| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing-Yi Liu, Yi-Chen Zhang, Rong-Rong Xie, Li-Ni Song, Wei-Li Yang, Zhong Xin, Xi Cao, Jin-Kui Yan. Nifuroxazide improves insulin secretion and attenuates high glucose-induced inflammation and apoptosis in INS-1 cells. European journal of pharmacology. vol 899. 2021-05-17. PMID:33745960. |
in conclusion, nifu can significantly improve the insulin secretion function, protect oxidative stress injury, and reduce inflammatory response and apoptosis in high glucose-induced ins-1 cells. |
2021-05-17 |
2023-08-13 |
cat |
| Min Wang, Jilou Wei, Ting Ji, Kui Zan. miRNA-770-5p expression is upregulated in patients with type 2 diabetes and miRNA-770-5p knockdown protects pancreatic β-cell function via targeting BAG5 expression. Experimental and therapeutic medicine. vol 22. issue 1. 2021-05-16. PMID:33986829. |
min6 cells were transfected with mir-770-5p inhibitor or mir-770-5p inhibitor + bag5-sirna for 48 h, followed by treatment with or without 5 mg/dl ua for 24 h. cell viability, apoptosis, apoptosis-related factor expression levels and insulin secretion were assessed. |
2021-05-16 |
2023-08-13 |
human |
| Min Wang, Jilou Wei, Ting Ji, Kui Zan. miRNA-770-5p expression is upregulated in patients with type 2 diabetes and miRNA-770-5p knockdown protects pancreatic β-cell function via targeting BAG5 expression. Experimental and therapeutic medicine. vol 22. issue 1. 2021-05-16. PMID:33986829. |
the results demonstrated that ua treatment significantly reduced cell viability, increased cell apoptosis and reduced insulin secretion in min6 cells compared with the control group. |
2021-05-16 |
2023-08-13 |
human |
| Min Wang, Jilou Wei, Ting Ji, Kui Zan. miRNA-770-5p expression is upregulated in patients with type 2 diabetes and miRNA-770-5p knockdown protects pancreatic β-cell function via targeting BAG5 expression. Experimental and therapeutic medicine. vol 22. issue 1. 2021-05-16. PMID:33986829. |
in ua-treated pancreatic β-cells, compared with the inhibitor control group, mir-770-5p knockdown regulated the expression of apoptosis-related genes, increased cell viability, inhibited cell apoptosis and increased insulin secretion by targeting bag5. |
2021-05-16 |
2023-08-13 |
human |
| Ali Al-Yasari, Shaima Jabbar, Miguel A Cabrera, Benedicte Rousseau, Dipak K Sarka. Preconception Alcohol Exposure Increases the Susceptibility to Diabetes in the Offspring. Endocrinology. vol 162. issue 1. 2021-05-14. PMID:33057655. |
these rats also showed increased levels of inflammatory cytokines and cellular apoptosis in the pancreas, altered insulin production and actions in the liver, and a reduced number of proopiomelanocortin neurons in the hypothalamus. |
2021-05-14 |
2023-08-13 |
rat |
| Cajsa Davegårdh, Johanna Säll, Anna Benrick, Christa Broholm, Petr Volkov, Alexander Perfilyev, Tora Ida Henriksen, Yanling Wu, Line Hjort, Charlotte Brøns, Ola Hansson, Maria Pedersen, Jens U Würthner, Klaus Pfeffer, Emma Nilsson, Allan Vaag, Elisabet Stener-Victorin, Karolina Pircs, Camilla Scheele, Charlotte Lin. VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics. Nature communications. vol 12. issue 1. 2021-05-10. PMID:33893273. |
vps39 knockdown in human myoblasts has profound effects on autophagic flux, insulin signaling, epigenetic enzymes, dna methylation and expression of myogenic regulators, and gene sets related to the cell cycle, muscle structure and apoptosis. |
2021-05-10 |
2023-08-13 |
human |
| David J Hil. Impact of the exposome on the development and function of pancreatic β-cells. Molecular aspects of medicine. 2021-05-09. PMID:33965231. |
