| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas Prudhomme, Karine Renaudin, Maria Letizia Lo Faro, Diego Cantarovich, Delphine Kervella, David Minault, Jérémy Hervouet, Stéphanie Le Bas-Bernardet, Georges Karam, Gilles Blancho, Julien Brancherea. Ex situ hypothermic perfusion of nonhuman primate pancreas: A feasibility study. Artificial organs. vol 44. issue 7. 2021-04-12. PMID:31995645. |
at 25 mm hg pp, focal congestion of islets appeared after 12-h. immunostaining for insulin, glucagon, and somatostatin was normal and similar in controls and perfused pancreas transplants even after 24-h. apoptosis index represented by cleaved caspase 3 activity, was less than 1% in perfusion and control groups, even after 24-h. hp of nonhuman primate pancreas is feasible and not deleterious as far as 24-h compared to scs. |
2021-04-12 |
2023-08-13 |
Not clear |
| b' Kamila Pucha\\xc5\\x82owicz, Monika Ewa Ra\\xc4\\x8. The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications-Update in Pathogenesis, Treatment and Monitoring. Cells. vol 9. issue 8. 2021-04-12. PMID:32796572.' |
the detrimental effects of cd36 signaling are mediated by the uptake of fatty acids and modified lipoproteins, deposition of lipids and their lipotoxicity, alterations in insulin response and the utilization of energy substrates, oxidative stress, inflammation, apoptosis, and fibrosis leading to the progressive, often irreversible organ dysfunction. |
2021-04-12 |
2023-08-13 |
Not clear |
| Li Zhang, Lianfeng Shi, Juanjuan Han, Zhenzuo L. Protection of β-pancreatic cells from dysfunctionality of insulin using vitexin by apoptosis of INS-1 cells. Archives of physiology and biochemistry. 2021-04-09. PMID:33835897. |
protection of β-pancreatic cells from dysfunctionality of insulin using vitexin by apoptosis of ins-1 cells. |
2021-04-09 |
2023-08-13 |
Not clear |
| Hyun Kyu Ahn, Young Hwa Lee, Kyo Chul Ko. Current Status and Application of Metformin for Prostate Cancer: A Comprehensive Review. International journal of molecular sciences. vol 21. issue 22. 2021-04-05. PMID:33198356. |
liver kinase b1 (lkb1) and adenosine monophosphate-activated protein kinase (ampk) activation, inhibition of the mammalian target of rapamycin (mtor) activity and protein synthesis, induction of apoptosis and autophagy by p53 and p21, and decreased blood insulin level have been suggested as direct anti-cancer mechanisms of metformin. |
2021-04-05 |
2023-08-13 |
Not clear |
| Jinkyung Cho, Youngju Choi, Pavol Sajgalik, Mi-Hyun No, Sang-Hyun Lee, Sujin Kim, Jun-Won Heo, Eun-Jeong Cho, Eunwook Chang, Ju-Hee Kang, Hyo-Bum Kwak, Dong-Ho Par. Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms. Cells. vol 9. issue 10. 2021-04-02. PMID:33066240. |
therefore, here, we review the pathophysiological mechanisms underlying sarcopenia in hf as well as current knowledge regarding the beneficial effects of exercise on sarcopenia in hf and related mechanisms, including hormonal changes, myostatin, oxidative stress, inflammation, apoptosis, autophagy, the ubiquitin-proteasome system, and insulin resistance. |
2021-04-02 |
2023-08-13 |
Not clear |
| Qinjie Weng, Mengting Zhao, Jiahuan Zheng, Lijun Yang, Zijie Xu, Zhikang Zhang, Jincheng Wang, Jiajia Wang, Bo Yang, Q Richard Lu, Meidan Ying, Qiaojun H. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation. vol 27. issue 1. 2021-04-02. PMID:31097787. |
notably, the defective secretion of insulin and β-cells apoptosis was completely rescued by pten ablation in stat3-null islets or pten inhibitor bpv(phen) treatment. |
2021-04-02 |
2023-08-13 |
mouse |
| Xue Wang, Xue-Liang Yang, Ke-Chun Liu, Wen-Long Sheng, Qing Xia, Rong-Chun Wang, Xi-Qiang Chen, Yun Zhan. Effects of streptozotocin on pancreatic islet β-cell apoptosis and glucose metabolism in zebrafish larvae. Fish physiology and biochemistry. vol 46. issue 3. 2021-04-01. PMID:31993854. |
