| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meliza G Ward, Ge Li, Valéria C Barbosa-Lorenzi, Mingming Ha. Stigmasterol prevents glucolipotoxicity induced defects in glucose-stimulated insulin secretion. Scientific reports. vol 7. issue 1. 2019-04-16. PMID:28842702. |
stigmasterol addition also inhibited early apoptosis, increased total insulin, promoted actin reorganization, and improved insulin secretion in cells exposed to glucolipotoxicity. |
2019-04-16 |
2023-08-13 |
human |
| Anissa Gamble, Rena Pawlick, Andrew R Pepper, Antonio Bruni, Adetola Adesida, Peter A Senior, Gregory S Korbutt, A M James Shapir. Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells. PloS one. vol 13. issue 11. 2019-04-09. PMID:30419033. |
islets co-cultured with ad-mscs for 48 hours had decreased cell death, superior viability as measured by membrane integrity, improved glucose stimulated insulin secretion and reduced apoptosis compared to control islets. |
2019-04-09 |
2023-08-13 |
mouse |
| Chao Chen, Hong-Cai Wang, Xu Zhai, Feng Huang, Dong Wu, Pei-Jing Ron. [Progress of Research on Mechanism of Acupuncture for Diabetes Mellitus]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 9. 2019-04-08. PMID:30232872. |
; 2) improving pancreas function, raising insulin sensitivity to improve insulin resistance possibly by activating amp-activated protein kinase and sirtuin 1/ peroxisome proliferator-activated receptor γ coactivator 1 α signaling, up-regulating activities of cholinergic nerve activity and nitric oxide synthase, and inhibiting apoptosis of pancreatic beta-cells; 3) lowering blood glucose possibly by increasing anaerobic glucose metabolism, regulating activities of vagal and sympathetic nerves; 4) adjusting the levels of related hormones such as melatonin, insulin, glucocorticold, epinephrine, etc. |
2019-04-08 |
2023-08-13 |
Not clear |
| Sima Kianpour Rad, Aditya Arya, Hamed Karimian, Priya Madhavan, Farzana Rizwan, Shajan Koshy, Girish Prabh. Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer's disease. Drug design, development and therapy. vol 12. 2019-03-26. PMID:30538427. |
interestingly, nfts and aps lead to the impairment of several crucial cascades, such as synaptogenesis, neurotrophy, and apoptosis, which are regulated by insulin, cholesterol, and glucose metabolism. |
2019-03-26 |
2023-08-13 |
Not clear |
| Francielle Graus-Nunes, Vanessa Souza-Mell. The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-25. PMID:30404071. |
insulin resistance alters pancreatic islet cell distribution and morphology and hypertrophied islets exhibit upregulated angiotensin ii type 1 receptor, which drives oxidative stress, apoptosis, and fibrosis, configuring beta cell dysfunction and diminishing islet lifespan. |
2019-03-25 |
2023-08-13 |
Not clear |
| Carolina Lisi Román, Bárbara Maiztegui, Héctor Del Zotto, Juan José Gagliardino, Luis Emilio Flore. INGAP-PP effects on β-cell mass and function are related to its positive effect on islet angiogenesis and VEGFA production. Molecular and cellular endocrinology. vol 470. 2019-03-22. PMID:29146554. |
normal islets cultured with ingap-pp and vegfa increased insulin and vegfa secretion while apoptosis decreased. |
2019-03-22 |
2023-08-13 |
rat |
| Peng Sun, Qiang Zeng, Daqing Cheng, Kuo Zhang, Jilin Zheng, Yupeng Liu, Yu-Feng Yuan, Yi-Da Tan. Caspase Recruitment Domain Protein 6 Protects Against Hepatic Steatosis and Insulin Resistance by Suppressing Apoptosis Signal-Regulating Kinase 1. Hepatology (Baltimore, Md.). vol 68. issue 6. 2019-03-22. PMID:29729191. |
caspase recruitment domain protein 6 protects against hepatic steatosis and insulin resistance by suppressing apoptosis signal-regulating kinase 1. |
2019-03-22 |
2023-08-13 |
mouse |
| Xubing Yuan, Junping Zheng, Lishi Ren, Siming Jiao, Cui Feng, Yuguang Du, Hongtao Li. Enteromorpha prolifera oligomers relieve pancreatic injury in streptozotocin (STZ)-induced diabetic mice. Carbohydrate polymers. vol 206. 2019-03-21. PMID:30553339. |
further, by using the quantitative real-time pcr (qpcr) assay and immunofluorescence staining, epo was proved to promote the insulin secretion by reducing pancreatic inflammation and apoptosis in diabetic mice. |
2019-03-21 |
2023-08-13 |
mouse |
| Mohammad L Rahman, Liming Liang, Linda Valeri, Li Su, Zhaozhong Zhu, Shangzhi Gao, Golam Mostofa, Qazi Qamruzzaman, Russ Hauser, Andrea Baccarelli, David C Christian. Regulation of birthweight by placenta-derived miRNAs: evidence from an arsenic-exposed birth cohort in Bangladesh. Epigenetics. vol 13. issue 6. 2019-02-28. PMID:30099960. |
gene enrichment analysis with in silico predicted targets identified cell proliferation, inflammation, apoptosis, insulin, and igf family signaling cascades associated with these mirnas. |
2019-02-28 |
2023-08-13 |
Not clear |
| Leila Shahriyary, Gholamhossein Riazi, Mohammad Reza Lornejad, Mansoureh Ghezlou, Bahareh Bigdeli, Behdad Delavari, Fatemeh Mamashli, Shayan Abbasi, Jamshid Davoodi, Ali Akbar Sabour. Effect of glycated insulin on the blood-brain barrier permeability: An in vitro study. Archives of biochemistry and biophysics. vol 647. 2019-02-18. PMID:29444458. |
