| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minggang Cheng, Yichen Guo, Weichuan Zhong, Xueyan Chen, Guangzhou Gu. Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten. Biochemical genetics. 2021-06-04. PMID:34085179. |
mir-296-3p mimic significantly alleviated ua-induced pancreatic β-cells dysfunction, and pten-plasmid eliminated the protective effect of mir-296-3p on insulin release, cell viability, and apoptosis of pancreatic β-cells in ua-stimulated min6 cells. |
2021-06-04 |
2023-08-13 |
Not clear |
| Jing Wang, Zhichun Dong, Liyin Lou, Lijuan Yang, Jingying Qi. MiR-122 Participates in Oxidative Stress and Apoptosis in STZ-Induced Pancreatic International journal of endocrinology. vol 2021. 2021-06-01. PMID:34054947. |
finally, the addition of ly increased insulin levels; reduced the activities of sod, cat, and gsh-px; and promoted apoptosis in stz-induced ins-1 cells. |
2021-06-01 |
2023-08-13 |
cat |
| Tingxu Yan, Tingting Nian, Fuyuan Li, Bosai He, Ying Jia, Kaishun Bi, Zhenzhong Wan. Salidroside from Rhodiola wallichiana var. cholaensis reverses insulin resistance and stimulates the GLP-1 secretion by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Journal of food biochemistry. vol 44. issue 11. 2021-05-26. PMID:32910486. |
cholaensis reverses insulin resistance and stimulates the glp-1 secretion by alleviating ros-mediated activation of mapks signaling pathway and mitigating apoptosis. |
2021-05-26 |
2023-08-13 |
Not clear |
| Tingxu Yan, Tingting Nian, Fuyuan Li, Bosai He, Ying Jia, Kaishun Bi, Zhenzhong Wan. Salidroside from Rhodiola wallichiana var. cholaensis reverses insulin resistance and stimulates the GLP-1 secretion by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Journal of food biochemistry. vol 44. issue 11. 2021-05-26. PMID:32910486. |
furthermore, sal was found to be able to inhibit pa-induced apoptosis that down-regulates cleaved caspase-3 and bax expressions, while up-regulating bcl-2 expression and up-regulates the bcl-2/bax ratio in glucosamine induced insulin resistance model. |
2021-05-26 |
2023-08-13 |
Not clear |
| Tingxu Yan, Tingting Nian, Fuyuan Li, Bosai He, Ying Jia, Kaishun Bi, Zhenzhong Wan. Salidroside from Rhodiola wallichiana var. cholaensis reverses insulin resistance and stimulates the GLP-1 secretion by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Journal of food biochemistry. vol 44. issue 11. 2021-05-26. PMID:32910486. |
our data demonstrated that sal could reverse insulin resistance and stimulates the glp-1 secretion by alleviating ros-mediated activation of mapks signaling pathway and mitigating apoptosis. |
2021-05-26 |
2023-08-13 |
Not clear |
| Jiahua Zhang, Yubang Shen, Xiaoyan Xu, Yafan Dai, Jiale L. Transcriptome Analysis of the Liver and Muscle Tissues of Black Carp (Mylopharyngodon piceus) of Different Growth Rates. Marine biotechnology (New York, N.Y.). vol 22. issue 5. 2021-05-26. PMID:32914204. |
the kegg pathway analysis showed significant differences in the expression of some genes involved in growth- and development-related metabolic pathways such as the foxo signaling pathway, p53 signaling pathway, pi3k-akt signaling pathway, apoptosis, tgf-β signaling pathway, and insulin signaling pathway. |
2021-05-26 |
2023-08-13 |
Not clear |
| Jorge Berlanga-Acosta, Gerardo Guillén-Nieto, Nadia Rodríguez-Rodríguez, Maria Luisa Bringas-Vega, Diana García-Del-Barco-Herrera, Jorge O Berlanga-Saez, Ariana García-Ojalvo, Mitchell Joseph Valdés-Sosa, Pedro A Valdés-Sos. Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review. Frontiers in endocrinology. vol 11. 2021-05-21. PMID:33224105. |
