| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhibiao Zhong, Weilan Su, Hongmei Che. MicroRNA‑532‑5p regulates oxidative stress and insulin secretion damage in high glucose‑induced pancreatic β cells by downregulating the expression levels of CCND1. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515323. |
overexpression of mir‑532‑5p could improve the hg‑induced decline in insulin secretion and inhibit hg‑induced oxidative stress and apoptosis in cells. |
2021-09-21 |
2023-08-13 |
Not clear |
| Zhibiao Zhong, Weilan Su, Hongmei Che. MicroRNA‑532‑5p regulates oxidative stress and insulin secretion damage in high glucose‑induced pancreatic β cells by downregulating the expression levels of CCND1. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515323. |
overexpression of mir‑532‑5p downregulated hg‑induced cell insulin secretion, oxidative stress and apoptosis by downregulating ccnd1, which is involved in regulating the expression of p53. |
2021-09-21 |
2023-08-13 |
Not clear |
| Nabila Bourebaba, Katarzyna Kornicka-Garbowska, Krzysztof Marycz, Lynda Bourebaba, Anna Kowalczu. Laurus nobilis ethanolic extract attenuates hyperglycemia and hyperinsulinemia-induced insulin resistance in HepG2 cell line through the reduction of oxidative stress and improvement of mitochondrial biogenesis - Possible implication in pharmacotherapy. Mitochondrion. vol 59. 2021-09-13. PMID:34091077. |
the aim of this study was to establish the potential effect of laurus nobilis ethanolic extract on improving insulin sensitivity and protecting liver cells from apoptosis, mitochondrial dysfunction, oxidative stress (os), and inflammation; all of which considered as major alterations occurring during insulin resistance (ir) as well as diabetes onset, in hyperinsulinemic and hyperglycemic-induced hepg2 cell line. |
2021-09-13 |
2023-08-13 |
Not clear |
| Yahong Cheng, Xin Zeng, Qianting Mai, Xinying Bai, Yuan Jiang, Jinjin Li, Shiqi Fan, Hong Din. Insulin injections inhibits PTZ-induced mitochondrial dysfunction, oxidative stress and neurological deficits via the SIRT1/PGC-1α/SIRT3 pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 6. 2021-09-10. PMID:33727197. |
this study was designed to evaluate the neuroprotective effects and underlying mechanisms of insulin on mitochondrial disruption, oxidative stress, cell apoptosis and neurological deficits after epilepsy seizures. |
2021-09-10 |
2023-08-13 |
mouse |
| Yahong Cheng, Xin Zeng, Qianting Mai, Xinying Bai, Yuan Jiang, Jinjin Li, Shiqi Fan, Hong Din. Insulin injections inhibits PTZ-induced mitochondrial dysfunction, oxidative stress and neurological deficits via the SIRT1/PGC-1α/SIRT3 pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 6. 2021-09-10. PMID:33727197. |
additionally, insulin pretreatment upregulated bcl-2, downregulated bax, and then played a neuroprotective role against hippocampal neuron apoptosis. |
2021-09-10 |
2023-08-13 |
mouse |
| Zhiqiang Fang, Guorui Dou, Lin Wan. MicroRNAs in the Pathogenesis of Nonalcoholic Fatty Liver Disease. International journal of biological sciences. vol 17. issue 7. 2021-09-10. PMID:33994867. |
here, we review the roles of mirnas in lipid metabolism, inflammation, apoptosis, fibrosis, hepatic stellate cell activation, insulin resistance, and oxidative stress, key factors that contribute to the occurrence and progression of nafld. |
2021-09-10 |
2023-08-13 |
Not clear |
| Louise Nugent, Boatemaa Ofori-Frimpong, Patricia E Martin, Colin R Green, Catherine S Wrigh. Cx31.1 expression is modulated in HaCaT cells exposed to UV-induced damage and scrape-wounding. Journal of cellular physiology. vol 236. issue 2. 2021-09-08. PMID:32592185. |