lower cell viability, higher apoptosis, and more ros were detected upon treatment of cells with glycated insulin. |
2019-02-18 |
2023-08-13 |
Not clear |
| Daniil Nikitin, Dmitry Penzar, Andrew Garazha, Maxim Sorokin, Victor Tkachev, Nicolas Borisov, Alexander Poltorak, Vladimir Prassolov, Anton A Buzdi. Profiling of Human Molecular Pathways Affected by Retrotransposons at the Level of Regulation by Transcription Factor Proteins. Frontiers in immunology. vol 9. 2019-02-14. PMID:29441061. |
the younger res regulate other aspects of immunity, cell cycle progression and apoptosis, pdgf, tgf beta, egfr, and p38 signaling, transcriptional repression, structure of nuclear lumen, catabolism of phospholipids, and heterocyclic molecules, insulin and ampk signaling, retrograde golgi-er transport, and estrogen signaling. |
2019-02-14 |
2023-08-13 |
human |
| Zengpeng Lv, Hao Fan, Beibei Zhang, Chao Ning, Kun Xing, Yuming Gu. Dietary genistein supplementation in laying broiler breeder hens alters the development and metabolism of offspring embryos as revealed by hepatic transcriptome analysis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 8. 2019-02-11. PMID:29518347. |
low-dose gen treatment increased insulin growth factor-binding protein (igfbp)3 mrna expression in the embryonic liver, whereas high-dose gen treatment increased igfbp5 expression and activated the apoptosis and protein tyrosine kinase signaling pathways. |
2019-02-11 |
2023-08-13 |
chicken |
| Eunjin Oh, Miwon Ahn, Solomon Afelik, Thomas C Becker, Bart O Roep, Debbie C Thurmon. Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass. Diabetes. vol 67. issue 12. 2019-02-08. PMID:30305365. |
human islet β-cells overexpressing stx4 exhibited enhanced insulin secretory capability; resilience against proinflammatory cytokine-induced apoptosis; and reduced expression of the |
2019-02-08 |
2023-08-13 |
mouse |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. |
2019-01-31 |
2023-08-13 |
mouse |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
a high-fat diet induces obesity in mice, leading to insulin resistance, decreased mitochondrial function, and increased apoptosis in the hippocampus, which eventually result in memory loss. |
2019-01-31 |
2023-08-13 |
mouse |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
the present study investigated the effect of physical exercise on memory, hippocampal mitochondrial function, and apoptosis in mice with in insulin resistance caused by obesity due to high-fat diet. |
2019-01-31 |
2023-08-13 |
mouse |
| Violeta Georgieva Tsonkova, Fredrik Wolfhagen Sand, Xenia Asbæk Wolf, Lars Groth Grunnet, Anna Kirstine Ringgaard, Camilla Ingvorsen, Louise Winkel, Mark Kalisz, Kevin Dalgaard, Christine Bruun, Johannes Josef Fels, Charlotte Helgstrand, Sven Hastrup, Fredrik Kryh Öberg, Erik Vernet, Michael Paolo Bastner Sandrini, Allan Christian Shaw, Carsten Jessen, Mads Grønborg, Jacob Hald, Hanni Willenbrock, Dennis Madsen, Rasmus Wernersson, Lena Hansson, Jan Nygaard Jensen, Annette Plesner, Tomas Alanentalo, Maja Borup Kjær Petersen, Anne Grapin-Botton, Christian Honoré, Jonas Ahnfelt-Rønne, Jacob Hecksher-Sørensen, Philippe Ravassard, Ole D Madsen, Claude Rescan, Thomas Frogn. The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates. Molecular metabolism. vol 8. 2019-01-29. PMID:29307512. |
to characterize the endoc-βh1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and er stress, with the objective to assess its potential as a screening platform for identification of novel anti-diabetic drug candidates. |
2019-01-29 |
2023-08-13 |
human |
| A Karatug Kacar, S Gezginci-Oktayoglu, S Bolken. 4-Methylcatechol stimulates apoptosis and reduces insulin secretion by decreasing betacellulin and inhibin beta-A in INS-1 beta-cells. Human & experimental toxicology. vol 37. issue 11. 2019-01-29. PMID:29473434. |
4-methylcatechol stimulates apoptosis and reduces insulin secretion by decreasing betacellulin and inhibin beta-a in ins-1 beta-cells. |
2019-01-29 |
2023-08-13 |
rat |
| A Karatug Kacar, S Gezginci-Oktayoglu, S Bolken. 4-Methylcatechol stimulates apoptosis and reduces insulin secretion by decreasing betacellulin and inhibin beta-A in INS-1 beta-cells. Human & experimental toxicology. vol 37. issue 11. 2019-01-29. PMID:29473434. |
the rate of apoptosis and the amount of insulin in the cell and the secretions were determined by the elisa method. |
2019-01-29 |
2023-08-13 |
rat |
| A Karatug Kacar, S Gezginci-Oktayoglu, S Bolken. 4-Methylcatechol stimulates apoptosis and reduces insulin secretion by decreasing betacellulin and inhibin beta-A in INS-1 beta-cells. Human & experimental toxicology. vol 37. issue 11. 2019-01-29. PMID:29473434. |
these results revealed that 4-mc induces apoptosis and decreases insulin secretion by reducing btc and inhibin beta-a in insulinoma ins-1 cells. |
2019-01-29 |
2023-08-13 |
rat |