| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanan Wang, Minggang Li, Zaizhong N. Primary study on the hypoglycemic mechanism of 5rolGLP-HV in STZ-induced type 2 diabetes mellitus mice. Journal of biosciences. vol 43. issue 5. 2019-01-29. PMID:30541952. |
5rolglp-hv treatment decreased the mda levels and the t-sod activity in serum and pancreatic of diabetic mice (but not up to significant difference), and significantly increased the expression of signal pathways related genes of rolglp-1, also the density of insulin expression and the numbers of apoptosis cells in islets of diabetic mice were significantly decreased in comparison to the negative diabetic mice. |
2019-01-29 |
2023-08-13 |
mouse |
| Wenhu Zhang, Shaozhuang Liu, Hanxiang Zhan, Zhibo Yan, Guangyong Zhan. Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma. Molecular medicine reports. vol 18. issue 4. 2019-01-09. PMID:30106143. |
genes in cluster 1 were significantly involved in metabolism of xenobiotics by cytochrome p450, genes in cluster 2 were majorly involved in apoptosis, tight junction formation, and platelet activation, genes in cluster 3 were primarily enriched in the p53 signaling pathway and genes in cluster 4 were significantly enriched in the insulin resistance pathway. |
2019-01-09 |
2023-08-13 |
Not clear |
| Wenhu Zhang, Shaozhuang Liu, Hanxiang Zhan, Zhibo Yan, Guangyong Zhan. Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma. Molecular medicine reports. vol 18. issue 4. 2019-01-09. PMID:30106143. |
in conclusion, pathways for metabolism of xenobiotics via cytochrome p450, apoptosis, tight junction formation, platelet activation, and insulin resistance may serve important roles in the progression of gastric adenocarcinoma. |
2019-01-09 |
2023-08-13 |
Not clear |
| Peng Duan, Jinxin Wang, Yang Li, Shiqiang Wei, Feng Su, Sanlin Zhang, Yuhui Duan, Lin Wang, Qinglei Zh. Opening of mitoKATP improves cardiac function and inhibits apoptosis via the AKT-Foxo1 signaling pathway in diabetic cardiomyopathy. International journal of molecular medicine. vol 42. issue 5. 2019-01-02. PMID:30132505. |
decreasing phosphorylation of akt‑foxo1 is closely associated with the onset of insulin resistance and apoptosis during diabetic cardiomyopathy (dcm). |
2019-01-02 |
2023-08-13 |
mouse |
| Peng Duan, Jinxin Wang, Yang Li, Shiqiang Wei, Feng Su, Sanlin Zhang, Yuhui Duan, Lin Wang, Qinglei Zh. Opening of mitoKATP improves cardiac function and inhibits apoptosis via the AKT-Foxo1 signaling pathway in diabetic cardiomyopathy. International journal of molecular medicine. vol 42. issue 5. 2019-01-02. PMID:30132505. |
similarly, dzx decreased the expression of the heart failure marker nt‑probnp, increased mitochondrial membrane potential, inhibited apoptosis, and increased the expression of p‑akt and p‑foxo1 when mimicking insulin resistance in cultured cardiomyocytes. |
2019-01-02 |
2023-08-13 |
mouse |
| Lu Liu, Xiaohuang Du, Zuo Zhang, Jiyin Zho. Trigonelline inhibits caspase 3 to protect β cells apoptosis in streptozotocin-induced type 1 diabetic mice. European journal of pharmacology. vol 836. 2018-12-27. PMID:30130525. |
after 4-week treatment, levels of blood glucose, serum insulin, and inflammatory factors, β cell apoptosis, insulin content, and oxidative stress parameters in pancreas were calculated. |
2018-12-27 |
2023-08-13 |
mouse |
| Lu Liu, Xiaohuang Du, Zuo Zhang, Jiyin Zho. Trigonelline inhibits caspase 3 to protect β cells apoptosis in streptozotocin-induced type 1 diabetic mice. European journal of pharmacology. vol 836. 2018-12-27. PMID:30130525. |
these results imply that trigonelline protects diabetic mice mediated by decreasing blood glucose, increasing insulin expression in β cells, regulating inflammatory response, suppressing β cells apoptosis partly by downregulating caspase 3 expression, and raising antioxidant enzyme activity. |
2018-12-27 |
2023-08-13 |
mouse |
