| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dezhao Li, Yaoshan Dun, Dake Qi, Jeffrey W Ripley-Gonzalez, Jie Dong, Nanjiang Zhou, Ling Qiu, Jie Zhang, Tanghao Zeng, Baiyang You, Suixin Li. Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease. Scientific reports. vol 13. issue 1. 2023-08-11. PMID:37567977. |
finally, the liver was then harvested to assess lipid deposition, lipid metabolism, apoptosis, and autophagy, while blood was collected to determine blood glucose and insulin. |
2023-08-11 |
2023-08-16 |
mouse |
| Kaixi Ding, Wei Jiang, Juejue Zhangwang, Yu Wang, Jing Zhang, Ming Le. The potential of traditional herbal active ingredients in the treatment of sarcopenia animal models: focus on therapeutic effects and mechanisms. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-01. PMID:37526688. |
the review results showed that the pathological mechanisms in sarcopenia-related animal models include imbalanced protein metabolism, oxidative stress, inflammation, apoptosis, insulin resistance, endoplasmic reticulum stress, impaired mitochondrial biogenesis, and autophagy-lysosome system aggravation. |
2023-08-01 |
2023-08-14 |
Not clear |
| Kehan Wu, Yaqiao Wang, Runmin Liu, Hao Wang, Tao Ru. The role of mammalian Sirtuin 6 in cardiovascular diseases and diabetes mellitus. Frontiers in physiology. vol 14. 2023-07-27. PMID:37497437. |
sirt6 enjoys a unique structure, important biological functions, and is involved in multiple cellular processes such as stress response, mitochondrial biogenesis, transcription, insulin resistance, inflammatory response, chromatin silencing, and apoptosis. |
2023-07-27 |
2023-08-14 |
human |
| Xue-Hua Wang, Zhong-Fu Zuo, Lu Meng, Qi Yang, Pan Lv, Li-Pan Zhao, Xiao-Bai Wang, Yu-Fei Wang, Ying Huang, Cong Fu, Wen-Qiang Liu, Xue-Zheng Liu, De-Yu Zhen. Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K/Akt/GSK-3β signaling pathway. Psychopharmacology. 2023-07-25. PMID:37490132. |
salidroside, a nature compound isolated from rhodiola rosea l, has the effects of anti-inflammatory and antioxidant, hypoglycemic and lipid-lowering, improving insulin resistance, inhibiting cell apoptosis, and protecting neurons. |
2023-07-25 |
2023-08-14 |
mouse |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
results have shown differentially expressed p53 target genes involved in apoptosis (bax, fas, pmaip1, and casp8), cell cycle (cyclins, cyclin dependent kinases), glucose metabolism and insulin resistance (thbs1), and p53 regulation (mdm2). |
2023-07-19 |
2023-08-14 |
human |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
p53 plays a critical role in the regulation of apoptosis and cell cycle arrest, metabolism and insulin resistance. |
2023-07-19 |
2023-08-14 |
human |
| Stanley T Lewis, Frank Greenway, Tori R Tucker, Michael Alexander, Levonika K Jackson, Scott A Hepford, Brian Loveridge, Jonathan R T Lake. A Receptor Story: Insulin Resistance Pathophysiology and Physiologic Insulin Resensitization's Role as a Treatment Modality. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446104. |
in the case of type-2 diabetes, β-cell mass is reduced due to apoptosis and β cells secrete insulin asynchronously. |
2023-07-14 |
2023-08-14 |
Not clear |
| Jianjia Huang, Xiaoyue Pang, Xinting Zhang, Wenyue Qiu, Xuluan Zhang, Rongmei Wang, Wenting Xie, Yuman Bai, Shuilian Zhou, Jianzhao Liao, Zhaojun Xiong, Zhaoxin Tang, Rongsheng S. N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF-α-mediated apoptotic pathways and affecting linear ubiquitination. Translational research : the journal of laboratory and clinical medicine. 2023-07-08. PMID:37422055. |
this study confirmed that nac combined with insulin can promote the linear ubiquitination of ripk1, nemo and c-flip and regulate the apoptosis pathway mediated by tnf-α to attenuate the myocardial injury caused by type 1 dm. |
2023-07-08 |
2023-08-14 |
Not clear |
| Ummul Fathima Shaik Mohamed Sayed, Said Moshawih, Hui Poh Goh, Nurolaini Kifli, Gaurav Gupta, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Andi Hermansyah, Hooi Leng Ser, Long Chiau Ming, Bey Hing Go. Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management. Frontiers in pharmacology. vol 14. 2023-07-06. PMID:37408757. |
natural products serve as attractive sources for anti-obesity agents as many of them can alter the host metabolic processes and maintain glucose homeostasis via metabolic and thermogenic stimulation, appetite regulation, pancreatic lipase and amylase inhibition, insulin sensitivity enhancing, adipogenesis inhibition and adipocyte apoptosis induction. |
2023-07-06 |
2023-08-14 |
Not clear |
| James R Tribble, Flora Hui, Heberto Quintero, Sana El Hajji, Katharina Bell, Adriana Di Polo, Pete A William. Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering. Molecular aspects of medicine. vol 92. 2023-06-18. PMID:37331129. |
this review will cover the recent advances from basic biology to on-going clinical trials for neuroprotection in glaucoma covering degenerative mechanisms, metabolism, insulin signaling, mtor, axon transport, apoptosis, autophagy, and neuroinflammation. |
2023-06-18 |
2023-08-14 |
Not clear |