insulin plays a major neuroprotective and trophic function for cerebral cell population, thus countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; and enhancing memory and learning processes. |
2021-05-21 |
2023-08-13 |
Not clear |
| Xiudan Li, Tingting Wan, Yanbo L. Role of FoxO1 in regulating autophagy in type 2 diabetes mellitus (Review). Experimental and therapeutic medicine. vol 22. issue 1. 2021-05-20. PMID:34007316. |
increasing evidence suggest that autophagy and foxo1 are involved in the pathogenesis of t2dm, including β-cell viability, apoptosis, insulin secretion and peripheral insulin resistance. |
2021-05-20 |
2023-08-13 |
Not clear |
| Cláudia Silva, Nelson Andrade, João Tiago Guimarães, Emília Patrício, Fátima Marte. The in vitro effect of the diabetes-associated markers insulin, leptin and oxidative stress on cellular characteristics promoting breast cancer progression is GLUT1-dependent. European journal of pharmacology. vol 898. 2021-05-19. PMID:33647254. |
our study aimed to investigate the in vitro effect of high levels of glucose, insulin, leptin, tnf-α, inf-γ and oxidative stress (induced with tert-butylhydroperoxide (tbh)), which are associated with t2dm, upon glucose uptake by breast cancer (mcf-7 and mda-mb-231) and non-cancer (mcf-12a) cells and to correlate this effect with their effects upon cellular characteristics associated with cancer progression (cell proliferation, viability, migration, angiogenesis and apoptosis). |
2021-05-19 |
2023-08-13 |
Not clear |
| Jie Meng, Lijun Wang, Chen Wang, Guangdong Zhao, Hongfang Wang, Baohua Xu, Xingqi Gu. AccPDIA6 from Apis cerana cerana plays important roles in antioxidation. Pesticide biochemistry and physiology. vol 175. 2021-05-18. PMID:33993956. |
its biological functions include modulating apoptosis, regulating the proliferation and invasion of cancer cells, supporting thrombosis and modulating insulin secretion. |
2021-05-18 |
2023-08-13 |
Not clear |
| Atefeh Pegah, Ebrahim Abbasi-Oshaghi, Iraj Khodadadi, Fatemeh Mirzaei, Heidar Tayebina. Probiotic and resveratrol normalize GLP-1 levels and oxidative stress in the intestine of diabetic rats. Metabolism open. vol 10. 2021-05-18. PMID:33997755. |
one of the important incretins in the improvement of diabetes is glucagon-like peptide (glp-1), which is secreted by the gut and reduces the apoptosis of pancreatic β-cells and improves insulin sensitivity. |
2021-05-18 |
2023-08-13 |
rat |
| Abdul Haye, Mohd Asif Ansari, Syed Obaidur Rahman, Yasmeen Shamsi, Danish Ahmed, Manju Sharm. Role of AMP-activated protein kinase on cardio-metabolic abnormalities in the development of diabetic cardiomyopathy: A molecular landscape. European journal of pharmacology. vol 888. 2021-05-17. PMID:32810493. |
during the development and progression of diabetic cardiomyopathy, a plethora of evidence demonstrate the beneficial role of ampk on cardio-metabolic abnormalities including altered substrate utilization, impaired cardiac insulin metabolic signaling, mitochondrial dysfunction and oxidative stress, myocardial inflammation, increased accumulation of advanced glycation end-products, impaired cardiac calcium handling, maladaptive activation of the renin-angiotensin-aldosterone system, endoplasmic reticulum stress, myocardial fibrosis, ventricular hypertrophy, cardiac apoptosis, and impaired autophagy. |
2021-05-17 |
2023-08-13 |
Not clear |
| Tao Zhang, Fen Qi. Icariin Protects Mouse Insulinoma Min6 Cell Function by Activating the PI3K/AKT Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-17. PMID:32885795. |