cellular limitations to plasticity include the balance between β-cell proliferation and apoptosis, the appearance of β-cell oxidative stress, impaired glucose-stimulated insulin secretion, and sensitivity to circulating cytokines and responsiveness to programmed death receptor-1. |
2021-05-09 |
2023-08-13 |
human |
| Yuan-Cai Zheng, Yi-Ling Feng, Yi-Hong Wang, Li-Jun Kong, Ming-Shi Zhou, Min-Min Wu, Cheng-Yang Liu, Hua-Chun Weng, Hong-Wei Wan. Islet transplantation ameliorates diabetes-induced testicular interstitial fibrosis and is associated with inhibition of TGF-β1/Smad2 pathway in a rat model of type 1 diabetes. Molecular medicine reports. vol 23. issue 5. 2021-05-07. PMID:33760134. |
it was more effective than insulin treatment in ameliorating diabetic-induced testicular interstitial fibrosis, leydig cells apoptosis, testosterone deficiency and poor sperm motility. |
2021-05-07 |
2023-08-13 |
rat |
| Mervat H El-Saka, Rehab E Abo El Gheit, Amira El Saadany, Ghada Mahmoud Alghazaly, Karima E Marea, Nermin M Mad. Effect of spexin on renal dysfunction in experimentally obese rats: potential mitigating mechanisms via galanin receptor-2. Archives of physiology and biochemistry. 2021-05-06. PMID:33632048. |
spx improved insulin resistance, dyslipidemia, renal oxidative stress, inflammation, apoptosis, and fibrosis. |
2021-05-06 |
2023-08-13 |
rat |
| Sara L Anacleto, Dragan Milenkovic, Paul A Kroon, Paul W Needs, Franco Maria Lajolo, Neuza M A Hassimott. Citrus flavanone metabolites protect pancreatic-β cells under oxidative stress induced by cholesterol. Food & function. vol 11. issue 10. 2021-05-04. PMID:32959863. |
moreover, all the flavanone metabolites improved mitochondrial function and insulin secretion, and reduced apoptosis. |
2021-05-04 |
2023-08-13 |
Not clear |
| Zhihui Huang, Aijun Ma, Shuangshuang Yang, Xiaofei Liu, Tingting Zhao, Jinsheng Zhang, Xin-An Wang, Zhibin Sun, Zhifeng Liu, Rongjing X. Transcriptome analysis and weighted gene co-expression network reveals potential genes responses to heat stress in turbot Scophthalmus maximus. Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 33. 2021-05-04. PMID:31715507. |
accordingly, enrichment analyses of go terms and kegg pathways showed that several pathways (e.g., fat metabolism, cell apoptosis, immune system, and insulin signaling) may be involved in the response of turbot to heat stress. |
2021-05-04 |
2023-08-13 |
Not clear |
| Prarambh S R Dwivedi, Pukar Khanal, Vishakha Parab Gaonkar, V P Rasal, B M Pati. Identification of PTP1B regulators from In silico pharmacology. vol 9. issue 1. 2021-05-02. PMID:33928007. |
identification of ptp1b regulators from ptp1b is identified as the insulin signaling pathway downregulator; involved in pancreatic β-cell apoptosis. |
2021-05-02 |
2023-08-13 |
Not clear |
| L Jotha-Mattos, A B Vieira, M da S M Castelo, A S de M Queiroz, H J M de Souza, N X de Alencar, L M T R Lim. Amyloidogenesis of feline amylin and plasma levels in cats with diabetes mellitus or pancreatitis. Domestic animal endocrinology. vol 74. 2021-04-29. PMID:32841886. |
amylin is a pancreatic hormone cosecreted along with insulin and involved in pancreatic amyloidosis and β-cell apoptosis in diabetic cats and humans. |
2021-04-29 |
2023-08-13 |
human |
| Ahmad Kobiita, Svenja Godbersen, Elisa Araldi, Umesh Ghoshdastider, Marc W Schmid, Giatgen Spinas, Holger Moch, Markus Stoffe. The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress. Cell reports. vol 32. issue 1. 2021-04-28. PMID:32640216. |
