| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rodrigo Carlessi, Jordan Rowlands, Gaewyn Ellison, Heloisa Helena de Oliveira Alves, Philip Newsholme, Cyril Mamott. Glutamine deprivation induces metabolic adaptations associated with beta cell dysfunction and exacerbate lipotoxicity. Molecular and cellular endocrinology. vol 491. 2020-05-11. PMID:31018148. |
palmitate led to insulin secretory dysfunction, loss of viability and apoptosis. |
2020-05-11 |
2023-08-13 |
Not clear |
| Yun Zhang, Guo-Xin Zhang, Li-Shuang Che, Shu-Han Shi, Wei-Yuan Li. miR-19 promotes development of renal fibrosis by targeting PTEN-mediated epithelial-mesenchymal transition. International journal of clinical and experimental pathology. vol 13. issue 4. 2020-05-05. PMID:32355512. |
in recent years, it has been found that mirna may play an important role in the field of gene regulation; mirnas can participate in the regulation of various physiologic processes such as cell differentiation, proliferation, apoptosis, metabolism, and insulin secretion by regulation of target genes. |
2020-05-05 |
2023-08-13 |
mouse |
| Fatemeh P Arasi, Mohammad K Shahrestanaki, Mahmoud Aghae. A2a adenosine receptor agonist improves endoplasmic reticulum stress in MIN6 cell line through protein kinase A/ protein kinase B/ Cyclic adenosine monophosphate response element-binding protein/ and Growth Arrest And DNA-Damage-Inducible 34/ eukaryotic Initiation Factor 2α pathways. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30417358. |
endoplasmic reticulum (er) stress is one of the main molecular events underlying pancreatic beta cell (pbc) failure, apoptosis, and a decrease in insulin secretion. |
2020-05-04 |
2023-08-13 |
Not clear |
| ChangHyuk Kwon, Jaw Long Sun, Ji Hoon Jeong, Tae Woo Jun. Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway. Biochemical and biophysical research communications. vol 526. issue 2. 2020-05-01. PMID:32245619. |
collectively, hn prevents palmitate-induced hepatic lipid accumulation, apoptosis, and insulin resistance via ampk-mediated suppression of the mtor/srebp1 pathway, suggesting that it may serve as a potential therapeutic agent in nafld treatment. |
2020-05-01 |
2023-08-13 |
Not clear |
| Yan Hao, Weiwei Wang, Dong Wu, Kai Liu, Yihan Su. Bilobalide alleviates tumor necrosis factor-alpha-induced pancreatic beta-cell MIN6 apoptosis and dysfunction through upregulation of miR-153. Phytotherapy research : PTR. vol 34. issue 2. 2020-04-30. PMID:31667906. |
min6 cells were treated by tnf-α; then, viability, apoptosis, and insulin secretion were assessed by performing cell counting kit-8 assay, flow cytometry, glucose-stimulated insulin secretion assay, and western blot. |
2020-04-30 |
2023-08-13 |
Not clear |
| Yan Hao, Weiwei Wang, Dong Wu, Kai Liu, Yihan Su. Bilobalide alleviates tumor necrosis factor-alpha-induced pancreatic beta-cell MIN6 apoptosis and dysfunction through upregulation of miR-153. Phytotherapy research : PTR. vol 34. issue 2. 2020-04-30. PMID:31667906. |
tnf-α declined viability and insulin secretion as well as raised apoptosis and inducible nitric oxide synthase (inos) expression in min6 cells. |
2020-04-30 |
2023-08-13 |
Not clear |
| Yan Hao, Weiwei Wang, Dong Wu, Kai Liu, Yihan Su. Bilobalide alleviates tumor necrosis factor-alpha-induced pancreatic beta-cell MIN6 apoptosis and dysfunction through upregulation of miR-153. Phytotherapy research : PTR. vol 34. issue 2. 2020-04-30. PMID:31667906. |
increase of viability and insulin secretion as well as decline of apoptosis and inos induced by bb treatment was alleviated by silencing mir-153. |
2020-04-30 |