a hacat skin model investigated whether normal (ngi) and high glucose and insulin (hgi; diabetic) conditions altered cx31.1 expression, and if these were apoptosis linked. |
2021-09-08 |
2023-08-13 |
Not clear |
| Bo Zhang, Lingyun Hu, Jianying Zhang, Hui Wu, Wei Li, Lin Gou, Hao Li. Insulin growth factor-1 enhances proliferation and inhibits apoptosis of neural progenitor cells by phosphorylation of Akt/mTOR/p70S6K molecules and triggering intrinsic apoptosis signaling pathway. Cell and tissue banking. 2021-09-08. PMID:34494222. |
insulin growth factor-1 enhances proliferation and inhibits apoptosis of neural progenitor cells by phosphorylation of akt/mtor/p70s6k molecules and triggering intrinsic apoptosis signaling pathway. |
2021-09-08 |
2023-08-13 |
rat |
| Pegah Javadpour, Sahar Askari, Fatemeh Sadat Rashidi, Leila Dargahi, Abolhassan Ahmadiani, Rasoul Ghasem. Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: Possible contribution of MAPKs and insulin signaling. Behavioural brain research. vol 408. 2021-09-02. PMID:33775777. |
imipramine alleviates memory impairment and hippocampal apoptosis in stz-induced sporadic alzheimer's rat model: possible contribution of mapks and insulin signaling. |
2021-09-02 |
2023-08-13 |
rat |
| Alpana Mathur, Vivek Kumar Pandey, Mohammad Fareed Khan, Poonam Kakka. PHLPP1/Nrf2-Mdm2 axis induces renal apoptosis via influencing nucleo-cytoplasmic shuttling of FoxO1 during diabetic nephropathy. Molecular and cellular biochemistry. vol 476. issue 10. 2021-09-01. PMID:34057658. |
morin treatment under the experimental conditions, effectively decreased blood glucose levels, ameliorated insulin resistance, alleviated oxidative stress and attenuated renal apoptosis in diabetic rats comparable to metformin thereby exhibiting tremendous potential against renal complications of diabetes. |
2021-09-01 |
2023-08-13 |
rat |
| Mehdi Zobeiri, Fatemeh Parvizi, Mohammad Reza Kalhori, Mohammad Bagher Majnooni, Mohammad Hosein Farzaei, Mohammad Abdollah. Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-08-25. PMID:34426744. |
micrornas play essential roles in regulating the cell's biological processes, such as apoptosis, migration, lipid metabolism, insulin resistance, and adipocyte differentiation, by controlling the posttranscriptional gene expression level. |
2021-08-25 |
2023-08-13 |
Not clear |
| Nikolaos-Andreas T Anastasopoulos, Georgios D Lianos, Vera Tatsi, Anastasia Karampa, Anna Goussia, Georgios K Glantzouni. Clinical heterogeneity in patients with non-alcoholic fatty liver disease-associated hepatocellular carcinoma. Expert review of gastroenterology & hepatology. vol 14. issue 11. 2021-08-24. PMID:32746645. |
although the mechanisms of disease remain partially obscure, insulin resistance, oxidative stress, apoptosis, iron overload, and excessive local and systemic inflammation are identified as culprits for hepatocarcinogenesis in the presence of nafld. |
2021-08-24 |
2023-08-13 |
Not clear |
| Zi-Zhen Zhang, Gang Wang, Shan-Hui Yin, Xiao-Hua Y. Midkine: A multifaceted driver of atherosclerosis. Clinica chimica acta; international journal of clinical chemistry. vol 521. 2021-08-19. PMID:34331952. |
importantly, midkine exerts a proatherogenic effect by altering multiple pathophysiological processes involving atherogenesis, including macrophage lipid accumulation, vascular inflammation, neointima formation, insulin resistance and macrophage apoptosis. |
2021-08-19 |
2023-08-13 |
Not clear |
