| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T-J Xu, Y Liu, P Li, X L Xu, J R Zen. Insulin in combination with selenium inhibits HG/Pal-induced cardiomyocyte apoptosis by Cbl-b regulating p38MAPK/CBP/Ku70 pathway. European review for medical and pharmacological sciences. vol 20. issue 15. 2017-07-26. PMID:27467007. |
in this study, we investigated whether insulin and selenium in combination (in/se) suppresses cardiomyocyte apoptosis and whether this protection is mediated by cbl-b regulating p38mapk/cbp/ku70 pathway. |
2017-07-26 |
2023-08-13 |
Not clear |
| Jun Zha, Xiao-Wei Chi, Xiao-Lin Yu, Xiang-Meng Liu, Dong-Qun Liu, Jie Zhu, Hui Ji, Rui-Tian Li. Interleukin-1β-Targeted Vaccine Improves Glucose Control and β-Cell Function in a Diabetic KK-Ay Mouse Model. PloS one. vol 11. issue 5. 2017-07-11. PMID:27152706. |
excess il-1β impairs islet function by inducing insulin resistance and β-cell apoptosis. |
2017-07-11 |
2023-08-13 |
mouse |
| Masaji Sakaguchi, Shiho Fujisaka, Weikang Cai, Jonathon N Winnay, Masahiro Konishi, Brian T O'Neill, Mengyao Li, Rubén García-Martín, Hirokazu Takahashi, Jiang Hu, Rohit N Kulkarni, C Ronald Kah. Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor. Cell metabolism. vol 25. issue 2. 2017-07-10. PMID:28065828. |
mice with a tamoxifen-inducible knockout of insulin and/or igf1 receptors (ir/igf1r) demonstrate a rapid loss of white and brown fat due to increased lipolysis and adipocyte apoptosis. |
2017-07-10 |
2023-08-13 |
mouse |
| Bárbara Maiztegui, Verónica Boggio, Carolina L Román, Luis E Flores, Héctor Del Zotto, Alejandro Ropolo, Daniel Grasso, María I Vaccaro, Juan J Gagliardin. VMP1-related autophagy induced by a fructose-rich diet in β-cells: its prevention by incretins. Clinical science (London, England : 1979). vol 131. issue 8. 2017-07-03. PMID:28188238. |
serum levels of metabolic/endocrine parameters, β-cell mass, morphology/ultrastructure and apoptosis, vacuole membrane protein 1 (vmp1) expression and glucose-stimulated insulin secretion (gsis) were studied. |
2017-07-03 |
2023-08-13 |
rat |
| Guizhen Qiu, Wei Tian, Mei Huan, Jinlong Chen, Haitao F. Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice. Experimental biology and medicine (Maywood, N.J.). vol 242. issue 2. 2017-06-29. PMID:27412955. |
in conclusion, formononetin exhibited anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice by inhibiting islet b cell apoptosis and promoting islet b cell regeneration, insulin secretion, hepatic glycogen synthesis, and hepatic glycolysis. |
2017-06-29 |
2023-08-13 |
mouse |
| Levent Demirtas, Aydin Guclu, Fatih Mehmet Erdur, Emin Murat Akbas, Adalet Ozcicek, Didem Onk, Kultigin Turkme. Apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus. The Indian journal of medical research. vol 144. issue 4. 2017-06-23. PMID:28256459. |
programmed cell death also named apoptosis is found to be associated with diabetes, and apoptosis of beta cells might be the main mechanism of relative insulin deficiency in dm. |
2017-06-23 |
2023-08-13 |
Not clear |
| María S Bianchi, Stefanía Bianchi, Andrés Hernado-Insúa, Leandro M Martinez, Néstor Lago, Carlos Libertun, Norma A Chasseing, Alejandro D Montaner, Victoria A Lux-Lanto. Proposed mechanisms for oligonucleotide IMT504 induced diabetes reversion in a mouse model of immunodependent diabetes. American journal of physiology. Endocrinology and metabolism. vol 311. issue 2. 2017-06-21. PMID:27329801. |
we determined blood glucose, glucose tolerance, serum insulin, islet morphology, islet infiltration, serum cytokines, progenitor cell markers, immunomodulatory proteins, proliferation, apoptosis, and islet gene expression. |
2017-06-21 |
2023-08-13 |
mouse |
| P Luppi, P Drai. C-peptide antioxidant adaptive pathways in β cells and diabetes. Journal of internal medicine. vol 281. issue 1. 2017-06-20. PMID:27251308. |
over the last decade, evidence has accumulated that supports models in which c-peptide, cosecreted with insulin by pancreatic β cells, acts on peripheral targets including the vascular endothelium to reduce oxidative stress and apoptosis subsequent to exposure to diabetic insults. |
2017-06-20 |
2023-08-13 |
human |
| Khalidur Rahman, Yunshan Liu, Pradeep Kumar, Tekla Smith, Natalie E Thorn, Alton B Farris, Frank A Anani. C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 8. 2017-06-19. PMID:27239734. |
four weeks of liraglutide treatment markedly attenuated steatohepatitis in hfcd-fed wt mice by improving insulin sensitivity, and suppressing de novo lipogenesis and er stress-mediated hepatocyte apoptosis. |
2017-06-19 |
2023-08-13 |
mouse |
| Khalidur Rahman, Yunshan Liu, Pradeep Kumar, Tekla Smith, Natalie E Thorn, Alton B Farris, Frank A Anani. C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 8. 2017-06-19. PMID:27239734. |
