| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jimin Kim, Su-Hyun Shin, Jong-Koo Kang, Jae Wha Ki. HX-1171 attenuates pancreatic β-cell apoptosis and hyperglycemia-mediated oxidative stress via Nrf2 activation in streptozotocin-induced diabetic model. Oncotarget. vol 9. issue 36. 2019-11-20. PMID:29849938. |
hx-1171 enhanced insulin secretion by reducing stz-induced cell apoptosis, and decreased intracellular reactive oxygen species (ros) generation by upregulating the expression of antioxidant enzymes through nrf2 activation in ins-1 pancreatic beta cells. |
2019-11-20 |
2023-08-13 |
mouse |
| Parvin Farzanegi, Amir Dana, Zeynab Ebrahimpoor, Mahdieh Asadi, Mohammad Ali Azarbayjan. Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation. European journal of sport science. vol 19. issue 7. 2019-11-13. PMID:30732555. |
it improves nafld by reducing intrahepatic fat content, increasing β-oxidation of fatty acids, inducing hepato-protective autophagy, overexpressing peroxisome proliferator-activated receptor- γ (ppar-γ), as well as attenuating hepatocyte apoptosis and increasing insulin sensitivity. |
2019-11-13 |
2023-08-13 |
Not clear |
| Lucie Ruiz, Tatyana Gurlo, Magalie A Ravier, Anne Wojtusciszyn, Julia Mathieu, Matthew R Brown, Christophe Broca, Gyslaine Bertrand, Peter C Butler, Aleksey V Matveyenko, Stéphane Dalle, Safia Coste. Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. Cell death & disease. vol 9. issue 6. 2019-11-05. PMID:29789539. |
in type 2 diabetes, amyloid oligomers, chronic hyperglycemia, lipotoxicity, and pro-inflammatory cytokines are detrimental to beta-cells, causing apoptosis and impaired insulin secretion. |
2019-11-05 |
2023-08-13 |
Not clear |
| Lijun Hao, Qian Li, Xin Zhao, Yanli Li, Ce Zhan. A long noncoding RNA LOC103690121 promotes hippocampus neuronal apoptosis in streptozotocin-induced type 1 diabetes. Neuroscience letters. vol 703. 2019-10-29. PMID:30851305. |
the diabetes-induced cognitive impairment is associated with insulin resistance and glucose-induced neuron apoptosis in the brain. |
2019-10-29 |
2023-08-13 |
rat |
| Flavia Lambertucci, Ainelén Arboatti, María Guillermina Sedlmeier, Omar Motiño, María de Luján Alvarez, María Paula Ceballos, Silvina R Villar, Eduardo Roggero, Juan A Monti, Gerardo Pisani, Ariel D Quiroga, Paloma Martín-Sanz, Cristina Ester Carnovale, Daniel Eleazar Francés, María Teresa Ronc. Disruption of tumor necrosis factor alpha receptor 1 signaling accelerates NAFLD progression in mice upon a high-fat diet. The Journal of nutritional biochemistry. vol 58. 2019-10-28. PMID:29860102. |
the aim of this work was to evaluate the effects of high-caloric feeding (hfd) (40% fat, for 16 weeks) on liver inflammation-induced apoptosis, insulin resistance, hepatic lipid accumulation and its progression toward nonalcoholic steatohepatitis (nash) in tnfr1 knock-out and wild-type mice. |
2019-10-28 |
2023-08-13 |
mouse |
| Flavia Lambertucci, Ainelén Arboatti, María Guillermina Sedlmeier, Omar Motiño, María de Luján Alvarez, María Paula Ceballos, Silvina R Villar, Eduardo Roggero, Juan A Monti, Gerardo Pisani, Ariel D Quiroga, Paloma Martín-Sanz, Cristina Ester Carnovale, Daniel Eleazar Francés, María Teresa Ronc. Disruption of tumor necrosis factor alpha receptor 1 signaling accelerates NAFLD progression in mice upon a high-fat diet. The Journal of nutritional biochemistry. vol 58. 2019-10-28. PMID:29860102. |
mechanisms involved in hfd-derived il-1β release and impairment of insulin signaling are still unknown, so we determined whether il-1β affects liver insulin sensitivity and apoptosis through tnfα receptor 1 (tnfr1)-dependent pathways. |
2019-10-28 |
2023-08-13 |
mouse |
