| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y-F Shi, N Liu, Y-X Li, C-L Song, X-J Song, Z Zhao, B Li. Insulin protects H9c2 rat cardiomyoblast cells against hydrogen peroxide-induced injury through upregulation of microRNA-210. Free radical research. vol 49. issue 9. 2016-05-24. PMID:25968948. |
insulin protects cardiomyocytes from reactive oxygen species (ros)-induced apoptosis after ischemic/reperfusion injury, but the mechanism is not clear. |
2016-05-24 |
2023-08-13 |
rat |
| Y-F Shi, N Liu, Y-X Li, C-L Song, X-J Song, Z Zhao, B Li. Insulin protects H9c2 rat cardiomyoblast cells against hydrogen peroxide-induced injury through upregulation of microRNA-210. Free radical research. vol 49. issue 9. 2016-05-24. PMID:25968948. |
this study investigated the protective mechanism of insulin in preventing cardiomyocyte apoptosis from ros injury. |
2016-05-24 |
2023-08-13 |
rat |
| Daniel-Constantin Manolescu, Marek Jankowski, Bogdan A Danalache, Donghao Wang, Tom L Broderick, Jean-Louis Chiasson, Jolanta Gutkowsk. All-trans retinoic acid stimulates gene expression of the cardioprotective natriuretic peptide system and prevents fibrosis and apoptosis in cardiomyocytes of obese ob/ob mice. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 39. issue 10. 2016-05-20. PMID:25017112. |
we hypothesized that all-trans ra (atra) treatment will improve the cardioprotective oxytocin-natriuretic peptides (ot-np) system, preventing apoptosis and collagen accumulation in hearts of ob/ob mice, a mouse model of obesity and insulin resistance. |
2016-05-20 |
2023-08-13 |
mouse |
| Ana Ines Cases, Takao Ohtsuka, Hideyo Kimura, Biao Zheng, Koji Shindo, Yoshinao Oda, Kazuhiro Mizumoto, Masafumi Nakamura, Masao Tanak. Significance of expression of glucagon-like peptide 1 receptor in pancreatic cancer. Oncology reports. vol 34. issue 4. 2016-05-20. PMID:26238361. |
glucagon-like peptide 1 (glp-1) induces insulin secretion and proliferation of pancreatic β-cells, and inhibits their apoptosis through the glp-1 receptor (glp-1r), thus providing a foundation for using glp-1-based therapies for the treatment of type 2 diabetes. |
2016-05-20 |
2023-08-13 |
Not clear |
| Jonathan M Locke, Hana Lango Allen, Lorna W Harrie. A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta diabetologica. vol 51. issue 2. 2016-05-19. PMID:23828613. |
changes in the levels of specific micrornas (mirnas) can reduce glucose-stimulated insulin secretion and increase beta-cell apoptosis, two causes of islet dysfunction and progression to type 2 diabetes. |
2016-05-19 |
2023-08-12 |
Not clear |
| Changhwan Ahn, Beum-Soo An, Eui-Bae Jeun. Streptozotocin induces endoplasmic reticulum stress and apoptosis via disruption of calcium homeostasis in mouse pancreas. Molecular and cellular endocrinology. vol 412. 2016-05-17. PMID:26003140. |
calcium acts not only as a ubiquitous second messenger involved in apoptosis along with various cell death inducers but also a regulator for the synthesis of enzymes/hormones such as insulin. |
2016-05-17 |
2023-08-13 |
mouse |
| Dan Lv, Jinye Liu, Lianying Guo, Dawei Wu, Ken Matsumoto, Lin Huan. PRAS40 deregulates apoptosis in Ewing sarcoma family tumors by enhancing the insulin receptor/Akt and mTOR signaling pathways. American journal of cancer research. vol 6. issue 2. 2016-05-17. PMID:27186418. |
pras40 deregulates apoptosis in ewing sarcoma family tumors by enhancing the insulin receptor/akt and mtor signaling pathways. |
2016-05-17 |
2023-08-13 |
Not clear |
| Q-A Altaf, A H Barnett, A A Tahran. Novel therapeutics for type 2 diabetes: insulin resistance. Diabetes, obesity & metabolism. vol 17. issue 4. 2016-05-13. PMID:25308775. |
such treatments need to be specific and reversible as many of the components of the insulin signalling pathway are involved in other cellular functions such as apoptosis. |
2016-05-13 |
2023-08-13 |
Not clear |
| Beom Seob Lee, Jaewon Oh, Sung Ku Kang, Sungha Park, Sang-Hak Lee, Donghoon Choi, Ji Hyung Chung, Youn Wook Chung, Seok-Min Kan. Insulin Protects Cardiac Myocytes from Doxorubicin Toxicity by Sp1-Mediated Transactivation of Survivin. PloS one. vol 10. issue 8. 2016-05-10. PMID:26271039. |
insulin inhibits ischemia/reperfusion-induced myocardial apoptosis through the pi3k/akt/mtor pathway. |
2016-05-10 |
2023-08-13 |
Not clear |
| Beom Seob Lee, Jaewon Oh, Sung Ku Kang, Sungha Park, Sang-Hak Lee, Donghoon Choi, Ji Hyung Chung, Youn Wook Chung, Seok-Min Kan. Insulin Protects Cardiac Myocytes from Doxorubicin Toxicity by Sp1-Mediated Transactivation of Survivin. PloS one. vol 10. issue 8. 2016-05-10. PMID:26271039. |
taken together, insulin pretreatment confers a protective effect against doxorubicin-induced cardiotoxicity by promoting sp1-mediated transactivation of survivin to inhibit apoptosis. |
