| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jolanta Skarbaliene, Kristoffer T Rigbolt, Keld Fosgerau, Nils Billestru. In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes. European journal of pharmacology. vol 815. 2018-07-05. PMID:28928089. |
here we tested the in-vitro effects of zp3022 on β-cell proliferation, islet apoptosis and glucose-stimulated insulin secretion (gsis) in rat islets of langerhans. |
2018-07-05 |
2023-08-13 |
mouse |
| Alaa Abou Daher, Tatiana El Jalkh, Assaad A Eid, Alessia Fornoni, Brian Marples, Youssef H Zeida. Translational Aspects of Sphingolipid Metabolism in Renal Disorders. International journal of molecular sciences. vol 18. issue 12. 2018-07-03. PMID:29186855. |
in addition to being involved in dynamic cellular processes like apoptosis, senescence and differentiation, sphingolipids are implicated in critical physiological functions such as immune responses and pathophysiological conditions like inflammation and insulin resistance. |
2018-07-03 |
2023-08-13 |
human |
| Ting Zhao, Jun Bai, Qingyun Zou, Feng Chen, Yan Xi. Insulin in combination with cisplatin induces the apoptosis of ovarian cancer cells via p53 and JNK activation. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:29039558. |
insulin in combination with cisplatin induces the apoptosis of ovarian cancer cells via p53 and jnk activation. |
2018-06-22 |
2023-08-13 |
Not clear |
| Ya-Fang Chen, Cecilia Hsuan Day, Nien-Hung Lee, Yu-Feng Chen, Jaw-Ji Yang, Chih-Hsueh Lin, Ray-Jade Chen, Peramaiyan Rajendran, Vijaya Padma Viswanadha, Chih-Yang Huan. Tanshinone IIA Inhibits β-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis. International journal of medical sciences. vol 14. issue 12. 2018-06-21. PMID:29104486. |
angiotensin ii (angii) stimulates the expression of insulin like-growth factors (igf-2) and igf-2 receptor (igf-2r) in h9c2 cardiomyoblasts and subsequently leads to apoptosis. |
2018-06-21 |
2023-08-13 |
Not clear |
| Ni Yang, Liuzhong Wu, Ying Zhao, Ning Zou, Chunfeng Li. MicroRNA-320 involves in the cardioprotective effect of insulin against myocardial ischemia by targeting survivin. Cell biochemistry and function. vol 36. issue 3. 2018-06-12. PMID:29521436. |
in this study, using a cell model of ischemia through culturing h9c2 cardiac myocytes in serum-free medium with hypoxia, we demonstrated that pretreatment with insulin significantly inhibited cell apoptosis and downregulated microrna-320 (mir-320) expression. |
2018-06-12 |
2023-08-13 |
Not clear |
| Ni Yang, Liuzhong Wu, Ying Zhao, Ning Zou, Chunfeng Li. MicroRNA-320 involves in the cardioprotective effect of insulin against myocardial ischemia by targeting survivin. Cell biochemistry and function. vol 36. issue 3. 2018-06-12. PMID:29521436. |
interestingly, mir-320 mimic impaired the cardioprotective effect of insulin against myocardial ischemia injury by targeting survivin, which is a member of the family of inhibitor of apoptosis proteins. |
2018-06-12 |
2023-08-13 |
Not clear |
| JunJun Ling, Shengyou Yang, Yi Huang, Dongfeng Wei, Weidong Chen. Identifying key genes, pathways and screening therapeutic agents for manganese-induced Alzheimer disease using bioinformatics analysis. Medicine. vol 97. issue 22. 2018-06-08. PMID:29851783. |
the top 5 items of kegg pathway analysis were cytokine-cytokine receptor interaction, apoptosis, oxidative phosphorylation, toll-like receptor signaling pathway, and insulin signaling pathway. |
2018-06-08 |
2023-08-13 |
Not clear |