min6 cells were treated with ica for 2 h, followed by 5 mg/dl ua for 24 h, and cell viability, apoptosis, apoptosis-associated protein levels and insulin secretion were assessed by mtt, flow cytometry, western blotting and glucose-stimulated insulin secretion assays, respectively. |
2021-05-17 |
2023-08-13 |
mouse |
| Tao Zhang, Fen Qi. Icariin Protects Mouse Insulinoma Min6 Cell Function by Activating the PI3K/AKT Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-17. PMID:32885795. |
ua decreased min6 cell viability, enhanced cell apoptosis and levels of cleaved caspase-3, and reduced pro-caspase3 levels and insulin secretion, with all of these effects reversed by ica in a dose-dependent manner. |
2021-05-17 |
2023-08-13 |
mouse |
| Kumar Ganesan, Kunka Mohanram Ramkumar, Baojun X. Vitexin restores pancreatic β-cell function and insulin signaling through Nrf2 and NF-κB signaling pathways. European journal of pharmacology. vol 888. 2021-05-17. PMID:32980348. |
our data suggest that vitexin improves insulin secretion by activating key proteins, including nf-κb and nrf2 in β-cells regulating apoptosis. |
2021-05-17 |
2023-08-13 |
Not clear |
| Xuesheng Pan, Yueqin Zhu, Xian Wu, Lan Liu, Ruixue Ying, Lili Wang, Na Du, Jin Zhang, Juan Jin, Xiaoming Meng, Fang Dai, Yan Huan. The interaction of ASIC1a and ERS mediates nerve cell apoptosis induced by insulin deficiency. European journal of pharmacology. vol 893. 2021-05-17. PMID:33345857. |
the interaction of asic1a and ers mediates nerve cell apoptosis induced by insulin deficiency. |
2021-05-17 |
2023-08-13 |
Not clear |
| Xuesheng Pan, Yueqin Zhu, Xian Wu, Lan Liu, Ruixue Ying, Lili Wang, Na Du, Jin Zhang, Juan Jin, Xiaoming Meng, Fang Dai, Yan Huan. The interaction of ASIC1a and ERS mediates nerve cell apoptosis induced by insulin deficiency. European journal of pharmacology. vol 893. 2021-05-17. PMID:33345857. |
in this study, we demonstrated that insulin deficiency was involved in the apoptosis of nerve cells, and it was related to the interaction between acid-sensitive ion channel 1a (asic1a) and endoplasmic reticulum stress (ers). |
2021-05-17 |
2023-08-13 |
Not clear |
| Xuesheng Pan, Yueqin Zhu, Xian Wu, Lan Liu, Ruixue Ying, Lili Wang, Na Du, Jin Zhang, Juan Jin, Xiaoming Meng, Fang Dai, Yan Huan. The interaction of ASIC1a and ERS mediates nerve cell apoptosis induced by insulin deficiency. European journal of pharmacology. vol 893. 2021-05-17. PMID:33345857. |
further research found that the binding of chop and c/ebpα was increased in the nucleus of cells cultured without insulin, and c/ebpα was competitively inhibited as a negative regulator of asic1a, which further increased the ers and lead to neuronal apoptosis. |
2021-05-17 |
2023-08-13 |
Not clear |
| Mengmeng Yang, Yixin Cui, Jia Song, Chen Cui, Lingshu Wang, Kai Liang, Chuan Wang, Sha Sha, Qin He, Huiqing Hu, Xinghong Guo, Nan Zang, Lei Sun, Li Che. Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. Biochemical and biophysical research communications. vol 546. 2021-05-17. PMID:33578292. |
our results demonstrated that msc-cm improved insulin resistance in diabetic mice, amended the pathological structure of the liver, enhanced the liver's total antioxidant capacity and mitochondrial function, reduced inflammation and cell apoptosis. |
2021-05-17 |
2023-08-13 |
mouse |
| Jing-Yi Liu, Yi-Chen Zhang, Rong-Rong Xie, Li-Ni Song, Wei-Li Yang, Zhong Xin, Xi Cao, Jin-Kui Yan. Nifuroxazide improves insulin secretion and attenuates high glucose-induced inflammation and apoptosis in INS-1 cells. European journal of pharmacology. vol 899. 2021-05-17. PMID:33745960. |
nifuroxazide improves insulin secretion and attenuates high glucose-induced inflammation and apoptosis in ins-1 cells. |
2021-05-17 |
2023-08-13 |
cat |