| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuri Kohara, Shuta Ikai, Akihide Yoshihara, Koji Murao, Yasunori Sugiyam. Effect of chronic exposure to ketohexoses on pancreatic β-cell function in INS-1 rat insulinoma cells. Bioscience, biotechnology, and biochemistry. 2022-11-22. PMID:36413460. |
glucotoxicity, impaired insulin secretion, suppression of insulin gene expression and apoptosis, in pancreatic β-cells caused by chronic hyperglycemia is a key component of the pathogenesis of type 2 diabetes. |
2022-11-22 |
2023-08-14 |
rat |
| Yuri Kohara, Shuta Ikai, Akihide Yoshihara, Koji Murao, Yasunori Sugiyam. Effect of chronic exposure to ketohexoses on pancreatic β-cell function in INS-1 rat insulinoma cells. Bioscience, biotechnology, and biochemistry. 2022-11-22. PMID:36413460. |
in this study, we investigated whether chronic exposure to ketohexoses causes glucotoxicity, suppression of insulin gene expression and apoptosis, in ins-1 rat pancreatic insulinoma cells. |
2022-11-22 |
2023-08-14 |
rat |
| Chen Meimei, Wang Fengzhen, Lei Huangwei, Li Candong, Yang Zhaoyan. Discovery of Taxus chinensis fruit wine as potentially functional food against Alzheimer's disease by UHPLC-QE-MS/MS, network pharmacology and molecular docking. Journal of food biochemistry. 2022-11-17. PMID:36394096. |
here, we found that tcfw may ameliorate ad by reversing many biological events, including oxidative stress, inflammatory response, neuronal apoptosis, insulin secretion, amyloid fibril formation, and t cell co-stimulation, which may provide some insights for the development and research of anti-ad drugs. |
2022-11-17 |
2023-08-14 |
human |
| Laongdao Thongnak, Onanong Jaruan, Nattavadee Pengrattanachot, Sasivimon Promsan, Nichakorn Phengpol, Prempree Sutthasupha, Krit Jaikumkao, Woraprapa Sriyotai, Sugunya Mahatheeranont, Anusorn Lungkaphi. Resistant starch from black rice, Oryza sativa L. var. ameliorates renal inflammation, fibrosis and injury in insulin resistant rats. Phytotherapy research : PTR. 2022-11-15. PMID:36379906. |
this study aimed to investigate the effect of resistant starch from br (rs) on renal inflammation, oxidative stress, and apoptosis in obese insulin resistant rats. |
2022-11-15 |
2023-08-14 |
rat |
| Chuanxing Feng, Yuge Jiang, Shiying Li, Yueting Ge, Yonghui Shi, Xue Tang, Guowei L. Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364766. |
in vivo, mr inhibited the damage and apoptosis of hippocampal neurons caused by a high-fat diet, reduced hippocampal oxidative stress, improved hippocampal glucose metabolism, relieved insulin resistance, and enhanced cognitive ability. |
2022-11-11 |
2023-08-14 |
mouse |
| Yu Zhang, Xi-An Zhou, Chuxin Liu, Qingwu Shen, Yanyang W. Vitamin B6 Inhibits High Glucose-Induced Islet β Cell Apoptosis by Upregulating Autophagy. Metabolites. vol 12. issue 11. 2022-11-10. PMID:36355132. |
in this study, vitamin b6-mediated autophagy and high glucose-induced apoptosis were tested to investigate the mechanism by which vitamin b6 regulates insulin release. |
2022-11-10 |
2023-08-14 |
Not clear |
| Haowen Fang, Yanting Ding, Sijing Xia, Qin Chen, Bing Ni. Loureirin B promotes insulin secretion through GLP-1R and AKT/PDX1 pathways. European journal of pharmacology. 2022-11-08. PMID:36347320. |
further, after inhibiting glp-1r activity, the results showed that lb promoted insulin secretion, ins-1 cell proliferation and reduced ins-1 cell apoptosis with reduced effect, indicating that lb achieved the above effects by activating glp-1ra. |
