| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongxiang Hong, Jianbin Su, Chao Huang, Xu Lu, Zhiming Cu. Comprehensive insights into the function and molecular and pharmacological regulation of neuron-derived orphan receptor 1, an orphan receptor. Frontiers in pharmacology. vol 13. 2022-09-16. PMID:36110555. |
these include regulation of cellular apoptosis and regeneration, neuron formation, contextual fearing memory, inflammation, vascular smooth muscle proliferation, insulin secretion, and tumor development, whereby nor1 mediates the pathogenesis of numerous diseases such as cerebral ischemia, depression, post-traumatic stress disorder, atherosclerosis, abdominal aortic aneurysm, cardiac hypertrophy, diabetes, osteoarthritis, rheumatoid arthritis, and cancer. |
2022-09-16 |
2023-08-14 |
Not clear |
| Hager H Shaaban, Ibrahim Alzaim, Ahmed El-Mallah, Rania G Aly, Ahmed F El-Yazbi, Ahmed Wahi. Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms. Life sciences. 2022-09-14. PMID:36103959. |
rats were fed an atherogenic diet containing 1.25 % cholesterol, 0.5 % cholic acid and 60 % cocoa butter for 6 weeks causing a number of metabolic and hepatic alterations including insulin resistance, dyslipidemia, systemic inflammation, increased hepatic oxidative stress and lipid peroxidation, hepatic steatosis, lobular inflammation, as well as increased markers of liver inflammation and hepatocyte apoptosis. |
2022-09-14 |
2023-08-14 |
rat |
| Suxin Yuan, Zhengyao Cai, Xingzhao Luan, Haibo Wang, Yi Zhong, Li Deng, Jian Fen. Gut microbiota: A new therapeutic target for diabetic cardiomyopathy. Frontiers in pharmacology. vol 13. 2022-09-12. PMID:36091756. |
the pathogenesis of diabetic cardiomyopathy is complex and multifactorial, and it is widely accepted that its mechanisms include oxidative stress, inflammation, insulin resistance, apoptosis, and autophagy. |
2022-09-12 |
2023-08-14 |
Not clear |
| Suxin Yuan, Zhengyao Cai, Xingzhao Luan, Haibo Wang, Yi Zhong, Li Deng, Jian Fen. Gut microbiota: A new therapeutic target for diabetic cardiomyopathy. Frontiers in pharmacology. vol 13. 2022-09-12. PMID:36091756. |
gut microbiota and its metabolites can affect the development of diabetic cardiomyopathy by regulating oxidative stress, inflammation, insulin resistance, apoptosis, and autophagy. |
2022-09-12 |
2023-08-14 |
Not clear |
| Poonam Yadav, Amit Khurana, Jasvinder Singh Bhatti, Ralf Weiskirchen, Umashanker Navi. Glucagon-like peptide 1 and fibroblast growth factor-21 in non-alcoholic steatohepatitis: An experimental to clinical perspective. Pharmacological research. vol 184. 2022-09-12. PMID:36075510. |
in addition, nash could be treated with therapies that target the metabolic abnormalities causing disease pathogenesis (such as de novo lipogenesis and insulin resistance) as well with medications targeting downstream processes such as cellular damage, apoptosis, inflammation, and fibrosis. |
2022-09-12 |
2023-08-16 |
Not clear |
| Peng-Fei Ding, Qi Zhu, Bin Sheng, Heng Yang, Hua-Jie Xu, Tao Tao, Zheng Peng, Xiang-Xin Chen, Xiao-Jian Li, Yan Zhou, Hua-Sheng Zhang, Yong-Yue Gao, Zong Zhuang, Chun-Hua Hang, Wei L. Alpha-Ketoglutarate Alleviates Neuronal Apoptosis Induced by Central Insulin Resistance through Inhibiting S6K1 Phosphorylation after Subarachnoid Hemorrhage. Oxidative medicine and cellular longevity. vol 2022. 2022-09-05. PMID:36062190. |
alpha-ketoglutarate alleviates neuronal apoptosis induced by central insulin resistance through inhibiting s6k1 phosphorylation after subarachnoid hemorrhage. |
2022-09-05 |
2023-08-14 |
Not clear |
| Xin Xiao, Wen-Hua Xu, Xiao-Qing Zhang, Jun-Feng Ding, Yue Jiang, Jun T. [Anti-oxidative and anti-apoptotic effects and molecular mechanisms of catalpol against H_2O_2-induced oxidative damage in pancreatic β cells (INS-1 cells)]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 16. 2022-09-01. PMID:36046869. |