2016-05-10 |
2023-08-13 |
Not clear |
| Laia Salvadó, Xavier Palomer, Emma Barroso, Manuel Vázquez-Carrer. Targeting endoplasmic reticulum stress in insulin resistance. Trends in endocrinology and metabolism: TEM. vol 26. issue 8. 2016-05-06. PMID:26078196. |
this response is linked to different processes involved in the development of insulin resistance (ir) and t2dm, including inflammation, lipid accumulation, insulin biosynthesis, and β-cell apoptosis. |
2016-05-06 |
2023-08-13 |
Not clear |
| Xiang Kong, Guo-Dong Wang, Ming-Zhe Ma, Ru-Yuan Deng, Li-Qun Guo, Jun-Xiu Zhang, Jie-Ren Yang, Qing S. Sesamin Ameliorates Advanced Glycation End Products-Induced Pancreatic β-Cell Dysfunction and Apoptosis. Nutrients. vol 7. issue 6. 2016-05-03. PMID:26066015. |
insulin content, ros generation and β-cell apoptosis in pancreatic islets were also measured. |
2016-05-03 |
2023-08-13 |
mouse |
| Yue-Yue Zhou, Xiong-Fei Ji, Jian-Ping Fu, Xiao-Juan Zhu, Rong-Hua Li, Chang-Kao Mu, Chun-Lin Wang, Wei-Wei Son. Gene Transcriptional and Metabolic Profile Changes in Mimetic Aging Mice Induced by D-Galactose. PloS one. vol 10. issue 7. 2016-05-03. PMID:26176541. |
the effects of d-galactose on aging could be attributed to glucose and 1ipid metabolic disorders, oxidative damage, accumulation of advanced glycation end products (ages), reduction in abnormal substance elimination, cell apoptosis, and insulin resistance. |
2016-05-03 |
2023-08-13 |
mouse |
| Lingyu Pan, Hongbo Weng, Hong Li, Zhenzhen Liu, Yanyan Xu, Chunjiao Zhou, Xiaoxiao Lu, Xiaoyu Su, Yunyi Zhang, Daofeng Che. Therapeutic Effects of Bupleurum Polysaccharides in Streptozotocin Induced Diabetic Mice. PloS one. vol 10. issue 7. 2016-05-02. PMID:26176625. |
additionally, bps adminstration improved the insulin expression and suppressed the apoptosis in pancreas of the diabetic mice. |
2016-05-02 |
2023-08-13 |
mouse |
| Kenneth Maies. Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR. Neural regeneration research. vol 11. issue 3. 2016-04-29. PMID:27127460. |
mtor and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis, insulin resistance, insulin secretion, stem cell proliferation and differentiation, pancreatic β-cell function, and programmed cell death with apoptosis and autophagy. |
2016-04-29 |
2023-08-13 |
Not clear |
| Kanikkai Raja Aseer, Sang Woo Kim, Myung-Sook Choi, Jong Won Yu. Opposite Expression of SPARC between the Liver and Pancreas in Streptozotocin-Induced Diabetic Rats. PloS one. vol 10. issue 6. 2016-04-22. PMID:26110898. |
taken together, opposite expression of sparc in the diabetic liver and pancreas may be related to inflammation and immune cell infiltration, degrees of apoptosis and fibrosis, cytoprotective machinery, and cellular insulin levels. |
2016-04-22 |
2023-08-13 |
rat |
| Xin Tong, Deqiang Zhang, Blake Arthurs, Pei Li, Leigh Durudogan, Neil Gupta, Lei Yi. Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes. PloS one. vol 10. issue 6. 2016-04-19. PMID:26075729. |
elevated levels of serum saturated fatty acid palmitate have been shown to promote insulin resistance, increase cellular ros production, and trigger cell apoptosis in hepatocytes during the development of obesity. |
2016-04-19 |
2023-08-13 |
Not clear |
| Takhar Kasumov, Ling Li, Min Li, Kailash Gulshan, John P Kirwan, Xiuli Liu, Stephen Previs, Belinda Willard, Jonathan D Smith, Arthur McCulloug. Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis. PloS one. vol 10. issue 5. 2016-04-18. PMID:25993337. |
wd caused hepatic oxidative stress, inflammation, apoptosis, increased hepatic long-chain ceramides associated with apoptosis (c16 and c18) and decreased very-long-chain ceramide c24 involved in insulin signaling. |
2016-04-18 |
2023-08-13 |
mouse |
| Jun Wada, Hirofumi Makin. Innate immunity in diabetes and diabetic nephropathy. Nature reviews. Nephrology. vol 12. issue 1. 2016-04-14. PMID:26568190. |
this review describes how innate immune system-driven inflammatory processes can lead to apoptosis, tissue fibrosis, and organ dysfunction resulting in insulin resistance, impaired insulin secretion, and renal failure. |
2016-04-14 |
2023-08-13 |
Not clear |
| Anna Motterle, Sonia Gattesco, Dorothée Caille, Paolo Meda, Romano Regazz. Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice. Diabetologia. vol 58. issue 8. 2016-04-13. PMID:26037202. |
exposure of pancreatic beta cells to cytokines released by islet-infiltrating immune cells induces alterations in gene expression, leading to impaired insulin secretion and apoptosis in the initial phases of type 1 diabetes. |
2016-04-13 |
2023-08-13 |
mouse |