| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhang, Quansheng Fen. Pharmacological Effects and Molecular Protective Mechanisms of Astragalus Polysaccharides on Nonalcoholic Fatty Liver Disease. Frontiers in pharmacology. vol 13. 2022-03-21. PMID:35308224. |
lipid metabolism, insulin resistance (ir), oxidative stress (os), endoplasmic reticulum stress (ers), inflammation, fibrosis, autophagy, and apoptosis are some of the pathogenic pathways involved. |
2022-03-21 |
2023-08-13 |
Not clear |
| Junyuan Deng, Yujie Guo, Jiali Du, Jichun Gu, Lei Kong, Boan Tao, Ji Li, Deliang F. The Intricate Crosstalk Between Insulin and Pancreatic Ductal Adenocarcinoma: A Review From Clinical to Molecular. Frontiers in cell and developmental biology. vol 10. 2022-03-07. PMID:35252207. |
on the other hand, insulin promotes pancreatic cancer initiation and sustains pda development by eliciting tumorigenic inflammation, regulating lipid and glucose metabolic reprogram, overcoming apoptosis through the crosstalk with igf-1, stimulating cancer metastasis, and activating tumor microenvironment formation (inflammation, fibrosis, and angiogenesis). |
2022-03-07 |
2023-08-13 |
Not clear |
| Mingyu Zou, Jinhua Chi, Zhiwen Jiang, Wei Zhang, Huiwen Hu, Ruibao Ju, Chenqi Liu, Tianjiao Xu, Shuo Wang, Zhilong Feng, Wanshun Liu, Baoqin Ha. Functional thermosensitive hydrogels based on chitin as RIN-m5F cell carrier for the treatment of diabetes. International journal of biological macromolecules. 2022-03-05. PMID:35247418. |
on the other hand, n-acetylglucosamine (nag) and carboxymethyl chitosan (cmcs) provided favorable capacity for promoting cell proliferation, delaying cell apoptosis, and facilitating the insulin secretion of rat pancreatic beta cells (rin-m5f) in three-dimensional culture. |
2022-03-05 |
2023-08-13 |
mouse |
| Lianbin Xu, Xueyan Lin, Xiuli Li, Zhiyong Hu, Qiuling Hou, Yun Wang, Zhonghua Wan. Integration of transcriptomics and metabolomics provides metabolic and functional insights into reduced insulin secretion in MIN6 β-cells exposed to deficient and excessive arginine. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 3. 2022-02-24. PMID:35199385. |
this descriptive bioinformatics analysis suggested that the disturbed carbohydrate, lipid, and amino acid metabolisms, as well as the increased apoptosis and elevated oxidative stress, contributed to the reduced insulin secretion and lower gsis in β-cells induced by la or ha treatments, while some underlying mechanisms need to be further explored. |
2022-02-24 |
2023-08-13 |
Not clear |
| Mengdi Wang, Zhuoran Zhang, Qingqing Huo, Maolong Wang, Yong Sun, Hongling Liu, Jing Chang, Bin He, Yan Lian. Targeted Polymeric Nanoparticles Based on Mangiferin for Enhanced Protection of Pancreatic β-Cells and Type 1 Diabetes Mellitus Efficacy. ACS applied materials & interfaces. 2022-02-24. PMID:35199981. |
as compared to free mgf, mgf/gdpp nanoparticles appeared to be more concentrated in the pancreas, with better blood glucose and glucose tolerance, enhanced insulin levels, increased β-cell proliferation, reduced β-cell apoptosis, and islet repair in vivo. |
2022-02-24 |
2023-08-13 |
Not clear |
| Jeffrey O Adoga, Mahendra L Channa, Anand Nada. Type-2 diabetic rat heart: The effect of kolaviron on mTOR-1, P70S60K, PKC-α, NF-kB, SOD-2, NRF-2, eNOS, AKT-1, ACE, and P38 MAPK gene expression profile. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 148. 2022-02-24. PMID:35202911. |
this study determined the effect of kolaviron on the expression profile of genes associated with the insulin signaling pathway and involved in regulating glucose and lipid metabolism, oxidative stress, inflammation, vascular functions, pro-survival and the apoptosis pathway in the heart of type-2 diabetic rats. |
2022-02-24 |
2023-08-13 |
rat |
