| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Yang, Jiuying Liu, Weiwei X. Naringenin and morin reduces insulin resistance and endometrial hyperplasia in the rat model of polycystic ovarian syndrome through enhancement of inflammation and autophagic apoptosis. Acta biochimica Polonica. 2022-02-10. PMID:35143137. |
naringenin and morin reduces insulin resistance and endometrial hyperplasia in the rat model of polycystic ovarian syndrome through enhancement of inflammation and autophagic apoptosis. |
2022-02-10 |
2023-08-13 |
rat |
| Xiudan Li, Chunying Bai, Hongjie Wang, Tingting Wan, Yanbo L. LncRNA MEG3 regulates autophagy and pyroptosis via FOXO1 in pancreatic β-cells. Cellular signalling. 2022-02-01. PMID:35101568. |
recent advances revealed that lncrna meg3 (meg3) promotes insulin secretion and inhibits pancreatic β-cells apoptosis in dm. |
2022-02-01 |
2023-08-13 |
mouse |
| Soulef Chahinez Maandi, Meriem Tinhinane Maandi, Anneka Patel, Rían W Manville, Jon Gunnarsson Mable. Divergent effects of HIV reverse transcriptase inhibitors on pancreatic beta-cell function and survival: Potential role of oxidative stress and mitochondrial dysfunction. Life sciences. 2022-01-29. PMID:35090905. |
our results show contrasting effects within the nnrti class as doravirine did not cause damaging effects in the rat insulinoma ins-1e cells while efavirenz and rilpivirine reduced insulin release and cell viability, and induced apoptosis in ins-1e cells. |
2022-01-29 |
2023-08-13 |
rat |
| Alex Cleber Improta-Caria, Ricardo Augusto Leoni De Sousa, Leonardo Roever, Tiago Fernandes, Edilamar Menezes de Oliveira, Roque Aras Júnior, Bruno Solano de Freitas Souz. MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise. Reviews in cardiovascular medicine. vol 23. issue 1. 2022-01-29. PMID:35092221. |
several pathophysiological processes contribute to the development, progression and aggravating of the disease, for example, decreased insulin synthesis and secretion, insulin resistance, inflammation, and apoptosis, all these processes are regulated by various epigenetic factors, including micrornas (mirnas). |
2022-01-29 |
2023-08-13 |
Not clear |
| Alex Cleber Improta-Caria, Ricardo Augusto Leoni De Sousa, Leonardo Roever, Tiago Fernandes, Edilamar Menezes de Oliveira, Roque Aras Júnior, Bruno Solano de Freitas Souz. MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise. Reviews in cardiovascular medicine. vol 23. issue 1. 2022-01-29. PMID:35092221. |
some scientific evidence shows that pe modulates mirnas beneficially and improves the signaling pathway of insulin resistance, however, little is known about the function of pe modulating mirnas associated with the processes of insulin secretion, inflammation, and apoptosis. |
2022-01-29 |
2023-08-13 |
Not clear |
| Alex Cleber Improta-Caria, Ricardo Augusto Leoni De Sousa, Leonardo Roever, Tiago Fernandes, Edilamar Menezes de Oliveira, Roque Aras Júnior, Bruno Solano de Freitas Souz. MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise. Reviews in cardiovascular medicine. vol 23. issue 1. 2022-01-29. PMID:35092221. |
thus, the objective of this review is to identify the mirnas expression pattern in t2dm and compare it with the exercise-induced mirnas expression pattern, identifying the signaling pathways that these mirnas are regulating in the processes of insulin secretion, insulin resistance, inflammation, and apoptosis in t2dm, and how pe may have a potential role in modulating these signal transduction pathways, promoting benefits for patients with t2dm. |
2022-01-29 |
2023-08-13 |
Not clear |
| Mark F McCarty, James J DiNicolantoni. Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity-Nutraceutical Options. Healthcare (Basel, Switzerland). vol 10. issue 1. 2022-01-21. PMID:35052168. |
