| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Liu, Yue Yang, Chenying Xu, Jianxing Liu, Jiale Chen, Guoqing Li, Bin Huang, Yi Pan, Yanfeng Zhang, Qiong Wei, Stephen J Pandol, Fangfang Zhang, Ling Li, Liang Ji. Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity. Nature communications. vol 14. issue 1. 2023-01-21. PMID:36681689. |
circglis3 overexpression enhances insulin secretion and inhibits obesity-induced apoptosis in vitro and in vivo. |
2023-01-21 |
2023-08-14 |
mouse |
| Yue Liu, Yue Yang, Chenying Xu, Jianxing Liu, Jiale Chen, Guoqing Li, Bin Huang, Yi Pan, Yanfeng Zhang, Qiong Wei, Stephen J Pandol, Fangfang Zhang, Ling Li, Liang Ji. Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity. Nature communications. vol 14. issue 1. 2023-01-21. PMID:36681689. |
mechanistically, circglis3 promotes insulin secretion by up-regulating neurod1 and creb1 via sponging mir-124-3p and decreases apoptosis via interacting with the pro-apoptotic factor scotin. |
2023-01-21 |
2023-08-14 |
mouse |
| Guifang Dong, Sangeeta Adak, George Spyropoulos, Qiang Zhang, Chu Feng, Li Yin, Sarah L Speck, Zeenat Shyr, Shuntaro Morikawa, Rie Asada Kitamura, Rahul S Kathayat, Bryan C Dickinson, Xue Wen Ng, David W Piston, Fumihiko Urano, Maria S Remedi, Xiaochao Wei, Clay F Semenkovic. Palmitoylation couples insulin hypersecretion with β cell failure in diabetes. Cell metabolism. 2023-01-12. PMID:36634673. |
expression of a mutated scamp1 incapable of being palmitoylated in apt1-deficient cells rescued insulin hypersecretion and nutrient-induced apoptosis. |
2023-01-12 |
2023-08-14 |
mouse |
| Huan Zhu, Qianqian Sun, Huiyu Tang, Yanyu Chen, Ke Tan, Xu Xu, Shuang Wan. A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption. Biogerontology. 2023-01-06. PMID:36607484. |
age-related changes in muscle mass and strength, histopathology, hfd-induced adiposity, and metabolic disturbances were compared between the three groups. comparing with dc group, rats of so (20 months, and fed by high-fat diet) exhibited a more prominent loss of muscle mass and strength, a more pronounced decline in myofibre number, ifm, increase in myocyte apoptosis accompanied with increased visceral fat, remarkable glycolipid metabolic disorders, and insulin resistance. |
2023-01-06 |
2023-08-14 |
rat |
| Cheng Zhu, Qian Huai, Xu Zhang, Hanren Dai, Xiaolei Li, Hua Wan. Insights into the roles and pathomechanisms of ceramide and sphigosine-1-phosphate in nonalcoholic fatty liver disease. International journal of biological sciences. vol 19. issue 1. 2023-01-03. PMID:36594091. |
on the other hand, ceramides as lipotoxic lipid have significant effects on hepatic inflammation, apoptosis and insulin resistance that contribute to nafld. |
2023-01-03 |
2023-08-14 |
Not clear |
| Cheng Tong, Yue Wu, Lingling Zhang, Ying Y. Insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: Association with PI3K signaling pathway. Frontiers in endocrinology. vol 13. 2023-01-02. PMID:36589825. |
insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: association with pi3k signaling pathway. |
2023-01-02 |
2023-08-14 |
Not clear |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the IR/IRS1/AKT/GSK3β/β-catenin signaling pathway. Ecotoxicology and environmental safety. vol 250. 2022-12-31. PMID:36586168. |
insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the ir/irs1/akt/gsk3β/β-catenin signaling pathway. |
2022-12-31 |
2023-08-14 |
mouse |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the IR/IRS1/AKT/GSK3β/β-catenin signaling pathway. Ecotoxicology and environmental safety. vol 250. 2022-12-31. PMID:36586168. |
in vitro experiments, we found that insulin (10 nm) inhibited apoptosis and up-regulated the protein expression levels of pakt, pgsk3β, β-catenin of ht22 cells induced by h |
2022-12-31 |
2023-08-14 |
mouse |
| Jun Chen, Aihua Mei, Yingying Wei, Chunlei Li, Hang Qian, Xinwen Min, Handong Yang, Lingli Dong, Xiaoquan Rao, Jixin Zhon. GLP-1 receptor agonist as a modulator of innate immunity. Frontiers in immunology. vol 13. 2022-12-26. PMID:36569936. |
glp-1 specifically binds to the glucagon-like peptide-1 receptor (glp-1r) in the body, directly stimulating the secretion of insulin by pancreatic β-cells, promoting proliferation and differentiation, and inhibiting cell apoptosis, thereby exerting a glycemic lowering effect. |
2022-12-26 |
2023-08-14 |
human |
| Peipei Yuan, Qi Zhang, Yang Fu, Ying Hou, Liyuan Gao, Yaxin Wei, Weisheng Feng, Xiaoke Zhen. Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose. Journal of natural medicines. 2022-12-15. PMID:36520340. |
potential mechanisms of action were explored in terms of oxidative stress, mitochondrial fission and division, apoptosis, and the insulin signaling pathway. |
2022-12-15 |
2023-08-14 |
rat |
| Jingwen Wang, Jiale Wang, Ying Wang, Ruiyang Ma, Shucong Zhang, Jin Zheng, Wujun Xue, Xiaoming Din. Bone marrow mesenchymal stem cells-derived miR-21-5p protects grafted islets against apoptosis by targeting PDCD4. Stem cells (Dayton, Ohio). 2022-12-13. PMID:36512434. |
