| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong Su Ha, Jin Yong Kang, Jeong Eun Kang, Seon Kyeong Park, Jong Min Kim, Chul-Woo Kim, Sung-Il Oh, Uk Lee, Dae-Ok Kim, Ho Jin He. Pentacyclic triterpenoid-rich fraction of the Hardy kiwi (Actinidia arguta) improves brain dysfunction in high fat diet-induced obese mice. Scientific reports. vol 10. issue 1. 2020-12-04. PMID:32238886. |
in addition, in a molecular biology study, it was observed that cfaa improves hfd-induced abnormal insulin signaling such as increase of irs phosphorylation at serine residues and reduction of akt phosphorylation caused by the increase of jnk phosphorylation and then inhibited apoptosis. |
2020-12-04 |
2023-08-13 |
mouse |
| Yue Hei Leung, Sonja Christiane Bäßler, Christian Koch, Theresa Scheu, Ulrich Meyer, Sven Dänicke, Korinna Huber, Ákos Kené. Sphingolipid Profiling Reveals Different Extent of Ceramide Accumulation in Bovine Retroperitoneal and Subcutaneous Adipose Tissues. Metabolites. vol 10. issue 11. 2020-12-01. PMID:33228142. |
sphingolipids are bioactive lipids that can modulate insulin sensitivity, cellular differentiation, and apoptosis in a tissue-specific manner. |
2020-12-01 |
2023-08-13 |
cattle |
| Yujie Chen, Wen Zhang, Bin Chen, Ying Liu, Yuhui Dong, Aimin Xu, Quan Ha. Crystal Structure of Human APPL BAR-PH Heterodimer Reveals a Flexible Dimeric BAR curve: Implication in Mutual Regulation of Endosomal Targeting. The Biochemical journal. 2020-12-01. PMID:33258922. |
and they play important roles in cell proliferation, apoptosis, glucose uptake, insulin secretion and sensitivity. |
2020-12-01 |
2023-08-13 |
human |
| Md Al-Tareq Mia, Md Golam Mosaib, Md Ibrahim Khalil, Md Asiful Islam, Siew Hua Ga. Potentials and Safety of Date Palm Fruit against Diabetes: A Critical Review. Foods (Basel, Switzerland). vol 9. issue 11. 2020-11-28. PMID:33126433. |
flavonoids in dates can stimulate β-cells by increasing the number of islets and β-cells, recovering endocrine pancreatic tissues, reducing β-cell apoptosis, activating insulin receptors following the increase in insulin secretion, in addition to improving diabetes-induced complications. |
2020-11-28 |
2023-08-13 |
human |
| Alexander E Berezin, Alexander A Berezin, Michael Lichtenaue. Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure Among Obese Patients With Prediabetes and Known Diabetes Mellitus. Frontiers in cardiovascular medicine. vol 7. 2020-11-27. PMID:33240938. |
however, systemic effects of white and brown adipose tissue can be different, and adipogenesis including browning of adipose tissue and deficiency of anti-inflammatory adipocytokines (visfatin, omentin, zinc-α2-glycoprotein, glypican-4) was frequently associated with adipose triglyceride lipase augmentation, altered glucose homeostasis, resistance to insulin of skeletal muscles, increased cardiomyocyte apoptosis, lowered survival, and weak function of progenitor endothelial cells, which could significantly influence on hf development, as well as end-organ fibrosis and multiple comorbidities. |
2020-11-27 |
2023-08-13 |
Not clear |
| Melvin R Hayde. An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms. Cells. vol 9. issue 11. 2020-11-25. PMID:33202960. |
this pandemic is associated with markedly elevated blood glucose levels and a remarkable degree of insulin resistance, which suggests pancreatic islet β-cell dysfunction or apoptosis and insulin's inability to dispose of glucose into cellular tissues. |
2020-11-25 |
2023-08-13 |
human |
| Jun Shirakawa, Yasuo Terauch. Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality. Endocrine journal. vol 67. issue 1. 2020-11-19. PMID:31694991. |
to investigate the mechanisms of glucose signaling in the regulation of β-cell functions, we analyzed the role of glucokinase in insulin secretion, β-cell proliferation and β-cell apoptosis, using β-cell-specific glucokinase-haploinsufficient (gck+/-) mice and allosteric glucokinase activators (gkas). |
2020-11-19 |
2023-08-13 |
mouse |
| Siddarth Agrawal, Marta Woźniak, Mateusz Łuc, Sebastian Makuch, Ewa Pielka, Anil Kumar Agrawal, Joanna Wietrzyk, Joanna Banach, Andrzej Gamian, Monika Pizon, Piotr Ziółkowsk. Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2. Scientific reports. vol 9. issue 1. 2020-11-10. PMID:31719636. |
to examine the effects of insulin on cell viability and apoptosis, we performed an in vitro analysis on colon cancer cell lines caco-2 and sw480. |
2020-11-10 |
2023-08-13 |
mouse |
| Aisha Osman, Tarek Benameur, Hesham M Korashy, Asad Zeidan, Abdelali Agoun. Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction. Biomedicines. vol 8. issue 10. 2020-11-03. PMID:33053883. |
er stress response by itself can result in endothelial dysfunction, a hallmark of cardiovascular disease, through various cellular mechanisms including apoptosis, insulin resistance, inflammation and oxidative stress. |
