| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anindya Ghosh, Shuiling Zhao, Chao-Sheng Lo, Hasna Maachi, Isabelle Chenier, Muhammad Abdul Lateef, Shaaban Abdo, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Cha. Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney. Scientific reports. vol 9. issue 1. 2020-10-14. PMID:31040360. |
we investigated the molecular mechanism(s) by which insulin prevents bcl2-modifying factor (bmf)-induced renal proximal tubular cell (rptc) apoptosis and loss in diabetic mice. |
2020-10-14 |
2023-08-13 |
mouse |
| Anindya Ghosh, Shuiling Zhao, Chao-Sheng Lo, Hasna Maachi, Isabelle Chenier, Muhammad Abdul Lateef, Shaaban Abdo, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Cha. Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney. Scientific reports. vol 9. issue 1. 2020-10-14. PMID:31040360. |
insulin treatment in akita mice and akita mice overexpressing hnrnp f suppressed bmf expression and rptc apoptosis. |
2020-10-14 |
2023-08-13 |
mouse |
| Anindya Ghosh, Shuiling Zhao, Chao-Sheng Lo, Hasna Maachi, Isabelle Chenier, Muhammad Abdul Lateef, Shaaban Abdo, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Cha. Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney. Scientific reports. vol 9. issue 1. 2020-10-14. PMID:31040360. |
our results demonstrate that hnrnp f suppression of bmf transcription is an important mechanism by which insulin protects rptcs from apoptosis in diabetes. |
2020-10-14 |
2023-08-13 |
mouse |
| Juwen C DuBois, Alex K Ray, Ross C Gruber, Yongwei Zhang, Ranee Aflakpui, Fernando Macian-Juan, Bridget Shafit-Zagard. Akt3-Mediated Protection Against Inflammatory Demyelinating Disease. Frontiers in immunology. vol 10. 2020-10-13. PMID:31404142. |
while the isoforms akt1 and akt2 are involved in apoptosis and insulin signaling, respectively, the role for akt3 remains uncertain. |
2020-10-13 |
2023-08-13 |
mouse |
| Maria Troullinaki, Lan-Sun Chen, Anke Witt, Iryna Pyrina, Julia Phieler, Ioannis Kourtzelis, Jindrich Chmelar, David Sprott, Bettina Gercken, Michael Koutsilieris, Triantafyllos Chavakis, Antonios Chatzigeorgio. Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 2. 2020-10-06. PMID:31916652. |
upon mlds induction, robo4-deficiency resulted in increased pancreatic vascular permeability, leukocyte infiltration to the islets and islet apoptosis, associated with reduced insulin levels and faster diabetes development. |
2020-10-06 |
2023-08-13 |
mouse |
| Li-Juan Cui, Tao Bai, Lin-Ping Zhi, Zhi-Hong Liu, Tao Liu, Huan Xue, Huan-Huan Yang, Xiao-Hua Yang, Min Zhang, Ya-Ru Niu, Yun-Feng Liu, Yi Zhan. Analysis of long noncoding RNA-associated competing endogenous RNA network in glucagon-like peptide-1 receptor agonist-mediated protection in β cells. World journal of diabetes. vol 11. issue 9. 2020-10-02. PMID:32994866. |
the use of glucagon-like peptide-1 receptor agonists (glp-1ras) is a novel therapeutic strategy that could promote insulin secretion and decrease the rate of β-cell apoptosis in type 2 diabetes mellitus (t2dm) patients. |
2020-10-02 |
2023-08-13 |
Not clear |
| Ke Xu, Dezhi Bian, Lanxiang Hao, Fei Huang, Min Xu, Jie Qin, Yanmei Li. microRNA-503 contribute to pancreatic beta cell dysfunction by targeting the mTOR pathway in gestational diabetes mellitus. EXCLI journal. vol 16. 2020-10-01. PMID:29285014. |
knockdown of mir-503 enhanced insulin secretion of pancreatic β-cells, promoted cell proliferation and protected cells from apoptosis, whereas overexpression of mir-503 showed the opposite effects. |
2020-10-01 |
2023-08-13 |
Not clear |
| Siyuan Kong, Jinxue Ruan, Kaiyi Zhang, Bingjun Hu, Yuzhu Cheng, Yubo Zhang, Shulin Yang, Kui L. Kill two birds with one stone: making multi-transgenic pre-diabetes mouse models through insulin resistance and pancreatic apoptosis pathogenesis. PeerJ. vol 6. 2020-10-01. PMID:29682407. |
kill two birds with one stone: making multi-transgenic pre-diabetes mouse models through insulin resistance and pancreatic apoptosis pathogenesis. |
2020-10-01 |
2023-08-13 |
mouse |
| Wen Pan, Yanan Zhang, Chun Zeng, Fen Xu, Jinhua Yan, Jianping Wen. miR-192 is upregulated in T1DM, regulates pancreatic β-cell development and inhibits insulin secretion through suppressing GLP-1 expression. Experimental and therapeutic medicine. vol 16. issue 3. 2020-10-01. PMID:30186503. |
collectively, the present results revealed that mir-192 was elevated in t1dm, and is implicated in pancreatic β-cell development through regulation of cell proliferation and apoptosis, thereby suppressing insulin secretion. |
2020-10-01 |
2023-08-13 |
rat |
| Minsun Kim, Qing Cai, Youngman O. Therapeutic potential of alpha-1 antitrypsin in human disease. Annals of pediatric endocrinology & metabolism. vol 23. issue 3. 2020-10-01. PMID:30286568. |
in addition, aat treatment can prevent overt hyperglycemia, increase insulin secretion, and reduce cytokine-mediated apoptosis of pancreatic β-cells in diabetes. |
2020-10-01 |
2023-08-13 |
human |