| Pegah Golabi, Haley Bush, Zobair M Younoss. Treatment Strategies for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis. Clinics in liver disease. vol 21. issue 4. 2018-06-05. PMID:28987260. |
some target insulin resistance and others focus on oxidative stress, inflammation, apoptosis, and fibrosis. |
2018-06-05 |
2023-08-13 |
Not clear |
| Natália Emerim Lemos, Letícia de Almeida Brondani, Cristine Dieter, Jakeline Rheinheimer, Ana Paula Bouças, Cristiane Bauermann Leitão, Daisy Crispim, Andrea Carla Baue. Use of additives, scaffolds and extracellular matrix components for improvement of human pancreatic islet outcomes in vitro: A systematic review. Islets. vol 9. issue 5. 2018-05-24. PMID:28678625. |
the effects of the reviewed additives, ecm or scaffolds on islet viability, apoptosis and function (glucose-stimulated insulin secretion - gsis) were heterogeneous, making any major conclusion hard to sustain. |
2018-05-24 |
2023-08-13 |
human |
| Hirohisa Nagahori, Kenji Nakamura, Kayo Sumida, Shingo Ito, Sumio Ohtsuk. Combining Genomics To Identify the Pathways of Post-Transcriptional Nongenotoxic Signaling and Energy Homeostasis in Livers of Rats Treated with the Pregnane X Receptor Agonist, Pregnenolone Carbonitrile. Journal of proteome research. vol 16. issue 10. 2018-05-22. PMID:28825834. |
proteins involved in insulin signaling pathways showed an increase in phosphorylation, possibly by protein kinase a, and those involved in apoptosis showed a decrease. |
2018-05-22 |
2023-08-13 |
rat |
| Ivana R Sequeira, Sally D Poppit. Unfolding Novel Mechanisms of Polyphenol Flavonoids for Better Glycaemic Control: Targeting Pancreatic Islet Amyloid Polypeptide (IAPP). Nutrients. vol 9. issue 7. 2018-05-18. PMID:28754022. |
amyloid fibrils form from spontaneously misfolded amylin, depositing in islet cells to elicit apoptosis, beta cell degeneration and decrease insulin secretion, with amyloidosis affecting up to 80% of pancreatic islet cells in t2d. |
2018-05-18 |
2023-08-13 |
Not clear |
| Lei Yang, Yan Li, Xiaojing Wang, Yuling Liu, Lingzhu Yan. MicroRNA‑320a inhibition decreases insulin‑induced KGN cell proliferation and apoptosis by targeting PCGF1. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849208. |
the present study aimed to explore the effect of mir‑320a on pcos cell proliferation and apoptosis following treatment with insulin, and to clarify the underlying mechanism. |
2018-05-11 |
2023-08-13 |
Not clear |
| Zodwa Dlamini, Fortunate Mokoena, Rodney Hul. Abnormalities in alternative splicing in diabetes: therapeutic targets. Journal of molecular endocrinology. vol 59. issue 2. 2018-05-10. PMID:28716821. |
these two predominant forms of dm cause a significant loss of functional pancreatic β-cell mass causing different degrees of insulin deficiency, most likely, due to increased β-cell apoptosis. |
2018-05-10 |
2023-08-13 |
Not clear |
| Arijit Ghosh, Lei Gao, Abhimanyu Thakur, Parco M Siu, Christopher W K La. Role of free fatty acids in endothelial dysfunction. Journal of biomedical science. vol 24. issue 1. 2018-05-01. PMID:28750629. |
free fatty acid-mediated endothelial dysfunction involves several mechanisms including impaired insulin signaling and nitric oxide production, oxidative stress, inflammation and the activation of the renin-angiotensin system and apoptosis in the endothelial cells. |
2018-05-01 |
2023-08-13 |
human |
