| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ze-Hua Liu, Bo L. Chlorogenic acid and β-glucan from highland barley grain ameliorate β-cell dysfunction Food & function. vol 12. issue 20. 2021-10-19. PMID:34515712. |
ca ameliorated β-cell dysfunction by inhibiting cell apoptosis and improving glucose-stimulated insulin secretion |
2021-10-19 |
2023-08-13 |
Not clear |
| Shantanu Sen, Prerana Singh, Narendra Kumar Mishra, Subramaniam Ganesh, Sri Sivakumar, Sandeep Verm. Blended polar/nonpolar peptide conjugate interferes with human insulin amyloid-mediated cytotoxicity. Bioorganic chemistry. vol 111. 2021-10-14. PMID:33882365. |
such insulin amyloid leads to enhanced immunogenicity and allow potential attachment to cell membranes leading to cell permeability and apoptosis. |
2021-10-14 |
2023-08-13 |
human |
| Tangying Li, Huibiao Quan, Huachuan Zhang, Leweihua Lin, Qianying Ou, Kaining Che. Silencing cyclophilin A improves insulin secretion, reduces cell apoptosis, and alleviates inflammation as well as oxidant stress in high glucose-induced pancreatic β-cells via MAPK/NF-kb signaling pathway. Bioengineered. vol 11. issue 1. 2021-10-13. PMID:32970961. |
silencing cyclophilin a improves insulin secretion, reduces cell apoptosis, and alleviates inflammation as well as oxidant stress in high glucose-induced pancreatic β-cells via mapk/nf-kb signaling pathway. |
2021-10-13 |
2023-08-13 |
Not clear |
| Tangying Li, Huibiao Quan, Huachuan Zhang, Leweihua Lin, Qianying Ou, Kaining Che. Silencing cyclophilin A improves insulin secretion, reduces cell apoptosis, and alleviates inflammation as well as oxidant stress in high glucose-induced pancreatic β-cells via MAPK/NF-kb signaling pathway. Bioengineered. vol 11. issue 1. 2021-10-13. PMID:32970961. |
knockdown of cyclophilin a was able to increase insulin secretion, decrease cell apoptosis, and alleviate inflammation as well as oxidant stress in hg-treated pancreatic β-cells via mapk/nf-kb pathway. |
2021-10-13 |
2023-08-13 |
Not clear |
| Itziar González-Moro, Izortze Santi. Long non-coding RNA-regulated pathways in pancreatic β cells: Their role in diabetes. International review of cell and molecular biology. vol 359. 2021-10-11. PMID:33832652. |
indeed, accumulating evidence based on numerous studies, has highlighted the implication of lncrnas in the regulation of pancreatic β cell differentiation and proliferation, insulin synthesis and secretion, and apoptosis. |
2021-10-11 |
2023-08-13 |
Not clear |
| Patricia Soriano Roque, Mehdi Hooshmandi, Laura Neagu-Lund, Shelly Yin, Noosha Yousefpour, Hiroaki Sato, Tamaki Sato, Yosuke Nakadate, Akiko Kawakami, Soroush Tahmasebi, Alfredo Ribeiro-da-Silva, Christos G Gkogkas, Masha Prager-Khoutorsky, Thomas Schricker, Linda Wykes, Arkady Khoutorsk. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Scientific reports. vol 11. issue 1. 2021-10-04. PMID:34326413. |
intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mtorc1. |
2021-10-04 |
2023-08-13 |
mouse |
| Patricia Soriano Roque, Mehdi Hooshmandi, Laura Neagu-Lund, Shelly Yin, Noosha Yousefpour, Hiroaki Sato, Tamaki Sato, Yosuke Nakadate, Akiko Kawakami, Soroush Tahmasebi, Alfredo Ribeiro-da-Silva, Christos G Gkogkas, Masha Prager-Khoutorsky, Thomas Schricker, Linda Wykes, Arkady Khoutorsk. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Scientific reports. vol 11. issue 1. 2021-10-04. PMID:34326413. |
moreover, intranasal insulin prevented anesthesia-induced apoptosis of hippocampal cells, which is thought to underlie cognitive impairment. |
2021-10-04 |
2023-08-13 |
mouse |