| Qing-Jiu Zhang, Jie Li, Song-Yun Zhan. Effects of TRPM7/miR-34a Gene Silencing on Spatial Cognitive Function and Hippocampal Neurogenesis in Mice with Type 1 Diabetes Mellitus. Molecular neurobiology. vol 55. issue 2. 2018-12-21. PMID:28185128. |
compared to the nc group, the mice in the t1dm group had increased expressions of trpm7 and mir-34a; decreased weight and fasting insulin; increased blood glucose and levels of ica, iaa, and gad-ab; prolonged escape latency; less time spent in the target quadrant; incomplete neuronal structure; reduced neuron numbers; increased cell apoptosis and expressions of activated bax, cyt-c, and cleaved caspase-3; but reduced bcl-2 expression. |
2018-12-21 |
2023-08-13 |
mouse |
| Qing-Jiu Zhang, Jie Li, Song-Yun Zhan. Effects of TRPM7/miR-34a Gene Silencing on Spatial Cognitive Function and Hippocampal Neurogenesis in Mice with Type 1 Diabetes Mellitus. Molecular neurobiology. vol 55. issue 2. 2018-12-21. PMID:28185128. |
in comparison to the t1dm group, the t1dm + si-trpm7, t1dm + si-mir-34a, and t1dm + si-trpm7 + si-mir-34a groups showed increased weight and fasting insulin; reduced blood glucose and levels of ica, iaa, and gad-ab; shortened escape latency; prolonged time spent in the target quadrant platform; intact neuronal structure; increased neuron numbers; repaired neurons; reduced cell apoptosis and expressions of activated bax, cyt-c, and cleaved caspase-3; but increased bcl-2 expression. |
2018-12-21 |
2023-08-13 |
mouse |
| Arnold N Onyang. Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance. Oxidative medicine and cellular longevity. vol 2018. 2018-12-19. PMID:30116482. |
the insulin resistance-inducing cellular stresses include oxidative, nitrosative, carbonyl/electrophilic, genotoxic, and endoplasmic reticulum stresses; the stress responses include the ubiquitin-proteasome pathway, the dna damage response, the unfolded protein response, apoptosis, inflammasome activation, and pyroptosis, while the dysregulated responses include the heat shock response, autophagy, and nuclear factor erythroid-2-related factor 2 signaling. |
2018-12-19 |
2023-08-13 |
Not clear |
| Shadab Abadpour, Sven O Göpel, Simen W Schive, Olle Korsgren, Aksel Foss, Hanne Schol. Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis. Scientific reports. vol 7. issue 1. 2018-12-17. PMID:28484241. |
herein, by mimicking those conditions in vitro, we have shown that gdnf significantly improved glucose stimulated insulin secretion, reduced apoptosis and proinsulin:insulin ratio in nutrient deprived human islets. |
2018-12-17 |
2023-08-13 |
mouse |
| Tomoko Okuyama, Jun Shirakawa, Hiromi Yanagisawa, Mayu Kyohara, Shunsuke Yamazaki, Kazuki Tajima, Yu Togashi, Yasuo Terauch. Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets. Scientific reports. vol 7. issue 1. 2018-12-17. PMID:28539593. |
glucokinase-mediated glucose signaling induces insulin secretion, proliferation, and apoptosis in pancreatic β-cells. |
2018-12-17 |
2023-08-13 |
mouse |
| Manuel Blandino-Rosano, Rebecca Barbaresso, Margarita Jimenez-Palomares, Nadejda Bozadjieva, Joao Pedro Werneck-de-Castro, Masayuki Hatanaka, Raghavendra G Mirmira, Nahum Sonenberg, Ming Liu, Markus A Rüegg, Michael N Hall, Ernesto Bernal-Mizrach. Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing. Nature communications. vol 8. 2018-12-11. PMID:28699639. |
here we show that β-cell-specific loss of mtorc1 causes diabetes and β-cell failure due to defects in proliferation, autophagy, apoptosis and insulin secretion by using mice with conditional (βrako) and inducible (mip-βrako |
2018-12-11 |
2023-08-13 |
mouse |
| Hui Xu, Qiushi Wang, Qian Sun, Yu Qin, Aohan Han, Ye Cao, Qianlei Yang, Ping Yang, Jiachun Lu, Qizhan Liu, Quanyong Xian. In type 2 diabetes induced by cigarette smoking, activation of p38 MAPK is involved in pancreatic β-cell apoptosis. Environmental science and pollution research international. vol 25. issue 10. 2018-12-11. PMID:29372523. |
