| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dawei Li, Yuru Shang, Chuanan Shen, Longzhu Li, Dongxu Zhao, Li Ma, Yongming Y. Effects of Exendin-4 on pancreatic islets function in treating hyperglycemia post severe scald injury in rats. The journal of trauma and acute care surgery. vol 85. issue 6. 2019-09-04. PMID:30211851. |
it has been established that glucagon-like peptide 1 (glp 1) inhibits pancreatic β-cell apoptosis, increases insulin secretion, and improves glucose tolerance in scald injury. |
2019-09-04 |
2023-08-13 |
rat |
| Wei Li, Ning Ma, Ming-Xin Liu, Bing-Jie Ye, Yan-Jun Li, Hong-Yao Hu, Yan-Hong Tan. C1q/TNF-related protein-9 attenuates retinal inflammation and protects blood-retinal barrier in db/db mice. European journal of pharmacology. vol 853. 2019-09-03. PMID:30978318. |
in addition, it can increase insulin sensitivity, decrease blood glucose level and inhibit the apoptosis of endothelial cells. |
2019-09-03 |
2023-08-13 |
mouse |
| Li-Bo Zhu, Ming-Ming Cao, Jun Wang, Ying Su, Wei Jiang, Guo-Dong Liu, Yan-Bo L. Role of autophagy in LPS‑induced inflammation in INS‑1 cells. Molecular medicine reports. vol 19. issue 6. 2019-09-03. PMID:31059020. |
inflammation has been implicated in the pathogenesis of type 2 diabetes (t2d), which is a progressive disease characterized by pancreatic β‑cell dysfunction and apoptosis with consequential insufficient insulin secretion. |
2019-09-03 |
2023-08-13 |
Not clear |
| Yingmei Zhang, Adam T Whaley-Connell, James R Sowers, Jun Re. Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management. Pharmacology & therapeutics. vol 191. 2019-08-30. PMID:29909238. |
findings from numerous population-based studies, clinical trials, and experimental evidence have consolidated a number of theories for the pathogenesis of cardiorenal metabolic anomalies including resistance to the metabolic action of insulin, abnormal glucose and lipid metabolism, oxidative and nitrosative stress, endoplasmic reticulum (er) stress, apoptosis, mitochondrial damage, and inflammation. |
2019-08-30 |
2023-08-13 |
Not clear |
| Krishnamachari Srira. Bifurcation analysis of insulin regulated mTOR signalling pathway in cancer cells. IET systems biology. vol 12. issue 5. 2019-08-30. PMID:30259865. |
in breast cancer cell lines, metformin has been shown to induce phosphorylation at specific serine sites in insulin regulated substrate of mtor pathway that results in apoptosis over cell proliferation. |
2019-08-30 |
2023-08-13 |
Not clear |
| Fernanda Crunfli, Caio Henrique Mazucanti, Ruan Carlos Macêdo de Moraes, Andressa Pereira Costa, Alice Cristina Rodrigues, Cristoforo Scavone, Andréa da Silva Torrã. NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance. Journal of Alzheimer's disease : JAD. vol 65. issue 4. 2019-08-26. PMID:30149447. |
we observed that stz injection causes cognitive impairment in the animals, a temporal variation of the insulin signaling-related proteins and apoptosis cell death in the hippocampus. |
2019-08-26 |
2023-08-13 |
rat |
| Jihong Han, Hao Tan, Yajun Duan, Yuanli Chen, Yan Zhu, Buchang Zhao, Yong Wang, Xiaxiao Yan. The cardioprotective properties and the involved mechanisms of NaoXinTong Capsule. Pharmacological research. vol 141. 2019-08-23. PMID:30660824. |
biologically, these cardioprotective effects can be correlated to the actions of nxt on inflammation, apoptosis, oxidative stress, neovascularization, insulin sensitivity and lipid/glucose metabolism. |
2019-08-23 |
2023-08-13 |
Not clear |
| Ying He, Dongmei Zhang, Yi Zeng, Junlei Ma, Jing Wang, Hui Guo, Ji Zhang, Mengqin Wang, Weijie Zhang, Nianqiao Gon. Bone Marrow-Derived Mesenchymal Stem Cells Protect Islet Grafts Against Endoplasmic Reticulum Stress-Induced Apoptosis During the Early Stage After Transplantation. Stem cells (Dayton, Ohio). vol 36. issue 7. 2019-08-20. PMID:29569832. |
furthermore, cocultured bmscs protected islets against ers-induced apoptosis as well as improved their insulin secretion, and bmscs alleviated ers by improving myc expression through both stromal cell-derived factor 1 signal and contact effect. |
2019-08-20 |
2023-08-13 |
mouse |
| Xian Wu Cheng, Megumi Narisawa, Enze Jin, Chenglin Yu, Wenhu Xu, Limei Pia. Dose rectification of an imbalance between DPP4 and GLP-1 ameliorates chronic stress-related vascular aging and atherosclerosis? Clinical and experimental pharmacology & physiology. vol 45. issue 5. 2019-08-16. PMID:29220092. |
over the past decade, emerging data has revealed unexpected roles for dpp-4 and glp-1 in intracellular signaling, oxidative stress production, lipid metabolism, cell apoptosis, immune activation, insulin resistance, and inflammation. |
2019-08-16 |
2023-08-13 |
Not clear |
| Nikolaj Nerup, Rikard Ambrus, Joanna Lindhe, Michael P Achiam, Palle B Jeppesen, Lars B Svendse. The effect of glucagon-like peptide-1 and glucagon-like peptide-2 on microcirculation: A systematic review. Microcirculation (New York, N.Y. : 1994). vol 26. issue 3. 2019-08-14. PMID:28266749. |