2022-11-08 |
2023-08-14 |
mouse |
| Claudia Di Muzio, Paola Cipriani, Piero Ruscitt. Rheumatoid Arthritis Treatment Options and Type 2 Diabetes: Unravelling the Association. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2022-11-02. PMID:36322327. |
in fact, il-1 inhibition could not only palliate glycaemia, but also decrease the progressive decline in insulin secretion associated with t2d, interfering with apoptosis of β-cells, improving their function, and ameliorating the peripheral insulin resistance. |
2022-11-02 |
2023-08-14 |
Not clear |
| Chang-Jun Jiang, Jun-Han L. [Research progress on mechanism of exercise improving non-alcoholic fatty liver disease through regulating endoplasmic reticulum stress]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 5. 2022-11-01. PMID:36319104. |
abnormal accumulation of lipids in hepatocytes, aggravated inflammatory response, increased apoptosis of hepatocytes and insulin resistance (ir) are the main pathogenic factors and characteristics of nafld, which are closely related to hepatic ers. |
2022-11-01 |
2023-08-14 |
Not clear |
| Moon Nyeo Park, Md Ataur Rahman, Md Hasanur Rahman, Jong Woo Kim, Min Choi, Jeong Woo Kim, Jinwon Choi, Myunghan Moon, Kazi Rejvee Ahmed, Bonglee Ki. Potential Therapeutic Implication of Herbal Medicine in Mitochondria-Mediated Oxidative Stress-Related Liver Diseases. Antioxidants (Basel, Switzerland). vol 11. issue 10. 2022-10-27. PMID:36290765. |
nafld is associated with a number of pathological factors, including insulin resistance, lipid metabolic dysfunction, oxidative stress, inflammation, apoptosis, and fibrosis. |
2022-10-27 |
2023-08-14 |
human |
| Kailash Singh, Orian Bricard, Jeason Haughton, Mikaela Björkqvist, Moa Thorstensson, Zhengkang Luo, Loriana Mascali, Emanuela Pasciuto, Chantal Mathieu, James Dooley, Adrian Listo. Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development. Biomolecules. vol 12. issue 10. 2022-10-27. PMID:36291702. |
in the beta-cell fragility model, partial loss of islet mass requires compensatory upregulation of insulin production in the remaining islets, driving a cellular stress capable of triggering apoptosis in the remaining cells. |
2022-10-27 |
2023-08-14 |
mouse |
| Jingyu Duan, Fang Zhang, Mengyuan Lu, Wenhao Deng, Yutong Zhai, Yangqi Zhao, Liangliang He, Zhonghui Bai, Yongjian Wang, Chunping Zhan. Swietenine and swietenolide from Swietenia macrophylla king improve insulin secretion and attenuate apoptosis in H Environmental toxicology. vol 37. issue 11. 2022-10-10. PMID:36214338. |
swietenine and swietenolide from swietenia macrophylla king improve insulin secretion and attenuate apoptosis in h oxidative stress is an important factor that causes pancreatic β-cell dysfunction leading to the development and aggravation of diabetes. |
2022-10-10 |
2023-08-14 |
Not clear |
| Jingyu Duan, Fang Zhang, Mengyuan Lu, Wenhao Deng, Yutong Zhai, Yangqi Zhao, Liangliang He, Zhonghui Bai, Yongjian Wang, Chunping Zhan. Swietenine and swietenolide from Swietenia macrophylla king improve insulin secretion and attenuate apoptosis in H Environmental toxicology. vol 37. issue 11. 2022-10-10. PMID:36214338. |
the aim of this study is to investigate the effects of stn and std on insulin secretion and apoptosis in h |
2022-10-10 |
2023-08-14 |
Not clear |
