| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiong Wang, Jing Shang, Yun Zhang, Wei Zho. Metformin and sitagliptin combination therapy ameliorates polycystic ovary syndrome with insulin resistance through upregulation of lncRNA H19. Cell cycle (Georgetown, Tex.). vol 18. issue 19. 2020-09-09. PMID:31405334. |
our results showed that co-treatment with tecos and dmbg attenuated the induced apoptosis and insulin resistance (ir) in pcos model cells, and improved reproductive hormone disorders, ovarian polycystic changes, and ir of pcos rats. |
2020-09-09 |
2023-08-13 |
human |
| Sujuan Ding, Sheng Xu, Yong Ma, Gang Liu, Hongmei Jang, Jun Fan. Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes. Biomolecules. vol 9. issue 12. 2020-09-02. PMID:31835423. |
this review summarizes the regulation of type 1 diabetes mellitus (t1dm) and type 2 diabetes mellitus (t2dm) by nlrp3 via modulation of glucose tolerance, insulin resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress in adipose tissue. |
2020-09-02 |
2023-08-13 |
mouse |
| Eugénie Koumakis, Joëlle Millet-Botti, Jamel El Benna, Christine Leroy, Valérie Boitez, Patrice Codogno, Gérard Friedlander, Anne Foran. Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing. Scientific reports. vol 9. issue 1. 2020-08-31. PMID:30755642. |
pit1/slc20a1 is an inorganic phosphate transporter with additional functions including the regulation of tnfα-induced apoptosis, erythropoiesis, cell proliferation and insulin signaling. |
2020-08-31 |
2023-08-13 |
Not clear |
| Xing Xiao, Pei Qiu, Hui-Zhen Gong, Xue-Ming Chen, Yan Sun, An Hong, Yi M. PACAP ameliorates hepatic metabolism and inflammation through up-regulating FAIM in obesity. Journal of cellular and molecular medicine. vol 23. issue 9. 2020-08-28. PMID:31270932. |
our previous study showed that fas apoptosis inhibitory molecule (faim) is a new mediator of akt2 signalling, increases the insulin signalling pathway and lipid metabolism. |
2020-08-28 |
2023-08-13 |
mouse |
| Shu-Hong Chen, Xiao-Nan Liu, Yan Pen. MicroRNA-351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus. Journal of cellular and molecular medicine. vol 23. issue 9. 2020-08-28. PMID:31287224. |
gestational diabetes mellitus mice were treated with a series of mimic, inhibitor and small interfering rna to explore the effect of mir-351 on insulin resistance (ir), cell apoptosis in pancreatic tissues and liver gluconeogenesis through evaluating gdm-related biochemical indexes, as well as expression of mir-351, flot2, pi3k/akt pathway-, ir- and liver gluconeogenesis-related genes. |
2020-08-28 |
2023-08-13 |
mouse |
| Shu-Hong Chen, Xiao-Nan Liu, Yan Pen. MicroRNA-351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus. Journal of cellular and molecular medicine. vol 23. issue 9. 2020-08-28. PMID:31287224. |
additionally, mir-351 overexpression and flot2 silencing decreased the levels of flot2, phosphoenolpyruvate carboxykinase, glucose-6-phosphatase, fasting blood glucose, fasting insulin, total cholesterol, triglyceride, glyeosylated haemoglobin and homeostasis model of assessment for ir index (homa-ir), extent of pi3k and akt phosphorylation, yet increased the levels of homa for islet β-cell function, homa for insulin sensitivity index and glucose transporter 2 expression, indicating reduced cell apoptosis in pancreatic tissues and alleviated ir and liver gluconeogenesis. |
2020-08-28 |
2023-08-13 |
mouse |
| Leticia P Roma, Jean-Christophe Jona. Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and β-Cells. Journal of molecular biology. vol 432. issue 5. 2020-08-28. PMID:31634466. |
