| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anila Khalique, Abdul Khader Mohammed, Nujood Mohammed Al-Khadran, Mutaz Al Gharaibeh, Eman Abu-Gharbieh, Waseem El-Huneidi, Nabil Sulaiman, Jalal Taneer. Reduced Retinoic Acid Receptor Beta (Rarβ) Affects Pancreatic β-Cell Physiology. Biology. vol 11. issue 7. 2023-03-08. PMID:36101450. |
silencing of rarβ in ins-1 cells impaired insulin secretion without affecting cell viability or apoptosis. |
2023-03-08 |
2023-08-16 |
human |
| Dongdong Zhao, Xiaozhou Zhang, Yongxin Bian, Lu Meng, Yutong Wu, Yidi Ma, Chen Li, Jingjing Wang, Zizheng Fu, Jingyuan Dai, Deqi Yin, Shumei Lin, Jianmin H. Taurine reduces apoptosis mediated by endoplasmic reticulum stress in islet β-cells induced by high-fat and -glucose diets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-03-02. PMID:36863558. |
poor eating habits, especially high-fat and -glucose diets intake, can lead to endoplasmic reticulum (er) stress in islet β-cells, insulin resistance, and islet β-cell dysfunction and cause islet β-cell apoptosis, which leads to type 2 diabetes mellitus (t2dm). |
2023-03-02 |
2023-08-14 |
human |
| Dongdong Zhao, Xiaozhou Zhang, Yongxin Bian, Lu Meng, Yutong Wu, Yidi Ma, Chen Li, Jingjing Wang, Zizheng Fu, Jingyuan Dai, Deqi Yin, Shumei Lin, Jianmin H. Taurine reduces apoptosis mediated by endoplasmic reticulum stress in islet β-cells induced by high-fat and -glucose diets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-03-02. PMID:36863558. |
in addition, taurine improves blood lipid content and islets pathological changes, regulates the relative protein expression in er stress and apoptosis, increases the insulin sensitivity index (homa-is), and reduces the insulin resistance index (homac-ir) of sd rats fed with a high-fat and -glucose diet. |
2023-03-02 |
2023-08-14 |
human |
| Maryam Mazraesefidi, Mehdi Mahmoodi, Mohammadreza Hajizade. Effects of silibinin on apoptosis and insulin secretion in rat RINm5F pancreatic β-cells. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023-02-10. PMID:36762428. |
effects of silibinin on apoptosis and insulin secretion in rat rinm5f pancreatic β-cells. |
2023-02-10 |
2023-08-14 |
rat |
| Pu Zang, Cuihua Yang, Haiyan Lei, Qingyu Guo, Wei Wang, Jiaqing Sha. Ghrelin regulates the proliferation and apoptosis of high glucose-induced islet cells through the PI3K-Akt signaling pathway. Cell biology international. 2023-01-31. PMID:36718083. |
the effects of ghrelin on the viability, proliferation, apoptosis, and insulin release of high glucose-induced islet cells were detected by cell counting kit-8, 5-ethynyl-2'-deoxyuridine, flow cytometry, and enzyme-linked immunosorbent assays, respectively. |
2023-01-31 |
2023-08-14 |
Not clear |
| Ayman Hyde. Naturally-occurring carboxylic acids from traditional antidiabetic plants as potential pancreatic islet FABP3 inhibitors. A molecular docking-aided study. Chemico-biological interactions. 2023-01-29. PMID:36709838. |
in diabetes, which is a lipid disease, long-term exposure of pancreatic islet beta cells to fatty acids (fas) increases basal insulin release, reduces glucose-stimulated insulin secretion, causes islet beta cell inflammation, failure and apoptosis. |
2023-01-29 |
2023-08-14 |
Not clear |
| Jian-Hong Qi, Pu-Yu Chen, Ding-Yuan Cai, Yi Wang, Yue-Lei Wei, Su-Ping He, Wei Zho. Exploring novel targets of sitagliptin for type 2 diabetes mellitus: Network pharmacology, molecular docking, molecular dynamics simulation, and SPR approaches. Frontiers in endocrinology. vol 13. 2023-01-26. PMID:36699034. |
it is well known that sitagliptin can specifically inhibit the activity of dpp4 to promote insulin secretion, inhibit islet β cell apoptosis and reduce blood glucose levels, while other pharmacological mechanisms are still unclear, such as improving insulin resistance, anti-inflammatory, anti-oxidative stress, and anti-fibrosis. |
2023-01-26 |
2023-08-14 |
Not clear |
| Antonino Belfiore, Rosaria Valentina Rapicavoli, Rosario Le Moli, Rosamaria Lappano, Andrea Morrione, Ernestina Marianna De Francesco, Veronica Vell. IGF2: A Role in Metastasis and Tumor Evasion from Immune Surveillance? Biomedicines. vol 11. issue 1. 2023-01-21. PMID:36672737. |
the involvement of igf2 in carcinogenesis depends on its ability to link high energy intake, increase cell proliferation, and suppress apoptosis to cancer risk, and this is likely the key mechanism bridging insulin resistance to cancer. |
2023-01-21 |
2023-08-14 |
Not clear |
| Yue Liu, Yue Yang, Chenying Xu, Jianxing Liu, Jiale Chen, Guoqing Li, Bin Huang, Yi Pan, Yanfeng Zhang, Qiong Wei, Stephen J Pandol, Fangfang Zhang, Ling Li, Liang Ji. Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity. Nature communications. vol 14. issue 1. 2023-01-21. PMID:36681689. |
circglis3 overexpression enhances insulin secretion and inhibits obesity-induced apoptosis in vitro and in vivo. |
2023-01-21 |
2023-08-14 |
mouse |
