| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mirwais Osmai, Yama Osmai, Claus H Bang-Berthelsen, Emil M H Pallesen, Anna L Vestergaard, Guy W Novotny, Flemming Pociot, Thomas Mandrup-Poulse. MicroRNAs as regulators of beta-cell function and dysfunction. Diabetes/metabolism research and reviews. vol 32. issue 4. 2017-01-09. PMID:26418758. |
even though we are presently in the initial stages of understanding how this novel class of posttranscriptional regulators are involved in diabetes, recent studies have demonstrated that mirnas are important regulators of the islet transcriptome, controlling apoptosis, differentiation and proliferation, as well as regulating unique islet and beta-cell functions and pathways such as insulin expression, processing and secretion. |
2017-01-09 |
2023-08-13 |
Not clear |
| Tianjiao Xu, Yong Liu, Yating Deng, Jin Meng, Ping Li, Xiaoli Xu, Jurong Zen. [Insulin combined with selenium inhibit p38MAPK/CBP pathway and suppresses cardiomyocyte apoptosis in rats with diabetic cardiomyopathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 7. 2017-01-03. PMID:27363274. |
[insulin combined with selenium inhibit p38mapk/cbp pathway and suppresses cardiomyocyte apoptosis in rats with diabetic cardiomyopathy]. |
2017-01-03 |
2023-08-13 |
rat |
| Tianjiao Xu, Yong Liu, Yating Deng, Jin Meng, Ping Li, Xiaoli Xu, Jurong Zen. [Insulin combined with selenium inhibit p38MAPK/CBP pathway and suppresses cardiomyocyte apoptosis in rats with diabetic cardiomyopathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 7. 2017-01-03. PMID:27363274. |
results insulin in combination with selenium significantly inhibited cardiomyocyte apoptosis, increased bcl-2 levels and decreased bax, cyclin d1, cyclin e, p38mapk, p-p38mapk, cbp, ku70 and acetylated ku70 levels. |
2017-01-03 |
2023-08-13 |
rat |
| Tianjiao Xu, Yong Liu, Yating Deng, Jin Meng, Ping Li, Xiaoli Xu, Jurong Zen. [Insulin combined with selenium inhibit p38MAPK/CBP pathway and suppresses cardiomyocyte apoptosis in rats with diabetic cardiomyopathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 7. 2017-01-03. PMID:27363274. |
conclusion the combined treatment of insulin and selenium suppresses cardiomyocyte apoptosis by inhibiting p38mapk/cbp pathway. |
2017-01-03 |
2023-08-13 |
rat |
| Xinyue Liu, Linjing Li, Jing Li, Yan Cheng, Jing Chen, Minghui Shen, Shangdi Zhang, Hulai We. Insulin resistance contributes to multidrug resistance in HepG2 cells via activation of the PERK signaling pathway and upregulation of Bcl-2 and P-gp. Oncology reports. vol 35. issue 5. 2016-12-27. PMID:26935266. |
our results demonstrated that insulin resistance in hepg2 cells promoted a protective unfolded protein response and upregulated the expression of er chaperone protein grp78, which resulted in the phosphorylation of perk kinase to activate the perk-mediated er stress signal transduction pathway and the upregulation of bcl-2 and p-gp, leading to the inhibition of the caspase-3-dependent apoptosis pathway and to the survival of liver tumor cells. |
2016-12-27 |
2023-08-13 |
Not clear |
| Kristine Kloster-Jensen, Afaf Sahraoui, Nils Tore Vethe, Olle Korsgren, Stein Bergan, Aksel Foss, Hanne Schol. Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids. Journal of diabetes research. vol 2016. 2016-12-20. PMID:26885529. |
islet function as well as apoptosis was assessed by glucose-stimulated insulin secretion (gsis) and cell death elisa. |
2016-12-20 |
2023-08-13 |
human |