| Patricia Soriano Roque, Mehdi Hooshmandi, Laura Neagu-Lund, Shelly Yin, Noosha Yousefpour, Hiroaki Sato, Tamaki Sato, Yosuke Nakadate, Akiko Kawakami, Soroush Tahmasebi, Alfredo Ribeiro-da-Silva, Christos G Gkogkas, Masha Prager-Khoutorsky, Thomas Schricker, Linda Wykes, Arkady Khoutorsk. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Scientific reports. vol 11. issue 1. 2021-10-04. PMID:34326413. |
inhibition of the mechanistic target of rapamycin complex 1 (mtorc1), a major intracellular effector of insulin receptor, blocked the beneficial effects of intranasal insulin on anesthesia-induced apoptosis. |
2021-10-04 |
2023-08-13 |
mouse |
| Patricia Soriano Roque, Mehdi Hooshmandi, Laura Neagu-Lund, Shelly Yin, Noosha Yousefpour, Hiroaki Sato, Tamaki Sato, Yosuke Nakadate, Akiko Kawakami, Soroush Tahmasebi, Alfredo Ribeiro-da-Silva, Christos G Gkogkas, Masha Prager-Khoutorsky, Thomas Schricker, Linda Wykes, Arkady Khoutorsk. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Scientific reports. vol 11. issue 1. 2021-10-04. PMID:34326413. |
our study demonstrates that intranasal insulin prevents general anesthesia-induced apoptosis of hippocampal cells, and deficits in synaptic plasticity and memory, and suggests that the rescue effect is mediated via mtorc1/4e-bp2 signaling. |
2021-10-04 |
2023-08-13 |
mouse |
| Seon Mee Kang, Hye Sook Jung, Min Jeong Kwon, Soon Hee Lee, Jeong Hyun Par. Testosterone Protects Pancreatic β-cells from Apoptosis and Stress-Induced Accelerated Senescence. The world journal of men's health. vol 39. issue 4. 2021-10-02. PMID:33474846. |
we wanted to know whether dihydrotestosterone (dht) can protect insulin secreting pancreatic β-cells from apoptosis and accelerated senescence induced by oxidative stress. |
2021-10-02 |
2023-08-13 |
Not clear |
| Peter McGranaghan, Jennifer A Kirwan, Mariel A Garcia-Rivera, Burkert Pieske, Frank Edelmann, Florian Blaschke, Sandeep Appunni, Anshul Saxena, Muni Rubens, Emir Veledar, Tobias Daniel Trippe. Lipid Metabolite Biomarkers in Cardiovascular Disease: Discovery and Biomechanism Translation from Human Studies. Metabolites. vol 11. issue 9. 2021-09-30. PMID:34564437. |
metabolomic studies in humans have supported previous findings into the pathomechanisms of cvd, namely atherosclerosis, apoptosis, inflammation, oxidative stress, and insulin resistance. |
2021-09-30 |
2023-08-13 |
human |
| Jianqiang Ma, Yifan Wu, Ying H. Silencing circRNA LRP6 down-regulates PRMT1 to improve the streptozocin-induced pancreatic β-cell injury and insulin secretion by sponging miR-9-5p. Journal of bioenergetics and biomembranes. vol 53. issue 3. 2021-09-29. PMID:33826088. |
after knocking down circlrp6, the cell viability and apoptosis were respectively measured by mtt and tdt-mediated dutp nick-end labeling (tunel) staining, and insulin release and oxidative stress were respectively measured by enzyme-linked immunosorbent assay (elisa) and corresponding kits. |
2021-09-29 |
2023-08-13 |
Not clear |
| Jianqiang Ma, Yifan Wu, Ying H. Silencing circRNA LRP6 down-regulates PRMT1 to improve the streptozocin-induced pancreatic β-cell injury and insulin secretion by sponging miR-9-5p. Journal of bioenergetics and biomembranes. vol 53. issue 3. 2021-09-29. PMID:33826088. |
silencing circlrp6 resulted in an increase in the cell viability, a decrease in the cell apoptosis, together with more insulin release. |
2021-09-29 |
2023-08-13 |
Not clear |
| Jianqiang Ma, Yifan Wu, Ying H. Silencing circRNA LRP6 down-regulates PRMT1 to improve the streptozocin-induced pancreatic β-cell injury and insulin secretion by sponging miR-9-5p. Journal of bioenergetics and biomembranes. vol 53. issue 3. 2021-09-29. PMID:33826088. |
the circlrp6/mir-9-5p/prmt1 regulatory network was then confirmed, which affected the cell viability, apoptosis, insulin release, and oxidative stress in stz-challenged ins-1 cells. in conclusion, this study first provides evidence that the circlrp6/mir-9-5p/prmt1 regulatory network can affect stz-induced cell viability, oxidative stress, and insulin secretion in ins-l cells, which can further impact the progression of diabetes. |