obvious apoptosis signals were also observed in the location of pancreatic islet, and insulin content decreased to be undetectable in stz-injected larvae. |
2021-04-01 |
2023-08-13 |
zebrafish |
| Tina Dahlby, Christian Simon, Marie Balslev Backe, Mattias Salling Dahllöf, Edward Holson, Bridget K Wagner, Marianne Böni-Schnetzler, Michal Tomasz Marzec, Morten Lundh, Thomas Mandrup-Poulse. Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in β-Cells. International journal of molecular sciences. vol 21. issue 21. 2021-03-29. PMID:33137873. |
we conclude that ezh2 deficiency protects from glucolipotoxicity-induced er stress, apoptosis and downregulation of the non-canonical nfκb pathway, but not from insulin secretory dysfunction. |
2021-03-29 |
2023-08-13 |
human |
| Lavi Rani, Sanjay Saini, Neha Shukla, Debapratim Kar Chowdhuri, Naveen Kumar Gauta. High sucrose diet induces morphological, structural and functional impairments in the renal tubules of Drosophila melanogaster: A model for studying type-2 diabetes mediated renal tubular dysfunction. Insect biochemistry and molecular biology. vol 125. 2021-03-26. PMID:32735915. |
impaired insulin signaling, oxidative stress, enhanced levels of age-rage and induction of apoptosis were observed in the mts of these flies. |
2021-03-26 |
2023-08-13 |
drosophila_melanogaster |
| Tsun-Jui Liu, Yueh-Chiao Yeh, Wen-Lieng Lee, Li-Chuan Wang, Hsiao-Wei Lee, Miau-Tsz Shiu, Chieh-Shou Su, Hui-Chin La. Insulin ameliorates hypoxia-induced autophagy, endoplasmic reticular stress and apoptosis of myocardial cells: In vitro and ex vivo models. European journal of pharmacology. vol 880. 2021-03-24. PMID:32360347. |
insulin ameliorates hypoxia-induced autophagy, endoplasmic reticular stress and apoptosis of myocardial cells: in vitro and ex vivo models. |
2021-03-24 |
2023-08-13 |
rat |
| Tsun-Jui Liu, Yueh-Chiao Yeh, Wen-Lieng Lee, Li-Chuan Wang, Hsiao-Wei Lee, Miau-Tsz Shiu, Chieh-Shou Su, Hui-Chin La. Insulin ameliorates hypoxia-induced autophagy, endoplasmic reticular stress and apoptosis of myocardial cells: In vitro and ex vivo models. European journal of pharmacology. vol 880. 2021-03-24. PMID:32360347. |
on the other hand, insulin pretreatment effectively ameliorated autophagy via pi3-k/akt signaling pathway, suppressed er stress, and prevented hypoxia-induced cellular apoptosis. |
2021-03-24 |
2023-08-13 |
rat |
| Tsun-Jui Liu, Yueh-Chiao Yeh, Wen-Lieng Lee, Li-Chuan Wang, Hsiao-Wei Lee, Miau-Tsz Shiu, Chieh-Shou Su, Hui-Chin La. Insulin ameliorates hypoxia-induced autophagy, endoplasmic reticular stress and apoptosis of myocardial cells: In vitro and ex vivo models. European journal of pharmacology. vol 880. 2021-03-24. PMID:32360347. |
in conclusion, hypoxia impedes cell viability through triggering autophagy, er stress and apoptosis, whereas insulin pretreatment effectively prevents these cytotoxic actions of hypoxia, preserves myocardial cell viability and reduces myocardial infarct size. |
2021-03-24 |
2023-08-13 |
rat |
| Yinqin Cheng, Qiaosheng Hu, Jie Zho. Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic β cell injury and enhances insulin secretory capacity by regulating miR-181a-5p. Canadian journal of physiology and pharmacology. vol 99. issue 3. 2021-03-22. PMID:32758099. |
after pvt1-knockdown, cell apoptosis, the contents of oxidative stress related markers, and changes in insulin secretion were detected. |
2021-03-22 |
2023-08-13 |
rat |
| Yinqin Cheng, Qiaosheng Hu, Jie Zho. Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic β cell injury and enhances insulin secretory capacity by regulating miR-181a-5p. Canadian journal of physiology and pharmacology. vol 99. issue 3. 2021-03-22. PMID:32758099. |
