| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin Jakab, Nina Ketterl, Johannes Fürst, Marlena Beyreis, Michael Kittl, Tobias Kiesslich, Cornelia Hauser-Kronberger, Martin Gaisberger, Markus Ritte. The H+/K+ ATPase Inhibitor SCH-28080 Inhibits Insulin Secretion and Induces Cell Death in INS-1E Rat Insulinoma Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 43. issue 3. 2017-12-26. PMID:28968600. |
to investigate if other proton extrusion mechanisms than nhes are involved in ph regulation, we tested for the presence of the non-gastric h+/k+ atpase in rat insulinoma cells and assessed effects of the h+/k+ atpase inhibitor sch-28080 on insulin secretion, cell viability and apoptosis. |
2017-12-26 |
2023-08-13 |
rat |
| Christoph Schmid, Claudia Ghirlanda, Markus Niesse. Prevention of tumour cell apoptosis associated with sustained protein kinase B phosphorylation is more sensitive to regulation by insulin signalling than stimulation of proliferation and extracellular signal-regulated kinase. Molecular and cellular biochemistry. vol 432. issue 1-2. 2017-12-21. PMID:28316059. |
prevention of tumour cell apoptosis associated with sustained protein kinase b phosphorylation is more sensitive to regulation by insulin signalling than stimulation of proliferation and extracellular signal-regulated kinase. |
2017-12-21 |
2023-08-13 |
Not clear |
| Christoph Schmid, Claudia Ghirlanda, Markus Niesse. Prevention of tumour cell apoptosis associated with sustained protein kinase B phosphorylation is more sensitive to regulation by insulin signalling than stimulation of proliferation and extracellular signal-regulated kinase. Molecular and cellular biochemistry. vol 432. issue 1-2. 2017-12-21. PMID:28316059. |
to test if continuous exposure to insulin can favour tumour growth, we studied insulin/igf1-dependent activation of erk1/2 and akt/pkb by western blotting, inhibition of apoptosis by elisa, and induction of proliferation by [ |
2017-12-21 |
2023-08-13 |
Not clear |
| Eva Tudurí, Miguel López, Carlos Diéguez, Angel Nadal, Rubén Nogueira. Glucagon-Like Peptide 1 Analogs and their Effects on Pancreatic Islets. Trends in endocrinology and metabolism: TEM. vol 27. issue 5. 2017-12-18. PMID:27062006. |
based on the results from in vitro and in vivo studies in humans and animal models, we describe the specific actions of glp-1 analogs on the synthesis, processing, and secretion of insulin, islet morphology, and β cell proliferation and apoptosis. |
2017-12-18 |
2023-08-13 |
Not clear |
| Janica C Wong, Van Vo, Priyatham Gorjala, Ronald R Fiscu. Pancreatic-β-cell survival and proliferation are promoted by protein kinase G type Iα and downstream regulation of AKT/FOXO1. Diabetes & vascular disease research. vol 14. issue 5. 2017-12-12. PMID:28631500. |
in this study, endothelial nitric oxide synthase/neuronal nitric oxide synthase inhibitor l-nio (l-n(5)-(1-iminoethyl)ornithine), soluble guanylyl cyclase inhibitor odq (1h-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one), atrial natriuretic peptide-receptor inhibitor a71915 and protein kinase g type iα kinase activity inhibitor dt-2 all increased apoptosis and decreased insulin secretion in rinm5f pancreatic β-cells, suggesting autocrine regulatory role for endogenous nitric oxide- and atrial natriuretic peptide-induced activation of protein kinase g type iα. |
2017-12-12 |
2023-08-13 |
Not clear |
| M D Bellin, G J Beilman, T B Dunn, T L Pruett, D E R Sutherland, S Chinnakotla, J S Hodges, A Lane, P Ptacek, K L Berry, B J Hering, A Mora. Sitagliptin Treatment After Total Pancreatectomy With Islet Autotransplantation: A Randomized, Placebo-Controlled Study. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 17. issue 2. 2017-12-11. PMID:27459721. |
insulin independence after total pancreatectomy and islet autotransplant (tpiat) for chronic pancreatitis is limited by a high rate of postprocedure beta cell apoptosis. |