2023-08-13 |
Not clear |
| Yan Hao, Weiwei Wang, Dong Wu, Kai Liu, Yihan Su. Bilobalide alleviates tumor necrosis factor-alpha-induced pancreatic beta-cell MIN6 apoptosis and dysfunction through upregulation of miR-153. Phytotherapy research : PTR. vol 34. issue 2. 2020-04-30. PMID:31667906. |
bb raised viability and insulin secretion, declined apoptosis and inos expression by up-regulating mir-153. |
2020-04-30 |
2023-08-13 |
Not clear |
| Xudong Wang, Ying-Tang Gao, Dan Jiang, Yuzhou Wang, Hongyan Du, Jili Lv, Shu Jie L. Hv1-deficiency protects β cells from glucotoxicity through regulation of NOX4 level. Biochemical and biophysical research communications. vol 513. issue 2. 2020-04-27. PMID:30967259. |
following 48 h of treatment with 30 mm high glucose, hv1 ko β cells showed higher cell viability, lower cell apoptosis and a more stable insulin gene expression level compared to wt β cells. |
2020-04-27 |
2023-08-13 |
Not clear |
| Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Wo. CD36 dependent redoxosomes promotes ceramide-mediated pancreatic β-cell failure via p66Shc activation. Free radical biology & medicine. vol 134. 2020-04-21. PMID:30735834. |
cd36 inhibition potentiated glucose-stimulated insulin secretion and prevented beta-cell apoptosis. |
2020-04-21 |
2023-08-13 |
Not clear |
| Anil Kumar Kalvala, Islauddin Khan, Chayanika Gundu, Ashutosh Kuma. An Overview on ATP Dependent and Independent Proteases Including an Anterograde to Retrograde Control on Mitochondrial Function; Focus on Diabetes and Diabetic Complications. Current pharmaceutical design. vol 25. issue 23. 2020-04-16. PMID:31317835. |
different experimental studies conducted on silencing the genes of these proteases have shown embryonic lethality, cancer cells death, increased hepatic glucose output, insulin tolerance, increased protein exclusion bodies, mitochondrial dysfunction, and defect in mitochondrial biogenesis, increased inflammation, apoptosis etc. |
2020-04-16 |
2023-08-13 |
human |
| Lingye Chen, Benjamin König, Tianbao Liu, Sumaira Pervaiz, Yasmin S Razzaque, Tobias Staube. More than just a pressure relief valve: physiological roles of volume-regulated LRRC8 anion channels. Biological chemistry. vol 400. issue 11. 2020-04-13. PMID:31091194. |
a plethora of studies have proposed a wide range of physiological roles for vrac beyond volume regulation including cell proliferation, differentiation and migration, apoptosis, intercellular communication by direct release of signaling molecules and by supporting the exocytosis of insulin. |
2020-04-13 |
2023-08-13 |
Not clear |
| Zahra Samadian, Asghar Tofighi, Mazdak Razi, Javad Tolouei Azar, Firouz Ghaderi Pakde. Moderate-intensity exercise training ameliorates the diabetes-suppressed spermatogenesis and improves sperm parameters: Insole and simultaneous with insulin. Andrologia. vol 51. issue 11. 2020-04-10. PMID:31642094. |
the tubular differentiation (tdi) and spermiogenesis (spi) indices, testicular total antioxidant capacity (tac), superoxide dismutase (sod) and glutathione peroxidase (gpx) contents, serum testosterone and insulin levels, the apoptosis ratio and sperm parameters were assessed. |
2020-04-10 |
2023-08-13 |
rat |
| Zahra Samadian, Asghar Tofighi, Mazdak Razi, Javad Tolouei Azar, Firouz Ghaderi Pakde. Moderate-intensity exercise training ameliorates the diabetes-suppressed spermatogenesis and improves sperm parameters: Insole and simultaneous with insulin. Andrologia. vol 51. issue 11. 2020-04-10. PMID:31642094. |