this raised the controversial hypothesis that any attempt to decrease β-cell oxidative stress and apoptosis in t2d would further impair insulin secretion. |
2020-08-28 |
2023-08-13 |
Not clear |
| Laongdao Thongnak, Varanuj Chatsudthipong, Aphisek Kongkaew, Anusorn Lungkaphi. Effects of dapagliflozin and statins attenuate renal injury and liver steatosis in high-fat/high-fructose diet-induced insulin resistant rats. Toxicology and applied pharmacology. vol 396. 2020-08-20. PMID:32259528. |
dapagliflozin and combination treatment could improve hff-induced insulin resistance, lipogenesis and lipotoxicity-related renal oxidative stress, inflammation, fibrosis and apoptosis leading to kidney dysfunction recovery. |
2020-08-20 |
2023-08-13 |
rat |
| Laongdao Thongnak, Varanuj Chatsudthipong, Aphisek Kongkaew, Anusorn Lungkaphi. Effects of dapagliflozin and statins attenuate renal injury and liver steatosis in high-fat/high-fructose diet-induced insulin resistant rats. Toxicology and applied pharmacology. vol 396. 2020-08-20. PMID:32259528. |
therefore, dapagliflozin combined with atorvastatin treatment exert the beneficial effects on lipid metabolism and lipotoxicity in liver and kidney injury via the attenuation of oxidative stress, fibrosis and apoptosis in insulin resistant model. |
2020-08-20 |
2023-08-13 |
rat |
| Yazeid Alhaidan, Henrik Thybo Christesen, Kurt Højlund, Mohammed A Al Balwi, Klaus Brusgaar. A novel gene in early childhood diabetes: EDEM2 silencing decreases SLC2A2 and PXD1 expression, leading to impaired insulin secretion. Molecular genetics and genomics : MGG. vol 295. issue 5. 2020-08-06. PMID:32556999. |
in conclusion, we describe edem2 as a likely/potential novel diabetes gene, in which inhibition in vitro reduces the expression of β-cell genes involved in the glucose-stimulated insulin secretion (gsis) pathway, leading to an overall suppression of insulin secretion but not apoptosis. |
2020-08-06 |
2023-08-13 |
rat |
| Jiyin Zhou, Zuo Zhang, Hongli Zhou, Guisheng Qia. Diabetic Cognitive Dysfunction: From Bench to Clinic. Current medicinal chemistry. vol 27. issue 19. 2020-08-05. PMID:30727866. |
the pathogenesis of type 2 diabetes with cognitive dysfunction involves hyperglycaemia, macrovascular and microvascular diseases, insulin resistance, inflammation, apoptosis, and disorders of neurotransmitters. |
2020-08-05 |
2023-08-13 |
Not clear |
| Yanjiao Zhang, Runqing Xiang, Shandan Fang, Kuan Huang, Yuan Fan, Tao Li. Experimental Study on the Effect of Tibetan Medicine Triphala on the Proliferation and Apoptosis of Pancreatic Islet β Cells through Incretin-cAMP Signaling Pathway. Biological & pharmaceutical bulletin. vol 43. issue 2. 2020-08-04. PMID:31813891. |
it has been reported that enhancing the activity of incretin-camp signaling pathway can also promote islet β cell proliferation, reduce β cell apoptosis and promote insulin secretion (diabetologia, 59, 2016, iida et al.). |
2020-08-04 |
2023-08-13 |
rat |
| Anne Jörns, Dirk Wedekind, Joachim Jähne, Sigurd Lenze. Pancreas Pathology of Latent Autoimmune Diabetes in Adults (LADA) in Patients and in a LADA Rat Model Compared With Type 1 Diabetes. Diabetes. vol 69. issue 4. 2020-08-03. PMID:31974139. |
islets in human and rat pancreases were analyzed by immunohistochemistry for immune cell infiltrate composition, by in situ rt-pcr and quantitative real-time pcr of laser microdissected islets for gene expression of proinflammatory cytokines, the proliferation marker proliferating cell nuclear antigen (pcna), the anti-inflammatory cytokine interleukin (il) 10, and the apoptosis markers caspase 3 and tunel as well as insulin. |
