| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanfang He, Jie Bai, Ping Liu, Jianxin Dong, Yajuan Tang, Jianli Zhou, Ping Han, Jun Xing, Yan Chen, Xiangyang Y. miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus. EXCLI journal. vol 16. 2020-09-30. PMID:29333131. |
furthermore, overexpression of mir-494 improved pancreatic β-cell dysfunction by enhancing insulin secretion and total insulin content, inducing cell proliferation, and inhibiting cell apoptosis, whereas mir-494 knockdown exhibited decreased insulin secretion and proliferation, as well as stimulated apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yanfang He, Jie Bai, Ping Liu, Jianxin Dong, Yajuan Tang, Jianli Zhou, Ping Han, Jun Xing, Yan Chen, Xiangyang Y. miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus. EXCLI journal. vol 16. 2020-09-30. PMID:29333131. |
more importantly, sirna-induced downregulation of pten reversed the effects of mir-494 knockdown on insulin secretion, cell proliferation, and apoptosis of pancreatic β-cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hengchang Li, Chun-Ling Dai, Jin-Hua Gu, Shengwei Peng, Jian Li, Qian Yu, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. Intranasal Administration of Insulin Reduces Chronic Behavioral Abnormality and Neuronal Apoptosis Induced by General Anesthesia in Neonatal Mice. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31354415. |
intranasal administration of insulin reduces chronic behavioral abnormality and neuronal apoptosis induced by general anesthesia in neonatal mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Hengchang Li, Chun-Ling Dai, Jin-Hua Gu, Shengwei Peng, Jian Li, Qian Yu, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. Intranasal Administration of Insulin Reduces Chronic Behavioral Abnormality and Neuronal Apoptosis Induced by General Anesthesia in Neonatal Mice. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31354415. |
importantly, insulin administered through intranasal delivery prior to anesthesia was found to prevent the anesthesia-induced long-term behavioral abnormalities, reduction of psd95, and activation of neuronal apoptosis. |
2020-09-30 |
2023-08-13 |
mouse |
| Hervé Le Stunff, Julien Véret, Nadim Kassis, Jessica Denom, Kelly Meneyrol, Jean-Louis Paul, Céline Cruciani-Guglielmacci, Christophe Magnan, Nathalie Jane. Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration. Frontiers in neurology. vol 10. 2020-09-30. PMID:31417486. |
these abnormalities propagate a cascade of neurodegeneration associated with oxidative stress and ceramide generation, which potentiate brain insulin resistance, apoptosis, myelin degeneration, and neuro-inflammation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yizhi He, Bingyin Shi, Xinrui Zhao, Jing Su. Sphingosine-1-phosphate induces islet β-cell proliferation and decreases cell apoptosis in high-fat diet/streptozotocin diabetic mice. Experimental and therapeutic medicine. vol 18. issue 5. 2020-09-30. PMID:31602216. |
the islets in the s1p group exhibited higher insulin immunostaining intensity than the dc group, as well as higher proliferation (p<0.05) and lower apoptosis rates (p<0.05). |
2020-09-30 |
2023-08-13 |
mouse |
| In Cheol Yoon, Jong Ryeol Eu. Pharmacologic therapy for nonalcoholic steatohepatitis focusing on pathophysiology. Yeungnam University journal of medicine. vol 36. issue 2. 2020-09-30. PMID:31620616. |
the pathophysiology is complex and associated with lipotoxicity, inflammatory cytokines, apoptosis, and insulin resistance. |
2020-09-30 |
2023-08-13 |
Not clear |
| Miaad Bader, Yazhou Li, David Tweedie, Nathan A Shlobin, Adi Bernstein, Vardit Rubovitch, Luis B Tovar-Y-Romo, Richard D DiMarchi, Barry J Hoffer, Nigel H Greig, Chaim G Pic. Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain Injury. Frontiers in cell and developmental biology. vol 7. 2020-09-29. PMID:31998717. |
the incretins glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are gastrointestinal hormones that induce glucose-dependent insulin secretion, promote β-cell proliferation, and enhance resistance to apoptosis. |
2020-09-29 |
2023-08-13 |
mouse |
| R James Barnar. Prevention of Cancer Through Lifestyle Changes. Evidence-based complementary and alternative medicine : eCAM. vol 1. issue 3. 2020-09-29. PMID:15841256. |
elevated levels of serum insulin impact on the liver primarily, increasing the production of insulin-like growth factor i (igf-i) while reducing the production of insulin-like growth factor binding protein 1 (igfbp-1) resulting in stimulation of tumor cell growth and inhibition of apoptosis (programmed cell death). |
2020-09-29 |
2023-08-12 |
Not clear |
| Victoria M Gershuni, Rexford S Ahima, Julia Tcho. Obesity and Breast Cancer: A Complex Relationship. Current surgery reports. vol 4. 2020-09-29. PMID:29623246. |
importantly, obesity is a modifiable risk factor; alterations in cell proliferation, apoptosis, circulating estrogen, and insulin sensitivity are observed in response to weight loss attainable through behavior modification including dietary and exercise changes. |