| Zhiyi Shen, Yongkai Yu, Yuqian Yang, Xiao Xiao, Tong Sun, Xiaoai Chang, Wei Tang, Yunxia Zhu, Xiao Ha. miR-25 and miR-92b regulate insulin biosynthesis and pancreatic β-cell apoptosis. Endocrine. 2022-02-23. PMID:35194770. |
mir-25 and mir-92b regulate insulin biosynthesis and pancreatic β-cell apoptosis. |
2022-02-23 |
2023-08-13 |
Not clear |
| Yue L. Gypenoside A attenuates dysfunction of pancreatic β cells by activating PDX1 signal transduction via the inhibition of miR-150-3p both in vivo and in vitro. Journal of biochemical and molecular toxicology. 2022-02-22. PMID:35191145. |
hfd administration suppressed glucose tolerance, delayed insulin release, and induced insulin resistance and pancreas apoptosis in mice, which was indicative of the dysfunction of β pancreatic cells. |
2022-02-22 |
2023-08-13 |
mouse |
| Yi Yang, Jiuying Liu, Weiwei X. Naringenin and morin reduces insulin resistance and endometrial hyperplasia in the rat model of polycystic ovarian syndrome through enhancement of inflammation and autophagic apoptosis. Acta biochimica Polonica. 2022-02-10. PMID:35143137. |
naringenin and morin reduces insulin resistance and endometrial hyperplasia in the rat model of polycystic ovarian syndrome through enhancement of inflammation and autophagic apoptosis. |
2022-02-10 |
2023-08-13 |
rat |
| Xiudan Li, Chunying Bai, Hongjie Wang, Tingting Wan, Yanbo L. LncRNA MEG3 regulates autophagy and pyroptosis via FOXO1 in pancreatic β-cells. Cellular signalling. 2022-02-01. PMID:35101568. |
recent advances revealed that lncrna meg3 (meg3) promotes insulin secretion and inhibits pancreatic β-cells apoptosis in dm. |
2022-02-01 |
2023-08-13 |
mouse |
| Soulef Chahinez Maandi, Meriem Tinhinane Maandi, Anneka Patel, Rían W Manville, Jon Gunnarsson Mable. Divergent effects of HIV reverse transcriptase inhibitors on pancreatic beta-cell function and survival: Potential role of oxidative stress and mitochondrial dysfunction. Life sciences. 2022-01-29. PMID:35090905. |
our results show contrasting effects within the nnrti class as doravirine did not cause damaging effects in the rat insulinoma ins-1e cells while efavirenz and rilpivirine reduced insulin release and cell viability, and induced apoptosis in ins-1e cells. |
2022-01-29 |
2023-08-13 |
rat |
| Alex Cleber Improta-Caria, Ricardo Augusto Leoni De Sousa, Leonardo Roever, Tiago Fernandes, Edilamar Menezes de Oliveira, Roque Aras Júnior, Bruno Solano de Freitas Souz. MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise. Reviews in cardiovascular medicine. vol 23. issue 1. 2022-01-29. PMID:35092221. |
several pathophysiological processes contribute to the development, progression and aggravating of the disease, for example, decreased insulin synthesis and secretion, insulin resistance, inflammation, and apoptosis, all these processes are regulated by various epigenetic factors, including micrornas (mirnas). |
2022-01-29 |
2023-08-13 |
Not clear |
| Alex Cleber Improta-Caria, Ricardo Augusto Leoni De Sousa, Leonardo Roever, Tiago Fernandes, Edilamar Menezes de Oliveira, Roque Aras Júnior, Bruno Solano de Freitas Souz. MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise. Reviews in cardiovascular medicine. vol 23. issue 1. 2022-01-29. PMID:35092221. |
some scientific evidence shows that pe modulates mirnas beneficially and improves the signaling pathway of insulin resistance, however, little is known about the function of pe modulating mirnas associated with the processes of insulin secretion, inflammation, and apoptosis. |
2022-01-29 |
2023-08-13 |
Not clear |
| Alex Cleber Improta-Caria, Ricardo Augusto Leoni De Sousa, Leonardo Roever, Tiago Fernandes, Edilamar Menezes de Oliveira, Roque Aras Júnior, Bruno Solano de Freitas Souz. MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise. Reviews in cardiovascular medicine. vol 23. issue 1. 2022-01-29. PMID:35092221. |