2020-11-03 |
2023-08-13 |
Not clear |
| Yukiko K Kaneko, Toshiyuki Kan, Tomohisa Ishikaw. [Citrus flavonoids as a target for the prevention of pancreatic β-cells dysfunction in diabetes.] Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 155. issue 4. 2020-11-02. PMID:32612030. |
we focused on β-cells and investigated the effects of nobiletin on insulin secretion and β-cell apoptosis. |
2020-11-02 |
2023-08-13 |
mouse |
| Ming Wang, Jihoon Jo, Juhyun Son. Adiponectin improves long-term potentiation in the 5XFAD mouse brain. Scientific reports. vol 9. issue 1. 2020-11-02. PMID:31222110. |
adiponectin is an adipokine that regulates apoptosis, glucose and lipid metabolism, and insulin sensitivity in metabolic diseases. |
2020-11-02 |
2023-08-13 |
mouse |
| Zhenkun Yang, Shuoxiong Wu, Jingjing Zhao, Zuoyu Wang, Min Yao, Peihua Lu, Wenyan Dong, Jie Su. Emulsified isoflurane protects beta cells against high glucose-induced apoptosis via inhibiting endoplasmic reticulum stress. Annals of palliative medicine. vol 9. issue 1. 2020-10-27. PMID:32005067. |
it has become evident that endoplasmic reticulum stress (ers)-induced apoptosis was contributed to beta cell dysfunction and insulin resistance. |
2020-10-27 |
2023-08-13 |
rat |
| Gerda M Sanvee, Jamal Bouitbir, Stephan Krähenbüh. Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31092879. |
decreased phosphorylation of akt at both phosphorylation sites and of downstream substrates as well as apoptosis were prevented concentration-dependently by insulin. |
2020-10-26 |
2023-08-13 |
Not clear |
| Gerda M Sanvee, Jamal Bouitbir, Stephan Krähenbüh. Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31092879. |
insulin could prevent the effects of simvastatin on the insulin signaling pathway and on apoptosis, but not on the endoplasmic reticulum (er) stress induction. |
2020-10-26 |
2023-08-13 |
Not clear |
| Somayeh Keshtkar, Maryam Kaviani, Zahra Jabbarpour, Bita Geramizadeh, Elahe Motevaseli, Saman Nikeghbalian, Alireza Shamsaeefar, Nasrin Motazedian, Ismail H Al-Abdullah, Mohammad Hossein Ghahremani, Negar Azarpir. Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31406275. |
then, the islets viability, apoptosis, insulin and c-peptide secretion, and apoptosis markers were evaluated. |
2020-10-26 |
2023-08-13 |
human |
| Enrique Jurado-Ruiz, Leticia Álvarez-Amor, Lourdes M Varela, Genoveva Berná, María S Parra-Camacho, María J Oliveras-Lopez, Enrique Martínez-Force, Anabel Rojas, Abdelkrim Hmadcha, Bernat Soria, Franz Martí. Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice. Scientific reports. vol 9. issue 1. 2020-10-23. PMID:31383924. |
moreover, evoo diets reduced β-cell apoptosis, increased β-cell number and normalized islet glucose metabolism and glucose induced insulin secretion. |
2020-10-23 |
2023-08-13 |
mouse |
| Chenglai Xia, Fang Yang, Zhihong He, Yantao Ca. iTRAQ-based quantitative proteomic analysis of the inhibition of cervical cancer cell invasion and migration by metformin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 123. 2020-10-22. PMID:31864213. |
our results indicate that metformin mainly regulates the insulin signaling pathway and interferes with cell proliferation and apoptosis to inhibit proliferation and invasion of cervical cancer cells. |
2020-10-22 |
2023-08-13 |
Not clear |
| Gregory B Li. MI causes insulin resistance via apoptosis of macrophages in VAT. Nature reviews. Cardiology. vol 17. issue 10. 2020-10-19. PMID:32753738. |
mi causes insulin resistance via apoptosis of macrophages in vat. |
2020-10-19 |
2023-08-13 |
Not clear |
| Ahmed M Sayed, Emad H M Hassanein, Shimaa H Salem, Omnia E Hussein, Ayman M Mahmou. Flavonoids-mediated SIRT1 signaling activation in hepatic disorders. Life sciences. vol 259. 2020-10-15. PMID:32750437. |
sirtuins are one of the main strategic controllers of different cellular processes, including cell cycle, mitochondrial biogenesis, insulin secretion, redox balance, inflammation, and apoptosis. |
2020-10-15 |
2023-08-13 |
Not clear |
| Teresa Vanessa Fiorentino, Francesca Casiraghi, Alberto M Davalli, Giovanna Finzi, Stefano La Rosa, Paul B Higgins, Gregory A Abrahamian, Alessandro Marando, Fausto Sessa, Carla Perego, Rodolfo Guardado-Mendoza, Subhash Kamath, Andrea Ricotti, Paolo Fiorina, Giuseppe Daniele, Ana M Paez, Francesco Andreozzi, Raul A Bastarrachea, Anthony G Comuzzie, Amalia Gastaldelli, Alberto O Chavez, Eliana S Di Cairano, Patrice Frost, Livio Luzi, Edward J Dick, Glenn A Halff, Ralph A DeFronzo, Franco Foll. Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas. JCI insight. vol 4. issue 20. 2020-10-15. PMID:31536476. |
herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons). |
2020-10-15 |
2023-08-13 |
Not clear |