2020-09-29 |
2023-08-13 |
Not clear |
| Keisuke Sumi, Tsuyoshi Okura, Youhei Fujioka, Masahiko Kato, Takeshi Imamura, Shin-Ichi Taniguchi, Kazuhiro Yamamot. Coenzyme Q10 suppresses apoptosis of mouse pancreatic β-cell line MIN6. Diabetology & metabolic syndrome. vol 10. 2020-09-29. PMID:29942356. |
in mitochondrial diabetes, apoptosis of β-cells caused by mitochondrial stress plays an important role in impaired insulin secretion. |
2020-09-29 |
2023-08-13 |
mouse |
| Owen Sander. Sildenafil for the Treatment of Alzheimer's Disease: A Systematic Review. Journal of Alzheimer's disease reports. vol 4. issue 1. 2020-09-28. PMID:32467879. |
plus, sildenafil should increase brain perfusion, insulin sensitivity, long-term potentiation, and neurogenesis while suppressing neural apoptosis and inflammation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yu Xu, Wei Guo, Cheng Zhang, Feiyu Chen, Hor Yue Tan, Sha Li, Ning Wang, Yibin Fen. Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32477116. |
the related critical pathological events are associated with the development of nafld including insulin resistance, lipid metabolism dysfunction, oxidative stress, inflammation, apoptosis, and fibrosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Patchara Rattanaporn, Sissades Tongsima, Thomas Mandrup-Poulsen, Saovaros Svasti, Dalina Tanyon. Combination of ferric ammonium citrate with cytokines involved in apoptosis and insulin secretion of human pancreatic beta cells related to diabetes in thalassemia. PeerJ. vol 8. 2020-09-28. PMID:32587797. |
combination of ferric ammonium citrate with cytokines involved in apoptosis and insulin secretion of human pancreatic beta cells related to diabetes in thalassemia. |
2020-09-28 |
2023-08-13 |
human |
| Chen Zhang, Chengshun Yang, Na Li, Xueqing Liu, Junlin He, Xuemei Chen, Yubin Ding, Chao Tong, Chuan Peng, Hubin Yin, Yingxiong Wang, Rufei Ga. Elevated insulin levels compromise endometrial decidualization in mice with decrease in uterine apoptosis in early-stage pregnancy. Archives of toxicology. vol 93. issue 12. 2020-09-23. PMID:31642978. |
elevated insulin levels compromise endometrial decidualization in mice with decrease in uterine apoptosis in early-stage pregnancy. |
2020-09-23 |
2023-08-13 |
mouse |
| Chen Zhang, Chengshun Yang, Na Li, Xueqing Liu, Junlin He, Xuemei Chen, Yubin Ding, Chao Tong, Chuan Peng, Hubin Yin, Yingxiong Wang, Rufei Ga. Elevated insulin levels compromise endometrial decidualization in mice with decrease in uterine apoptosis in early-stage pregnancy. Archives of toxicology. vol 93. issue 12. 2020-09-23. PMID:31642978. |
in conclusion, we demonstrated that elevated insulin levels could compromise mice decidualization in early-stage pregnancy and pi3k/p-akt-regulated apoptosis was essential for this role. |
2020-09-23 |
2023-08-13 |
mouse |
| Jia Liu, Xuan Li, Qingguo Lu, Di Ren, Xiaodong Sun, Thomas Rousselle, Ji Li, Jiyan Len. AMPK: a balancer of the renin-angiotensin system. Bioscience reports. vol 39. issue 9. 2020-09-18. PMID:31413168. |
in recent studies, ras has also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation of several signaling pathways such as proliferation, apoptosis and autophagy, and insulin resistance. |
2020-09-18 |
2023-08-13 |
Not clear |
| Yumei Zhang, Mingzhu Li, Yiru Wang, Xueying Liu, Libin Zhou, Chunling Zhang, Li Sha. Histone deacetylase inhibition by MS-275 potentiates glucose-stimulated insulin secretion without affecting glucose oxidation. Life sciences. vol 257. 2020-09-16. PMID:32663574. |
inhibition of class i histone deacetylase (hdac) has been proved to protect beta-cells from palmitate- or cytokine-induced apoptosis and increase insulin secretion. |
2020-09-16 |
2023-08-13 |
Not clear |
| Anna Zalewska, Mateusz Maciejczyk, Julita Szulimowska, Monika Imierska, Agnieszka Błachnio-Zabielsk. High-Fat Diet Affects Ceramide Content, Disturbs Mitochondrial Redox Balance, and Induces Apoptosis in the Submandibular Glands of Mice. Biomolecules. vol 9. issue 12. 2020-09-15. PMID:31847462. |
this is the first study to investigate the relationship between ceramides, the mitochondrial respiratory system, oxidative stress, inflammation, and apoptosis in the submandibular gland mitochondria of mice with insulin resistance (ir). |
2020-09-15 |
2023-08-13 |
mouse |
| Krystallenia I Alexandraki, Nikolaos V Apostolopoulos, Christos Adamopoulos, Evangelia Stamouli, Georgia Dalagiorgou, Theodoros G Papaioannou, Antonios Analitis, Marianna Karamanou, Konstantinos Makrilakis, Antonios Politis, Christina Piper. Differential Expression of Apoptotic and Low-Grade Inflammatory Markers in Alzheimer Disease Compared to Diabetes Mellitus Type 1 and 2. The journal of applied laboratory medicine. vol 3. issue 6. 2020-09-11. PMID:31639691. |
neuroinflammation, impaired brain insulin signaling, and neuronal apoptosis may be interrelated in the pathophysiology of people with alzheimer disease (ad) and diabetes, either type 1 or 2 diabetes (t1d or t2d, respectively). |
2020-09-11 |
2023-08-13 |
Not clear |