| Zi-Jun Sha, Cai-Feng Li, Shi-Huan Tang, Hong-Jun Yang, Yi Zhang, Zhi-Yong Li, Bin Yan. [Efficacy and mechanism of new resource medicinal materia Moringa oleifera leaves against hyperlipidemia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402268. |
the signaling pathway analysis of clusters showed that among the common pathways,nonalcoholic fatty liver,insulin resistance,mapk signaling pathway,estrogen signaling pathway,cell apoptosis and hif-1 signaling pathway were associated with hyperlipidemia. |
2021-08-18 |
2023-08-13 |
Not clear |
| Min Tan, Yanxiang Cheng, Xiaozhu Zhong, Dongyong Yang, Sushi Jiang, Yang Ye, Miao Ding, Guijun Guan, Dongzi Yang, Xiaomiao Zha. LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway. Aging. vol 13. issue 3. 2021-08-16. PMID:33495419. |
polycystic ovary syndrome (pcos), which is often accompanied by insulin resistance, is closely related to increased apoptosis of ovarian granulosa cells. |
2021-08-16 |
2023-08-13 |
Not clear |
| Roya Naderi, Alireza Shirpoor, Mahrokh Samadi, Bagher Pourheydar, Azam Mosleh. Tropisetron attenuates pancreas apoptosis in the STZ-induced diabetic rats: involvement of SIRT1/NF-κB signaling. Pharmacological reports : PR. vol 72. issue 6. 2021-08-12. PMID:32725585. |
type 1 diabetes mellitus (t1dm) is characterized by insulin deficiency and beta cells apoptosis. |
2021-08-12 |
2023-08-13 |
rat |
| Aline Fernandes-da-Silva, Carolline Santos Miranda, Daiana Araujo Santana-Oliveira, Brenda Oliveira-Cordeiro, Camilla Rangel-Azevedo, Flávia Maria Silva-Veiga, Fabiane Ferreira Martins, Vanessa Souza-Mell. Endoplasmic reticulum stress as the basis of obesity and metabolic diseases: focus on adipose tissue, liver, and pancreas. European journal of nutrition. vol 60. issue 6. 2021-08-12. PMID:33742254. |
the scientific community seeks strategies to alleviate er stress by avoiding inflammation, apoptosis, lipogenesis suppression, and insulin sensitivity augmentation through pharmacological and non-pharmacological interventions. |
2021-08-12 |
2023-08-13 |
Not clear |
| Chien-Ting Wu, Peter V Lidsky, Yinghong Xiao, Ivan T Lee, Ran Cheng, Tsuguhisa Nakayama, Sizun Jiang, Janos Demeter, Romina J Bevacqua, Charles A Chang, Robert L Whitener, Anna K Stalder, Bokai Zhu, Han Chen, Yury Goltsev, Alexandar Tzankov, Jayakar V Nayak, Garry P Nolan, Matthias S Matter, Raul Andino, Peter K Jackso. SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment. Cell metabolism. vol 33. issue 8. 2021-08-11. PMID:34081912. |
we demonstrated that sars-cov-2 infection attenuates pancreatic insulin levels and secretion and induces β cell apoptosis, each rescued by nrp1 inhibition. |
2021-08-11 |
2023-08-13 |
human |
| Jin Wang, Dan Li, Zhinan Zhang, Yan Zhang, Zhandong Lei, Wenwen Jin, Jimin Cao, Xiangying Jia. Autoantibody against angiotensin II type I receptor induces pancreatic β-cell apoptosis via enhancing autophagy. Acta biochimica et biophysica Sinica. vol 53. issue 6. 2021-08-10. PMID:33928341. |
at1-aa markedly reduced ins-1 cell viability, promoted cell apoptosis, and decreased insulin secretion in vitro. |
2021-08-10 |
2023-08-13 |
rat |
| Jin Wang, Dan Li, Zhinan Zhang, Yan Zhang, Zhandong Lei, Wenwen Jin, Jimin Cao, Xiangying Jia. Autoantibody against angiotensin II type I receptor induces pancreatic β-cell apoptosis via enhancing autophagy. Acta biochimica et biophysica Sinica. vol 53. issue 6. 2021-08-10. PMID:33928341. |
meanwhile, it was determined that treatment with autophagy inhibitor 3-methyladenine and angiotensin ii type 1 receptor (at1r) blocker telmisartan could improve insulin secretion and apoptosis in vitro and in vivo. |
2021-08-10 |
2023-08-13 |
rat |