2017-12-11 |
2023-08-13 |
human |
| Yueting Dong, Zhiye Xu, Ziyi Zhang, Xueyao Yin, Xihua Lin, Hong Li, Fenping Zhen. Impaired adipose expansion caused by liver X receptor activation is associated with insulin resistance in mice fed a high-fat diet. Journal of molecular endocrinology. vol 58. issue 3. 2017-12-07. PMID:28258092. |
in conclusion, these findings reveal that lxr activation impairs adipose expansion by increasing adipocyte apoptosis, lipolysis and antagonising pparγ-mediated transcriptional activity, which contributes to decreased insulin sensitivity in whole body. |
2017-12-07 |
2023-08-13 |
mouse |
| Piotr Zabielski, Agnieszka Urszula Błachnio-Zabielska, Beata Wójcik, Adrian Chabowski, Jan Górsk. Effect of plasma free fatty acid supply on the rate of ceramide synthesis in different muscle types in the rat. PloS one. vol 12. issue 11. 2017-12-04. PMID:29095868. |
dynamics of ceramide synthesis is important in the several biological processes, such as induction of apoptosis or insulin resistance. |
2017-12-04 |
2023-08-13 |
rat |
| Baozhong Zhuge, Guohong L. MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator. Biochemical and biophysical research communications. vol 494. issue 3-4. 2017-11-21. PMID:29107687. |
mir-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting casp8 and fadd-like apoptosis regulator. |
2017-11-21 |
2023-08-13 |
mouse |
| Annalisa Natalicchio, Nicola Marrano, Giuseppina Biondi, Rosaria Spagnuolo, Rossella Labarbuta, Immacolata Porreca, Angelo Cignarelli, Marco Bugliani, Piero Marchetti, Sebastio Perrini, Luigi Laviola, Francesco Giorgin. The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion. Diabetes. vol 66. issue 11. 2017-11-20. PMID:28724742. |
recombinant irisin stimulated insulin biosynthesis and glucose-stimulated insulin secretion (gsis) in a pka-dependent manner and prevented saturated fatty acid-induced apoptosis in human and rat pancreatic β-cells, as well as in human and murine pancreatic islets, via akt/bcl2 signaling. |
2017-11-20 |
2023-08-13 |
mouse |
| Dawood Khan, Srividya Vasu, R Charlotte Moffett, Nigel Irwin, Peter R Flat. Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival. Molecular and cellular endocrinology. vol 436. 2017-11-17. PMID:27465830. |
in the present study expression of pyy and its npy receptors on mouse islets and immortalised rodent and human beta-cells was examined together with the effects of both major circulating forms of pyy, namely pyy(1-36) and pyy(3-36), on beta-cell function, murine islet adaptions to insulin deficiency/resistance, as well as direct effects on cultured beta-cell proliferation and apoptosis. |
2017-11-17 |
2023-08-13 |
mouse |
| Cláudia Silva, Catarina Nunes, Ana Correia-Branco, João R Araújo, Fátima Marte. Insulin Exhibits an Antiproliferative and Hypertrophic Effect in First Trimester Human Extravillous Trophoblasts. Reproductive sciences (Thousand Oaks, Calif.). vol 24. issue 4. 2017-11-16. PMID:27662903. |
in contrast, exposure to insulin (10 nmol/l; 48 hours) showed no significant effect on cell viability, apoptosis, and migration capacity. |
2017-11-16 |
2023-08-13 |
human |
| Guanghong Jia, Yan Jia, James R Sower. Contribution of Maladaptive Adipose Tissue Expansion to Development of Cardiovascular Disease. Comprehensive Physiology. vol 7. issue 1. 2017-11-16. PMID:28135006. |
visceral white adipocyte tissue (wat) expansion and associated fibrosis/stiffness of wat promote insulin resistance and cvd through increases in proinflammatory adipokines, oxidative stress, activation of renin-angiotensin-aldosterone system, dysregulation of adipocyte apoptosis and autophagy, dysfunctional immune modulation, and adverse changes in the gut microbiome. |
2017-11-16 |
2023-08-13 |
Not clear |