however, in the absence of chop, liraglutide did not improve insulin sensitivity, nor suppress peroxisomal β-oxidation or er stress-mediated hepatocyte apoptosis. |
2017-06-19 |
2023-08-13 |
mouse |
| Jonàs Juan-Mateu, Tatiana H Rech, Olatz Villate, Esther Lizarraga-Mollinedo, Anna Wendt, Jean-Valery Turatsinze, Letícia A Brondani, Tarlliza R Nardelli, Tatiane C Nogueira, Jonathan L S Esguerra, Maria Inês Alvelos, Piero Marchetti, Lena Eliasson, Décio L Eiziri. Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival. The Journal of biological chemistry. vol 292. issue 8. 2017-06-19. PMID:28077579. |
silencing of elavl4 and nova2 increased beta cell apoptosis, whereas silencing of rbfox1 and rbfox2 increased insulin content and secretion. |
2017-06-19 |
2023-08-13 |
human |
| Zhu Zeng, Rui Yu, Fanglei Zuo, Bo Zhang, Deju Peng, Huiqin Ma, Shangwu Che. Heterologous Expression and Delivery of Biologically Active Exendin-4 by Lactobacillus paracasei L14. PloS one. vol 11. issue 10. 2017-06-13. PMID:27764251. |
the secreted exendin-4 significantly enhanced insulin secretion of ins-1 β-cells, along with an increment in their proliferation and inhibition of their apoptosis, corresponding to the effect of glp-1 on these cells. |
2017-06-13 |
2023-08-13 |
Not clear |
| Aki S Havulinna, Marko Sysi-Aho, Mika Hilvo, Dimple Kauhanen, Reini Hurme, Kim Ekroos, Veikko Salomaa, Reijo Laaksone. Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort. Arteriosclerosis, thrombosis, and vascular biology. vol 36. issue 12. 2017-06-12. PMID:27765765. |
ceramides are molecular lipids implicated in apoptosis, inflammation, obesity, and insulin resistance. |
2017-06-12 |
2023-08-13 |
Not clear |
| Simona Cernea, Avivit Cahn, Itamar Ra. Pharmacological management of nonalcoholic fatty liver disease in type 2 diabetes. Expert review of clinical pharmacology. vol 10. issue 5. 2017-06-08. PMID:28276774. |
hepatic steatosis results as a consequence of excessive hepatic lipid accumulation which correlates with insulin resistance and lipotoxicity, with subsequent oxidative stress, inflammation, apoptosis and fibrosis. |
2017-06-08 |
2023-08-13 |
Not clear |
| Mahendra Prasad Bhatt, Yeon-Ju Lee, Se-Hui Jung, Yong Ho Kim, Jong Yun Hwang, Eun-Taek Han, Won Sun Park, Seok-Ho Hong, Young-Myeong Kim, Kwon-Soo H. C-peptide protects against hyperglycemic memory and vascular endothelial cell apoptosis. The Journal of endocrinology. vol 231. issue 1. 2017-06-05. PMID:27554111. |
c-peptide, but not insulin, also prevented hgm-induced endothelial apoptosis in the murine diabetic aorta. |
2017-06-05 |
2023-08-13 |
mouse |
| Katharina Nimptsch, Annika Steffen, Tobias Pischo. Obesity and Oesophageal Cancer. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. vol 208. 2017-06-05. PMID:27909902. |
other lines of evidence point to an independent role of metabolic pathways modulating cell proliferation, apoptosis and cell growth such as pro-inflammatory cytokines, adipokines and insulin resistance, the role of which in oesophageal carcinogenesis is, however, as to date insufficiently understood. |
2017-06-05 |
2023-08-13 |
Not clear |
| Xavier Palomer, Emma Barroso, Mohammad Zarei, Gaia Botteri, Manuel Vázquez-Carrer. PPARβ/δ and lipid metabolism in the heart. Biochimica et biophysica acta. vol 1861. issue 10. 2017-06-01. PMID:26825692. |
in addition, pparβ/δ regulates glucose metabolism, the cardiac levels of endogenous antioxidants, mitochondrial biogenesis, cardiomyocyte apoptosis, the insulin signaling pathway and lipid-induced myocardial inflammatory responses. |
2017-06-01 |
2023-08-13 |
Not clear |
| Ernest Sargsyan, Konstantin Artemenko, Levon Manukyan, Jonas Bergquist, Peter Bergste. Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response. Biochimica et biophysica acta. vol 1861. issue 9 Pt A. 2017-06-01. PMID:27344025. |
long-term exposure of beta cells to saturated fatty acids impairs insulin secretion and increases apoptosis. |
2017-06-01 |
2023-08-13 |
Not clear |
| E Bucris, A Beck, S Boura-Halfon, R Isaac, Y Vinik, T Rosenzweig, S R Sampson, Y Zic. Prolonged insulin treatment sensitizes apoptosis pathways in pancreatic β cells. The Journal of endocrinology. vol 230. issue 3. 2017-05-31. PMID:27411561. |
prolonged insulin treatment sensitizes apoptosis pathways in pancreatic β cells. |
2017-05-31 |
2023-08-13 |
mouse |
| E Bucris, A Beck, S Boura-Halfon, R Isaac, Y Vinik, T Rosenzweig, S R Sampson, Y Zic. Prolonged insulin treatment sensitizes apoptosis pathways in pancreatic β cells. The Journal of endocrinology. vol 230. issue 3. 2017-05-31. PMID:27411561. |
we conclude that prolonged elevated levels of insulin may prime apoptosis and cell death-inducing mechanisms as a result of oxidative stress in pancreatic cells. |
2017-05-31 |
2023-08-13 |
mouse |