2021-09-29 |
2023-08-13 |
Not clear |
| R Dhanya, C C Karth. Quercetin improves oxidative stress-induced pancreatic beta cell alterations via mTOR-signaling. Molecular and cellular biochemistry. vol 476. issue 11. 2021-09-27. PMID:34129156. |
quercetin was found to reduce tbhp induced apoptosis and trigger insulin secretion in response to glucose, in a dose-dependent manner. |
2021-09-27 |
2023-08-13 |
Not clear |
| Giacoma Galizzi, Laura Palumbo, Antonella Amato, Alice Conigliaro, Domenico Nuzzo, Simona Terzo, Luca Caruana, Pasquale Picone, Riccardo Alessandro, Flavia Mulè, Marta Di Carl. Altered insulin pathway compromises mitochondrial function and quality control both in in vitro and in vivo model systems. Mitochondrion. vol 60. 2021-09-27. PMID:34454074. |
in vitro aβ insult induced the opening of mitochondrial permeability transition pore (mptp), mitochondrial membrane potential (ΔΨm) loss, and apoptosis while insulin addition ameliorated these dysfunctions. |
2021-09-27 |
2023-08-13 |
mouse |
| Waseem El-Huneidi, Shabana Anjum, Khuloud Bajbouj, Eman Abu-Gharbieh, Jalal Taneer. The Coffee Diterpene, Kahweol, Ameliorates Pancreatic β-Cell Function in Streptozotocin (STZ)-Treated Rat INS-1 Cells through NF-kB and p-AKT/Bcl-2 Pathways. Molecules (Basel, Switzerland). vol 26. issue 17. 2021-09-23. PMID:34500601. |
herein, by using clonal rat ins-1 (832/13) cells, we performed several functional experiments including; cell viability, apoptosis analysis, insulin secretion and glucose uptake measurements, reactive oxygen species (ros) production, as well as western blotting analysis to investigate the potential role of kahweol pre-treatment on damage induced by streptozotocin (stz) treatment. |
2021-09-23 |
2023-08-13 |
rat |
| Waseem El-Huneidi, Shabana Anjum, Khuloud Bajbouj, Eman Abu-Gharbieh, Jalal Taneer. The Coffee Diterpene, Kahweol, Ameliorates Pancreatic β-Cell Function in Streptozotocin (STZ)-Treated Rat INS-1 Cells through NF-kB and p-AKT/Bcl-2 Pathways. Molecules (Basel, Switzerland). vol 26. issue 17. 2021-09-23. PMID:34500601. |
ins-1 cells pre-incubated with different concentrations of kahweol (2.5 and 5 µm) for 24 h, then exposed to stz (3 mmol/l) for 3 h reversed the stz-induced effect on cell viability, apoptosis, insulin content, and secretion in addition to glucose uptake and ros production. |
2021-09-23 |
2023-08-13 |
rat |
| Waseem El-Huneidi, Shabana Anjum, Khuloud Bajbouj, Eman Abu-Gharbieh, Jalal Taneer. The Coffee Diterpene, Kahweol, Ameliorates Pancreatic β-Cell Function in Streptozotocin (STZ)-Treated Rat INS-1 Cells through NF-kB and p-AKT/Bcl-2 Pathways. Molecules (Basel, Switzerland). vol 26. issue 17. 2021-09-23. PMID:34500601. |
in conclusion, our study suggested that kahweol has anti-diabetic properties on pancreatic β-cells by suppressing stz induced apoptosis, increasing insulin secretion and glucose uptake. |
2021-09-23 |
2023-08-13 |
rat |
| Mona F Mahmoud, Shimaa Abdelaal, Heba Osama Mohammed, Assem M El-Shazly, Rachid Daoud, Mohamed A El Raey, Mansour Sobe. Syzygium jambos extract mitigates pancreatic oxidative stress, inflammation and apoptosis and modulates hepatic IRS-2/AKT/GLUT4 signaling pathway in streptozotocin-induced diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34463263. |
in the pancreatic and hepatic tissue of diabetic rats, sj effectively recovered pancreatic cells by reducing hyperglycemia through activating endogenous antioxidants, dynamic insulin production, and suppressing inflammation and apoptosis. |
2021-09-22 |
2023-08-13 |
rat |