| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriela Alves Bronczek, Gabriela Moreira Soares, Carine Marmentini, Antonio Carlos Boschero, José Maria Costa-Júnio. Resistance Training Improves Beta Cell Glucose Sensing and Survival in Diabetic Models. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012692. |
when cells were exposed to pro-inflammatory cytokines (in vitro type 1 diabetes), trained serum preserved both insulin secretion and gck expression, reduced expression of proteins related to apoptotic pathways, and also protected cells from cytokine-induced apoptosis. |
2022-08-26 |
2023-08-14 |
mouse |
| Yanlan Sun, Zhou Yu, Yulei Zhang, Hairong Wang, Zhenjing Chi, Xiaoqin Chen, Dong X. Downregulation of microRNA-342-3p Eases Insulin Resistance and Liver Gluconeogenesis via Regulating Rfx3 in Gestational Diabetes Mellitus. Critical reviews in eukaryotic gene expression. vol 32. issue 6. 2022-08-23. PMID:35997120. |
enzyme-linked immunosorbent assay, hematoxylin-eosin staining, terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling staining and periodic acid-schiff staining were conducted to detect the influence of mir-342-3p knockdown on the levels of blood glucose, insulin, biochemical indices as well as the apoptosis and pathological changes in placenta or pancreatic tissues of gdm mice. |
2022-08-23 |
2023-08-14 |
mouse |
| Yanlan Sun, Zhou Yu, Yulei Zhang, Hairong Wang, Zhenjing Chi, Xiaoqin Chen, Dong X. Downregulation of microRNA-342-3p Eases Insulin Resistance and Liver Gluconeogenesis via Regulating Rfx3 in Gestational Diabetes Mellitus. Critical reviews in eukaryotic gene expression. vol 32. issue 6. 2022-08-23. PMID:35997120. |
in addition, mir-342-3p depletion decreased the levels of blood glucose, insulin, biochemical indices as well as restrained the apoptosis and pathological changes in gdm mouse placenta and pancreatic tissues. |
2022-08-23 |
2023-08-14 |
mouse |
| Vira Chumak, Katarzyna Sielatycka, Andrzej Ciechanowicz, Kamila Bujko, Mariusz Z Ratajczak, Magdalena Kuci. Proteomic Analysis of Murine Bone Marrow Very Small Embryonic-like Stem Cells at Steady-State Conditions and after In Vivo Stimulation by Nicotinamide and Follicle-Stimulating Factor Reflects their Germ-Lineage Origin and Multi Germ Layer Differentiation Potential. Stem cell reviews and reports. 2022-08-19. PMID:35986128. |
we have identified several go biological processes regulating development, organogenesis, gene expression, signal transduction, wnt signaling, insulin signaling, cytoskeleton organization, cell adhesion, inhibiting apoptosis, responses to extra- and intracellular stimuli, protein transport and stabilization, protein phosphorylation and ubiquitination, dna repair, immune response, and regulation of circadian rhythm. |
2022-08-19 |
2023-08-14 |
Not clear |
| Jingling Duan, Mingqing Yang, Yi Liu, Shengjun Xiao, Xiaoling Zhan. Curcumin protects islet beta cells from streptozotocin‑induced type 2 diabetes mellitus injury via its antioxidative effects. Endokrynologia Polska. 2022-08-16. PMID:35971926. |
in addition, curcumin improved the survival and function of islet cells with decreased cell apoptosis in langerhans islet and increased insulin secretion in the stz-induced t2dm rat model. |
2022-08-16 |
2023-08-14 |
rat |
| Hend Alfadul, Shaun Sabico, Nasser M Al-Daghr. The role of interleukin-1β in type 2 diabetes mellitus: A systematic review and meta-analysis. Frontiers in endocrinology. vol 13. 2022-08-15. PMID:35966098. |
among the emerging inflammatory markers observed to be associated with β-cell damage is interleukin 1β (il1β), a proinflammatory cytokine that modulates important metabolic processes including insulin secretion and β-cell apoptosis. |