in vivo, the grafted islets overexpressing mir-21-5p showed a higher survival rate, better insulin secretion function, and a lower apoptosis rate. |
2022-12-13 |
2023-08-14 |
Not clear |
| Roya Naderi, Bagher Pourheydar, Azam Mosleh. Tropisetron improved testicular inflammation in the streptozotocin-induced diabetic rats: The role of toll-like receptor 4 (TLR4) and mir146a. Journal of biochemical and molecular toxicology. 2022-12-12. PMID:36504472. |
as a serotonin antagonist, tropisetron positively affects blood glucose lowering, insulin synthesis, pancreas inflammation, and apoptosis in diabetes. |
2022-12-12 |
2023-08-14 |
rat |
| Desh Deepak Singh, Ali A Shati, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K Yada. Development of Dementia in Type 2 Diabetes Patients: Mechanisms of Insulin Resistance and Antidiabetic Drug Development. Cells. vol 11. issue 23. 2022-12-11. PMID:36497027. |
brain cells becoming resistant to insulin leads to elevated blood glucose levels, impaired synaptic plasticity, microglial overactivation, mitochondrial dysfunction, neuronal apoptosis, nutrient deprivation, tau (tubulin-associated unit) phosphorylation, and cholinergic dysfunction. |
2022-12-11 |
2023-08-14 |
Not clear |
| Desh Deepak Singh, Ali A Shati, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K Yada. Development of Dementia in Type 2 Diabetes Patients: Mechanisms of Insulin Resistance and Antidiabetic Drug Development. Cells. vol 11. issue 23. 2022-12-11. PMID:36497027. |
we discuss the pathological and physiological mechanisms behind the association between type 2 diabetes mellitus and dementia, such as insulin resistance, insulin signaling, and sporadic forms of dementia; the relationship between insulin receptor activation and tau phosphorylation; dementia and mrna expression and downregulation of related receptors; neural modulation due to insulin secretion and glucose homeostasis; and neuronal apoptosis due to insulin resistance and type 2 diabetes mellitus. |
2022-12-11 |
2023-08-14 |
Not clear |
| Silvio Schmidt, Madlen Haase, Lena Best, Marco Groth, Julia Lindner, Otto W Witte, Christoph Kaleta, Christiane Frah. Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach. Cells. vol 11. issue 23. 2022-12-11. PMID:36497123. |
of these, bcl3, cttnbp2, diexf, esr2, grb10, il4ra, inhba, rras2, rps6ka1 and socs3 appear to be particularly relevant as key regulators involved in dendritic spine plasticity and in age-relevant molecular signaling cascades mediating senescence, insulin resistance, apoptosis and tissue regeneration. |
2022-12-11 |
2023-08-14 |
mouse |
| Luca Iamartino, Maria Luisa Brand. The calcium-sensing receptor in inflammation: Recent updates. Frontiers in physiology. vol 13. 2022-12-05. PMID:36467702. |
the casr is found to be ubiquitously expressed in the body, playing a plethora of additional functions spanning from fluid secretion, insulin release, neuronal development, vessel tone to cell proliferation and apoptosis, to name but a few. |
2022-12-05 |
2023-08-14 |
Not clear |
| Shang-Der Chen, Yao-Chung Chuang, Tsu-Kung Lin, Jenq-Lin Yan. Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases. European journal of pharmacology. 2022-12-05. PMID:36470445. |
through pancreatic effects, glp-1r agonists can stimulate insulin secretion, increase β-cell proliferation, reduce β-cell apoptosis, and inhibit glucagon secretion in patients with t2dm. |
2022-12-05 |
2023-08-14 |
Not clear |
| Muhammad Fauzi, Takaaki Murakami, Daisuke Yabe, Nobuya Inagak. Current understanding of imeglimin action on pancreatic β-cells: Involvement of mitochondria and endoplasmic reticulum homeostasis. Journal of diabetes investigation. 2022-12-01. PMID:36453164. |
imeglimin may enhance glucose-induced insulin secretion (giis) and inhibit apoptosis of pancreatic ß-cells leading to preserved β-cell mass by maintaining or restoring the functional and structural integrity of the mitochondria and the endoplasmic reticulum homeostasis in pancreatic β-cells. |
2022-12-01 |
2023-08-14 |
Not clear |
| Aditya Naldurtiker, Phaneendra Batchu, Brou Kouakou, Thomas H Terrill, Arshad Shaik, Govind Kanna. RNA-Seq exploration of the influence of stress on meat quality in Spanish goats. Scientific reports. vol 12. issue 1. 2022-11-29. PMID:36446782. |
among these differentially expressed genes (degs), klf9, ampk, foxo3, ptx3, gadd45, ptpn1, casp7, mapk4, hspa12a, and jak-stat were probably associated with the effects of stress on skeletal muscle proteins and involved in biological process such as cellular response to corticosteroid stimulus, endoplasmic reticulum stress, insulin resistance, dna repair, apoptosis, mapk cascade and regulation of proteolysis. |
2022-11-29 |
2023-08-14 |
Not clear |
| Omar Ramos-Lope. Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease. Genes. vol 13. issue 11. 2022-11-24. PMID:36421817. |
mafld is associated with obesity, involving multiple mechanisms such as alterations in lipid metabolism, insulin resistance, hyperinflammation, mitochondrial dysfunction, cell apoptosis, oxidative stress, and extracellular matrix formation. |
2022-11-24 |
2023-08-14 |
human |