the present study investigated the anti-oxidative and anti-apoptotic effects and molecular mechanisms of catalpol on the h_2o_2-induced pancreatic β-cells(ins-1 cells).the oxidative damage model of ins-1 cells was induced and optimized by the stimulation of h_2o_2 of different concentrations for different time.cck-8 assay was used to detect cell viability after catalpol intervention(1, 5, 10, 20, 40, 80, and 160 μmol·l~(-1)) for 24 h.intracellular reactive oxygen species(ros), superoxide dismutase(sod), and lipid peroxide malondialdehyde(mda) were measured by dcfh-da fluorescent probe, wst-1, and tba respectively.moreover, the apo-ptotic effect was detected by ao-eb and annexin v-fitc/pi staining.in addition, the protein expression levels were detected by wes-tern blot, and intracellular insulin concentration was measured by elisa.the results showed that the oxidative damage model of ins-1 cells was stably induced by 50 μmol·l~(-1) h_2o_2 treatment for 2 h, and catalpol at 1-80 μmol·l~(-1) did not affect cell viability of ins-1 cells.compared with the conditions in the model group, 1, 5, and 10 μmol·l~(-1) catalpol intervention for 2 h could protect ins-1 cells from oxidative damage(p<0.001), reduce ros and mda, increase sod, and inhibit excessive cell apoptosis.moreover, 1, 5, and 10 μmol·l~(-1) catalpol could also up-regulate the phosphorylation of nuclear transcription factor nf-e2 related factors, negatively regulate kelch-like ech-associated protein 1(keap1), phosphorylation of extracellular signal-regulated kinase(erk), and heme oxyge-nase 1(ho-1), and promote the protein expression of pancreatic-duodenal homeobox factor-1(pdx-1) and glucose transporter 2(glut2).in addition, 1, 5, and 10 μmol·l~(-1) catalpol increased insulin secretion of ins-1 cells under oxidative damage in the high-glucose culture medium, indicating function recovery of pancreatic β cells.pdx-1 is a key nuclear transcription factor of pancreatic β cell function that directly regulates glut2 and insulin synthesis, and affects glucose homeostasis.in conclusion, catalpol can reduce the oxidative damage and apoptosis of ins-1 cells, activate antioxidant pathway, protect the function of pancreatic β cells, and improve insulin synthesis and secretion. |
2022-09-01 |
2023-08-14 |
Not clear |
| Shan Jiang, Chun-Mei Xu, Shuai Yao, Rui Zhang, Xian-Zhi Li, Ru-Zhen Zhang, Tian-Yue Xie, Yi-Qian Xing, Qian Zhang, Xiao-Jun Zhou, Lin Liao, Jian-Jun Don. Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion. Frontiers in endocrinology. vol 13. 2022-08-29. PMID:36034435. |
cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion. |
2022-08-29 |
2023-08-14 |
Not clear |
| Shan Jiang, Chun-Mei Xu, Shuai Yao, Rui Zhang, Xian-Zhi Li, Ru-Zhen Zhang, Tian-Yue Xie, Yi-Qian Xing, Qian Zhang, Xiao-Jun Zhou, Lin Liao, Jian-Jun Don. Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion. Frontiers in endocrinology. vol 13. 2022-08-29. PMID:36034435. |
therefore, we aimed to investigate cell division cycle 42 (cdc42)-mediated podocyte apoptosis and its effect on insulin secretion in islet β-cells. |
2022-08-29 |
2023-08-14 |
Not clear |
| Ronghui Han, Hemeng Huang, Weiyi Xia, Jingjin Liu, Hui Luo, Jing Tang, Zhengyuan Xi. Perspectives for Forkhead box transcription factors in diabetic cardiomyopathy: Their therapeutic potential and possible effects of salvianolic acids. Frontiers in cardiovascular medicine. vol 9. 2022-08-29. PMID:36035917. |
molecular mechanisms underlying these pathological changes in diabetic hearts are complicated and multifactorial, including but not limited to insulin resistance, oxidative stress, lipotoxicity, cardiomyocytes apoptosis or autophagy, inflammatory response, and myocardial metabolic dysfunction. |
2022-08-29 |
2023-08-14 |
Not clear |
| Yun Wu, Ziping Qi, Beilei Wang, Junjie Wang, Qingwang Liu, Aoli Wang, Chenliang Shi, Bin Zhou, Qianmao Liang, Wenliang Wang, Fengming Zou, Shuang Qi, Zuowei Wang, Li Wang, Wenchao Wang, Jing Liu, Qingsong Li. Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes. Journal of medicinal chemistry. 2022-08-29. PMID:36037148. |
mammalian ste20-like protein 1 kinase (mst1) plays vital roles in the apoptosis and insulin secretion of β cells. |
2022-08-29 |
2023-08-14 |
Not clear |
| Mali Wu, Jie Zhang, Ran Gu, Fangfang Dai, Dongyong Yang, Yajing Zheng, Wei Tan, Yifan Jia, Bingshu Li, Yanxiang Chen. The role of Sirtuin 1 in the pathophysiology of polycystic ovary syndrome. European journal of medical research. vol 27. issue 1. 2022-08-27. PMID:36030228. |
pathophysiological processes such as cell proliferation and apoptosis, autophagy, metabolism, inflammation, antioxidant stress and insulin resistance play a crucial role. |
2022-08-27 |
2023-08-14 |
human |
| Gabriela Alves Bronczek, Gabriela Moreira Soares, Carine Marmentini, Antonio Carlos Boschero, José Maria Costa-Júnio. Resistance Training Improves Beta Cell Glucose Sensing and Survival in Diabetic Models. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012692. |