| Jing Cen, Ernest Sargsyan, Anders Forslund, Peter Bergste. Mechanisms of beneficial effects of metformin on fatty acid-treated human islets Journal of molecular endocrinology. vol 61. issue 3. 2019-10-28. PMID:30307162. |
insulin secretion, oxygen consumption rate (ocr), ampk activation, endoplasmic reticulum (er) stress and apoptosis were examined in isolated human islets after exposure to elevated levels of palmitate in the absence or presence of metformin. |
2019-10-28 |
2023-08-13 |
human |
| Seisuke Sato, Hitomi Imachi, Jingya Lyu, Yumi Miyai, Kensaku Fukunaga, Tao Dong, Tomohiro Ibata, Toshihiro Kobayashi, Takuo Yoshimoto, Fumi Kikuchi, Kazuko Yonezaki, Nao Yamaji, Hisakazu Iwama, Koji Mura. Effect of TNF-α on the expression of ABCA1 in pancreatic β-cells. Journal of molecular endocrinology. vol 61. issue 4. 2019-10-25. PMID:30131353. |
tumor necrosis factor (tnf)-α is a pleiotropic cytokine that elicits a wide spectrum of physiological events, including cell proliferation, differentiation, and apoptosis, and is also known to decrease glucose-dependent insulin secretion in pancreatic islets. |
2019-10-25 |
2023-08-13 |
rat |
| Meng Jiang, Chun Li, Qiaoshu Liu, Aimin Wang, Minxiang Le. Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease. Frontiers in endocrinology. vol 10. 2019-10-23. PMID:31616384. |
ceramides are central molecules of sphingolipid biosynthesis and catabolism and play an important role in insulin resistance, apoptosis, and inflammation. |
2019-10-23 |
2023-08-13 |
rat |
| Lifeng Wang, Junhua Chen, Chao Ning, Dongyu Lei, Jun Re. Endoplasmic Reticulum Stress Related Molecular Mechanisms in Nonalcoholic Fatty Liver Disease (NAFLD). Current drug targets. vol 19. issue 9. 2019-10-17. PMID:29766802. |
although er stress may lead to a cascade of compensatory responses that help to restore er homeostasis, cell survival and adaptation, prolonged er stress is known to impose detrimental pathological outcome, involving insulin resistance, ectopic fat deposition, inflammation, apoptosis, and dysregulated autophagy. |
2019-10-17 |
2023-08-13 |
Not clear |
| Zahra Malekpour-Dehkordi, Shahram Teimourian, Mitra Nourbakhsh, Yousof Naghiaee, Roya Sharifi, Javad Mohiti-Ardakan. Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. Life sciences. vol 233. 2019-09-30. PMID:31348945. |
metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/erk, collagen vi, apoptosis, and necrosis reduction. |
2019-09-30 |
2023-08-13 |
Not clear |
| Zahra Malekpour-Dehkordi, Shahram Teimourian, Mitra Nourbakhsh, Yousof Naghiaee, Roya Sharifi, Javad Mohiti-Ardakan. Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. Life sciences. vol 233. 2019-09-30. PMID:31348945. |
here we investigated the effect of antidiabetic drug, metformin, on the factors that play role in fibrosis such as; integrin/erk pathway, collagen vi, mmp2, mmp9, apoptosis markers including dapk1, dapk3, dap, siva, necrosis markers including ripk1, ripk3, and mlkl in insulin resistant and hypertrophied adipocytes. |
2019-09-30 |
2023-08-13 |
Not clear |
| Yun-Ching Chang, Hung-Wen Liu, Yi-Tien Chen, Yun-An Chen, Yen-Ju Chen, Sue-Joan Chan. Resveratrol protects muscle cells against palmitate-induced cellular senescence and insulin resistance through ameliorating autophagic flux. Journal of food and drug analysis. vol 26. issue 3. 2019-09-24. PMID:29976399. |
resveratrol protected muscle cells from palmitate-induced cellular senescence, apoptosis during differentiation, and insulin resistance via ameliorating autophagic flux. |
2019-09-24 |
2023-08-13 |
Not clear |
| Yue Wang, Quan Liu, Yi Huan, Rongcui Li, Caina Li, Sujuan Sun, Nan Guo, Miaomiao Yang, Shuainan Liu, Zhufang She. Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction. Experimental cell research. vol 371. issue 1. 2019-09-18. PMID:30098330. |