| Joseph Nowell, Eleanor Blunt, Dhruv Gupta, Paul Ediso. Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease. Ageing research reviews. 2023-06-16. PMID:37328112. |
targeting brain incretin receptors reduces inflammation, inhibits apoptosis, prevents toxic protein aggregation, enhances long-term potentiation and autophagy as well as restores dysfunctional insulin signalling. |
2023-06-16 |
2023-08-14 |
Not clear |
| Jalal Taneera, Anila Khalique, Aissaoui Salima, Abdul Khader Mohammed, Ahmed Saad Sawan, Hamam Aneis, Peter Habib, Sham Abdrabh, Noha M Elemam, Narjes Saheb Sharif-Askari, Eman Abu-Gharbieh, Maha Saber-Ayad, Waseem El-Huneid. Disrupting of family with sequence similarity 105, member A (Fam105a) deteriorates pancreatic β-cell physiology and insulin secretion in INS-1 cells. Molecular and cellular endocrinology. 2023-06-13. PMID:37311518. |
silencing of fam105a impaired insulin release, content, glucose uptake, and mitochondria atp content but did not affect cell viability, reactive oxygen species (ros) or apoptosis levels. |
2023-06-13 |
2023-08-14 |
human |
| Dario Domenico Lofrumento, Alessandro Miraglia, Velia La Pesa, Antonella Sonia Treglia, Marcello Chieppa, Francesco De Nuccio, Giuseppe Nicolardi, Claudia Miele, Francesco Beguinot, Corrado Garbi, Bruno Di Jes. Increased hexosamine biosynthetic pathway flux alters cell-cell adhesion in INS-1E cells and murine islets. Endocrine. 2023-06-12. PMID:37306934. |
in type 2 diabetes, β-cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction (dedifferentiation, decline of glucose-stimulated insulin secretion). |
2023-06-12 |
2023-08-14 |
Not clear |
| Zhi Lin, Xi Cheng, Hui Zhen. Umbelliferon: a review of its pharmacology, toxicity and pharmacokinetics. Inflammopharmacology. 2023-06-12. PMID:37308634. |
the action mechanisms of umbelliferone include inhibition of oxidative stress, inflammation, and apoptosis, improvement of insulin resistance, myocardial hypertrophy, and tissue fibrosis, in addition to regulation of blood glucose and lipid metabolism. |
2023-06-12 |
2023-08-14 |
Not clear |
| Alyson M Curry, Stacia Rymarchyk, Noah B Herrington, Dickson Donu, Glen E Kellogg, Yana Ce. Nicotinamide Riboside Activates SIRT5 Deacetylation. The FEBS journal. 2023-06-08. PMID:37289138. |
human sirtuins play important roles in various cellular events including dna repair, gene silencing, mitochondrial biogenesis, insulin secretion as well as apoptosis. |
2023-06-08 |
2023-08-14 |
human |
| Dudley H McNitt, Bryan A Joosse, James W Thomas, Rachel H Bonam. Productive Germinal Center Responses Depend on the Nature of Stimuli Received by Anti-Insulin B Cells in Type 1 Diabetes-Prone Mice. ImmunoHorizons. vol 7. issue 6. 2023-06-01. PMID:37261716. |
dual immunization against self (insulin) and foreign (4-hydroxy-3-nitrophenylacetyl hapten conjugated to keyhole limpet hemocyanin) ags showed an anti-insulin (but not anti-4-hydroxy-3-nitrophenylacetyl) ab block that tracked with increased expression of the apoptosis marker, activated caspase 3, in self-reactive gc b cells. |
2023-06-01 |
2023-08-14 |
mouse |
| Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyam. Glucose-Lowering Effects of Imeglimin and Its Possible Beneficial Effects on Diabetic Complications. Biology. vol 12. issue 5. 2023-05-27. PMID:37237539. |
imeglimin reduces reactive oxygen species production, improves mitochondrial function and integrity, and also improves the structure and function of endoplasmic reticulum (er), changes which enhance glucose-stimulated insulin secretion and inhibit the apoptosis of β-cells, leading to β-cell mass preservation. |
2023-05-27 |
2023-08-14 |
Not clear |
| Fariborz Ahmadi, Abbas Sahebghadam Lotfi, Mona Navaei-Nigjeh, Mehdi Kadiva. Trimetazidine Preconditioning Potentiates the Effect of Mesenchymal Stem Cells Secretome on the Preservation of Rat Pancreatic Islet Survival and Function In Vitro. Applied biochemistry and biotechnology. 2023-05-15. PMID:37184724. |
insulin content, glucose-stimulated insulin secretion, islet cell apoptosis, and mrna expression of pro-apoptotic (bax, bak-1, and puma) and anti-apoptotic factors (bcl-2, bcl-xl, and xiap) in rat islets were assessed after 24 and 48 h of culture. |
2023-05-15 |
2023-08-14 |
rat |
| Haihong Hu, Hanbin Wang, Xiaoyan Yang, Zhicheng Li, Wendi Zhan, HongXia Zhu, Taolan Zhan. Network pharmacology analysis reveals potential targets and mechanisms of proton pump inhibitors in breast cancer with diabetes. Scientific reports. vol 13. issue 1. 2023-05-10. PMID:37165049. |
we identified 33 shared targets for breast cancer, diabetes, and ppis including lansoprazole, omeprazole, and pantoprazole, which play a critical role in fatty acid transport, insulin resistance, apoptosis, and cancer-related signaling pathways. |
2023-05-10 |
2023-08-14 |
Not clear |
| Yukiko K Kanek. Development of Therapeutic Agents with a Novel Mechanism of Action Targeting Pancreatic β-Cells for Diabetes. Biological & pharmaceutical bulletin. vol 46. issue 5. 2023-04-30. PMID:37121690. |
we have investigated the mechanisms for the regulation of insulin secretion, the prevention of β-cell apoptosis, and the increase in β-cell mass. |
2023-04-30 |
2023-08-14 |
Not clear |