| Kadri Atay, Billur Canbakan, Emine Koroglu, Ibrahim Hatemi, Mustafa Canbakan, Nuray Kepil, Murat Tuncer, Hakan Sentur. Apoptosis and Disease Severity is Associated with Insulin Resistance in Non-alcoholic Fatty Liver Disease. Acta gastro-enterologica Belgica. vol 80. issue 2. 2018-04-30. PMID:29560693. |
apoptosis and disease severity is associated with insulin resistance in non-alcoholic fatty liver disease. |
2018-04-30 |
2023-08-13 |
Not clear |
| Dawood Khan, Srividya Vasu, R Charlotte Moffett, Nigel Irwin, Peter R Flat. Differential expression of glucagon-like peptide-2 (GLP-2) is involved in pancreatic islet cell adaptations to stress and beta-cell survival. Peptides. vol 95. 2018-04-26. PMID:28746825. |
we assessed the impact of glucagon-like peptide-2 (glp-2) on beta-cell secretory function, proliferation and apoptosis, as well as glucose tolerance, feeding behaviour and islet adaptions to chemically-induced insulin deficiency and resistance. |
2018-04-26 |
2023-08-13 |
mouse |
| Titikorn Chunchai, Bencharunan Samniang, Jirapas Sripetchwandee, Hiranya Pintana, Wanpitak Pongkan, Sirinart Kumfu, Krekwit Shinlapawittayatorn, Bruce H KenKnight, Nipon Chattipakorn, Siriporn C Chattipakor. Vagus Nerve Stimulation Exerts the Neuroprotective Effects in Obese-Insulin Resistant Rats, Leading to the Improvement of Cognitive Function. Scientific reports. vol 6. 2018-04-24. PMID:27226157. |
however, the effects of chronic vns therapy on brain insulin sensitivity, dendritic spine density, brain mitochondrial function, apoptosis and cognition in obese-insulin resistant subjects have never been investigated. |
2018-04-24 |
2023-08-13 |
human |
| Titikorn Chunchai, Bencharunan Samniang, Jirapas Sripetchwandee, Hiranya Pintana, Wanpitak Pongkan, Sirinart Kumfu, Krekwit Shinlapawittayatorn, Bruce H KenKnight, Nipon Chattipakorn, Siriporn C Chattipakor. Vagus Nerve Stimulation Exerts the Neuroprotective Effects in Obese-Insulin Resistant Rats, Leading to the Improvement of Cognitive Function. Scientific reports. vol 6. 2018-04-24. PMID:27226157. |
at the end of treatment, cognitive function, metabolic parameters, brain insulin sensitivity, brain mitochondrial function, brain apoptosis, and dendritic spines were determined in each rat. |
2018-04-24 |
2023-08-13 |
human |
| Titikorn Chunchai, Bencharunan Samniang, Jirapas Sripetchwandee, Hiranya Pintana, Wanpitak Pongkan, Sirinart Kumfu, Krekwit Shinlapawittayatorn, Bruce H KenKnight, Nipon Chattipakorn, Siriporn C Chattipakor. Vagus Nerve Stimulation Exerts the Neuroprotective Effects in Obese-Insulin Resistant Rats, Leading to the Improvement of Cognitive Function. Scientific reports. vol 6. 2018-04-24. PMID:27226157. |
the hfd-fed with sham therapy developed brain insulin resistance, brain oxidative stress, brain inflammation, and brain apoptosis, resulting in the cognitive decline. |
2018-04-24 |
2023-08-13 |
human |
| Titikorn Chunchai, Bencharunan Samniang, Jirapas Sripetchwandee, Hiranya Pintana, Wanpitak Pongkan, Sirinart Kumfu, Krekwit Shinlapawittayatorn, Bruce H KenKnight, Nipon Chattipakorn, Siriporn C Chattipakor. Vagus Nerve Stimulation Exerts the Neuroprotective Effects in Obese-Insulin Resistant Rats, Leading to the Improvement of Cognitive Function. Scientific reports. vol 6. 2018-04-24. PMID:27226157. |
these findings suggest that vns attenuates cognitive decline in obese-insulin resistant rats by attenuating brain mitochondrial dysfunction, improving brain insulin sensitivity, decreasing cell apoptosis, and increasing dendritic spine density. |
2018-04-24 |
2023-08-13 |
human |