glucolipotoxicity-induced production of reactive oxygen species (ros), stemming from both mitochondria and the nox2 isoform of nadph oxidase, drives an increase in c-jun n-terminal kinase (jnk) activity that promotes nuclear export of pdx1, and impairs autocrine insulin signaling; the latter effect decreases pdx1 expression at the transcriptional level and up-regulates beta cell apoptosis. |
2022-01-21 |
2023-08-13 |
Not clear |
| Mark F McCarty, James J DiNicolantoni. Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity-Nutraceutical Options. Healthcare (Basel, Switzerland). vol 10. issue 1. 2022-01-21. PMID:35052168. |
nutraceuticals that quell an increase in beta cell ros production, that amplify or mimic autocrine insulin signaling, or that boost glp-1 production, should help to maintain gsis and suppress beta cell apoptosis in the face of glucolipotoxicity, postponing or preventing onset of type 2 diabetes. |
2022-01-21 |
2023-08-13 |
Not clear |
| Guoqing Huang, Mingcai Li, Xiaoqing Tian, Qiankai Jin, Yushan Mao, Yan L. The emerging roles of IL-36, IL-37, and IL-38 in diabetes mellitus and its complications. Endocrine, metabolic & immune disorders drug targets. 2022-01-20. PMID:35049442. |
there is sufficient evidence that proinflammatory mediators, such as interleukin (il)-1β, il-6, macrophage chemotactic protein-1, and tumor necrosis factor-α, are engaged in the insulin resistance in peripheral adipose tissue and the apoptosis of pancreatic β-cells. |
2022-01-20 |
2023-08-13 |
Not clear |
| Tayebeh Noori, Mousa Sahebgharani, Antoni Sureda, Eduardo Sobarzo-Sanchez, Sajad Fakhri, Samira Shirooi. Targeting PI3K by Natural Products: A potential therapeutic strategy for Attention-Deficit Hyperactivity Disorder? Current neuropharmacology. 2022-01-19. PMID:35043762. |
phosphoinositide 3-kinases (pi3ks) are a conserved family of lipid kinases that control a number of cellular processes, including cell proliferation, differentiation, migration, insulin metabolism, and apoptosis. |
2022-01-19 |
2023-08-13 |
human |
| Lijie Ma, Chengfei Zhang, Lili Wu, Lingling Qin, Tonghua Li. Diosgenin reduces phosphodiesterase 3B (PDE3B) through AMP-activated protein kinase/ mechanistic target of rapamycin (AMPK/mTOR) signaling pathway to ameliorate streptozotocin-induced pancreatic β-cell apoptosis and dysfunction. Bioengineered. vol 13. issue 2. 2022-01-15. PMID:35030973. |
the results showed that in stz-induced ins-1 cells, dg could improve cell viability, inhibit apoptosis, attenuate oxidative stress levels and increase insulin secretion. |
2022-01-15 |
2023-08-13 |
rat |
| Teresa Vezza, Pedro Díaz-Pozo, Francisco Canet, Aranzazu M de Marañón, Zaida Abad-Jiménez, Celia García-Gargallo, Ildefonso Roldan, Eva Solá, Celia Bañuls, Sandra López-Domènech, Milagros Rocha, Víctor M Vícto. The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes. The world journal of men's health. 2022-01-12. PMID:35021300. |
in this sense, fragmentation of mitochondrial networks is often associated with defects in cellular energy production and increased apoptosis, leading, in turn, to excessive reactive oxygen species release, mitochondrial dysfunction, and metabolic alterations, which can ultimately contribute to β-cell dysfunction and insulin resistance. |
2022-01-12 |
2023-08-13 |
Not clear |
| Jinwang Li, Siyu Xie, Wendi Ten. Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis. Nutrients. vol 14. issue 1. 2022-01-11. PMID:35010950. |
moreover, sfa treatment reduced hfd-induced body weight gain, alleviated insulin resistance, decreased serum tg, total cholesterol (tc), and alanine aminotransferase (alt) levels, and prevented lipid deposition and apoptosis in the liver. |