thus, the objective of this review is to identify the mirnas expression pattern in t2dm and compare it with the exercise-induced mirnas expression pattern, identifying the signaling pathways that these mirnas are regulating in the processes of insulin secretion, insulin resistance, inflammation, and apoptosis in t2dm, and how pe may have a potential role in modulating these signal transduction pathways, promoting benefits for patients with t2dm. |
2022-01-29 |
2023-08-13 |
Not clear |
| Mark F McCarty, James J DiNicolantoni. Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity-Nutraceutical Options. Healthcare (Basel, Switzerland). vol 10. issue 1. 2022-01-21. PMID:35052168. |
glucolipotoxicity-induced production of reactive oxygen species (ros), stemming from both mitochondria and the nox2 isoform of nadph oxidase, drives an increase in c-jun n-terminal kinase (jnk) activity that promotes nuclear export of pdx1, and impairs autocrine insulin signaling; the latter effect decreases pdx1 expression at the transcriptional level and up-regulates beta cell apoptosis. |
2022-01-21 |
2023-08-13 |
Not clear |
| Mark F McCarty, James J DiNicolantoni. Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity-Nutraceutical Options. Healthcare (Basel, Switzerland). vol 10. issue 1. 2022-01-21. PMID:35052168. |
nutraceuticals that quell an increase in beta cell ros production, that amplify or mimic autocrine insulin signaling, or that boost glp-1 production, should help to maintain gsis and suppress beta cell apoptosis in the face of glucolipotoxicity, postponing or preventing onset of type 2 diabetes. |
2022-01-21 |
2023-08-13 |
Not clear |
| Guoqing Huang, Mingcai Li, Xiaoqing Tian, Qiankai Jin, Yushan Mao, Yan L. The emerging roles of IL-36, IL-37, and IL-38 in diabetes mellitus and its complications. Endocrine, metabolic & immune disorders drug targets. 2022-01-20. PMID:35049442. |
there is sufficient evidence that proinflammatory mediators, such as interleukin (il)-1β, il-6, macrophage chemotactic protein-1, and tumor necrosis factor-α, are engaged in the insulin resistance in peripheral adipose tissue and the apoptosis of pancreatic β-cells. |
2022-01-20 |
2023-08-13 |
Not clear |
| Tayebeh Noori, Mousa Sahebgharani, Antoni Sureda, Eduardo Sobarzo-Sanchez, Sajad Fakhri, Samira Shirooi. Targeting PI3K by Natural Products: A potential therapeutic strategy for Attention-Deficit Hyperactivity Disorder? Current neuropharmacology. 2022-01-19. PMID:35043762. |
phosphoinositide 3-kinases (pi3ks) are a conserved family of lipid kinases that control a number of cellular processes, including cell proliferation, differentiation, migration, insulin metabolism, and apoptosis. |
2022-01-19 |
2023-08-13 |
human |
| Lijie Ma, Chengfei Zhang, Lili Wu, Lingling Qin, Tonghua Li. Diosgenin reduces phosphodiesterase 3B (PDE3B) through AMP-activated protein kinase/ mechanistic target of rapamycin (AMPK/mTOR) signaling pathway to ameliorate streptozotocin-induced pancreatic β-cell apoptosis and dysfunction. Bioengineered. vol 13. issue 2. 2022-01-15. PMID:35030973. |
the results showed that in stz-induced ins-1 cells, dg could improve cell viability, inhibit apoptosis, attenuate oxidative stress levels and increase insulin secretion. |
2022-01-15 |
2023-08-13 |
rat |
| Teresa Vezza, Pedro Díaz-Pozo, Francisco Canet, Aranzazu M de Marañón, Zaida Abad-Jiménez, Celia García-Gargallo, Ildefonso Roldan, Eva Solá, Celia Bañuls, Sandra López-Domènech, Milagros Rocha, Víctor M Vícto. The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes. The world journal of men's health. 2022-01-12. PMID:35021300. |
in this sense, fragmentation of mitochondrial networks is often associated with defects in cellular energy production and increased apoptosis, leading, in turn, to excessive reactive oxygen species release, mitochondrial dysfunction, and metabolic alterations, which can ultimately contribute to β-cell dysfunction and insulin resistance. |
2022-01-12 |
2023-08-13 |
Not clear |