| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Estela Lorza-Gil, Alessandro G Salerno, Amarylis C B A Wanschel, Jean F Vettorazzi, Mônica S Ferreira, Thiago Rentz, Rodrigo R Catharino, Helena C F Oliveir. Chronic use of pravastatin reduces insulin exocytosis and increases β-cell death in hypercholesterolemic mice. Toxicology. vol 344-346. 2016-07-28. PMID:26875785. |
isolated pancreatic islets were assayed for insulin secretion rates, intracellular calcium oscillations, cholesterol levels, nad(p)h and snare protein levels, apoptosis indicators and lipidomic profile. |
2016-07-28 |
2023-08-13 |
mouse |
| Ştefana Bâlici, Modeste Wankeu-Nya, Dan Rusu, Gheorghe Z Nicula, Mariana Rusu, Adrian Florea, Horea Mate. Ultrastructural Analysis of In Vivo Hypoglycemiant Effect of Two Polyoxometalates in Rats with Streptozotocin-Induced Diabetes. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. vol 21. issue 5. 2016-07-22. PMID:26343528. |
based on our in vivo studies, we concluded that the two poms tested achieved hypoglycemiant effects by preventing stz-triggered apoptosis of pancreatic β-cells and stimulation of insulin synthesis. |
2016-07-22 |
2023-08-13 |
rat |
| Miklós Csal. [Hyper-free fatty acidemia - insulin resistance and β-cell death]. Orvosi hetilap. vol 157. issue 19. 2016-07-22. PMID:27133272. |
activated stress kinases interfere with insulin signaling, and often facilitate apoptosis. |
2016-07-22 |
2023-08-13 |
Not clear |
| R Cassel, S Ducreux, M R Alam, F Dingreville, C Berlé, K Burda-Jacob, M A Chauvin, K Chikh, L Païta, R Al-Mawla, C Crola Da Silva, J Rieusset, C Thivolet, F Van Coppenolle, A M Made. Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon. PloS one. vol 11. issue 2. 2016-07-19. PMID:26862742. |
palmitate treatment was used as ffa model to induce a mild lipotoxic effect: er calcium content was reduced, er stress but not apoptosis were induced and glucose induced insulin secretion was decreased in our beta cells. |
2016-07-19 |
2023-08-13 |
human |
| Jia-An Teng, San-Gang Wu, Jia-Xin Chen, Qiang Li, Fang Peng, Zhou Zhu, Jian Qin, Zhen-Yu H. The Activation of ERK1/2 and JNK MAPK Signaling by Insulin/IGF-1 Is Responsible for the Development of Colon Cancer with Type 2 Diabetes Mellitus. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901856. |
insulin and igf-1 alone or together elevated proliferation and reduced apoptosis in colon cancer mc38 cells. |
2016-07-18 |
2023-08-13 |
mouse |
| Jia-An Teng, San-Gang Wu, Jia-Xin Chen, Qiang Li, Fang Peng, Zhou Zhu, Jian Qin, Zhen-Yu H. The Activation of ERK1/2 and JNK MAPK Signaling by Insulin/IGF-1 Is Responsible for the Development of Colon Cancer with Type 2 Diabetes Mellitus. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901856. |
treatment with erk1/2 or jnk inhibitor in the presence of insulin and igf-1 significantly decreased b-cell lymphoma 2 (bcl-2) and increased bcl-2-associated x protein (bax) expression and finally increased apoptosis and inhibited the proliferation. |
2016-07-18 |
2023-08-13 |
mouse |
| Kyung Min Chung, Hyunhee Park, Seonghee Jung, Shinwon Ha, Seung-Jun Yoo, Hanwoong Woo, Hyang Ju Lee, Seong Who Kim, Eun-Kyoung Kim, Cheil Moon, Seong-Woon Y. Calpain Determines the Propensity of Adult Hippocampal Neural Stem Cells to Autophagic Cell Death Following Insulin Withdrawal. Stem cells (Dayton, Ohio). vol 33. issue 10. 2016-07-06. PMID:26086870. |
we have previously reported that adult rat hippocampal neural stem (hcn) cells underwent autophagic cell death (acd) rather than apoptosis following insulin withdrawal despite their intact apoptotic capabilities. |
2016-07-06 |
2023-08-13 |
rat |