| Husam M Salah, Marat Fudi. Sodium-glucose Cotransporter 2 Inhibitors and Nonalcoholic Fatty Liver Disease. Heart failure clinics. vol 18. issue 4. 2022-10-10. PMID:36216491. |
this review summarizes the evidence from preclinical and human studies supporting the use of sglt2 inhibitors in nafld and proposes several mechanisms that may drive these favorable effects (ie, increasing insulin sensitivity, decreasing intrahepatic fat accumulation and lipotoxicity, decreasing oxidative stress and endoplasmic reticulum (er) stress, improving autophagy, and inhibiting apoptosis). |
2022-10-10 |
2023-08-14 |
human |
| Xiaojuan Zhang, Feng Guo, Dujuan Cao, Yinan Yan, Ning Zhang, Kaili Zhang, Xinyi Li, Prashant Kumar, Xiaojuan Zhan. Neuroprotective Effect of Ponicidin Alleviating the Diabetic Cognitive Impairment: Regulation of Gut Microbiota. Applied biochemistry and biotechnology. 2022-09-26. PMID:36155887. |
plasma insulin level, antioxidant, inflammatory cytokines, apoptosis marker and faecal gut microbiota compositions were estimated. |
2022-09-26 |
2023-08-14 |
rat |
| Malsawmhriatzuala Jeremy, Guruswami Gurusubramanian, Rajesh Kumar Kharwar, Vikas Kumar Ro. Evaluation of a single dose of intra-testicular insulin treatment in heat-stressed mice model. Andrologia. 2022-09-26. PMID:36156807. |
insulin treatment has also increased the proliferation of germ cells (increased pcna and gcn), survival (bcl2), and decreased apoptosis (active caspase-3). |
2022-09-26 |
2023-08-14 |
mouse |
| Meliha Koldemir Gündüz, Güllü Kaymak, Ertan Kanbur, Derya Berikten, Harun Şene. Exenatide increases CTRP3 gene expression in adipose cells by inhibiting adipogenesis and induces apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. 2022-09-24. PMID:36152787. |
this study aimed to investigate the cytotoxicity of exenatide, a glp-1a, on 3 t3-l1 adipocytes and the effect of exenatide on the expression of adipogenesis-related genes, insulin and glucose levels, and apoptosis. |
2022-09-24 |
2023-08-14 |
Not clear |
| Sahar Askari, Pegah Javadpour, Fatemeh Sadat Rashidi, Leila Dargahi, Khosrow Kashfi, Rasoul Ghasem. Behavioral and Molecular Effects of Thapsigargin-Induced Brain ER- Stress: Encompassing Inflammation, MAPK, and Insulin Signaling Pathway. Life (Basel, Switzerland). vol 12. issue 9. 2022-09-23. PMID:36143409. |
in addition, the activation of er stress markers, including bip, chop, and some related apoptosis and pro-inflammatory proteins, such as caspase-3, bax, bcl-2, tnf-α, mapk, and insulin signaling markers, were assessed by western-blots. |
2022-09-23 |
2023-08-14 |
rat |
| Manoja K Brahma, Peng Xiao, Madalina Popa, Javier Negueruela, Valerie Vandenbempt, Stéphane Demine, Alessandra K Cardozo, Esteban N Gurzo. Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice. Nutrients. vol 14. issue 18. 2022-09-23. PMID:36145242. |
previous in vitro studies indicated that nova1 is necessary for glucose-stimulated insulin secretion and its deficiency-enhanced cytokine-induced apoptosis. |
2022-09-23 |
2023-08-14 |
mouse |
| Leya He, Xian Wang, Zehuan Ding, Lin Liu, Henghui Cheng, Donalyn Bily, Chaodong Wu, Ke Zhang, Linglin Xi. Deleting Gata4 in hepatocytes promoted the progression of NAFLD via increasing steatosis and apoptosis, and desensitizing insulin signaling. The Journal of nutritional biochemistry. 2022-09-23. PMID:36150682. |
deleting gata4 in hepatocytes promoted the progression of nafld via increasing steatosis and apoptosis, and desensitizing insulin signaling. |
2022-09-23 |
2023-08-14 |
mouse |