| Rana Malekiyan, Alireza Abdanipour, Davood Sohrabi, Iraj Jafari Anarkool. Antioxidant and neuroprotective effects of lycopene and insulin in the hippocampus of streptozotocin-induced diabetic rats. Biomedical reports. vol 10. issue 1. 2020-10-01. PMID:30588303. |
in the present study the antioxidant and neuroprotective effects of insulin and lycopene on passive avoidance memory, total antioxidant capacity (tac), malondialdehyde activity (mda) and prevention of apoptosis in the hippocampus streptozotocin-induced diabetic rats were examined. |
2020-10-01 |
2023-08-13 |
rat |
| Miruna Nemecz, Alina Constantin, Madalina Dumitrescu, Nicoleta Alexandru, Alexandru Filippi, Gabriela Tanko, Adriana Georgesc. The Distinct Effects of Palmitic and Oleic Acid on Pancreatic Beta Cell Function: The Elucidation of Associated Mechanisms and Effector Molecules. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30719005. |
to address this problem, the oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis and their mediator molecules have been investigated in the insulin releasing beta cells exposed to palmitic and/or oleic acid. |
2020-10-01 |
2023-08-13 |
human |
| Mette Eskild Bornstedt, Nina Gjerlaugsen, Milaim Pepaj, May K L Bredahl, Per M Thorsb. Vitamin D Increases Glucose Stimulated Insulin Secretion from Insulin Producing Beta Cells (INS1E). International journal of endocrinology and metabolism. vol 17. issue 1. 2020-10-01. PMID:30881469. |
vitamin d affects the pancreatic beta cell function and in vitro studies have shown that vitamin d may influence insulin secretion, apoptosis, and gene regulation. |
2020-10-01 |
2023-08-13 |
Not clear |
| Qingxue Li, Shaohui Jia, Lei Xu, Biao Li, Ning Che. Metformin-induced autophagy and irisin improves INS-1 cell function and survival in high-glucose environment via AMPK/SIRT1/PGC-1α signal pathway. Food science & nutrition. vol 7. issue 5. 2020-10-01. PMID:31139382. |
upon 24-hr cultivation, the proliferation and glucose-stimulated insulin secretion (gsis) of ins-1 cells were determined, and the expression of irisin and other proteins associated with ampk/sirt1/pgc-1α signal pathway, autophagy, and apoptosis was evaluated. |
2020-10-01 |
2023-08-13 |
Not clear |
| Honghua Fei, Mingyan Shi, Lianhong Chen, Zhe Wang, Lihua Su. MicroRNA-18 promotes apoptosis of islet β-cells via targeting NAV1. Experimental and therapeutic medicine. vol 18. issue 1. 2020-10-01. PMID:31258677. |
it was demonstrated that mir-18 promotes apoptosis of islet β-cells at least partially by inhibiting nav1 expression and insulin production via suppression of the pi3k/akt pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jacqueline Tan, Murat Digicaylioglu, Stacy X J Wang, Jonathan Dresselhuis, Shoukat Dedhar, Julia Mill. Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism. Heliyon. vol 5. issue 8. 2020-10-01. PMID:31463398. |
insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism. |
2020-10-01 |
2023-08-13 |
Not clear |
| Sher Zaman Safi, Rajes Qvist, Gracie Ong, Hamed Karimian, Muhammad Imran, Ikram Sha. Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells. Archives of medical science : AMS. vol 13. issue 2. 2020-09-30. PMID:28261303. |
in this study we investigated the effect of a β-adrenergic receptor agonist and antagonist on raf-1 and pdx-1, and their respective effects on apoptosis and insulin release in rin-m5f cells. |
2020-09-30 |
2023-08-13 |
rat |
| Joseph W Kim, John Z Luo, Luguang Lu. The Biochemical Cascades of the Human Pancreatic Journal of bioanalysis & biomedicine. vol 7. issue 6. 2020-09-30. PMID:28503255. |
we have reviewed and presented how mirs fine tune four biochemical cascades in islet β cells: glucose stimulated insulin secretion, β cell replication, apoptosis, and development. |
2020-09-30 |
2023-08-13 |
human |
| Jiuqiang Guan, Keren Long, Jideng Ma, Jinwei Zhang, Dafang He, Long Jin, Qianzi Tang, Anan Jiang, Xun Wang, Yaodong Hu, Shilin Tian, Zhi Jiang, Mingzhou Li, Xiaolin Lu. Comparative analysis of the microRNA transcriptome between yak and cattle provides insight into high-altitude adaptation. PeerJ. vol 5. 2020-09-30. PMID:29109913. |
functional analysis revealed that differentially expressed mirnas were enriched in hypoxia-related pathways, such as the hif-1α signaling pathway, the insulin signaling pathway, the pi3k-akt signaling pathway, nucleotide excision repair, cell cycle, apoptosis and fatty acid metabolism, which indicated the important roles of mirnas in high altitude adaptation. |
2020-09-30 |
2023-08-13 |
cattle |
| Yanfang He, Jie Bai, Ping Liu, Jianxin Dong, Yajuan Tang, Jianli Zhou, Ping Han, Jun Xing, Yan Chen, Xiangyang Y. miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus. EXCLI journal. vol 16. 2020-09-30. PMID:29333131. |
furthermore, overexpression of mir-494 improved pancreatic β-cell dysfunction by enhancing insulin secretion and total insulin content, inducing cell proliferation, and inhibiting cell apoptosis, whereas mir-494 knockdown exhibited decreased insulin secretion and proliferation, as well as stimulated apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |