| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiliang Du, Mingchao Liu, Wenjun Tai, Hao Yu, Xue Hao, Juan J Loor, Qianming Jiang, Zhiyuan Fang, Xinxing Gao, Minghe Fan, Wenwen Gao, Lin Lei, Yuxiang Song, Zhe Wang, Cai Zhang, Guowen Liu, Xinwei L. Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes. Journal of dairy science. 2022-08-14. PMID:35965124. |
overall, tnf-α impairs insulin sensitivity and induces lipolysis and apoptosis in bovine adipocytes, which may be partly mediated by activation of nf-κb and jnk. |
2022-08-14 |
2023-08-14 |
cattle |
| Pedro H Reis-Barbosa, Thatiany Souza Marinho, Cristiane Matsuura, Marcia Barbosa Aguila, Jorge J de Carvalho, Carlos Alberto Mandarim-de-Lacerd. The obesity and nonalcoholic fatty liver disease mouse model revisited: Liver oxidative stress, hepatocyte apoptosis, and proliferation. Acta histochemica. vol 124. issue 7. 2022-08-11. PMID:35952484. |
in conclusion, the findings in the dio mouse model reproduce the nafld profile relative to the human nafld's apoptosis, insulin signaling, lipogenesis, beta-oxidation, and oxidative stress. |
2022-08-11 |
2023-08-14 |
mouse |
| Xun Luo, Yajun Zhang, Changjie Lu, Jiaming Zhan. Role of insulin signaling pathway in apoptosis induced by food chain delivery of nano-silver under the action of environmental factors. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022-08-09. PMID:35944823. |
role of insulin signaling pathway in apoptosis induced by food chain delivery of nano-silver under the action of environmental factors. |
2022-08-09 |
2023-08-14 |
caenorhabditis_elegans |
| Fatima El Zahra M Fathi, Kadry M Sadek, Asmaa F Khafaga, Abd Elwahab A Alsenosy, Hanan A Ghoneim, Sahar F Mahmoud, Mohamed M Zewei. Correction to: Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin‑induced diabetes. Environmental science and pollution research international. 2022-08-06. PMID:35932351. |
correction to: vitamin d regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin‑induced diabetes. |
2022-08-06 |
2023-08-14 |
rat |
| Aaron M Taylor, Jiayi M Sun, Alexander Yu, Horatiu Voicu, Jianhe Shen, Donald A Barkauskas, Timothy J Triche, Julie M Gastier-Foster, Tsz-Kwong Man, Ching C La. Integrated DNA Copy Number and Expression Profiling Identifies IGF1R as a Prognostic Biomarker in Pediatric Osteosarcoma. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887382. |
insulin growth factor receptor 1 (igf1r) is a receptor tyrosine kinase which binds igf1 and igf2 to activate downstream pathways involved in cell apoptosis and proliferation. |
2022-07-27 |
2023-08-14 |
Not clear |
| Fatima El Zahra M Fathi, Kadry M Sadek, Asmaa F Khafaga, Abdel Wahab Al Senosy, Hanan A Ghoniem, Sahar Fayez, Mohamed F Zewei. Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes. Environmental science and pollution research international. 2022-07-21. PMID:35864405. |
vitamin d regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes. |
2022-07-21 |
2023-08-14 |
rat |
| Tapan Behl, Muskan Wadhwa, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Simona Bunga. Mechanistic insights into the role of FOXO in diabetic retinopathy. American journal of translational research. vol 14. issue 6. 2022-07-15. PMID:35836845. |
blockage of insulin turns into an exaggerated level of glucose in the bloodstream and can upshot into the exaggerated triggering of foxo1, which can ultimately uplift the production of several factors of apoptosis and inflammation, such as tnf-α, nf-kb, and various others, as well as reactive oxygen species, which can also come up with diabetic retinopathy. |
2022-07-15 |
2023-08-14 |
Not clear |
| Suat Peng Neo, Asfa Alli-Shaik, Sheena Wee, Zijie Lim, Jayantha Gunaratn. Englerin A Rewires Phosphosignaling via Hsp27 Hyperphosphorylation to Induce Cytotoxicity in Renal Cancer Cells. Journal of proteome research. 2022-07-15. PMID:35838755. |
ea has been shown to induce apoptosis and cell death through cell-cycle arrest and/or insulin signaling pathways. |
2022-07-15 |
2023-08-14 |
Not clear |
| Kushan De Silva, Ryan T Demmer, Daniel Jönsson, Aya Mousa, Andrew Forbes, Joanne Enticot. Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflow. Functional & integrative genomics. 2022-07-05. PMID:35788821. |
downstream analyses identified enrichments of shared genes with certain other diabetes phenotypes; insulin synthesis and action-related pathways and metabolomics; mechanistic associations with apoptosis and immunity-related pathways; covid-19-related gene sets; and cell types demonstrating over- and under-expression of marker genes of t2d. |
2022-07-05 |
2023-08-14 |
Not clear |
| Sahdeo Prasad, Rajiv Lal. Zinc-curcumin based complexes in health and diseases: An approach in chemopreventive and therapeutic improvement. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 73. 2022-07-03. PMID:35780653. |
these protective and therapeutic efficacies of zinc-curcumin conjugates were associated with modulation of multiple molecular mechanisms including decreased inflammatory cytokines, increased antioxidant enzymes, quenched free radicals, decreased blood glucose levels, decreased insulin resistance, induced apoptosis markers, and restored function of tumor suppressor protein p53 in cancer cells. |
2022-07-03 |
2023-08-14 |
Not clear |
| Xiao-Dong Yu, Jiong-Wei Wan. Ceramide de novo synthesis in non-alcoholic fatty liver disease: pathogenic mechanisms and therapeutic perspectives. Biochemical pharmacology. 2022-07-01. PMID:35777449. |
ceramides have been shown to exacerbate nafld development through enhancing insulin resistance, reactive oxygen species production, liver steatosis, lipotoxicity and hepatocyte apoptosis, and eventually causing hepatic inflammation and fibrosis. |
2022-07-01 |
2023-08-14 |
Not clear |
| Hao Hong, Yu-Meng Li, Xiang-Min Meng, Tian Deng, Bing-Mei Zh. [Histone methylation and diabetic cardiomyopathy]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 3. 2022-06-30. PMID:35770643. |
a great deal of evidence has shown that histone methylation is closely related to hyperglycemia, insulin resistance, lipid and advanced glycation end products deposition, inflammatory and oxidative stress, endoplasmic reticulum stress and cell apoptosis, and these pathological factors play an important role in the pathogenesis of diabetic cardiomyopathy. |
2022-06-30 |
2023-08-14 |
Not clear |
| Shengyang Fu, Shu Zhao, Huili Chen, Weitao Yang, Xiaohuan Xia, Xiaonan Xu, Zhanping Liang, Xuanran Feng, Zhuo Wang, Pu Ai, Lu Ding, Qingyuan Cai, Yi Wang, Yanyan Zhang, Jie Zhu, Bingbo Zhang, Jialin C Zhen. Insulin-incubated palladium clusters promote recovery after brain injury. Journal of nanobiotechnology. vol 20. issue 1. 2022-06-25. PMID:35752849. |
we found that the positive therapeutic effects of the pd@insulin clusters were mainly attributed to their ros-scavenging ability, as they inhibited excessive neuroinflammation, reduced cell apoptosis, and prevented neuronal loss. |
2022-06-25 |
2023-08-14 |
mouse |
| Hu Zhang, Ji-Ling Liang, Qiu-Yue Wu, Jin-Xiu Li, Ya Liu, Liang-Wen Wu, Jie-Lun Huang, Xiao-Wen Wu, Ming-Hui Wang, Ning Che. Swimming Suppresses Cognitive Decline of HFD-Induced Obese Mice through Reversing Hippocampal Inflammation, Insulin Resistance, and BDNF Level. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745162. |