the exercise in sole (ex) and simultaneous forms with ins (dm + ins + ex group) ameliorated the dm-suppressed spermatogenesis and spermiogenesis indices, up-regulated the serum testosterone and insulin levels, enhanced testicular sod content, inhibited the apoptosis and improved almost all sperm parameters. |
2020-04-10 |
2023-08-13 |
rat |
| Habib Yaribeygi, Stephen L Atkin, Amirhossein Sahebka. Mitochondrial dysfunction in diabetes and the regulatory roles of antidiabetic agents on the mitochondrial function. Journal of cellular physiology. vol 234. issue 6. 2020-04-08. PMID:30417488. |
many pathophysiological pathways such as oxidative stress, inflammatory responses, adipokines, obesity-induced insulin resistance, improper insulin signaling, and beta cell apoptosis are associated with the development of t2dm. |
2020-04-08 |
2023-08-13 |
Not clear |
| Siddavaram Nagini, Josephraj Sophia, Rajakishore Mishr. Glycogen synthase kinases: Moonlighting proteins with theranostic potential in cancer. Seminars in cancer biology. vol 56. 2020-04-03. PMID:29309927. |
glycogen synthase kinase-3 (gsk-3), a serine/threonine kinase is an archetypal multifunctional moonlighting protein involved in diverse cellular processes including metabolism, insulin signaling, proliferation, differentiation, apoptosis, neuronal function and embryonic development. |
2020-04-03 |
2023-08-13 |
Not clear |
| Yangyang Ding, Yongchao Liu, Fan Fei, Liuqing Yang, Guanghua Mao, Ting Zhao, Zhehan Zhang, Mengjiao Yan, Weiwei Feng, Xiangyang W. Study on the metabolism toxicity, susceptibility and mechanism of di-(2-ethylhexyl) phthalate on rat liver BRL cells with insulin resistance in vitro. Toxicology. vol 422. 2020-04-03. PMID:31152848. |
the results showed that dehp could cause cell damage with alt and ast activities and mda levels increased, cell apoptosis with caspase-3 levels increased and insulin resistance with ir-β levels decreased in brl cells with resistance and normal brl cells. |
2020-04-03 |
2023-08-13 |
rat |
| Juan F Mejia, Kelsey M Hirschi, Kary Y F Tsai, Matthew G Long, Benton C Tullis, Eliza E K Bitter, Benjamin T Bikman, Paul R Reynolds, Juan A Arroy. Differential placental ceramide levels during gestational diabetes mellitus (GDM). Reproductive biology and endocrinology : RB&E. vol 17. issue 1. 2020-03-23. PMID:31647034. |
our objective was to examine ceramide, a key sphingolipid, hyperosmolarity, and apoptosis in placentas from gdm patients treated with insulin or diet. |
2020-03-23 |
2023-08-13 |
Not clear |
| Elin Hall, Josefine Jönsson, Jones K Ofori, Petr Volkov, Alexander Perfilyev, Marloes Dekker Nitert, Lena Eliasson, Charlotte Ling, Karl Baco. Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets. Diabetes. vol 68. issue 10. 2020-03-18. PMID:31420409. |
glucolipotoxicity impaired insulin secretion, increased apoptosis, and significantly (false discovery rate <5%) altered the expression of 1,855 genes, including 35 genes previously implicated in t2d by genome-wide association studies (e.g., |
2020-03-18 |
2023-08-13 |
human |
| Ni Zeng, Zhen Zhang, Hongmei Jiang, Ruobi Li, Chong Chang, Fei Wang, Dandan Xu, Qiming Fan, Ting Wang, Yongmei Xiao, Wen Chen, Zhixin Shan, Zhenlie Huang, Qing Wan. LncRNA-241 inhibits 1,2-Dichloroethane-induced hepatic apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. vol 61. 2020-03-18. PMID:31520740. |
in vitro intervention studies revealed that the repression of lncrna241 expression after 2-ca exposure led to the down-regulation of anti-apoptosis-associated factor insulin growth factor-1 (igf1) at mrna and protein levels through modulation of their common target mmu-mir-451a, which promoted hepatic apoptosis. |
2020-03-18 |
2023-08-13 |
mouse |