| K Zhao, H Hao, J Liu, C Tong, Y Cheng, Z Xie, L Zang, Y Mu, W Ha. Bone marrow-derived mesenchymal stem cells ameliorate chronic high glucose-induced β-cell injury through modulation of autophagy. Cell death & disease. vol 6. 2016-07-06. PMID:26379190. |
prolonged exposure to hg decreased cell viability, increased cell apoptosis and impaired basal insulin secretion and glucose-stimulated insulin secretion of ins-1 cells, but bm-msc treatment significantly alleviated these glucotoxic alternations. |
2016-07-06 |
2023-08-13 |
rat |
| K Zhao, H Hao, J Liu, C Tong, Y Cheng, Z Xie, L Zang, Y Mu, W Ha. Bone marrow-derived mesenchymal stem cells ameliorate chronic high glucose-induced β-cell injury through modulation of autophagy. Cell death & disease. vol 6. 2016-07-06. PMID:26379190. |
meanwhile, bm-msc infusion upregulated lamp2 expression and enhanced formation of autophagosomes and autolysosomes, combined with reduced β-cell apoptosis and increased number of insulin granules. |
2016-07-06 |
2023-08-13 |
rat |
| Tsung-Yuan Yang, Cheng-Chieh Yen, Kuan-I Lee, Chin-Chuan Su, Ching-Yao Yang, Chin-Ching Wu, Shang-Shu Hsieh, Kwo-Chang Ueng, Chun-Fa Huan. Molybdenum induces pancreatic β-cell dysfunction and apoptosis via interdependent of JNK and AMPK activation-regulated mitochondria-dependent and ER stress-triggered pathways. Toxicology and applied pharmacology. vol 294. 2016-06-29. PMID:26806093. |
in this study, the results revealed dysfunction of insulin secretion and apoptosis in the pancreatic β-cell-derived rin-m5f cells and the isolated mouse islets in response to mo. |
2016-06-29 |
2023-08-13 |
mouse |
| Andre De Souza, Khadija Irfan Khawaja, Faisal Masud, Muhammad Wasif Sai. Metformin and pancreatic cancer: Is there a role? Cancer chemotherapy and pharmacology. vol 77. issue 2. 2016-06-26. PMID:26740120. |
metformin influences various cellular pathways, including activation of the lkb1/ampk pathway, inhibition of cell division, promotion of apoptosis and autophagy, down-regulation of circulating insulin, and activation of the immune system. |
2016-06-26 |
2023-08-13 |
Not clear |
| Nathalie Assayag-Asherie, Dror Sever, Marika Bogdani, Pamela Johnson, Talya Weiss, Ariel Ginzberg, Sharon Perles, Lola Weiss, Lora Eshkar Sebban, Eva A Turley, Elimelech Okon, Itamar Raz, David Nao. Can CD44 Be a Mediator of Cell Destruction? The Challenge of Type 1 Diabetes. PloS one. vol 10. issue 12. 2016-06-23. PMID:26624007. |
expression of cd44 on insulin-secreting β cells renders them susceptible to the autoimmune attack, and is associated with a diminution in β-cells function (e.g., less insulin production and/or insulin secretion) and possibly also with an enhanced apoptosis rate. |
2016-06-23 |
2023-08-13 |
mouse |
| Yufeng Zhang, Haiyan Chen, Dan Chen, Di Wu, Xiaoqiang Chen, Sheng Hua Liu, Jun Yi. A fluorescent turn-on H2S-responsive probe: design, synthesis and application. Organic & biomolecular chemistry. vol 13. issue 38. 2016-06-21. PMID:26252421. |
hydrogen sulfide (h2s) is considered as the third signaling molecule in vivo and it plays an important role in various physiological processes and pathological processes in vivo, such as vasodilation, apoptosis, neurotransmission, ischemia/reperfusion-induced injury, insulin secretion and inflammation. |
2016-06-21 |
2023-08-13 |
Not clear |
| Ruey-Lin Chang, Jing-Wei Lin, Dennis Jine-Yuan Hsieh, Yu-Lan Yeh, Chia-Yao Shen, Cecilia-Hsuan Day, Tsung-Jung Ho, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huan. Long-term hypoxia exposure enhanced IGFBP-3 protein synthesis and secretion resulting in cell apoptosis in H9c2 myocardial cells. Growth factors (Chur, Switzerland). vol 33. issue 4. 2016-06-17. PMID:26340107. |