in the present study, the obesity-induced cognition-declined model was established using 4-week-old mice continuously fed with a high-fat diet (hfd) for 12 weeks, and then the model mice were subjected to an 8-week swimming intervention and corresponding evaluation of relevant indicators, including cognitive capacity, inflammation, insulin signal pathway, brain-derived neurotrophic factor (bndf), and apoptosis, for exploring potential regulatory mechanisms. |
2022-06-24 |
2023-08-14 |
mouse |
| Wendy M McKimpson, Richard N Kitsi. Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets. STAR protocols. vol 3. issue 2. 2022-06-20. PMID:35719268. |
type 2 diabetes is mediated by insulin resistance and pancreatic β-cell failure, the latter reflecting a combination of β-cell dysfunction, dedifferentiation, and apoptosis. |
2022-06-20 |
2023-08-14 |
mouse |
| Constanza Salinas, Gabriel Espinosa, Natalia Morales, Claudio Henríquez, Gabriel Morán, Gonzalo Gajardo, Rafael A Burgos, Benjamin Ubert. Evaluation of peripheral blood polymorphonuclear cell functions after an oral carbohydrate overload in obese and insulin dysregulated horses. Veterinary immunology and immunopathology. vol 250. 2022-06-18. PMID:35716440. |
this study evaluated the effect of acute induced transient hyperglycemia on apoptosis, phagocytosis and oxidative burst activity of peripheral blood polymorphonuclear cells (pmn) of lean and obese adult horses with or without insulin dysregulation. |
2022-06-18 |
2023-08-14 |
Not clear |
| Xian Zhang, Songyuan Luo, Minjie Wang, Qin Huang, Wenqian Fang, Jie Li, Tianxiao Liu, Yuanyuan Zhang, Zhiyong Deng, Cong-Lin Liu, Shuling Guan, Julio E Ayala, Richard A Flavell, Rohit N Kulkarni, Peter Libby, Junli Guo, Zhangsuo Liu, Guo-Ping Sh. IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells. Developmental cell. 2022-06-08. PMID:35675813. |
the deficiency of these receptors reduces islet size, β cell proliferation, and insulin secretion but increases β cell apoptosis and exocrine macrophage accumulation after diet-induced glucose intolerance or streptozotocin-induced hyperglycemia. |
2022-06-08 |
2023-08-14 |
mouse |
| Xian Zhang, Songyuan Luo, Minjie Wang, Qin Huang, Wenqian Fang, Jie Li, Tianxiao Liu, Yuanyuan Zhang, Zhiyong Deng, Cong-Lin Liu, Shuling Guan, Julio E Ayala, Richard A Flavell, Rohit N Kulkarni, Peter Libby, Junli Guo, Zhangsuo Liu, Guo-Ping Sh. IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells. Developmental cell. 2022-06-08. PMID:35675813. |
the β cell-selective depletion of the ncc or acinar-cell-selective il18r depletion reduces glucose tolerance and insulin sensitivity with impaired β cell proliferation, enhanced β cell apoptosis and macrophage expansion, and inflammation in mouse hyperglycemic pancreas. |
2022-06-08 |
2023-08-14 |
mouse |
| Xing-Xing Lai, Cui-Ping Zhang, Yu-Xin Wu, Yang Yang, Ming-Qing Zhang, Wei-Jian Qin, Rui-Xuan Wang, Hu Sh. Comparative transcriptome analysis reveals physiological responses in liver tissues of Epinephelus coioides under acute hypoxia stress. Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 43. 2022-06-02. PMID:35653833. |
enrichment analysis using the gene ontology database showed that the degs were mainly enriched for functions related to cell apoptosis signaling pathways, insulin resistance, antioxidant enzymes, and glycolysis/gluconeogenesis signaling pathways. |
2022-06-02 |
2023-08-14 |
Not clear |
| Chae-Gwan Kong, Jong-Beom Park, Seung Hyo Ki. Inhibitory Effect of Insulin Treatment on Apoptosis of Intervertebral Disc Cells in a Streptozotocin-Induced Diabetic Rat Model. Asian spine journal. 2022-06-02. PMID:35654105. |
inhibitory effect of insulin treatment on apoptosis of intervertebral disc cells in a streptozotocin-induced diabetic rat model. |
2022-06-02 |
2023-08-14 |
rat |