for min6 cells, cigarette smoke extract (cse) decreased insulin secretion and content; enhanced apoptosis, as illustrated by decreases of bcl-2 levels, increases of bax and cleaved caspase-3 levels, and an increased apoptotic index; and activated the p38 mapk pathway. |
2018-12-11 |
2023-08-13 |
Not clear |
| Hui Xu, Qiushi Wang, Qian Sun, Yu Qin, Aohan Han, Ye Cao, Qianlei Yang, Ping Yang, Jiachun Lu, Qizhan Liu, Quanyong Xian. In type 2 diabetes induced by cigarette smoking, activation of p38 MAPK is involved in pancreatic β-cell apoptosis. Environmental science and pollution research international. vol 25. issue 10. 2018-12-11. PMID:29372523. |
for min6 cells, inhibition of p-p38 mapk by sb203580 prevented enhanced apoptosis and the dysfunction of insulin secretion induced by cse. |
2018-12-11 |
2023-08-13 |
Not clear |
| Nadia Cobo-Vuilleumier, Petra I Lorenzo, Noelia García Rodríguez, Irene de Gracia Herrera Gómez, Esther Fuente-Martin, Livia López-Noriega, José Manuel Mellado-Gil, Silvana-Yanina Romero-Zerbo, Mathurin Baquié, Christian Claude Lachaud, Katja Stifter, German Perdomo, Marco Bugliani, Vincenzo De Tata, Domenico Bosco, Geraldine Parnaud, David Pozo, Abdelkrim Hmadcha, Javier P Florido, Miguel G Toscano, Peter de Haan, Kristina Schoonjans, Luis Sánchez Palazón, Piero Marchetti, Reinhold Schirmbeck, Alejandro Martín-Montalvo, Paolo Meda, Bernat Soria, Francisco-Javier Bermúdez-Silva, Luc St-Onge, Benoit R Gauthie. LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29662071. |
here, we show that bl001, a small lrh-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammation of pancreas in murine models of t1dm, and beta cell apoptosis in islets of type 2 diabetic patients, while increasing beta cell mass and insulin secretion. |
2018-12-11 |
2023-08-13 |
Not clear |
| Ching-Chi Chang, Tzu-Chin Lin, Hsiao-Li Ho, Chien-Yin Kuo, Hsin-Hua Li, Tatiana A Korolenko, Wei-Jen Chen, Te-Jen Lai, Ying-Jui Ho, Chih-Li Li. GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. International journal of molecular sciences. vol 19. issue 9. 2018-12-11. PMID:30149534. |
our results demonstrated that mhtt overexpression significantly impairs insulin signaling and causes apoptosis in neuronal cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Muhammad Sohail Anjum, Azra Mehmood, Faiza Mahmood, Muhammad Ali, Moazzam Nazir Tarrar, Shaheen N Khan, Sheikh Riazuddi. Journal of biosciences. vol 43. issue 4. 2018-12-11. PMID:30207311. |
the results showed that ipcs pretreated with a combination of sdf1α and bfgf exhibited maximally alleviated apoptosis, senescence and cell damage with a concomitantly increased release of insulin, enhanced cell proliferation and greater upregulation of insulin 1, insulin 2, ngn3, pdx1 and nkx6.2 when stressed with 33 mm glucose. |
2018-12-11 |
2023-08-13 |
Not clear |
| Raymond Vanholder, Tessa Gryp, Griet Glorieu. Urea and chronic kidney disease: the comeback of the century? (in uraemia research). Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 33. issue 1. 2018-11-27. PMID:28407121. |
first of all, at least five studies indicate that urea itself induces molecular changes related to insulin resistance, free radical production, apoptosis and disruption of the protective intestinal barrier. |
2018-11-27 |
2023-08-13 |
Not clear |
| Rania G Abdel-Latif, Gehan H Heeba, Ashraf Taye, Mohamed M A Khalif. Lixisenatide, a novel GLP-1 analog, protects against cerebral ischemia/reperfusion injury in diabetic rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 391. issue 7. 2018-11-26. PMID:29671019. |
apart from ameliorating glucose intolerance and insulin resistance, lixisenatide was found to be superior to glimepiride as protective treatment in terms of enhancing behavioral/neurological functions and suppressing cerebral oxidative stress, inflammation, and apoptosis in cerebral i/r-injured diabetic rats. |
2018-11-26 |
2023-08-13 |
rat |