chronic exposure to excess palmitate and glucose (high-pa-g) induced apoptosis and suppressed glucose-stimulated insulin secretion in β cells. |
2019-09-18 |
2023-08-13 |
Not clear |
| Wen Zeng, Jiansong Tang, Haicheng Li, Haixia Xu, Hongyun Lu, Hangya Peng, Chuwen Lin, Rili Gao, Shuo Lin, Keyi Lin, Kunying Liu, Yan Jiang, Jianping Weng, Longyi Zen. Caveolin-1 deficiency protects pancreatic β cells against palmitate-induced dysfunction and apoptosis. Cellular signalling. vol 47. 2019-09-17. PMID:29596872. |
previous studies have suggested that the membrane protein caveolin-1 (cav-1) is implicated in β-cell apoptosis and insulin secretion, however, the underlying mechanisms still remains unclear. |
2019-09-17 |
2023-08-13 |
Not clear |
| Wen Zeng, Jiansong Tang, Haicheng Li, Haixia Xu, Hongyun Lu, Hangya Peng, Chuwen Lin, Rili Gao, Shuo Lin, Keyi Lin, Kunying Liu, Yan Jiang, Jianping Weng, Longyi Zen. Caveolin-1 deficiency protects pancreatic β cells against palmitate-induced dysfunction and apoptosis. Cellular signalling. vol 47. 2019-09-17. PMID:29596872. |
in this study, we found that cav-1 silencing significantly promoted β-cell proliferation, inhibited palmitate (pa)-induced pancreatic β-cell apoptosis and enhanced insulin production and secretion. |
2019-09-17 |
2023-08-13 |
Not clear |
| Lichun Zhao, Xue Wang, Junxiu Li, Xiaoming Tan, Lanlan Fan, Zhenwei Zhang, Jing Len. Effect of Cyclocarya Paliurus on Hypoglycemic Effect in Type 2 Diabetic Mice. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-11. PMID:31011149. |
conclusions cpe has the effects of decreasing blood glucose and insulin resistance, and enhancing glucose tolerance in dm mice, which may be related to its effects of reducing oxidation and reduced apoptosis, and relieving stz in pancreatic beta cell injury. |
2019-09-11 |
2023-08-13 |
mouse |
| Matthew Riopel, Jong Bae Seo, Gautam K Bandyopadhyay, Pingping Li, Joshua Wollam, Heekyung Chung, Seung-Ryoung Jung, Anne Murphy, Maria Wilson, Ron de Jong, Sanjay Patel, Deepika Balakrishna, James Bilakovics, Andrea Fanjul, Artur Plonowski, Duk-Su Koh, Christopher J Larson, Jerrold M Olefsky, Yun Sok Le. Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function. The Journal of clinical investigation. vol 128. issue 4. 2019-09-10. PMID:29504946. |
here, we demonstrate that chronic administration of a long-acting form of fkn, fkn-fc, can exert durable effects to improve glucose tolerance with increased glucose-stimulated insulin secretion and decreased β cell apoptosis in obese rodent models. |
2019-09-10 |
2023-08-13 |
Not clear |
| Attilio Pingitore, Noemi Gonzalez-Abuin, Inmaculada Ruz-Maldonado, Guo C Huang, Gary Frost, Shanta J Persau. Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: Role of free fatty acid receptor 2. Diabetes, obesity & metabolism. vol 21. issue 2. 2019-09-09. PMID:30203438. |
short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: role of free fatty acid receptor 2. |
2019-09-09 |
2023-08-13 |
mouse |
| Lihong Weng, Fengying Zhang, Rui Wang, Wei Ma, Yingshi Son. A review on protective role of genistein against oxidative stress in diabetes and related complications. Chemico-biological interactions. vol 310. 2019-09-09. PMID:31125535. |
in the course of recent years, various examinations have shown that genistein has hostile to diabetic impacts, specifically, direct consequences for β-cell expansion, glucose-triggered insulin discharge, and safety towards apoptosis, unbiased of its functions as an estrogen receptor agonist, cancer prevention agent, or tyrosine kinase inhibitor. |
2019-09-09 |
2023-08-13 |
Not clear |