2022-08-15 |
2023-08-14 |
human |
| Xiliang Du, Mingchao Liu, Wenjun Tai, Hao Yu, Xue Hao, Juan J Loor, Qianming Jiang, Zhiyuan Fang, Xinxing Gao, Minghe Fan, Wenwen Gao, Lin Lei, Yuxiang Song, Zhe Wang, Cai Zhang, Guowen Liu, Xinwei L. Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes. Journal of dairy science. 2022-08-14. PMID:35965124. |
combining tnf-α and iso aggravated tnf-α-induced apoptosis, insulin insensitivity and lipolysis. |
2022-08-14 |
2023-08-14 |
cattle |
| Xiliang Du, Mingchao Liu, Wenjun Tai, Hao Yu, Xue Hao, Juan J Loor, Qianming Jiang, Zhiyuan Fang, Xinxing Gao, Minghe Fan, Wenwen Gao, Lin Lei, Yuxiang Song, Zhe Wang, Cai Zhang, Guowen Liu, Xinwei L. Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes. Journal of dairy science. 2022-08-14. PMID:35965124. |
in the presence of tnf-α, inhibition of nf-κb and jnk alleviated tnf-α-induced apoptosis, insulin insensitivity and lipolysis. |
2022-08-14 |
2023-08-14 |
cattle |
| Xiliang Du, Mingchao Liu, Wenjun Tai, Hao Yu, Xue Hao, Juan J Loor, Qianming Jiang, Zhiyuan Fang, Xinxing Gao, Minghe Fan, Wenwen Gao, Lin Lei, Yuxiang Song, Zhe Wang, Cai Zhang, Guowen Liu, Xinwei L. Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes. Journal of dairy science. 2022-08-14. PMID:35965124. |
overall, tnf-α impairs insulin sensitivity and induces lipolysis and apoptosis in bovine adipocytes, which may be partly mediated by activation of nf-κb and jnk. |
2022-08-14 |
2023-08-14 |
cattle |
| Pedro H Reis-Barbosa, Thatiany Souza Marinho, Cristiane Matsuura, Marcia Barbosa Aguila, Jorge J de Carvalho, Carlos Alberto Mandarim-de-Lacerd. The obesity and nonalcoholic fatty liver disease mouse model revisited: Liver oxidative stress, hepatocyte apoptosis, and proliferation. Acta histochemica. vol 124. issue 7. 2022-08-11. PMID:35952484. |
in conclusion, the findings in the dio mouse model reproduce the nafld profile relative to the human nafld's apoptosis, insulin signaling, lipogenesis, beta-oxidation, and oxidative stress. |
2022-08-11 |
2023-08-14 |
mouse |
| Xun Luo, Yajun Zhang, Changjie Lu, Jiaming Zhan. Role of insulin signaling pathway in apoptosis induced by food chain delivery of nano-silver under the action of environmental factors. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022-08-09. PMID:35944823. |
role of insulin signaling pathway in apoptosis induced by food chain delivery of nano-silver under the action of environmental factors. |
2022-08-09 |
2023-08-14 |
caenorhabditis_elegans |
| Fatima El Zahra M Fathi, Kadry M Sadek, Asmaa F Khafaga, Abd Elwahab A Alsenosy, Hanan A Ghoneim, Sahar F Mahmoud, Mohamed M Zewei. Correction to: Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin‑induced diabetes. Environmental science and pollution research international. 2022-08-06. PMID:35932351. |
correction to: vitamin d regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin‑induced diabetes. |
2022-08-06 |
2023-08-14 |
rat |
| Aaron M Taylor, Jiayi M Sun, Alexander Yu, Horatiu Voicu, Jianhe Shen, Donald A Barkauskas, Timothy J Triche, Julie M Gastier-Foster, Tsz-Kwong Man, Ching C La. Integrated DNA Copy Number and Expression Profiling Identifies IGF1R as a Prognostic Biomarker in Pediatric Osteosarcoma. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887382. |
insulin growth factor receptor 1 (igf1r) is a receptor tyrosine kinase which binds igf1 and igf2 to activate downstream pathways involved in cell apoptosis and proliferation. |
2022-07-27 |
2023-08-14 |
Not clear |