the accumulated igfbp3 sequestered insulin growth factor 1 (igf-1) away from the type i igf receptor (igf-1 r), which blocked the igf1r/pi3k/akt survival signaling pathway, resulting in cell apoptosis. |
2016-06-17 |
2023-08-13 |
Not clear |
| Swarna Gowri Thota, Rashna Bhandar. The emerging roles of inositol pyrophosphates in eukaryotic cell physiology. Journal of biosciences. vol 40. issue 3. 2016-06-14. PMID:26333405. |
these energy-rich small molecules are present in all eukaryotic cells, from yeast to mammals, and are involved in a wide range of cellular functions including apoptosis, vesicle trafficking, dna repair, osmoregulation, phosphate homeostasis, insulin sensitivity, immune signalling, cell cycle regulation, and ribosome synthesis. |
2016-06-14 |
2023-08-13 |
Not clear |
| Thierry Ntimbane, Geneviève Mailhot, Schohraya Spahis, Remi Rabasa-Lhoret, Marie-Laure Kleme, Danielle Melloul, Emmanuelle Brochiero, Yves Berthiaume, Emile Lev. CFTR silencing in pancreatic β-cells reveals a functional impact on glucose-stimulated insulin secretion and oxidative stress response. American journal of physiology. Endocrinology and metabolism. vol 310. issue 3. 2016-06-14. PMID:26625901. |
the decreased insulin secretion in cftr-silenced min6 cells was associated with high levels of nf-κb (the major participant in inflammatory responses), raised apoptosis, and diminished atp production in response to the fe/asc challenge. |
2016-06-14 |
2023-08-13 |
human |
| Deng Hao, Zhen-yu Ding, Chuan Wang, Shuang-qing Li, He He, Li-bo Lian. [Effects of VEGF on Proliferation, Apoptosis and Insulin Secretion in Rat Pancreatic Islet Cells]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 47. issue 1. 2016-06-10. PMID:27062778. |
[effects of vegf on proliferation, apoptosis and insulin secretion in rat pancreatic islet cells]. |
2016-06-10 |
2023-08-13 |
rat |
| Deng Hao, Zhen-yu Ding, Chuan Wang, Shuang-qing Li, He He, Li-bo Lian. [Effects of VEGF on Proliferation, Apoptosis and Insulin Secretion in Rat Pancreatic Islet Cells]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 47. issue 1. 2016-06-10. PMID:27062778. |
to investigate the effect of vascular endothelial growth factor (vegf) on proliferation, apoptosis, insulin secretion and related gene expression in rat pancreatic islet cell (ins-1). |
2016-06-10 |
2023-08-13 |
rat |
| Boris L Gala-Lopez, Andrew R Pepper, Rena L Pawlick, Doug O'Gorman, Tatsuya Kin, Antonio Bruni, Nasser Abualhassan, Mariusz Bral, Austin Bautista, Jocelyn E Manning Fox, Lachlan G Young, Patrick E MacDonald, A M James Shapir. Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice. Diabetes. vol 65. issue 2. 2016-06-01. PMID:26581595. |
the addition of aagp reduced oxidative stress, enhanced insulin exocytosis, improved apoptosis, and improved engraftment in mice by decreasing expression of interleukin (il)-1β, il-6, keratinocyte chemokine, and tumor necrosis factor-α. |
2016-06-01 |
2023-08-13 |
mouse |
| Alper Sonmez, Cem Haymana, Aydogan Aydogdu, Serkan Tapan, Yalcin Basaran, Coskun Meric, Kamil Baskoy, Mustafa Dinc, Mahmut Yazici, Abdullah Taslipinar, Cem Barcin, Mahmut Ilker Yilmaz, Erol Bolu, Omer Aza. Endothelial dysfunction, insulin resistance and inflammation in congenital hypogonadism, and the effect of testosterone replacement. Endocrine journal. vol 62. issue 7. 2016-05-24. PMID:25924666. |
the demographic parameters, asymmetric dimethylarginine (adma), tnf-like weak inducer of apoptosis (tweak), high sensitive c reactive protein (hs-crp) and homeostatic model assessment of insulin resistance (homa-ir) levels were measured before and after trt. |
2016-05-24 |
2023-08-13 |
human |