excessive and long-lasting stimulation of insulin secretion can elicit endoplasmic reticulum (er) stress, unfolded protein response, and β-cell apoptosis. |
2021-04-28 |
2023-08-13 |
human |
| Ruan Carlos Macêdo de Moraes, Monique Patricio Singulani, Alisson Carvalho de Gonçalves, Guilherme Vannucchi Portari, Andrea da Silva Torrã. Oral benfotiamine reverts cognitive deficit and increase thiamine diphosphate levels in the brain of a rat model of neurodegeneration. Experimental gerontology. vol 141. 2021-04-27. PMID:32987117. |
this led to an improvement in mitochondria enzymes and insulin signaling pathway, with inactivation of gsk3α/β and erk1/2, which are two tau-kinases related to the progression of ad, which could decrease tau hyperphosphorylation and apoptosis signaling. |
2021-04-27 |
2023-08-13 |
rat |
| Antonia Diaz-Ganete, Aranzazu Quiroga-de-Castro, Rosa M Mateos, Francisco Medina, Carmen Segundo, Alfonso M Lechuga-Sanch. Toxicity Induced by Cytokines, Glucose, and Lipids Increase Apoptosis and Hamper Insulin Secretion in the 1.1E7 Beta Cell-Line. International journal of molecular sciences. vol 22. issue 5. 2021-04-26. PMID:33806355. |
toxicity induced by cytokines, glucose, and lipids increase apoptosis and hamper insulin secretion in the 1.1e7 beta cell-line. |
2021-04-26 |
2023-08-13 |
human |
| Antonia Diaz-Ganete, Aranzazu Quiroga-de-Castro, Rosa M Mateos, Francisco Medina, Carmen Segundo, Alfonso M Lechuga-Sanch. Toxicity Induced by Cytokines, Glucose, and Lipids Increase Apoptosis and Hamper Insulin Secretion in the 1.1E7 Beta Cell-Line. International journal of molecular sciences. vol 22. issue 5. 2021-04-26. PMID:33806355. |
under these conditions, we measured cell viability and apoptosis (mtt, caspase glo and tunel assays, as well as caspase-8 and -9 levels by western blotting), endoplasmic reticulum stress markers (eif2ak3, hspa4, eif2a, and hspa5) by real-time pcr, and insulin secretion with a glucose challenge. |
2021-04-26 |
2023-08-13 |
human |
| Antonia Diaz-Ganete, Aranzazu Quiroga-de-Castro, Rosa M Mateos, Francisco Medina, Carmen Segundo, Alfonso M Lechuga-Sanch. Toxicity Induced by Cytokines, Glucose, and Lipids Increase Apoptosis and Hamper Insulin Secretion in the 1.1E7 Beta Cell-Line. International journal of molecular sciences. vol 22. issue 5. 2021-04-26. PMID:33806355. |
all of these stimuli (i) induce apoptosis and er stress markers expression, (ii) reduce mrna amounts of 2-5 components of genes involved in the insulin secretory pathway, and (iii) abrogate the insulin release capability of 1.1e7 cells in response to glucose. |
2021-04-26 |
2023-08-13 |
human |
| Zitai Guo, Shengtao Gao, Jialiang Ouyang, Lu Ma, Dengpan B. Impacts of Heat Stress-Induced Oxidative Stress on the Milk Protein Biosynthesis of Dairy Cows. Animals : an open access journal from MDPI. vol 11. issue 3. 2021-04-13. PMID:33800015. |
the os induced by hs likely contributes to the reduction in milk protein content, since insulin resistance and apoptosis are promoted by os and are negatively associated with the synthesis of milk proteins. |
2021-04-13 |
2023-08-13 |
Not clear |
| Zitai Guo, Shengtao Gao, Jialiang Ouyang, Lu Ma, Dengpan B. Impacts of Heat Stress-Induced Oxidative Stress on the Milk Protein Biosynthesis of Dairy Cows. Animals : an open access journal from MDPI. vol 11. issue 3. 2021-04-13. PMID:33800015. |
the apoptosis in the mammary gland directly decreases the amount of mammary epithelial cells, while the insulin resistance affects the regulation of insulin on mtor pathways. |
2021-04-13 |
2023-08-13 |
Not clear |