| Laura J Cobb, Changhan Lee, Jialin Xiao, Kelvin Yen, Richard G Wong, Hiromi K Nakamura, Hemal H Mehta, Qinglei Gao, Carmel Ashur, Derek M Huffman, Junxiang Wan, Radhika Muzumdar, Nir Barzilai, Pinchas Cohe. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging. vol 8. issue 4. 2017-11-03. PMID:27070352. |
naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. |
2017-11-03 |
2023-08-13 |
human |
| Shafat Ali, Shazia Nafis, Ponnusamy Kalaiarasan, Ekta Rai, Swarkar Sharma, Rameshwar N Bameza. Understanding Genetic Heterogeneity in Type 2 Diabetes by Delineating Physiological Phenotypes: SIRT1 and its Gene Network in Impaired Insulin Secretion. The review of diabetic studies : RDS. vol 13. issue 1. 2017-11-03. PMID:27563694. |
the individual risk of developing t2d is determined by an altered genetic background of the en-zymes involved in several metabolism-related biological mechanisms, including glucose homeostasis, insulin metab-olism, the glucose and ion transporters involved in glucose uptake, transcription factors, signaling intermediates of insulin signaling pathways, insulin production and secretion, pancreatic tissue development, and apoptosis. |
2017-11-03 |
2023-08-13 |
Not clear |
| Pradeep Bompada, David Atac, Cheng Luan, Robin Andersson, Judit Domènech Omella, Emilia Ottosson Laakso, Jason Wright, Leif Groop, Yang De Marini. Histone acetylation of glucose-induced thioredoxin-interacting protein gene expression in pancreatic islets. The international journal of biochemistry & cell biology. vol 81. issue Pt A. 2017-11-02. PMID:27989964. |
in ins1 832/13 cells, ep300 knock-out by crispr/cas9 elevated glucose-induced insulin secretion and greatly reduced glucose-stimulated txnip expression and cell apoptosis. |
2017-11-02 |
2023-08-13 |
human |
| T T Zhou, L L Quan, L P Chen, T Du, K X Sun, J C Zhang, L Yu, Y Li, P Wan, L L Chen, B H Jiang, L H Hu, J Chen, X She. SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways. Cell death & disease. vol 7. 2017-10-31. PMID:27148689. |
kv2.1 as a voltage-gated potassium (kv) channel subunit has a pivotal role in the regulation of glucose-stimulated insulin secretion (gsis) and pancreatic β-cell apoptosis, and is believed to be a promising target for anti-diabetic drug discovery, although the mechanism underlying the kv2.1-mediated β-cell apoptosis is obscure. |
2017-10-31 |
2023-08-13 |
mouse |
| Gérald J Prud'homme, Yelena Glinka, Merve Kurt, Wenjuan Liu, Qinghua Wan. The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells. Biochemical and biophysical research communications. vol 493. issue 4. 2017-10-30. PMID:28993191. |
in beta cells, it increases insulin secretion, prevents apoptosis, and induces regeneration. |
2017-10-30 |
2023-08-13 |
mouse |
| Sigurd Lenze. Chemistry and biology of reactive species with special reference to the antioxidative defence status in pancreatic β-cells. Biochimica et biophysica acta. General subjects. vol 1861. issue 8. 2017-10-26. PMID:28527893. |
dysfunction and subsequent loss of the β-cells in the islets of langerhans through apoptosis ultimately cause a life-threatening insulin deficiency. |
2017-10-26 |
2023-08-13 |
Not clear |
| Giovanni Musso, Maurizio Cassader, Franco De Michieli, Elena Paschetta, Silvia Pinach, Francesca Saba, Daria Bongiovanni, Luciana Framarin, Mara Berrutti, Nicola Leone, Stefania Corvisieri, Renato Parente, Federica Molinaro, Antonio Sircana, Simona Bo, Roberto Gambin. MERTK rs4374383 variant predicts incident nonalcoholic fatty liver disease and diabetes: role of mononuclear cell activation and adipokine response to dietary fat. Human molecular genetics. vol 26. issue 9. 2017-10-17. PMID:28334911. |
despite comparable fastign and postprandial lipid profiles, mertk a-allele carriers showed lower resistin and mcp-1 responses, milder mnc nf-κb activation, and a higher postprandial adiponectin response to fat, which predicted tissue insulin resistance hepatocyte apoptosis and liver histology. |
2017-10-17 |
2023-08-13 |
human |