when cells were exposed to pro-inflammatory cytokines (in vitro type 1 diabetes), trained serum preserved both insulin secretion and gck expression, reduced expression of proteins related to apoptotic pathways, and also protected cells from cytokine-induced apoptosis. |
2022-08-26 |
2023-08-14 |
mouse |
| Yanlan Sun, Zhou Yu, Yulei Zhang, Hairong Wang, Zhenjing Chi, Xiaoqin Chen, Dong X. Downregulation of microRNA-342-3p Eases Insulin Resistance and Liver Gluconeogenesis via Regulating Rfx3 in Gestational Diabetes Mellitus. Critical reviews in eukaryotic gene expression. vol 32. issue 6. 2022-08-23. PMID:35997120. |
enzyme-linked immunosorbent assay, hematoxylin-eosin staining, terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling staining and periodic acid-schiff staining were conducted to detect the influence of mir-342-3p knockdown on the levels of blood glucose, insulin, biochemical indices as well as the apoptosis and pathological changes in placenta or pancreatic tissues of gdm mice. |
2022-08-23 |
2023-08-14 |
mouse |
| Yanlan Sun, Zhou Yu, Yulei Zhang, Hairong Wang, Zhenjing Chi, Xiaoqin Chen, Dong X. Downregulation of microRNA-342-3p Eases Insulin Resistance and Liver Gluconeogenesis via Regulating Rfx3 in Gestational Diabetes Mellitus. Critical reviews in eukaryotic gene expression. vol 32. issue 6. 2022-08-23. PMID:35997120. |
in addition, mir-342-3p depletion decreased the levels of blood glucose, insulin, biochemical indices as well as restrained the apoptosis and pathological changes in gdm mouse placenta and pancreatic tissues. |
2022-08-23 |
2023-08-14 |
mouse |
| Vira Chumak, Katarzyna Sielatycka, Andrzej Ciechanowicz, Kamila Bujko, Mariusz Z Ratajczak, Magdalena Kuci. Proteomic Analysis of Murine Bone Marrow Very Small Embryonic-like Stem Cells at Steady-State Conditions and after In Vivo Stimulation by Nicotinamide and Follicle-Stimulating Factor Reflects their Germ-Lineage Origin and Multi Germ Layer Differentiation Potential. Stem cell reviews and reports. 2022-08-19. PMID:35986128. |
we have identified several go biological processes regulating development, organogenesis, gene expression, signal transduction, wnt signaling, insulin signaling, cytoskeleton organization, cell adhesion, inhibiting apoptosis, responses to extra- and intracellular stimuli, protein transport and stabilization, protein phosphorylation and ubiquitination, dna repair, immune response, and regulation of circadian rhythm. |
2022-08-19 |
2023-08-14 |
Not clear |
| Jingling Duan, Mingqing Yang, Yi Liu, Shengjun Xiao, Xiaoling Zhan. Curcumin protects islet beta cells from streptozotocin‑induced type 2 diabetes mellitus injury via its antioxidative effects. Endokrynologia Polska. 2022-08-16. PMID:35971926. |
in addition, curcumin improved the survival and function of islet cells with decreased cell apoptosis in langerhans islet and increased insulin secretion in the stz-induced t2dm rat model. |
2022-08-16 |
2023-08-14 |
rat |
| Hend Alfadul, Shaun Sabico, Nasser M Al-Daghr. The role of interleukin-1β in type 2 diabetes mellitus: A systematic review and meta-analysis. Frontiers in endocrinology. vol 13. 2022-08-15. PMID:35966098. |
among the emerging inflammatory markers observed to be associated with β-cell damage is interleukin 1β (il1β), a proinflammatory cytokine that modulates important metabolic processes including insulin secretion and β-cell apoptosis. |
2022-08-15 |
2023-08-14 |
human |
| Xiliang Du, Mingchao Liu, Wenjun Tai, Hao Yu, Xue Hao, Juan J Loor, Qianming Jiang, Zhiyuan Fang, Xinxing Gao, Minghe Fan, Wenwen Gao, Lin Lei, Yuxiang Song, Zhe Wang, Cai Zhang, Guowen Liu, Xinwei L. Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes. Journal of dairy science. 2022-08-14. PMID:35965124. |
combining tnf-α and iso aggravated tnf-α-induced apoptosis, insulin insensitivity and lipolysis. |
2022-08-14 |
2023-08-14 |
cattle |
| Xiliang Du, Mingchao Liu, Wenjun Tai, Hao Yu, Xue Hao, Juan J Loor, Qianming Jiang, Zhiyuan Fang, Xinxing Gao, Minghe Fan, Wenwen Gao, Lin Lei, Yuxiang Song, Zhe Wang, Cai Zhang, Guowen Liu, Xinwei L. Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes. Journal of dairy science. 2022-08-14. PMID:35965124. |
in the presence of tnf-α, inhibition of nf-κb and jnk alleviated tnf-α-induced apoptosis, insulin insensitivity and lipolysis. |
2022-08-14 |
2023-08-14 |
cattle |