2020-08-03 |
2023-08-13 |
human |
| Austin L Good, Doris A Stoffer. Stress-Induced Translational Regulation Mediated by RNA Binding Proteins: Key Links to β-Cell Failure in Diabetes. Diabetes. vol 69. issue 4. 2020-08-03. PMID:32198193. |
chronic exposure to stress causes impaired insulin secretion, apoptosis, and loss of cell identity, and a combination of these processes leads to β-cell failure and severe hyperglycemia. |
2020-08-03 |
2023-08-13 |
Not clear |
| Mengqiu Wu, Weiyi Chen, Shengnan Zhang, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Ji. Rotenone protects against β-cell apoptosis and attenuates type 1 diabetes mellitus. Apoptosis : an international journal on programmed cell death. vol 24. issue 11-12. 2020-08-03. PMID:31485878. |
type 1 diabetes mellitus (t1dm) is caused by pancreatic β-cell dysfunction and apoptosis, with consequent severe insulin deficiency. |
2020-08-03 |
2023-08-13 |
mouse |
| Mengqiu Wu, Weiyi Chen, Shengnan Zhang, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Ji. Rotenone protects against β-cell apoptosis and attenuates type 1 diabetes mellitus. Apoptosis : an international journal on programmed cell death. vol 24. issue 11-12. 2020-08-03. PMID:31485878. |
rot treatment exerted a hypoglycemic effect, restored the insulin level, and decreased inflammation and cell apoptosis in the pancreas. |
2020-08-03 |
2023-08-13 |
mouse |
| Yilu Chen, Xu Zh. Roles of Vitamin D in Reproductive Systems and Assisted Reproductive Technology. Endocrinology. vol 161. issue 4. 2020-07-31. PMID:32067036. |
vitamin d, an essential steroid hormone in the human body, plays an important role in not only the regulation of calcium and phosphorus metabolism, but also in various physiological processes, such as cell differentiation and apoptosis, inflammation, and insulin resistance. |
2020-07-31 |
2023-08-13 |
human |
| Na Han, Hai-Yan Fang, Jie-Xuan Jiang, Qian X. Downregulation of microRNA-873 attenuates insulin resistance and myocardial injury in rats with gestational diabetes mellitus by upregulating IGFBP2. American journal of physiology. Endocrinology and metabolism. vol 318. issue 5. 2020-07-29. PMID:31910027. |
in addition, the inhibition of mir-873 in gdm rats modulated the insulin resistance and reduced myocardial apoptosis. |
2020-07-29 |
2023-08-13 |
rat |
| Yunxia Zhu, Yi Sun, Yuncai Zhou, Yan Zhang, Tao Zhang, Yating Li, Weiyan You, Xiaoai Chang, Li Yuan, Xiao Ha. MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis. Journal of molecular cell biology. vol 11. issue 9. 2020-07-17. PMID:30753517. |
we found that mir-24 overabundance protected beta cells from thapsigargin-induced apoptosis at the cost of accelerating the impairment of glucose-stimulated insulin secretion (gsis) and enhancing the presence of dedifferentiation markers. |
2020-07-17 |
2023-08-13 |
Not clear |
| Myriam P Hoyeck, Hannah Blair, Muna Ibrahim, Shivani Solanki, Mariam Elsawy, Arina Prakash, Kayleigh R C Rick, Geronimo Matteo, Shannon O'Dwyer, Jennifer E Brui. Long-term metabolic consequences of acute dioxin exposure differ between male and female mice. Scientific reports. vol 10. issue 1. 2020-07-13. PMID:31996693. |
furthermore, a single high-dose of tcdd (200 µg/kg) suppressed both fasting and glucose-induced plasma insulin levels and promoted beta-cell apoptosis after 7 days in male mice. |
2020-07-13 |
2023-08-13 |
mouse |