PI3K-AKT-mTOR Signaling Pathway. Genes. vol 14. issue 10. 2023-10-30. PMID:37895324. |
collectively, this study demonstrates that insulin reduces apoptosis and ferroptosis and enhances cell proliferation in a dose-dependent manner via the pi3k-akt-mtor signaling pathway in pgcs, providing a new addition to the theory of the regulatory role of the growth and proliferation of pgc in vitro cultures. |
2023-10-30 |
2023-11-08 |
chicken |
| Tagyedeen H Shoaib, Mohammed A Almogaddam, Yusra Saleh Andijani, Samaher Ahmad Saib, Najwa Mahmoud Almaghrabi, Abdulaziz Fahad Elyas, Rahmah Yasin Azzouni, Ehda Ahmad Awad, Shaimaa G A Mohamed, Gamal A Mohamed, Sabrin R M Ibrahim, Hazem G A Hussein, Wadah Osman, Ahmed Ashour, Asmaa E Sherif, Abdulrahim A Alzai. Marine-Derived Compounds for CDK5 Inhibition in Cancer: Integrating Multi-Stage Virtual Screening, MM/GBSA Analysis and Molecular Dynamics Investigations. Metabolites. vol 13. issue 10. 2023-10-27. PMID:37887415. |
cyclin-dependent kinase 5 (cdk5) plays a crucial role in various biological processes, including immune response, insulin secretion regulation, apoptosis, dna (deoxyribonucleic acid) damage response, epithelial-mesenchymal transition (emt), cell migration and invasion, angiogenesis, and myogenesis. |
2023-10-27 |
2023-11-08 |
Not clear |
| Heba A Mubarak, Manal M Kamal, Yossra Mahmoud, Fatma S Abd-Elsamea, Eman Abdelbary, Marwa G Gamea, Reham I El-Mahd. The ameliorating effects of mesenchymal stem cells compared to α-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. Journal of cellular biochemistry. 2023-10-05. PMID:37796145. |
histopathological examination of the pancreas, the expression levels of insulin, cd44, caspase-3, autophagy markers, p13k/akt, and pancreas/duodenum homeobox protein 1, in pancreatic tissue, and glucose-dependent insulinotropic polypeptide (gip) in the duodenum were detected by hematoxylin and eosin staining, immunofluorescence labeling, and by quantitative real-time polymerase chain reaction. the diabetic rats showed reduced insulin, hyperglycemia, nitrosative stress (no, cat), augmented apoptosis (caspase 3), impaired autophagy (p62/sqstm1, lc3), downregulated pi3k/akt pathway and increased gip expression, and degeneration of pancreatic islets. |
2023-10-05 |
2023-10-07 |
rat |
| Heba A Mubarak, Manal M Kamal, Yossra Mahmoud, Fatma S Abd-Elsamea, Eman Abdelbary, Marwa G Gamea, Reham I El-Mahd. The ameliorating effects of mesenchymal stem cells compared to α-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. Journal of cellular biochemistry. 2023-10-05. PMID:37796145. |
treatment with either bm-mscs or α-toc suppressed the nitrosative stress, reduced apoptosis, recovered autophagy, upregulated pi3k/akt pathway, and subsequently increased insulin levels, decreased blood glucose, and downregulated gip expression with partial restoration of pancreatic islets. based on our findings, the cytoprotective effects of bm-mscs and α-toc in type 1-induced diabetes appeared to be related to repaired autophagy and recovered pi3k/akt signaling. |
2023-10-05 |
2023-10-07 |
rat |
| Joon Kim, Chang-Myung Oh, Hyeongseok Ki. The Interplay of Adipokines and Pancreatic Beta Cells in Metabolic Regulation and Diabetes. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37761031. |
chronic obesity and insulin resistance can lead to the release of excess fatty acids and inflammatory molecules from the adipose tissue, contributing to beta cell dysfunction and apoptosis, which are key factors in developing type 2 diabetes. |
2023-09-28 |
2023-10-07 |
Not clear |
| Eman Fawzy El Azab, Saleha Y M Alakilli, Abdulrahman M Saleh, Hassan H Alhassan, Hamad H Alanazi, Heba Bassiony Ghanem, Sara Osman Yousif, Heba Abu Alrub, Nahla Anber, Elyasa Mustafa Elfaki, Alneil Hamza, Shaymaa Abdulmale. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762060. |
type 2 diabetes (t2d) is a chronic metabolic condition associated with obesity, oxidative stress-mediated inflammation, apoptosis, and impaired insulin signaling. |
2023-09-28 |
2023-10-07 |
Not clear |
| Uma D Kabra, Martin Jastroc. Mitochondrial Dynamics and Insulin Secretion. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762083. |
the disruption of mitochondrial dynamics is linked to defects in energy production and increased apoptosis, ultimately impairing insulin secretion and β cell death. |
2023-09-28 |
2023-10-07 |
Not clear |
| Marakiya T Moetlediwa, Rudzani Ramashia, Carmen Pheiffer, Salam J J Titinchi, Sithandiwe E Mazibuko-Mbeje, Babalwa U Jac. Therapeutic Effects of Curcumin Derivatives against Obesity and Associated Metabolic Complications: A Review of In Vitro and In Vivo Studies. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762669. |
these curcumin derivatives modulated adipogenesis, lipid metabolism, insulin resistance, steatosis, lipotoxicity, inflammation, oxidative stress, endoplasmic reticulum stress, apoptosis, autophagy, fibrosis, and dyslipidemia to a greater extent than curcumin. |
2023-09-28 |
2023-10-07 |
Not clear |
| Jiahui Li, Caiyan Xue, Hongyan Yang, Jiaxin Zhang, Guohua Li, Jijun Li, Fang Kuang, Jing Chen, Shu Zhang, Feng Gao, Zhenzhen Kou, Xing Zhang, Ling Don. Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. Life sciences. 2023-09-27. PMID:37758017. |
these data suggest that long-term simulated weightlessness induces cognitive impairment as well as neuronal apoptosis and neural degeneration, partially through hippocampal insulin resistance via pten up-regulation. |
2023-09-27 |
2023-10-07 |
rat |
| Liang Yan, Yachun Ya. Therapeutic potential of sulforaphane in liver diseases: a review. Frontiers in pharmacology. vol 14. 2023-09-14. PMID:37705537. |
recently, a growing number of studies have reported that sfn could significantly ameliorate hepatic steatosis and prevent the development of fatty liver, improve insulin sensitivity, attenuate oxidative damage and liver injury, induce apoptosis, and inhibit the proliferation of hepatoma cells through multiple signaling pathways. |
2023-09-14 |
2023-10-07 |
human |