| Fatima El Zahra M Fathi, Kadry M Sadek, Asmaa F Khafaga, Abdel Wahab Al Senosy, Hanan A Ghoniem, Sahar Fayez, Mohamed F Zewei. Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes. Environmental science and pollution research international. 2022-07-21. PMID:35864405. |
vitamin d regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes. |
2022-07-21 |
2023-08-14 |
rat |
| Tapan Behl, Muskan Wadhwa, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Simona Bunga. Mechanistic insights into the role of FOXO in diabetic retinopathy. American journal of translational research. vol 14. issue 6. 2022-07-15. PMID:35836845. |
blockage of insulin turns into an exaggerated level of glucose in the bloodstream and can upshot into the exaggerated triggering of foxo1, which can ultimately uplift the production of several factors of apoptosis and inflammation, such as tnf-α, nf-kb, and various others, as well as reactive oxygen species, which can also come up with diabetic retinopathy. |
2022-07-15 |
2023-08-14 |
Not clear |
| Suat Peng Neo, Asfa Alli-Shaik, Sheena Wee, Zijie Lim, Jayantha Gunaratn. Englerin A Rewires Phosphosignaling via Hsp27 Hyperphosphorylation to Induce Cytotoxicity in Renal Cancer Cells. Journal of proteome research. 2022-07-15. PMID:35838755. |
ea has been shown to induce apoptosis and cell death through cell-cycle arrest and/or insulin signaling pathways. |
2022-07-15 |
2023-08-14 |
Not clear |
| Kushan De Silva, Ryan T Demmer, Daniel Jönsson, Aya Mousa, Andrew Forbes, Joanne Enticot. Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflow. Functional & integrative genomics. 2022-07-05. PMID:35788821. |
downstream analyses identified enrichments of shared genes with certain other diabetes phenotypes; insulin synthesis and action-related pathways and metabolomics; mechanistic associations with apoptosis and immunity-related pathways; covid-19-related gene sets; and cell types demonstrating over- and under-expression of marker genes of t2d. |
2022-07-05 |
2023-08-14 |
Not clear |
| Sahdeo Prasad, Rajiv Lal. Zinc-curcumin based complexes in health and diseases: An approach in chemopreventive and therapeutic improvement. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 73. 2022-07-03. PMID:35780653. |
these protective and therapeutic efficacies of zinc-curcumin conjugates were associated with modulation of multiple molecular mechanisms including decreased inflammatory cytokines, increased antioxidant enzymes, quenched free radicals, decreased blood glucose levels, decreased insulin resistance, induced apoptosis markers, and restored function of tumor suppressor protein p53 in cancer cells. |
2022-07-03 |
2023-08-14 |
Not clear |
| Xiao-Dong Yu, Jiong-Wei Wan. Ceramide de novo synthesis in non-alcoholic fatty liver disease: pathogenic mechanisms and therapeutic perspectives. Biochemical pharmacology. 2022-07-01. PMID:35777449. |
ceramides have been shown to exacerbate nafld development through enhancing insulin resistance, reactive oxygen species production, liver steatosis, lipotoxicity and hepatocyte apoptosis, and eventually causing hepatic inflammation and fibrosis. |
2022-07-01 |
2023-08-14 |
Not clear |
| Hao Hong, Yu-Meng Li, Xiang-Min Meng, Tian Deng, Bing-Mei Zh. [Histone methylation and diabetic cardiomyopathy]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 3. 2022-06-30. PMID:35770643. |
a great deal of evidence has shown that histone methylation is closely related to hyperglycemia, insulin resistance, lipid and advanced glycation end products deposition, inflammatory and oxidative stress, endoplasmic reticulum stress and cell apoptosis, and these pathological factors play an important role in the pathogenesis of diabetic cardiomyopathy. |
2022-06-30 |
2023-08-14 |
Not clear |