| Thomas K Sin, Angus P Yu, Benjamin Y Yung, Shea P Yip, Lawrence W Chan, Cesar S Wong, John A Rudd, Parco M Si. Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle. Acta diabetologica. vol 52. issue 6. 2016-12-13. PMID:25959421. |
activation of foxo1 is known to promote apoptosis and disturbances to insulin signalling. |
2016-12-13 |
2023-08-13 |
mouse |
| A Ahmadi, M Khalili, Sh Margedari, B Nahri-Niknaf. The Effects of Solvent Polarity on Hypoglycemic and Hypolipidemic Activities of Securigera Securidaca (L.) Seeds. Drug research. vol 66. issue 3. 2016-12-13. PMID:26125283. |
then antidiabetic and antilipidemic activies of different extracts were investigated in streptozotocine-induced diabetic rats and compared to glibenclamide as known chemical drug for diabetes.the results indicated that, carbon tetrachloride extract of securigera securidaca seeds showed the best and significant hypoglycemic and hypolipidemic activities compared to other extracts because of its more sterols and fatty acids content with beta cells protecting effect from high glucose-induced apoptosis and also increasing in insulin level and sensitivity. |
2016-12-13 |
2023-08-13 |
rat |
| H-S Lee, J-G Lee, H J Yeom, Y S Chung, B Kang, S Hurh, B Cho, H Park, J I Hwang, J B Park, C Ahn, S J Kim, J Yan. The Introduction of Human Heme Oxygenase-1 and Soluble Tumor Necrosis Factor-α Receptor Type I With Human IgG1 Fc in Porcine Islets Prolongs Islet Xenograft Survival in Humanized Mice. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 16. issue 1. 2016-12-13. PMID:26430779. |
both ho-1 and stnf-αr-fc reduced islet apoptosis under in vitro hypoxia or cytokine stimuli and suppressed rantes induction without compromising insulin secretion. |
2016-12-13 |
2023-08-13 |
mouse |
| Jing Gong, Hui Dong, Shu-Jun Jiang, Ding-Kun Wang, Ke Fang, De-Sen Yang, Xin Zou, Li-Jun Xu, Kai-Fu Wang, Fu-Er L. Fenugreek lactone attenuates palmitate-induced apoptosis and dysfunction in pancreatic β-cells. World journal of gastroenterology. vol 21. issue 48. 2016-12-13. PMID:26730156. |
to investigate the effect of fenugreek lactone (fl) on palmitate (pa)-induced apoptosis and dysfunction in insulin secretion in pancreatic nit-1 β-cells. |
2016-12-13 |
2023-08-13 |
Not clear |
| Xiangmin Zhang, Divyasri Damacharla, Danjun Ma, Yue Qi, Rebecca Tagett, Sorin Draghici, Anjaneyulu Kowluru, Zhengping Y. Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells. Molecular and cellular endocrinology. vol 424. 2016-12-13. PMID:26780722. |
our data suggest that pp2a interacts with various signaling proteins necessary for physiological insulin secretion as well as signaling proteins known to regulate cell dysfunction and apoptosis in the pancreatic β-cells. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yingnv Gao, Chen Liu, Guoqing Wan, Xinshuo Wang, Xiaodong Cheng, Yu O. Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2. Food & function. vol 7. issue 2. 2016-12-13. PMID:26805012. |
the β-cell is the main target cell of type 2 diabetes, and its insulin secretion injury and cell apoptosis can be due to mitochondrial dysfunction. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yulia Khodneva, Anath Shalev, Stuart J Frank, April P Carson, Monika M Saffor. Calcium channel blocker use is associated with lower fasting serum glucose among adults with diabetes from the REGARDS study. Diabetes research and clinical practice. vol 115. 2016-12-13. PMID:26818894. |
ca(2+) channel blockers (ccb) and verapamil in particular prevented β-cell apoptosis and enhanced endogenous insulin levels in recent studies of mouse models of diabetes. |
2016-12-13 |