the rescue assays revealed that mir-181a-5p inhibitor dramatically abrogated the effects of pvt1 silencing on oxidative stress, apoptosis, and insulin secretion. |
2021-03-22 |
2023-08-13 |
rat |
| Yinqin Cheng, Qiaosheng Hu, Jie Zho. Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic β cell injury and enhances insulin secretory capacity by regulating miR-181a-5p. Canadian journal of physiology and pharmacology. vol 99. issue 3. 2021-03-22. PMID:32758099. |
taken together, these findings demonstrated that pvt1-knockdown could ameliorate stz-induced oxidative stress and apoptosis and elevate insulin secretory capacity in pancreatic β cells by regulating mir-181a-5p, suggesting a promising biomarker in dm diagnosis and treatment. |
2021-03-22 |
2023-08-13 |
rat |
| Jinwoo Park, Tae Woo Jung, Yoon Hee Chung, Eon Sub Park, Ji Hoon Jeon. 1,2-Dilinoleoyl-sn-glycero-3-phosphocholine increases insulin sensitivity in palmitate-treated myotubes and induces lipolysis in adipocytes. Biochemical and biophysical research communications. vol 533. issue 1. 2021-03-18. PMID:32943187. |
in conclusion, dlpc enhanced lipolysis and apoptosis via a tnfα-dependent pathway in adipocytes and attenuated palmitate-induced insulin resistance through pparα-mediated suppression of inflammation in myocytes. |
2021-03-18 |
2023-08-13 |
Not clear |
| Nianbin Song, Srona Sengupta, Stanislav Khoruzhenko, Robin A Welsh, AeRyon Kim, Mithra R Kumar, Søren Ulrik Sønder, John-William Sidhom, Hao Zhang, Chunfa Jie, Robert F Siliciano, Scheherazade Sadegh-Nasser. Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence. Cellular immunology. vol 357. 2021-03-09. PMID:32987276. |
we observed that differentiation into long lived memory cells is associated with increased expression of genes inhibiting cell proliferation and apoptosis as well as genes promoting dna repair response, lipid metabolism, and insulin resistance. |
2021-03-09 |
2023-08-13 |
mouse |
| Qin Sun, Tingxin Li, Yamei Li, Lingling Wei, Min Zhang, Shaoping Den. Bactericidal/Permeability-Increasing Protein Improves Cognitive Impairment in Diabetic Mice Frontiers in physiology. vol 11. 2021-03-03. PMID:33643054. |
hfd mice following lps treatment showed significantly increased serum levels of tumor necrosis factor-α (tnf-α), interleukin (il)-1β, and il-6, and expressions of bcl-2-associated x protein (bax) and aβ but decreased expression of bcl-2 in hippocampal tissues, as well as enhanced fasting blood glucose, plasma insulin, glucose tolerance, insulin tolerance, cell apoptosis, aggravated hippocampal tissue injury and, ultimately, cognitive impairment. |
2021-03-03 |
2023-08-13 |
mouse |
| H Yaribeygi, S Bo, M Ruscica, A Sahebka. Ceramides and diabetes mellitus: an update on the potential molecular relationships. Diabetic medicine : a journal of the British Diabetic Association. vol 37. issue 1. 2021-03-02. PMID:30803019. |
ceramides are primarily recognized as lipid bilayer building blocks, but recent work has shown that these endogenous molecules are important intracellular signalling mediators and may exert some diabetogenic effects via molecular pathways involved in insulin resistance, β-cell apoptosis and inflammation. |
2021-03-02 |
2023-08-13 |
Not clear |
| H Yaribeygi, S Bo, M Ruscica, A Sahebka. Ceramides and diabetes mellitus: an update on the potential molecular relationships. Diabetic medicine : a journal of the British Diabetic Association. vol 37. issue 1. 2021-03-02. PMID:30803019. |
specifically, the mechanistic evidence involves β-cell apoptosis, pancreatic inflammation, mitochondrial stress, endoplasmic reticulum stress, adipokine release, insulin receptor substrate 1 phosphorylation, oxidative stress and insulin synthesis. |
2021-03-02 |
2023-08-13 |
Not clear |