2022-01-11 |
2023-08-13 |
mouse |
| Francesca Romana Prandi, Isabella Evangelista, Domenico Sergi, Alberto Palazzuoli, Francesco Rome. Mechanisms of cardiac dysfunction in diabetic cardiomyopathy: molecular abnormalities and phenotypical variants. Heart failure reviews. 2022-01-10. PMID:35001338. |
metabolic alterations such as hyperglycemia, insulin resistance, hyperinsulinemia, and increased metabolism of free fatty acids result in oxidative stress, inflammation, advanced glycation end products formation, abnormalities in calcium homeostasis, and apoptosis that are responsible for structural remodeling. |
2022-01-10 |
2023-08-13 |
Not clear |
| Mohammad Fareed Khan, Alpana Mathur, Vivek Kumar Pandey, Poonam Kakka. Endoplasmic reticulum stress-dependent activation of TRB3-FoxO1 signaling pathway exacerbates hyperglycemic nephrotoxicity: Protection accorded by naringenin. European journal of pharmacology. 2022-01-09. PMID:34998792. |
naringenin also reduced insulin resistance, apoptosis and glycogen accumulation along with enhancement of glucose tolerance in diabetic rats. |
2022-01-09 |
2023-08-13 |
rat |
| Yaodong Wang, Haitao Yu, Jinchun H. Involvement of the Hippo Pathway in the Development of Diabetes. Discovery medicine. vol 31. issue 162. 2021-12-29. PMID:34965370. |
however, various disorders and dysfunctions caused by disruptions in hippo signaling harm parental pancreatic islet cells, promote apoptosis of parental cells, and impair insulin secretion -- leading to the occurrence of diabetes. |
2021-12-29 |
2023-08-13 |
Not clear |
| Selvaraj Jayaraman, Anitha Roy, Srinivasan Vengadassalapathy, Ramya Sekar, Vishnu Priya Veeraraghavan, Ponnulakshmi Rajagopal, Gayathri Rengasamy, Raktim Mukherjee, Durairaj Sekar, Reji Manjunatha. An Overview on the Therapeutic Function of Foods Enriched with Plant Sterols in Diabetes Management. Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34943006. |
at the molecular level, these changes induce apoptosis in pancreatic cells and hence lead to insulin insufficiency. |
2021-12-24 |
2023-08-13 |
Not clear |
| Wenjing Zai, Wei Chen, Hongrui Liu, Dianwen J. Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease: From Molecular Mechanisms to Clinical Applications. Biomedicines. vol 9. issue 12. 2021-12-24. PMID:34944732. |
emerging evidence suggests that il-22 plays important protective functions against nafld by improving insulin sensitivity, modulating lipid metabolism, relieving oxidative and endoplasmic reticulum (er) stress, and inhibiting apoptosis. |
2021-12-24 |
2023-08-13 |
Not clear |
| Ruojia Ma, Yike Zhan, Yamei Zhang, Liangan Wu, Xing Wang, Ming Gu. Schisandrin B ameliorates non-alcoholic liver disease through anti-inflammation activation in diabetic mice. Drug development research. 2021-12-20. PMID:34927282. |
sch b ameliorated insulin resistance and lipid accumulation under high glucose conditions, which was partly associated with its inhibition of apoptosis and anti-inflammatory actions. |
2021-12-20 |
2023-08-13 |
mouse |
| Kalie L Tommerdahl, Kristen J Nadeau, Petter Bjornsta. Mechanisms of Cardiorenal Protection of Glucagon-Like Peptide-1 Receptor Agonists. Advances in chronic kidney disease. vol 28. issue 4. 2021-12-19. PMID:34922690. |
glucagon-like peptide-1 (glp-1) receptor agonists (ras), incretin hormones that stimulate postprandial insulin secretion, serve as a promising avenue for treatment of t2d as they result in a variety of antihyperglycemic effects including increased endogenous insulin secretion, decreased gluconeogenesis, inhibition of pancreatic α-cell glucagon production, decreased pancreatic β-cell apoptosis, and increased β-cell proliferation. |
2021-12-19 |
2023-08-13 |
Not clear |