| Yue Liu, Yue Yang, Chenying Xu, Jianxing Liu, Jiale Chen, Guoqing Li, Bin Huang, Yi Pan, Yanfeng Zhang, Qiong Wei, Stephen J Pandol, Fangfang Zhang, Ling Li, Liang Ji. Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity. Nature communications. vol 14. issue 1. 2023-01-21. PMID:36681689. |
mechanistically, circglis3 promotes insulin secretion by up-regulating neurod1 and creb1 via sponging mir-124-3p and decreases apoptosis via interacting with the pro-apoptotic factor scotin. |
2023-01-21 |
2023-08-14 |
mouse |
| Guifang Dong, Sangeeta Adak, George Spyropoulos, Qiang Zhang, Chu Feng, Li Yin, Sarah L Speck, Zeenat Shyr, Shuntaro Morikawa, Rie Asada Kitamura, Rahul S Kathayat, Bryan C Dickinson, Xue Wen Ng, David W Piston, Fumihiko Urano, Maria S Remedi, Xiaochao Wei, Clay F Semenkovic. Palmitoylation couples insulin hypersecretion with β cell failure in diabetes. Cell metabolism. 2023-01-12. PMID:36634673. |
expression of a mutated scamp1 incapable of being palmitoylated in apt1-deficient cells rescued insulin hypersecretion and nutrient-induced apoptosis. |
2023-01-12 |
2023-08-14 |
mouse |
| Huan Zhu, Qianqian Sun, Huiyu Tang, Yanyu Chen, Ke Tan, Xu Xu, Shuang Wan. A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption. Biogerontology. 2023-01-06. PMID:36607484. |
age-related changes in muscle mass and strength, histopathology, hfd-induced adiposity, and metabolic disturbances were compared between the three groups. comparing with dc group, rats of so (20 months, and fed by high-fat diet) exhibited a more prominent loss of muscle mass and strength, a more pronounced decline in myofibre number, ifm, increase in myocyte apoptosis accompanied with increased visceral fat, remarkable glycolipid metabolic disorders, and insulin resistance. |
2023-01-06 |
2023-08-14 |
rat |
| Cheng Zhu, Qian Huai, Xu Zhang, Hanren Dai, Xiaolei Li, Hua Wan. Insights into the roles and pathomechanisms of ceramide and sphigosine-1-phosphate in nonalcoholic fatty liver disease. International journal of biological sciences. vol 19. issue 1. 2023-01-03. PMID:36594091. |
on the other hand, ceramides as lipotoxic lipid have significant effects on hepatic inflammation, apoptosis and insulin resistance that contribute to nafld. |
2023-01-03 |
2023-08-14 |
Not clear |
| Cheng Tong, Yue Wu, Lingling Zhang, Ying Y. Insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: Association with PI3K signaling pathway. Frontiers in endocrinology. vol 13. 2023-01-02. PMID:36589825. |
insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: association with pi3k signaling pathway. |
2023-01-02 |
2023-08-14 |
Not clear |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the IR/IRS1/AKT/GSK3β/β-catenin signaling pathway. Ecotoxicology and environmental safety. vol 250. 2022-12-31. PMID:36586168. |
insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the ir/irs1/akt/gsk3β/β-catenin signaling pathway. |
2022-12-31 |
2023-08-14 |
mouse |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the IR/IRS1/AKT/GSK3β/β-catenin signaling pathway. Ecotoxicology and environmental safety. vol 250. 2022-12-31. PMID:36586168. |
in vitro experiments, we found that insulin (10 nm) inhibited apoptosis and up-regulated the protein expression levels of pakt, pgsk3β, β-catenin of ht22 cells induced by h |
2022-12-31 |
2023-08-14 |
mouse |
| Jun Chen, Aihua Mei, Yingying Wei, Chunlei Li, Hang Qian, Xinwen Min, Handong Yang, Lingli Dong, Xiaoquan Rao, Jixin Zhon. GLP-1 receptor agonist as a modulator of innate immunity. Frontiers in immunology. vol 13. 2022-12-26. PMID:36569936. |
glp-1 specifically binds to the glucagon-like peptide-1 receptor (glp-1r) in the body, directly stimulating the secretion of insulin by pancreatic β-cells, promoting proliferation and differentiation, and inhibiting cell apoptosis, thereby exerting a glycemic lowering effect. |
2022-12-26 |
2023-08-14 |
human |
| Peipei Yuan, Qi Zhang, Yang Fu, Ying Hou, Liyuan Gao, Yaxin Wei, Weisheng Feng, Xiaoke Zhen. Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose. Journal of natural medicines. 2022-12-15. PMID:36520340. |
potential mechanisms of action were explored in terms of oxidative stress, mitochondrial fission and division, apoptosis, and the insulin signaling pathway. |
2022-12-15 |
2023-08-14 |
rat |
| Jingwen Wang, Jiale Wang, Ying Wang, Ruiyang Ma, Shucong Zhang, Jin Zheng, Wujun Xue, Xiaoming Din. Bone marrow mesenchymal stem cells-derived miR-21-5p protects grafted islets against apoptosis by targeting PDCD4. Stem cells (Dayton, Ohio). 2022-12-13. PMID:36512434. |
in vivo, the grafted islets overexpressing mir-21-5p showed a higher survival rate, better insulin secretion function, and a lower apoptosis rate. |
2022-12-13 |
2023-08-14 |
Not clear |
| Roya Naderi, Bagher Pourheydar, Azam Mosleh. Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a. Journal of biochemical and molecular toxicology. 2022-12-12. PMID:36504472. |
as a serotonin antagonist, tropisetron positively affects blood glucose lowering, insulin synthesis, pancreas inflammation, and apoptosis in diabetes. |
2022-12-12 |
2023-08-14 |
rat |