2023-08-13 |
mouse |
| Yumi Imai, Anca D Dobrian, Margaret A Morris, David A Taylor-Fishwick, Jerry L Nadle. Lipids and immunoinflammatory pathways of beta cell destruction. Diabetologia. vol 59. issue 4. 2016-12-13. PMID:26868492. |
the compounds we have identified show promise: they protect beta cell lines and human islets from apoptosis and preserve insulin secretion when challenged by proinflammatory cytokine mixture. |
2016-12-13 |
2023-08-13 |
mouse |
| E M Varin, A Wojtusciszyn, C Broca, D Muller, M A Ravier, F Ceppo, E Renard, J-F Tanti, S Dall. Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4. Cell death & disease. vol 7. 2016-11-09. PMID:26794660. |
tpl2 inhibition protects β-cells, mouse and human islets from cytokine-induced apoptosis and preserves glucose-induced insulin secretion in mouse and human islets exposed to cytokines. |
2016-11-09 |
2023-08-13 |
mouse |
| Wen-qian Dong, Min Chao, Qing-hua Lu, Wei-li Chai, Wei Zhang, Xue-ying Chen, Er-shun Liang, Ling-bo Wang, Hong-liang Tian, Yu-guo Chen, Ming-xiang Zhan. Prohibitin overexpression improves myocardial function in diabetic cardiomyopathy. Oncotarget. vol 7. issue 1. 2016-11-02. PMID:26623724. |
rats with dcm showed severe insulin resistance, left ventricular dysfunction, fibrosis and apoptosis. |
2016-11-02 |
2023-08-13 |
human |
| Emmanuelle Ghys, Matthew Dallemagne, Delphine De Troy, Caroline Sauvegarde, Abdelmounaim Errachid, Isabelle Donna. Female bovine blastocysts are more prone to apoptosis than male ones. Theriogenology. vol 85. issue 4. 2016-10-31. PMID:26506912. |
day 7 blastocysts obtained after ivf with sex-sorted semen and culture in two synthetic oviductal fluid-based media (containing fetal calf serum [fcs] or bsa, insulin, transferrin, and selenium) were simultaneously evaluated for two markers of apoptosis after 3d reconstruction from confocal images: active caspase 3 by immunofluorescence and dna fragmentation by terminal deoxynucleotidyl transferase dutp nick end labeling. |
2016-10-31 |
2023-08-13 |
cattle |
| Uma Bhandari, Vinay Kumar, Parveen Kumar, C D Tripathi, Geetika Khann. Protective effect of pioglitazone on cardiomyocyte apoptosis in low-dose streptozotocin & high-fat diet-induced type-2 diabetes in rats. The Indian journal of medical research. vol 142. issue 5. 2016-10-31. PMID:26658596. |
cardiomyocyte apoptosis is one of the pathologic phenomena associated with diabetes and related conditions including obesity, insulin resistance and hyperlipidaemia. |
2016-10-31 |
2023-08-13 |
rat |
| Suijun Wang, Zhen Yang, Ying Gao, Quanzhong Li, Yong Su, Yanfang Wang, Yun Zhang, Hua Man, Hongxia Li. Pyruvate kinase, muscle isoform 2 promotes proliferation and insulin secretion of pancreatic β-cells via activating Wnt/CTNNB1 signaling. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-28. PMID:26823761. |
cell proliferation by thiazolyl blue assay, cell apoptosis by annexin v-fluorescein isothiocyanate/prodium iodide staining and insulin secretion assay by elisa were performed in each group. |
2016-10-28 |
2023-08-13 |
mouse |
| Suijun Wang, Zhen Yang, Ying Gao, Quanzhong Li, Yong Su, Yanfang Wang, Yun Zhang, Hua Man, Hongxia Li. Pyruvate kinase, muscle isoform 2 promotes proliferation and insulin secretion of pancreatic β-cells via activating Wnt/CTNNB1 signaling. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-28. PMID:26823761. |
its overexpression significantly suppressed nit-1 cell apoptosis (p < 0.01), and induced cell proliferation (p < 0.05) and insulin secretion (p < 0.05). |
2016-10-28 |
2023-08-13 |
mouse |