glp-1 attenuates insulin resistance and glp-2 reduces enterocyte apoptosis and enhances crypt cell proliferation in the small intestine. |
2019-08-14 |
2023-08-13 |
rat |
| Leandro Bueno Berganti. Hypertension, Diabetes and Neurodegenerative Diseases: Is there a Clinical Link through the Ca2+/cAMP Signalling Interaction? Current hypertension reviews. vol 15. issue 1. 2019-08-13. PMID:30117399. |
a possible mechanism of action under debate could be attributed to a restoration of insulin secretion, then achieving glycemic control, and reduction of pancreatic β-cell apoptosis. |
2019-08-13 |
2023-08-13 |
Not clear |
| Naoaki Sakata, Gumpei Yoshimatsu, Shohta Kodam. Development and Characteristics of Pancreatic Epsilon Cells. International journal of molecular sciences. vol 20. issue 8. 2019-08-08. PMID:31014006. |
ghrelin contributes to increased blood glucose levels by suppressing insulin release from β cells and is also involved in the growth and proliferation of β cells and the prevention of β cell apoptosis. |
2019-08-08 |
2023-08-13 |
Not clear |
| Li Zhong, Qing Liu, Yan Sie Ting, Vun Yien Thien, Nurwafa Syafiqah Binti Kalong, Dehua Yang, Ming-Wei Wan. Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression. Chemical biology & drug design. vol 92. issue 6. 2019-08-01. PMID:30043441. |
overexpression of thioredoxin-interacting protein (txnip) is associated with reduced insulin sensitivity and β-cell apoptosis. |
2019-08-01 |
2023-08-13 |
Not clear |
| Li Zhong, Qing Liu, Yan Sie Ting, Vun Yien Thien, Nurwafa Syafiqah Binti Kalong, Dehua Yang, Ming-Wei Wan. Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression. Chemical biology & drug design. vol 92. issue 6. 2019-08-01. PMID:30043441. |
in this study, we describe structural modification and optimization of w2476 leading to three more active derivatives, 8d, 8g, and 9h, capable of suppressing txnip expression in bg73 and ins-1e cells, increasing insulin production, and reducing high glucose-induced apoptosis in ins-1e cells. |
2019-08-01 |
2023-08-13 |
Not clear |
| Kung-Ha Choi, Mi Hwa Park, Hyun Ah Lee, Ji-Sook Ha. Cyanidin-3-rutinoside protects INS-1 pancreatic β cells against high glucose-induced glucotoxicity by apoptosis. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 73. issue 7-8. 2019-07-29. PMID:29924740. |
exposure to high levels of glucose may cause glucotoxicity, leading to pancreatic β cell dysfunction, including cell apoptosis and impaired glucose-stimulated insulin secretion. |
2019-07-29 |
2023-08-13 |
Not clear |
| He Tian, Zhan-You Wan. Zinc Chelator Inhibits Zinc-Induced Islet Amyloid Polypeptide Deposition and Apoptosis in INS-1 Cells. Biological trace element research. vol 189. issue 1. 2019-07-22. PMID:30027367. |
furthermore, we analyzed the effect of zinc and tpen on the apoptosis and insulin level. |
2019-07-22 |
2023-08-13 |
Not clear |
| He Tian, Zhan-You Wan. Zinc Chelator Inhibits Zinc-Induced Islet Amyloid Polypeptide Deposition and Apoptosis in INS-1 Cells. Biological trace element research. vol 189. issue 1. 2019-07-22. PMID:30027367. |
the results showed that tpen could reverse zinc-induced ins-1 cell apoptosis and insulin secretion. |
2019-07-22 |
2023-08-13 |
Not clear |
| Wensong Li, Manli Chang, Mingli Qiu, Yangli Chen, Xiaochen Zhang, Qiang Li, Can Cu. Exogenous obestatin decreases beta-cell apoptosis and alfa-cell proliferation in high fat diet and streptozotocin induced type 2 diabetic rats. European journal of pharmacology. vol 851. 2019-07-22. PMID:30776368. |
these results demonstrated that obestatin might have a potential therapeutic relevance in improving islet cell function, including increasing insulin secretion through inhibiting beta cell apoptosis and decreasing glucagon secretion by inhibiting alfa cell proliferation in type 2 diabetes. |
2019-07-22 |
2023-08-13 |
rat |
| Qingfeng Sheng, Xiangwei Xiao, Krishna Prasadan, Congde Chen, Yungching Ming, Joseph Fusco, Nupur N Gangopadhyay, David Ricks, George K Gitte. Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet. Scientific reports. vol 7. issue 1. 2019-07-12. PMID:29180700. |
depletion of atg7, a necessary component of the autophagy pathway, in beta cells by pancreatic intra-ductal aav8-shatg7 infusion in c57bl/6 mice, resulted in decreased beta cell mass, impaired glucose tolerance, defective insulin secretion, and increased apoptosis when a combined high-fat and high-glucose diet was given, seemingly due to suppression of autophagy. |
2019-07-12 |
2023-08-13 |
mouse |
| J Tan, A Tong, Y X. Pancreatic β-cell function is inhibited by miR-3666 in type 2 diabetes mellitus by targeting adiponectin. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 6. 2019-07-10. PMID:31141089. |
overexpression of mir-3666 inhibited cell proliferation, reduced insulin secretion, and promoted cell apoptosis of pancreatic β-cell line (ins-1 cells). |
2019-07-10 |
2023-08-13 |
human |